Abstract: The present invention relates to targeted polymerized liposomes for oral and/or mucosal delivery of vaccines, allergens and therapeutics. In particular, the present invention relates to polymerized liposomes which have been modified on their surface to contain a molecule or ligand which targets the polymerized liposome to a specific site or cell type. More particularly, the invention relates to the use of polymerized liposomes modified to contain a carbohydrate or lectin on their surface.

Abstract: A device for detecting the posture a finger or forces applied to a finger, the finger having a fingernail illuminated by light, comprises at least one photodetector for measuring a change in light reflected by an area of the finger beneath the fingernail in response to the posture of the finger or forces applied to the finger. The photodetector provides a signal corresponding to the change in light reflected. The device also includes a processor for receiving the signal and determining whether the change corresponds to a specified condition. The photodetector may be enclosed in a housing and coupled to the fingernail.

Abstract: All-optical bit phase sensors that utilize nonlinear interferometers are described. An all-optical bit phase sensor that utilizes an optical fiber and a detector optically coupled to the core of the fiber, perpendicular to the longitudinal direction of the core, is described. In addition, an electrooptic bit phase sensor that utilizes a semiconductor diode and an electrical detector electrically coupled to the active layer is described. Electrooptical and all-optical phase lock loops, optical processors, and optical networks that utilize these bit phase sensing are also described.

Abstract: A method of generating a signal pulse in an optical fiber characterized by dispersion and a refraction index that has a nonlinear regime of operation, the method including generating a sequence of coherent optical pulses each of which has an associated energy; and introducing the sequence of pulses into the optical fiber, wherein the pulses in the sequence of pulses are sufficiently close in spacing so that after traveling a predetermined length down the optical fiber, the pulses of the sequence of pulses overlap and interfere to form an interference pattern, and wherein the associated energy of at least one of the pulses of the sequence of pulses is within the nonlinear regime of the optical fiber.

Abstract: The present invention provides a biological system for expanding the dethiazolidine ring of penicillins into the dehydrothiazine ring of cephalosporins or cephalosporin precursors. In particular, the invention defines reaction conditions under which expandase enzyme can convert penicillin substrates other than penicillin N into cephalosporins. The invention therefore provides a relatively inexpensive, uncomplicated, and environmentally friendly biological system for cephalosporin production from penicillins, which system can replace the synthetic chemical approaches currently utilized. In particular, the invention provides a system for producing DOAG and/or DAG, which can be enzymatically converted into 7-ADCA and 7-ADAC, which, in turn, can be enzymatically or chemically converted into valuable cephalosporins of commerce.

Abstract: An ultrasonic defect detection system includes a steered beam transmitter for directing an ultrasonic beam through the front face to the back face of a specimen; a sensor device for sensing the location on the front face of the near shadow of a defect from the beam reflected from the back face before the defect and the far shadow of the defect from the beam reflected from the back face after the defect; and an arithmetic circuit responsive to the location of the shadows on the front face for determining the distance between the transmitter and the near and far boundary of the near shadow and at least the near boundary of the far shadow for calculating the location and/or the size and/or the orientation of the defect.

Abstract: It has been discovered that the stimulation of &bgr;-adrenergic receptors, which activate cAMP formation, give rise to increased APP and GFAP synthesis in astrocytes. Hence, the in vitro or in vivo exposure of neuronal cells to certain compositions comprising &bgr;-adrenergic receptor ligands or agonists, including, e.g., norepinephrine, isoproterenol and the like, increases APP mRNA transcription and consequent APP overproduction. These increases are blocked by &bgr;-adrenergic receptor antagonists, such as propranolol. The in vitro or in vivo treatment of these cells with 8Br-cAMP, prostaglandin E2 (PG E2), forskolin, and nicotine ditartrate also increased APP synthesis, including an increase in mRNA and holoprotein levels, as well as an increase in the expression of glial fibrillary acidic protein (GFAP). Compositions and methods are disclosed of regulating APP overexpression and mediating reactive astrogliosis through cAMP signaling or the activation of &bgr;-adrenergic receptors.

Abstract: The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.

Abstract: A handle module actuates handles of a user interface for various applications, including minimally invasive surgery (“MIS”). A modified MIS tool handle has two shafts that translate relative to each other upon relative motion of the handles. They also can rotate relative to each other. A housing engages both. The first is translationally fixed and rotatably free relative to the housing. An actuator actuates rotation of the first shaft. The second shaft is coupled to the housing such that it is rotationally fixed about and translatable along the axis of its elongation. The second shaft is fixed to a cartridge that is a linear capstan and translates relative to the housing, in response to relative translation of the shafts. A jaw action actuator is coupled to the cartridge through a cable drive, and can actuate the relative translation of the shafts, and thus, the handles. The jaw action actuator can actuate jaw action of a tool in a tool environment, either virtual, or actual.

Abstract: A high-temperature balance includes a piezoelectric material, such as langasite, that is stable at high temperatures. The frequency response of the balance is monitored to determine the change in mass of material deposited on the balance in a high-temperature environment. Accordingly, the balance can be used to monitor high-temperature deposition rates or to perform thermogravimetric analysis. The high-temperature balance of this invention can further be operated as a nanobalance to measure monolayer changes in film thickness.

Abstract: Curious caching improves upon cache snooping by allowing a snooping cache to insert data from snooped bus operations that is not currently in the cache and independent of any prior accesses to the associated memory location. In addition, curious caching allows software to specify which data producing bus operations, e.g., reads and writes, result in data being inserted into the cache. This is implemented by specifying “memory regions of curiosity” and insertion and replacement policy actions for those regions. In column caching, the replacement of data can be restricted to particular regions of the cache. By also making the replacement address-dependent, column caching allows different regions of memory to be mapped to different regions of the cache. In a set-associative cache, a replacement policy specifies the particular column(s) of the set-associative cache in which a page of data can be stored.

Abstract: An optical amplifier includes first and second optical fibers. The first optical fiber has a core, a first cladding surrounding the core and a second cladding surrounding the first cladding. The second optical fiber has an end physically coupled to a side portion of the first optical fiber. The end transmits light to the first cladding.

Abstract: A computer software system includes interdependent collections of software components. That is, at the architectural level, software components and their interdependencies are two distinct equally important entities. The software components represent the core functional pieces of an application and deal with concepts specific to an application domain. Interdependencies relate to concepts orthogonal to the problem domain in most applications, such as transportation, sharing of resources and synchronization constraints among components. An architectural description language which represents activities and dependencies between activities as separate entities. Dependencies are managed by coordination processes associated with the dependency. Activities and dependencies are connected through ports which encode interfaces between activities and coordination processes. The language may also represent resources which may be understood as the output of some activity beyond the scope of the system. Each entity, i.e.

Abstract: This invention involves method and apparatus for guiding ablative therapy of abnormal biological electrical excitation. In particular, it is designed for treatment of cardiac arrhythmias. In the method of this invention electrical signals are acquired from passive electrodes, and an inverse dipole method is used to identify the site of origin of an arrhythmia. The location of the tip of the ablation catheter is similarly localized from signals acquired from the passive electrodes while electrical energy is delivered to the tip of the catheter. The catheter tip is then guided to the site of origin of the arrhythmia, and ablative radio frequency energy is delivered to its tip to ablate the site.

Abstract: Neural prosthesis for implantation within an eye. The prosthesis includes a foldable substrate and at least one electronic component supported by the substrate. At least one microchannel is disposed within the substrate. Upon inflation, the foldable substrate will unfold to provide for close contact of the electronic component with neural tissue, thus facilitating surgical implantation through a narrow incision, yet allowing the unfolded device to cover a sufficiently large portion of the patient's retina to provide useful vision.

Abstract: A method and apparatus for determining forces to be applied to a user through a haptic interface. The method includes the steps of generating a representation of an object in graphic space, sensing the position of the user in real space and calculating a force to be applied to a user in response to the user's haptic interface and the user's fiducial object. The user's fiducial object represents the location in graphic space at which the user's haptic interface would be located if the haptic interface could not penetrate the surfaces of virtual objects. In one embodiment, the method calculates a stiffness force to be applied to the user. In other embodiments, the method calculates damping and friction forces to be applied to the user. In one embodiment the step of generating a representation of an object in graphic space includes defining the object as a mesh of planar surfaces and associating surface condition values to each of the nodes defining the planar surfaces.

Abstract: This invention describes self assembled monolayers (SAMs) manufactured by imprinting reactive peptides onto solid supports. The invention further relates to methods of preparing and using these improved SAMs.

Abstract: Oxygen is supplied to cells in vitro or in vivo by generating oxygen with an oxygen generator that electrolyzes water to oxygen and hydrogen. Oxygen can be generated substantially without generating free hydrogen using a multilayer electrolyzer sheet having a proton exchange membrane sandwiched by an anode layer and a cathode layer. The oxygen generator may be used to supply oxygen to cells contained by a culture plate, a culture flask, a microtiter plate or an extracorporeal circuit, or to cells in an encapsulating chamber for implanting in the body such as an immunoisolation chamber bounded by a semipermeable barrier layer that allows selected components to enter and leave the chamber. A bioactive molecule may be present with the cells.

Abstract: Disclosed herein are expression systems that make use of Ero1 to enhance disulfide bond formation and thereby to increase the yield of properly folded recombinant proteins. Also disclosed herein are recombinant Ero1 polypeptides, nucleic acids, vectors, and cells for expressing such polypeptides.

Abstract: A method and system of locating discontinuities, measuring distances, locating unknown sources, and measuring the thickness of multimode dispersive medium includes sensing a multimode dispersive acoustic guided wave and frequency decomposing that wave using spectral temporal analysis; selecting a frequency which identifies a group delay of the guided wave for each mode occurring at that frequency; selecting a mode from the group delays of the selected mode, determining the group velocity from the dispersion curves and computing the desired parameter.