Patents Assigned to The MCW Research Foundation, Inc.
-
Publication number: 20150031623Abstract: The present invention provides therapeutic modalities for the treatment of an ischemic event (e.g., stroke) that creates or embodies a risk of neurological damage in CNS sites by administration of a thrombopoietin receptor ligand.Type: ApplicationFiled: September 29, 2011Publication date: January 29, 2015Applicant: MCW RESEARCH FOUNDATION, INC.Inventor: John E. Baker
-
Patent number: 8518883Abstract: A therapeutic or prophylactic treatment method of ischemia, such as due to myocardial infarction, by administering thrombopoietin, alone or in combination with other drugs, to a patient suffering from or at risk of cardiac injury, such as myocardial ischemia. The thrombopoietin is administered in a concentration such that the subject's platelet count or production of platelets is not significantly affected.Type: GrantFiled: December 17, 2010Date of Patent: August 27, 2013Assignee: MCW Research Foundation, Inc.Inventors: John E. Baker, Yang Shi
-
Patent number: 8404640Abstract: The invention provides a method of diagnosing carcinoma in a patient, the method comprising providing a sample of colorectal cells from a human patient and analyzing the sample for CXCL12 hypermethylation.Type: GrantFiled: October 21, 2008Date of Patent: March 26, 2013Assignee: MCW Research Foundation, Inc.Inventors: Michael B. Dwinell, Priscilla A. Johanesen, Michael K. Wendt
-
Patent number: 8388936Abstract: A system and method for acquiring MR imaging data from a subject includes administering positively-charged nitroxides or gadolinium chelates for in vivo mitochondrial labeling, acquiring MR imaging data from the subject, and reconstructing an image of the subject having enhanced contrast in areas including metabolic and/or mitotic activity.Type: GrantFiled: February 23, 2009Date of Patent: March 5, 2013Assignee: MCW Research Foundation, Inc.Inventors: Balaraman Kalyanaraman, Joy Joseph, Kathleen Marie Schmainda, Douglas Edward Prah, Marcos Lopez, Micael J. Hardy
-
Patent number: 8101347Abstract: A method of inhibiting, moderating or diagnosing Pseudomonas aeruginosa infection is disclosed. In one embodiment, this method comprises inoculating a patient with an effective amount of PcrV antigen.Type: GrantFiled: January 16, 2009Date of Patent: January 24, 2012Assignee: MCW Research Foundation, Inc.Inventors: Dara W. Frank, Jeannine Wiener-Kronish, Timothy L. Yahr, Teiji Sawa, Robert B. Fritz
-
Patent number: 8021892Abstract: A magnetic resonance imaging (MRI) system includes a transmitter that produces an RF excitation pulse that is applied to a subject positioned in the MRI system to induce emission of at least one of an NMR signal and an ESR signal therefrom, and that produces a reference signal indicative of the phase of the RF excitation pulse. A first analog-to-digital converter has an input for receiving the reference signal that is synchronous with the RF excitation pulse. One or more additional analog-to-digital converters/processors have inputs for receiving the at least one of NMR signals and ESR signals produced by a subject placed in the MRI system and produce one or more complex digital signals therefrom. A normalizer is connected to receive and normalize the digital reference signal and a mixer is connected to receive the normalized digital reference signal and the digital signal. Accordingly, the mixer is operable to multiply the normalized complex digital reference signal with the complex digital signal.Type: GrantFiled: August 31, 2010Date of Patent: September 20, 2011Assignee: MCW Research Foundation Inc.Inventor: Andrzej Jesmanowicz
-
Patent number: 7943631Abstract: The present invention relates a method of treating drug addiction in an individual by administering to the addicted individual a therapeutically effective amount of dextro-morphine capable of activating an opioid receptor. It is disclosed here that dextro-morphine is suitable for treating addiction to natural opiates, semi-synthetic opiates, fully synthetic opioids, and endogenous opioid peptides, as well as nicotine.Type: GrantFiled: February 20, 2008Date of Patent: May 17, 2011Assignee: MCW Research Foundation, Inc.Inventor: Leon F. Tseng
-
Patent number: 7879318Abstract: A therapeutic or prophylactic treatment method of ischemia, such as due to myocardial infarction, by administering thrombopoietin, alone or in combination with other drugs, to a patient suffering from or at risk of cardiac injury, such as myocardial ischemia. The thrombopoietin is administered in a concentration such that the subject's platelet count or production of platelets is not significantly affected.Type: GrantFiled: January 17, 2007Date of Patent: February 1, 2011Assignee: MCW Research Foundation, Inc.Inventors: John E. Baker, Yang Shi
-
Patent number: 7867496Abstract: The disclosure relates to methods of ameliorating nephrotoxic side effects of immunosuppressive agents whose immunosuppressive activity is mediated via upregulation of TGF-? such as, for example, cyclosporine (CsA). The disclosure provides treatment modalities for use in patients that require immunosuppression, e.g., patients at risk of transplant rejection or having an autoimmune disease. In the methods of the invention, a TGF-? antagonist, e.g., an anti-TGF-? antibody, is administered to a patient treated with an immunosuppressive agent. Such a TGF-? antagonist is administered in a therapeutically effective amount sufficient to alleviate the nephrotoxic effects of the immunosuppressive agent without substantially interfering with immunosuppressive activity of the agent.Type: GrantFiled: September 22, 2005Date of Patent: January 11, 2011Assignees: Genzyme Corporation, The MCW Research Foundation, Inc., National Institutes of HealthInventors: Ashwani K. Khanna, Steven Ledbetter
-
Patent number: 7838561Abstract: A method for treating or preventing cardiac hypertrophy in a mammal, comprising manipulating levels of RBP, retinoids, or an affiliated signaling and regulatory pathway in the mammal. Preferably, the method comprises reducing or inhibiting the level of RBP or retinoids or their signaling pathway, or an affiliated signaling pathway, via a dietary, genetic, protein-based, or pharmacologic approach, or a combination thereof. Also disclosed are pharmaceutical composition suitable for the method.Type: GrantFiled: June 14, 2005Date of Patent: November 23, 2010Assignees: Wisconsin Alumni Research Foundation, MCW Research Foundation, Inc.Inventors: Susan M. Smith, John W. Lough, George R. Flentke
-
Patent number: 7807474Abstract: A magnetic resonance imaging (MRI) system includes a transmitter that produces an RF excitation pulse that is applied to a subject positioned in the MRI system to induce emission of at least one of an NMR signal and an ESR signal therefrom, and that produces a reference signal indicative of the phase of the RF excitation pulse. A first analog-to-digital converter has an input for receiving the reference signal that is synchronous with the RF excitation pulse. One or more additional analog-to-digital converters/processors have inputs for receiving the at least one of NMR signals and ESR signals produced by a subject placed in the MRI system and produce one or more complex digital signals therefrom. A normalizer is connected to receive and normalize the digital reference signal and a mixer is connected to receive the normalized digital reference signal and the digital signal. Accordingly, the mixer is operable to multiply the normalized complex digital reference signal with the complex digital signal.Type: GrantFiled: March 23, 2007Date of Patent: October 5, 2010Assignee: MCW Research Foundation, Inc.Inventor: Andrzej Jesmanowicz
-
Patent number: 7603240Abstract: The present invention provides a peptide identification method along with related peptide databases, method of generating the databases, computer usable media, and computer program products. The peptide identification method involves the use of qualitative amino acid composition or partial qualitative amino acid composition information of a query peptide obtained by mass spectrometry to correlate the query peptide to one or more peptides with defined amino acid sequences in a peptide database generated according to the present invention.Type: GrantFiled: January 19, 2005Date of Patent: October 13, 2009Assignee: MCW Research Foundation, Inc.Inventors: Brian D. Halligan, Edward A. Dratz
-
Patent number: 7577472Abstract: Time course MRI data is acquired from the hippocampal region of the brain and processed to produce two indices that are a measure of the functional connectivity between locations therein. The MRI data is acquired while the brain is substantially at rest and the spontaneous low frequency component of the time course data at each location in the hippocampus is extracted and compared in a cross-correlation process. Also acquired is fMRI data which indicates those locations in the brain that should be included in the index calculations.Type: GrantFiled: March 14, 2006Date of Patent: August 18, 2009Assignee: The MCW Research Foundation Inc.Inventors: Shi-Jiang Li, Yin Xu, Guofan Xu, Gaohong Wu
-
Patent number: 7507871Abstract: A rat model of diabetic nephropathy is disclosed. In another embodiment of the invention, a method of evaluating a test compound's effect of diabetic nephropathy is disclosed. In one embodiment, this method comprises the steps of (a) exposing the test compound to the rat of claim 1, wherein the rat would develop progressive proteinuria and glomerulosclerosis leading to diabetic nephropathy in the absence of the test compound, and (b) comparing the rat's development of diabetic nephropathy with a control T2DN mimic rat that has not been exposed to the test compound.Type: GrantFiled: July 23, 2003Date of Patent: March 24, 2009Assignee: MCW Research Foundation, Inc.Inventors: Howard J. Jacob, Richard J. Roman, Marcelo Nobrega
-
Patent number: 7494653Abstract: A method of inhibiting, moderating or diagnosing Pseudomonas aeruginosa infection is disclosed. In one embodiment, this method comprises inoculating a patient with an effective amount of PcrV antigen.Type: GrantFiled: January 25, 2002Date of Patent: February 24, 2009Assignees: MCW Research Foundation, Inc., The Regents of the University of CaliforniaInventors: Dara W. Frank, Jeannine Wiener-Kronish, Timothy L. Yahr, Teiji Sawa, Robert B. Fritz
-
Patent number: 7469159Abstract: Neurovascular uncoupling that causes fMRI data to underestimate viable neuronal activity in the brain is detected and indicated to assist in pre-surgical planning. Tasks associated with the cortical region in question are performed while the fMRI measurement of brain activity is measured and the same tasks are performed while task performance is measured directly. Neurovascular uncoupling is detected and indicated by comparing the results of fMRI measurement and direct measurement.Type: GrantFiled: May 26, 2005Date of Patent: December 23, 2008Assignee: The MCW Research Foundation, Inc.Inventors: Edgar DeYoe, John L. Ulmer
-
Patent number: 7354432Abstract: A method of treating visual system disease is disclosed. One embodiment comprises the steps of (a) exposing a component of a patient's visual system to light treatment, wherein the light treatment is characterized by wavelength of between 630-1000 nm and power intensity between 10-90 mW/cm2 for a time of 1-3 minutes, and (b) observing restoration of visual system function.Type: GrantFiled: January 16, 2004Date of Patent: April 8, 2008Assignee: MCW Research Foundation, Inc.Inventors: Janis T. Eells, Margaret T. T. Wong-Riley, Harry T. Whelan
-
Patent number: 7328054Abstract: A perfusion image is produced by acquiring a series of time course MR images from an imaging slice. During the acquisition spins flowing into the slice are repeatedly tagged with an RF tagging pulse having a flip angle that is modulated according to a tagging pattern. Voxels in the series of reconstructed MR images having signals which vary according to the tagging pattern indicate perfusion. Perfusion images indicating either flow or velocity are produced.Type: GrantFiled: April 9, 2003Date of Patent: February 5, 2008Assignee: The MCW Research Foundation, Inc.Inventor: Andrzej Jesmanowicz
-
Patent number: 7307101Abstract: A method for treating cerebral vascular diseases in a human or non-human animal is disclosed. The method involves inhibiting 20-HETE synthesizing enzyme activity sufficiently to increase or prevent a decrease in cerebral blood flow in the human or non-human animal.Type: GrantFiled: September 6, 2001Date of Patent: December 11, 2007Assignees: MCW Research Foundation, Inc., Taisho Pharmaceutical Co., Ltd.Inventors: Richard J. Roman, David R. Harder, Noriyuki Miyata, Masakazu Sato, Kazuya Kameo, Shigeru Okuyama
-
Patent number: 7223864Abstract: The inventors have purified the fluorescent product in the hydroethidine-based supeorxide detection assays and further identified the product as 2-hydroxyethidium. Methods for synthesizing 2-hydroxyethidium and for detecting and quantifying superoxide are provided.Type: GrantFiled: April 8, 2004Date of Patent: May 29, 2007Assignee: MCW Research Foundation, Inc.Inventors: Balaraman Kalyanaraman, Hongtao Zhao