Abstract: The present disclosure provides compositions and methods for efficient and effective protein delivery in vitro and in vivo. In some aspects, proteins are reversibly crosslinked to each other and/or modified with functional groups and protected from protease degradation by a polymer-based or silica-based nanoshell.

Abstract: The invention provides methods for treating tissue damage associated with impaired blood flow using ApoD, or an active variant thereof, or an agent that increases the expression of ApoD. The invention also encompasses active variants of ApoD for use in the methods.

Abstract: An electrolytic recycling method recovers two or more component elements of one or more compounds simultaneously. A compound, such as a compound semiconductor, to be recycled is dissolved in a liquid electrolyte. Electrolysis of the dissolved compound recovers component elements simultaneously at respective negative and positive electrodes by reduction and oxidation respectively. The component elements produced may be in respective condensed phases or include a gaseous phase.

Abstract: Systems and methods for altering neurite growth are generally described. In some embodiments, a system may include a neuron comprising a neurite and electrodes able to generate a physical guidance cue. The physical guidance cue may be used to alter the growth of the neurite and may be temporally and spatially dynamic, such that neurite growth may be altered in a spatial and/or temporal manner. Dynamic control of neurite growth may be used to form directional neural connections, intersections, and/or overlaps.

Abstract: Systems and methods for altering neurite growth are generally described. In some embodiments, a system may include a neuron comprising a neurite and electrodes able to generate a physical guidance cue. The physical guidance cue may be used to alter the growth of the neurite and may be temporally and spatially dynamic, such that neurite growth may be altered in a spatial and/or temporal manner. Dynamic control of neurite growth may be used to form directional neural connections, intersections, and/or overlaps.

Abstract: Multi-resolution encoded files are stored on a plurality of disk drives using systematic network coded storage. In some embodiments, the stored files are used to provide video streaming services for users.

Abstract: An insertable light-dispensing catheter device, comprising a shaft including a proximal and distal end, a light guide extending through the shaft, and a mirror displaceably extendable from the catheter into a position where the mirror receives and reflects light emitted from the light guide. The mirror can be in the form of a coating on an inflatable balloon; and the balloon, when inflated, can press a patch against a defect (e.g., a ventricular septical defect), while the light cures an adhesive that binds the patch to the structure with the defect, thereby remedying the defect.

Abstract: There is provided a photodiode array including a semiconducting substrate and a plurality of photodiodes that are disposed at a surface of the substrate. Each photodiode is laterally spaced apart from neighboring photodiodes by a lateral substrate surface region. An optical interface surface of the substrate is arranged for accepting external input radiation. A plurality of electrically conducting fuses are disposed on the substrate surface. Each fuse is connected to a photodiode in the plurality of photodiodes. Each fuse is disposed at a lateral substrate surface region that is spaced apart from neighboring photodiodes in the plurality of photodiodes.

Abstract: Systems, methods, and apparatus are provided for tuning a functional property of a device. The device (210) includes a layer of a dielectric material (214) disposed over and forming an interface (216) with a layer of an electrically conductive target material (222). The dielectric material layer includes at least one ionic species having a high ion mobility. The target material is configured such that a potential difference applied to the device can cause the at least one ionic species to migrate reversibly across the interface into or out of the target material layer. The mobility of the at least one ionic species can be tuned by exposing the device to electromagnetic radiation and/or a temperature change.

Abstract: Methods and system for solid phase peptide synthesis are provided. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. New amino acid residues are added via a coupling reaction between an activated amino acid and an amino acid residue of the immobilized peptide. Amino acids may be activated using, e.g., a base and an activating agent. Certain inventive concepts, described herein, relate to methods and systems for the activation of amino acids. These systems and methods may allow for fewer side reactions and a higher yield compared to conventional activation techniques as well as the customization of the coupling reaction on a residue-by-residue basis without the need for costly and/or complex processes.

Abstract: Methods and systems for control of solid phase peptide synthesis are generally described. Control of solid phase peptide synthesis involves the use of feedback from one or more reactions and/or processes (e.g., reagent removal) taking place in the solid phase peptide synthesis system. In some embodiments, a detector may detect one or more fluids flowing across a detection zone of a solid phase peptide synthesis system and one or more signals may be generated corresponding to the fluid(s). For instance, an electromagnetic radiation detector positioned downstream of a reactor may detect a fluid exiting the reactor after a deprotection reactor and produce a signal(s). In some embodiments, based at least in part on information derived from the signal(s), a parameter of the system may be modulated prior to and/or during one or more subsequent reactions and/or processes taking place in the solid phase peptide synthesis system.

Abstract: Methods and apparatuses for bonding polymeric parts are disclosed. Specifically, in one embodiment, the polymeric parts are bonded by plastically deforming them against each other while they are below the glass transition temperatures. A method includes: placing a first polymeric part in contact with a second polymeric part; and plastically deforming the first polymeric part and the second polymeric part against each other to bond the first polymeric part to the second polymeric part. Additionally, during the plastic deformation, a temperature of the first polymeric part is less than a glass transition temperature of the first polymeric part and a temperature of the second polymeric part is less than a glass transition temperature of the second polymeric part.

Abstract: Reflectors for solar concentration and methods for formation thereof. A reflective assembly (1340) may include a plurality of elongate panels (370) forming a continuous trough (1330), and a frame (1230) configured to support the panels, with the frame with attached panels defining a parabolic contour on the top side of the trough.

Abstract: An integrated circuit (400) adapted for mobile communication is disclosed. The circuit comprises a first device layer formed of a first semiconductor material and having at least a first circuit portion (402); and a second device layer formed of a second semiconductor material different to the first semiconductor material and having at least a second circuit portion (404), wherein the first and second device layers are integrally formed, and the first circuit portion is electrically coupled to the second circuit portion to enable the mobile communication using first and second wireless communication protocols. A related mobile computing device is also disclosed.

Abstract: In exemplary implementations of this invention, a main content feed is displayed on a main screen. A user may select one or more auxiliary feeds of content to display simultaneously on a second screen. The second screen is located on a handheld device. The user makes the selection by changing the orientation of the handheld device relative to the main screen. For example, the user may select which auxiliary feed to display by pointing the device at different areas that are around the periphery of the main screen. The handheld device includes one or more sensors for gathering data, and one or more processors for (a) processing the sensor data to calculate the orientation of the handheld device relative to the main screen and (b) based at least in part on that orientation, selecting which of the auxiliary feeds to display.

Abstract: Ultra-wide bandwidth (UWB) transmission is a promising technology for indoor localization due to its fine delay resolution and obstacle-penetration capabilities. However, the presence of walls and other obstacles present a significant challenge in terms of localization, as they result in positively biased distance estimates. Measurement campaigns with FCC-compliant UWB radios can quantify effects of non-line-of-sight (NLOS) propagation. Features of waveforms measured during a campaign can be extracted for use in distinguishing between NLOS and line-of-sight situations in embodiments of the present invention. Embodiments further include classification and regression methods based on machine learning that improve the localization performance while relying solely on the received signal. Applications for systems employing an example embodiment of the invention include indoor or outdoor search and recovery with high accuracy and low cost.

Abstract: A distributed traffic signal control method is provided for a directed network comprising a plurality of junctions, each junction having a plurality of links connected thereto, the links comprising one or more upstream links and one or more downstream links, the method comprising: activating one of a plurality of phases of the junction for a predetermined time period which maximizes the directed network throughput based on current differential traffic backlogs between said one or more upstream links and said one or more downstream links, each phase providing a unique combination of traffic signals at the junction for guiding traffic from the upstream link(s) to the downstream link(s). There is also provided a corresponding traffic signal controller, a traffic control system comprising the traffic signal controller, and a computer readable medium having stored therein computer executable codes for instructing a computer processor to execute the distributed traffic signal control method.

Abstract: Disclosed are methods of preparing antifouling coatings on reverse osmosis membranes with initiated chemical vapor deposition. The coatings enhance the stability and lifetime of membranes without sacrificing performance characteristics, such as permeability or salt retention.

Abstract: Nonlinear spring. In one embodiment, the spring includes two opposed curved surfaces curving away from one another. A flexible cantilever member is disposed between the two opposed curved surfaces and a mass is attached to a free end of the cantilever member wherein the flexible cantilever member wraps around one of the curved surfaces as the cantilever member deflects to form a nonlinear spring. Energy harvesting devices and a load cell are also disclosed.

Abstract: The invention specifies the use of feedback in the radio frequency (RF) drive for a synchrocyclotron, controlling the phase and/or amplitude of the accelerating field as a means to assure optimal acceleration of the beam, to increase the average beam current and to alter the beam orbit in order to allow appropriate extraction as the beam energy is varied. The effect of space charge is reduced by rapid acceleration and extraction of the beam, and the repetition rate of the pulses can be increased. Several means are presented to monitor the phase of the beam in synchrocyclotrons and to adjust the phase and amplitude of the RF to optimize the acceleration of the beam and to adjust the extraction and injection of the beam. Also, the use of a pulsed ion source that matches the acceptance window of the synchrocyclotron is described.