Patents Assigned to The Medical College of PA
  • Synthetic analogs of thrombospondin and therapeutic use thereof
    Patent number: 6239110
    Abstract: Compounds and compositions comprising fragments and synthetic analogs of human thrombospondin are provided together with methods for their use as thrombospondin-like agents.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 29, 2001
    Assignees: W.R. Grace & Co. -Conn., Medical College of PA
    Inventors: Jacob Eyal, Bruce King Hamilton, George Paul Tuszynski
  • Piptide fragments and analogs of thrombospondin
    Patent number: 5426100
    Abstract: Compounds and compositions comprising fragments and synthetic analogs of human thrombospondin are provided together with methods for their use as thrombospondin-like agents.
    Type: Grant
    Filed: August 20, 1993
    Date of Patent: June 20, 1995
    Assignees: W. R. Grace & Co.-Conn., Medical College of PA
    Inventors: Alan H. Deutch, Goerge Tuszynski
  • Cys-Ser-Val-Thr-Cys-Gly specific tumor cell adhesion receptor
    Patent number: 5367059
    Abstract: The present invention provides a cell matrix receptor specific for the Cys Ser Val Thr Cys Gly (SEQ ID NO: 1) region of thrombospondin. Also provided are purification, cloning and expression methods. Antibodies directed against the receptor protein are useful in numerous diagnostic, prophylactic and therapeutic areas.
    Type: Grant
    Filed: May 14, 1992
    Date of Patent: November 22, 1994
    Assignees: W. R. Grace & Co.-Conn., The Medical College of PA
    Inventors: George P. Tuszynski, Jacob Eyal, Bruce K. Hamilton