Abstract: A drop on demand printer has a nozzle with an orifice and a surrounding annular land. Surrounding the land is an edge, which is surrounded by a perimetrical surface that is inclined to the land at an angle ?. A pressure controller maintains a positive overpressure on liquid to be printed such that a cap of liquid is substantially always present covering the orifice and the land. The edge between the land and the perimetrical surface prevents liquid from overflowing, and maintains the cap, if the pressure is maintained between lower and upper limits disclosed. The liquid to be printed preferably wets the orifice land, which may be alumina, glass, ceramic, and others. Liquids with very small, even zero, wetting angles relative to the land may be used, such as water and organic solvents, including, isopropyl and ethyl alcohol and chloroform. The liquid can be loaded with dissolved polymers, or particles, such as of polymer or ceramic.

Abstract: A new feedback linearization approach to advanced control of single-unit and multi-unit HVAC systems is described. In accordance with the approach of the invention, this new nonlinear control includes a model-based feedback linearization part to compensate for the nonlinearity in the system dynamics. Therefore, the evaporating temperature and superheat values can be controlled by linear PI control designs to achieve desired system performance and reliability. The main advantages of the new nonlinear control approach include (1) better performance even with large model errors, (2) being able to adapt to indoor unit turn on/off operation, (3) much smaller PI control gains compared to that of current feedback PI controls, (4) much easier design procedures since there is no need for tuning the PI control gains over wide range operation.

Abstract: A device for converting frequency of electromagnetic radiation includes a nonlinear medium that forms a moving grating in the nonlinear medium by introducing at opposite ends of the nonlinear medium a first set of electromagnetic radiation having varying frequencies. Electromagnetic radiation is inputted into the nonlinear medium at a first frequency and extracted at a second frequency from the nonlinear medium. The moving grating in the nonlinear medium allows for electromagnetic radiation to be converted into the second frequency.

Abstract: A method for fabricating metal glasses in bulk form uses electrodeposition. Careful control is maintained of: (i) bath chemistry, (ii) deposition temperature; and (iii) electrical plating conditions, such as the current density, for an extended period of time, such as six hours. Composition of electrodeposition liquid is closely controlled, and adjusted when it differs from desired. Monitoring can be active, as by spectrophotometric analysis, or by comparison of time to a calibration table. A dissolving anode can replenish depleted components. Temperature of the liquid is typically maintained within ±2° C.

Abstract: The invention relates to the immobilization of polysaccharides on a substrate. In particular, the invention relates to biologically active surfaces formed by the immobilization of glycosaminoglycans on a substrate. The invention also provides biologically active surfaces that contain one or more different glycosaminoglycans and, optionally, one or more other agents. These agents can be biological or therapeutic agents. The invention also relates to methods of using the surfaces of the invention, such as, methods of affecting biological processes, eliciting patterns of cellular response, screening, treatment, diagnosis and preventing food contamination and/or spoilage.

Abstract: Nucleozymes containing ribonucleotides and deoxyribonucleotides or nucleic acid analogues are described herein. The nucleozymes have catalytic activity and are significantly more resistant to degradation than their all-RNA ribozyme counterparts. Also described are methods for preparing the nucleozymes along with methods of using nucleozymes, e.g., as therapeutic agents.

Abstract: Provided is a method of fabrication of a blooming control structure for an imager. The structure is produced in a semiconductor substrate in which is configured an electrical charge collection region. The electrical charge collection region is configured to accumulate electrical charge that is photogenerated in the substrate, up to a characteristic charge collection capacity. A blooming drain region is configured in the substrate laterally spaced from the charge collection region. The blooming drain region includes an extended path of a conductivity type and level that are selected for conducting charge in excess of the characteristic charge collection capacity away from the charge collection region. A blooming barrier region is configured in the substrate to be adjacent to and laterally spacing the charge collection and blooming drain regions by a blooming barrier width. This barrier width corresponds to an acute blooming barrier impurity implantation angle with the substrate.

Abstract: A turbopump including a rotor having a first face and a second face and being characterized by a rotor axial height between the first and second rotor faces and by a rotor diameter. A rotor housing includes bearing surfaces for supporting rotation of the rotor, includes turbine inlet and turbine outlet ports and pump inlet and pump outlet ports, and includes pump and turbine fluid sealing surfaces. A plurality of turbine blades of a turbine blade axial height, and a plurality of pump blades of a pump blade axial height, are disposed on a face of the rotor. The turbine blades and pump blades can be together disposed on the rotor first face. Further or alternatively, a turbopump axial height including rotor bearings, turbine blade and pump blade axial height, and rotor axial height, can be less than rotor diameter.

Abstract: An interactive media table that includes a tabletop that supports of plurality of movable objects each of which is identified by a unique identification code and each of which can be moved from place to place on said tabletop surface by one or more media table users. A display unit produces a visual image on the surface of the tabletop surface and a position tracking system determines the current positions of each of said movable objects by transmitting timed acoustic signals to each movable object, sensing the timing of arrival of these signals using an acoustic pickup on each object, and estimating the location of the object by triangulation. An infrared communications network exchanges timing information, commands and data between the objects and a controller which provides an API to a personal computer which executes an application program that controls the display.

Abstract: Devices are provided for medical diagnostics comprising a substrate; an array of reservoirs; one or more electrodes located at least partially inside the reservoirs; a plurality of discrete reservoir caps covering openings in the plurality reservoirs; control circuitry for selectively disintegrating or permeabilizing the reservoir cap over a reservoir opening; and, optionally, a diagnostic reagent in the reservoirs. Devices also are provided for the controlled delivery of molecules comprising a substrate; an array of reservoirs; a release system in the reservoirs comprising molecules for release; one or more electrodes attached to the substrate inside the reservoirs or to a surface outside of the reservoirs, wherein the electrodes are not reservoir caps; and means for applying an electric current or potential across the electrodes effective to activate release of the molecules from the reservoirs. The devices can be adapted for implantation for in vivo diagnostics or drug delivery.

Abstract: Described herein are genes shown to be essential for programmed cell death in C. elegans, their encoded products (RNA and polypeptides), antibodies directed against the encoded polypeptides; probes for identifying structurally related genes and bioassays for identifying functionally related cell death genes from various organisms; methods and agents for altering (increasing or decreasing) the activity of the cell death-genes and, thus, of altering cell death; and uses therefor. Specifically, two genes shown to be essential for almost all of the cell deaths which occur in the development of C. elegans, referred to as ced-3 and ced-4, have been cloned, sequenced and characterized.

Abstract: A coupling element includes a first stage having a dielectric waveguide that is transitioned to a waveguide having a sequence of resonators with a fixed period. A second stage transitions the waveguide to a photonic crystal waveguide by gradually bringing closer at an angle the cladding bulk of the photonic crystal to the waveguide.

Abstract: Devices are provided for the controlled release of drug or other molecules. The devices include (1) a substrate, which optionally includes two or more substrate portions bonded together, (2) at least two reservoirs in the substrate, (3) a release system disposed in the reservoirs that includes the molecules for release and optionally a matrix material, and (4) active or passive means for controlling release of the molecules from the reservoirs. In one embodiment, a reservoir cap is positioned on, or within a portion of, the reservoir and over the molecules, so that the molecules are controllably released from the device by diffusion through or upon disintegration of the reservoir cap.

Abstract: An integrated optic polarization splitter, includes a pair of waveguide elements with a first waveguide element having horizontal orientation and a second waveguide element having a vertical orientation formed from a plurality of waveguide core layers. The first and second waveguide elements are intersected or nearly intersected at one end of the structure and separated at the other end of the structure and the transition there between is made to be adiabatic. The waveguide elements receive an optical signal having both a TE component and a TM component. The TE component propagates along the horizontally oriented waveguide element and the TM component propagates along the vertically oriented waveguide element.

Abstract: An optical, multi-channel, Differential Phase Shift Keying (DPSK) receiver demodulates multiple Wavelength Division Multiplexed (WDM) channels using a single interferometer. This distributes expense of the interferometer over all channels of an optical signal, allowing for deployment of cost-effective, scalable, wideband, WDM DPSK systems. For example, for an 80 channel WDM link, the receiver uses a single interferometer instead of eighty interferometers and associated stabilization hardware, dramatically reducing size, weight, power, and cost. The receiver is architecturally compatible with existing interferometer technologies so previous development and qualification efforts can be leveraged. This allows for expedited technology insertion into existing optical communications networks, including terrestrial and space-based optical networks.

Abstract: A transdermal transport device includes a reservoir for holding a formulation of an active principle, and one or more needles. Each needle has a bore through which the formulation is transported between the reservoir and a biological body, and has an end portion that is substantially aligned in a plane parallel to a surface of the biological body when the device is placed on the surface. The device also includes a vacuum generator which creates a suction to draw a portion of the surface beyond the plane of the end portions to enable the end portions to penetrate the portion of the surface as the needles are translated along an axis that is substantially parallel to the plane.

Abstract: The invention involves identification of a mechanism of ?-amyloid peptide cytotoxicity, which enables treatment of conditions caused by ?-amyloid peptide aggregates by administration of compounds which antagonize the mechanism of cytotoxicity. The invention includes the identification and isolation of compounds which can reduce the neurotoxic effects of such aggregates. Methods for treating conditions resulting from neurotoxic ?-amyloid peptide aggregates, such as Alzheimer's disease and pharmaceutical preparations are provided. Also provided are methods for selecting additional compounds which can reduce the neurotoxic effects of ?-amyloid aggregates.

Abstract: Methods of tuning, switching or modulating, or, in general, changing the resonance of waveguide micro-resonators. Changes in the resonance can be brought about, permanently or temporarily, by changing the size of the micro-resonator with precision, by changing the local physical structure of the device or by changing the effective and group indices of refraction of the mode in the micro-resonator. Further changing the asymmetry of the index profile around a waveguide can alter the birefringence of the waveguide and allows one to control the polarization in the waveguide. This change in index profile may be used to change the polarization dependence or birefringence of the resonators.

Abstract: A multi-layer integrated semiconductor structure is provided, which includes at least a first semiconductor structure and a second semiconductor structure coupled together via an interface. The interface includes at least a first portion adapted to provide a communication interface between the first semiconductor structure and the second semiconductor structure and at least a second portion adapted to reduce electrical interference between the first semiconductor structure and the second semiconductor structure.

Abstract: Methods for synthesis of nanocyrstalline apatites are presented, as well as a series of specific reaction parameters that can be adjusted to tailor, in specific ways, properties in the recovered product. Particulate apatite compositions having aveage crystal size of less than 150 nm are provided. Products also can have a surface area of at least 40 m2/g and can be of high density. Hydroxyapatite material is investigated in particular detail. Compositions of the invention can be used as prosthetic implants and coatings for prosthetic implants.