Abstract: A detector can detect an analyte including a carbon-carbon multiple bond moiety and capable of undergoing Diels-Alder reaction with a heteroaromatic compound having an extrudable group. The detector can detect, differentiate, and quantify ethylene.

Abstract: According to some aspects, a method of designing a three-dimensional object based on a shape of the object, the object to be fabricated via additive fabrication from a plurality of materials, is provided. The method comprises selecting, for a first volume element of the object, one of the plurality of materials based at least in part on a position of the first volume element within the object, at least one spatial decomposition of the object, the at least one spatial decomposition identifying a plurality of volumetric subregions of the object, and a material composition of at least a first volumetric subregion of the plurality of volumetric subregions, wherein the first volumetric subregion comprises the position of the first volume element.

Abstract: Message dissemination speed is increased during multicast operations in a network by intelligently selecting one or more feedback time slots for use by destination nodes. In at least one implementation, a feedback time slot is selected based upon probabilities that a plurality of data packets will be successfully distributed to a plurality of destination nodes by various future time slots. These probabilities may be estimated based on, for example, packet erasure probabilities in the network. In some implementations, only destination nodes that have not yet successfully received a plurality of data packets are permitted to transmit feedback during feedback time slots.

Abstract: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U, J, V, X, R2a, R2b, R2c, R5 and t are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. These compounds are useful for promoting cognitive function and enhancing learning and memory formation. In addition, these compounds are useful for treating, alleviating, and/or preventing various conditions, including for example, neurological disorders, memory and cognitive function disorders/impairments, extinction learning disorders, fungal diseases and infections, inflammatory diseases, hematological diseases, and neoplastic diseases in humans and animals.

Abstract: This disclosure describes techniques and systems for extracting energy from the endocochlear potential (EP) in animal subjects (e.g., human subjects) and using the extracted energy to operate circuits (e.g., electronic device, sensors, and transmitters). The subject matter of this disclosure is embodied, for example, in a system for extracting energy from an endocochlear potential of an animal, wherein the system includes a pair of electrodes, and a circuit coupled to the pair of electrodes. The circuit includes a boost converter, an energy buffer component configured to receive voltage from the boost converter, a start-up rectifier configured to provide voltage to the energy buffer component, and a control component configured to provide control signals to the boost converter. The power extracted from the endocochlear potential is equal or larger than the quiescent power of the circuit.

Abstract: An apparatus for detecting electromagnetic radiation within a target frequency range is provided. The apparatus includes a substrate and one or more resonator structures disposed on the substrate. The substrate can be a dielectric or semiconductor material. Each of the one or more resonator structures has at least one dimension that is less than the wavelength of target electromagnetic radiation within the target frequency range, and each of the resonator structures includes at least two conductive structures separated by a spacing. Charge carriers are induced in the substrate near the spacing when the resonator structures are exposed to the target electromagnetic radiation. A measure of the change in conductivity of the substrate due to the induced charge carriers provides an indication of the presence of the target electromagnetic radiation.

Abstract: Systems and methods are disclosed that provide high-level, ontology-based analysis of low-level data stored within an unstructured key/value store. The systems and methods allow an analyst to make sense of massive amounts of data from diverse sources without having any knowledge of the underlying physical data storage. Additional features include feasibility queries to determine if requested data exists in the key/value store before performing an expensive query; automatic query optimization using secondary indexes; and a usage history service to identify performance bottlenecks and fine tune the storage schema.

Abstract: Disclosed are fibers that include a composite of at least three different materials, where the at least three different materials include a conductor, an insulator, and a non-centrosymmetric material, and where each material is disposed in one or more different cross-sectional regions of the fiber, with each region extending along a common length of the fiber.

Abstract: Distributed content caching is implemented in an efficient, low cost manner within a content delivery network (CDN). In various embodiments, content is identified for caching at a number of gateway devices within a CDN by minimizing a cost function associated with content delivery in the network. The cost function may take into consideration costs of delivering content to users from gateway devices as well as costs associated with delivering content to users from centralized locations of a CDN.

Abstract: An electropermanent linear actuator has a stator, forcer, drive circuitry, and feedback control mechanism. The stator includes at least one electropermanent magnet with a coil that passes current pulses that change the magnetization of the magnet, which change persists after current is removed. The forcer moves with respect to the stator in response to the persistent changes in magnetization. Drive circuitry controls the position or speed of the actuator by controlling the timing, magnitude, and/or shape of the current pulses. The voltage and duration of pulses are of sufficient magnitude to cause the magnetization change to persist after cessation of current, with voltage and current returning substantially to zero between pulses. The feedback control mechanism determines, based on actuator velocity or position, when the next current pulse should be issued, pulse issuance being timed so that the actuator will continue to move throughout the absence of applied current between pulses.

Abstract: The present invention provides multi-tailed lipid compounds, and salts and stereoisomers thereof, and methods of preparing the compounds. Also provided are compositions including a compound of the invention and an agent (e.g., an siRNA, mRNA, plasmid DNA, small molecule, protein, peptide). The present invention also provides methods, and kits using the compositions for delivering an agent to a subject (e.g., to the liver, spleen, or lung of the subject) or cell and for treating and/or preventing a range of diseases, such as genetic diseases, proliferative diseases, hematological diseases, neurological diseases, immunological diseases, gastrointestinal diseases (e.g., liver diseases), respiratory diseases (e.g., lung diseases), painful conditions, psychiatric disorders, metabolic disorders, and spleen diseases.

Abstract: A volume holographic imaging system, apparatus and/or method enables the projection of a two-dimensional (2D) slice of a four-dimensional (4D) probing object A 4D probing source object is illuminated to emit or scatter an optical field. A holographic element having one or more recorded holograms receives and diffracts the optical field into a diffracted plane beam having spectral information. A 4-ftelecentric relay system includes a pupil filter on the relayed conjugate plane of the volume hologram and images the pupil of the volume hologram onto the front focal plane of the collector lens. A collector lens focuses the diffracted plane beam to a 2D slice of the 4D probing source object. The focused 2D slice is projected onto a 2D imaging plane. The holographic element may have multiple multiplexed holograms that are arranged to diffract light from the corresponding slice of the 4D probing source object.

Abstract: The present invention provides polymeric materials arranged as photonic crystals, or portions of photonic crystals, having properties which can be easily tuned over a large range of wavelengths upon exposure to an external stimulus. In some embodiments, the photonic crystals comprise at least one portion which can undergo a change in a physical, chemical, dielectric, or other property upon exposure to an altering stimulus, resulting in a change in a diffracted wavelength of electromagnetic radiation (e.g, light) by the photonic crystal. Embodiments of the invention may advantageously exhibit large stop band tunability and rapid response times. Photonic crystals of the invention may be useful in a wide variety of applications, such as colorimetric sensors, active components of simple display devices, electrically controlled tunable optically pumped laser, photonic switches, multiband filters, and the like.

Abstract: The invention relates to recombinant expression of a taxadiene synthase enzyme and a geranylgeranyl diphosphate synthase (GGPPS) enzyme in cells and the production of terpenoids.

Abstract: The present disclosure provides protein-containing compositions, methods and uses thereof. A conjugate comprises a globular protein conjugated with a polymer that preserves the folded and functional structure of a protein. In some embodiments, a fusion protein comprises a globular protein conjugated with an elastin-mimic polymer (EMP). Also disclosed is an assembled solid-state or gel-state nanostructure comprising a plurality of conjugates, wherein each comprises a globular protein conjugated with a polymer that preserving the folded and functional structure of a protein. In certain embodiments, provided compositions and methods further comprise an additive.

Abstract: An ionic liquid ion source can include a microfabricated body including a base and a tip. The body can be formed of a porous material compatible with at least one of an ionic liquid or room-temperature molten salt. The body can have a pore size gradient that decreases from the base of the body to the tip of the body, such that the at least one of an ionic liquid or room-temperature molten salt is capable of being transported through capillarity from the base to the tip.

Abstract: Data blocks to be stored on a disk-based data storage device (e.g., a hard disk drive, etc.) are coded together to form a plurality of linearly independent network coded blocks. The network coded blocks are then stored on the data storage device. Coded seeking may then be used to retrieve the original data blocks from the data storage device in a time-efficient manner. A read request may be sent to the data storage device requesting an innovative coded packet associated with the original data blocks. In response to the read request, the data storage device may read an innovative coded packet from the disk that is closest to current position of a read element of the device.

Abstract: A system and method for creating three-dimensional nanostructures is disclosed. The system includes a substrate bonded to a carrier using a bonding agent. The bonding agent may be vaporizable or sublimable. The carrier may be a glass or glass-like substance. In some embodiments, the carrier may be permeable having one or a plurality of pores through which the bonding agent may escape when converted to a gaseous state with heat, pressure, light or other methods. A substrate is bonded to the carrier using the bonding agent. The substrate is then processed to form a membrane. This processing may include grinding, polishing, etching, patterning, or other steps. The processed membrane is then aligned and affixed to a receiving substrate, or a previously deposited membrane. Once properly attached, the bonding agent is then heated, depressurized or otherwise caused to sublime or vaporize, thereby releasing the processed membrane from the carrier.

Abstract: Systems and methods in which the flow of fluid is electrically driven, including electrospinning and electrospraying systems and methods, are generally described.

Abstract: The present invention provides a device and methods of use thereof in concentrating a species of interest and/or controlling liquid flow in a device. The methods make use of a device comprising a fluidic chip comprising a planar array of channels through which a liquid comprising a species of interest can be made to pass with at least one rigid substrate connected thereto such that at least a portion of a surface of the substrate bounds the channels, and a high aspect ratio ion-selective membrane is embedded within the chip, attached to at least a portion of the channels. The device comprises a unit to induce an electric field in the channel and a unit to induce an electrokinetic or pressure driven flow in the channel.