Patents Assigned to The Medical College of Wisconsin
  • Publication number: 20200165678
    Abstract: Provided herein are methods and computer-readable storage media related to cell-free DNA and uses thereof to determine risk of a condition, such as transplant rejection or cancer, in a subject.
    Type: Application
    Filed: October 28, 2019
    Publication date: May 28, 2020
    Applicant: The Medical College of Wisconsin, Inc.
    Inventors: Aoy Tomita Mitchell, Michael Mitchell
  • Patent number: 10660653
    Abstract: An esophageal device is used to recognize, diagnose, characterize, or relieve an impact of an abnormal or defective UES anatomy, physiology, or functionality. In one implementation, the esophageal device measures a UES response to esophageal fluid infusion to detect or characterize an abnormality or defective UES anatomy, physiology, or functionality. An Upper Esophageal Sphincter compression device is used to increase intra-luminal pressure within the Upper Esophageal Sphincter of a patient in order relieve an impact of an abnormal or defective UES anatomy, physiology, or functionality.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: May 26, 2020
    Assignee: The Medical College of Wisconsin, Inc.
    Inventor: Reza Shaker
  • Patent number: 10638949
    Abstract: A method includes: accessing MRI data acquired from a joint area, the MRI data including a series of spatially mapped spectral data points; generating MRI images of the joint area; receiving information encoding a region of interest that encompasses a suspected metal particle deposition area over at least one of the MRI images; constructing magnetic field maps using the MRI data, each representing off-resonance frequency shifts over the joint area; removing a background of off-resonance field inhomogeneity from the magnetic field map such that the region of interest is free from off-resonance field inhomogeneity; identifying clusters from the magnetic field maps with the background of off-resonance field inhomogeneity removed, the clusters defined over a first dimension of offset frequencies and a second dimension of cluster volumes; and computing a quantitative metric by combining information from the identified clusters according to both the first dimension and the second dimension.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: May 5, 2020
    Assignees: New York Society for the Ruptured and Crippled Maintaining the Hospital for Special Surgery, Medical College of Wisconsin
    Inventors: Kevin Matthew Koch, Matthew F. Koff, Hollis Potter
  • Patent number: 10582932
    Abstract: A swallow exerciser device that exercises and thereby strengthens the muscles involved in swallowing includes a rigid shell, an adjustable fastener, and an inflatable pad. The rigid shell has a longitudinal dimension such that the shell extends above and below the larynx of the subject when the swallow exerciser device is positioned over the larynx of the subject. The adjustable fastener is dimensioned to secure the shell around a neck of the subject with the shell positioned over the larynx of the subject. The inflatable pad is connected to a proximal surface of the shell. The inflatable pad is dimensioned to apply resistance to force of at least one swallowing muscle of the subject when the shell positioned over the larynx of the subject and when the inflatable pad is in an inflated position. The swallow exerciser device can be used in a method for improving swallowing function in a subject.
    Type: Grant
    Filed: August 11, 2015
    Date of Patent: March 10, 2020
    Assignees: The Medical College of Wisconsin, University of Southern California
    Inventors: Reza Shaker, Anisa Shaker
  • Patent number: 10576093
    Abstract: The present invention provides modified metformin compounds, particularly mito-metformin compounds, and pharmaceutical compositions thereof. Methods of using the compounds to provide neuroprotection and in the treatment and/or prevention of neurodegenerative diseases are also described.
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: March 3, 2020
    Assignees: Iowa State University Research Foundation, Inc., The Medical College of Wisconsin, Inc.
    Inventors: Anumantha Kanthasamy, Balaraman Kalyanaraman
  • Patent number: 10570204
    Abstract: The present invention relates to methods of treating hematologic cancers using a combination of inhibitors of PD-1 or PD-L1 and TIM-3, LAG-3 or CTLA-4. In one embodiment, an inhibitor of PD-1 or PD-L1 is administered in combination with an inhibitor of TIM-3. In another embodiment, an inhibitor of PD-1 or PD-L1 is administered in combination with an inhibitor of LAG-3. In yet another embodiment, an inhibitor of PD-1 or PD-L1 is administered in combination with an inhibitor of CTLA-4.
    Type: Grant
    Filed: September 25, 2014
    Date of Patent: February 25, 2020
    Assignees: The Medical College of Wisconsin, Inc., Novartis AG
    Inventors: Bryon Duane Johnson, Robert Millman
  • Publication number: 20200032340
    Abstract: Provided herein are methods and computer-readable storage media related to cell-free DNA and uses thereof to determine risk of a condition, such as transplant rejection or cancer, in a subject.
    Type: Application
    Filed: July 8, 2019
    Publication date: January 30, 2020
    Applicant: The Medical College of Wisconsin, Inc.
    Inventors: Aoy Tomita Mitchell, Michael Mitchell
  • Patent number: 10537613
    Abstract: The present invention provides a CXCL121 peptide engineered to resist peptide-induced dimerization by maintaining steric repulsion of the chemokine helix, pharmaceutical compositions thereof, and methods of using said dimer in the treatment of cancer, inflammatory disorders, autoimmune disease, and HIV/AIDS.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: January 21, 2020
    Assignee: The Medical College of Wisconsin, Inc.
    Inventors: Brian Volkman, Joshua Ziarek, Christopher Veldkamp, Francis Peterson
  • Publication number: 20190367972
    Abstract: This invention relates to methods and compositions for assessing risk by measuring total and specific cell-free nucleic acids (such as DNA) in a subject. The methods and compositions provided herein can be used to determine risk of a condition, such as transplant rejection.
    Type: Application
    Filed: November 2, 2017
    Publication date: December 5, 2019
    Applicant: The Medical College of Wisconsin, Inc.
    Inventors: Aoy Tomita Mitchell, Michael Mitchell, Karl Stamm
  • Patent number: 10495651
    Abstract: Methods and kits for measuring levels of von Willebrand factor function in a sample without using a platelet aggregation agonist, such as ristocetin, comprising recombinant glycoprotein Ib? having a combination of G233V, D235Y and M239V mutations and an agent to detect a complex between the recombinant glycoprotein Ib? and von Willebrand factor.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: December 3, 2019
    Assignees: Versiti Blood Research Institute Foundation, Inc., The Medical College of Wisconsin, Inc.
    Inventor: Robert Montgomery
  • Publication number: 20190360033
    Abstract: This invention relates to methods and compositions for assessing an amount of non-native nucleic acids in a sample, such as from a subject. The methods and compositions provided herein can be used to determine risk of a condition, such as transplant rejection, in subject.
    Type: Application
    Filed: November 2, 2017
    Publication date: November 28, 2019
    Applicant: The Medical College of Wisconsin, Inc.
    Inventors: Karl Stamm, Aoy Tomita Mitchell, Michael Mitchell
  • Patent number: 10478090
    Abstract: A magnetic resonance imaging (MRI) system can include a magnetic resonance imaging (MRI) scanner, having a plurality of radio frequency (RF) receivers, and a processor. The MRI scanner can perform a full field of view (fFOV) scan on an anatomy area including an implant to acquire first multi-spectral MRI data associated with a plurality of frequency bins. The processor can generate, for each pair of a single RF receiver and a single frequency bin, a respective spectral sensitivity map using at least a portion of the fFOV multi-spectral MRI data. The MRI scanner can perform a reduced FOV (rFOV) scan to acquire second multi-spectral MRI data associated with the plurality of frequency bins. The processor can reconstruct one or more MRI images according to the rFOV using the rFOV multi-spectral MRI data and the spectral sensitivity maps.
    Type: Grant
    Filed: April 24, 2017
    Date of Patent: November 19, 2019
    Assignee: Medical College of Wisconsin
    Inventors: Kevin Matthew Koch, Andrew Scott Nencka
  • Patent number: 10478196
    Abstract: A compression device is used to increase intra-luminal pressure within the upper esophageal sphincter of a patient in order relieve an impact of an abnormal or defective upper esophageal sphincter anatomy, physiology, or functionality. In one implementation, the compression device is used in conjunction with an external pressure sensing device to determine the external pressure that is to be applied to the cricoid for a specific patient. The compression device can be a means for the management and/or treatment of abnormal upper esophageal sphincter functionality, or a means for strengthening an esophageal sphincter of a subject, or a means for curing esophageal reflux disease of a subject, or a means for improving vocal function in a subject, or a means for managing lung aspiration, or a means for applying cricoid pressure during anesthesia intubation, or a means for stabilizing body structures such as during medical imaging or radiation treatment.
    Type: Grant
    Filed: May 15, 2014
    Date of Patent: November 19, 2019
    Assignees: The Medical College of Wisconsin, Inc., Somna Therapeutics, LLC
    Inventors: Nick T. Maris, James S. Miller, Reza Shaker, Timothy Bachman, Nathan Schlueter, Eugene Paul Maloney, Eric David North, Paul Raine, Peter Alex
  • Patent number: 10472680
    Abstract: Provided herein are methods and computer-readable storage media related to cell-free DNA and uses thereof to determine risk of a condition, such as transplant rejection or cancer, in a subject.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: November 12, 2019
    Assignee: Medical College of Wisconsin, Inc.
    Inventors: Aoy Tomita Mitchell, Michael Mitchell
  • Patent number: 10385396
    Abstract: Provided herein are methods and computer-readable storage media related to cell-free DNA and uses thereof to determine risk of a condition, such as transplant rejection or cancer, in a subject.
    Type: Grant
    Filed: April 19, 2013
    Date of Patent: August 20, 2019
    Assignee: The Medical College of Wisconsin, Inc.
    Inventors: Aoy Tomita Mitchell, Michael Mitchell
  • Patent number: 10316287
    Abstract: Provided herein are methods of reducing or eliminating undifferentiated pluripotent stem cells, where the methods comprise contacting an effective amount of a compound to a heterogeneous cell population or sample comprising or suspected of comprising differentiated cell types and undifferentiated pluripotent stem cells, whereby the contacting selectively reduces or eliminates undifferentiated pluripotent stem cells from the cell population or sample. Also provided are methods for obtaining a population of stem cell-derived cell types substantially free of undifferentiated pluripotent stem cells as well as isolated populations of such of stem cell-derived cell types.
    Type: Grant
    Filed: January 21, 2015
    Date of Patent: June 11, 2019
    Assignee: The Medical College of Wisconsin, Inc.
    Inventors: Rebekah L. Gundry, Kenneth R. Boheler, Erin M. Kropp
  • Patent number: 10302962
    Abstract: Certain embodiments of the present invention are directed to therapeutic intervention in patients with eye-length-related disorders to prevent, ameliorate, or reverse the effects of the eye-length-related disorders. Embodiments of the present invention include methods for early recognition of patients with eye-length-related disorders, therapeutic methods for inhibiting further degradation of vision in patients with eye-length-related disorders, reversing, when possible, eye-length-related disorders, and preventing eye-length-related disorders. Additional embodiments of the present invention are directed to particular devices used in therapeutic intervention in patients with eye-length-related disorders.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: May 28, 2019
    Assignee: THE MEDICAL COLLEGE OF WISCONSIN
    Inventors: Jay Neitz, Maureen Neitz
  • Publication number: 20190153521
    Abstract: This invention relates to methods and compositions for assessing an amount of non-native nucleic acids in a sample, such as from a subject. The methods and compositions provided herein can be used to determine risk of a condition in a subject.
    Type: Application
    Filed: April 29, 2017
    Publication date: May 23, 2019
    Applicant: The Medical College of Wisconsin, Inc.
    Inventors: Aoy Tomita Mitchell, Karl Stamm
  • Publication number: 20190150781
    Abstract: A magnetic resonance imaging (MRI) system can include a magnetic resonance imaging (MRI) scanner, having a plurality of radio frequency (RF) receivers, and a processor. The MRI scanner can perform a full field of view (fFOV) scan on an anatomy area including an implant to acquire first multi-spectral MRI data associated with a plurality of frequency bins. The processor can generate, for each pair of a single RF receiver and a single frequency bin, a respective spectral sensitivity map using at least a portion of the fFOV multi-spectral MRI data. The MRI scanner can perform a reduced FOV (rFOV) scan to acquire second multi-spectral MRI data associated with the plurality of frequency bins. The processor can reconstruct one or more MRI images according to the rFOV using the rFOV multi-spectral MRI data and the spectral sensitivity maps.
    Type: Application
    Filed: April 24, 2017
    Publication date: May 23, 2019
    Applicant: Medical College of Wisconsin
    Inventors: Kevin Matthew Koch, Andrew Scott Nencka
  • Publication number: 20190153525
    Abstract: This invention relates to methods and compositions for assessing an amount of non-native nucleic acids in a sample, such as from a pregnant subject with the non-native nucleic acids being fetal specific. The methods and compositions provided herein can be used to determine risk of a condition, such as a fetal condition, in a pregnant subject.
    Type: Application
    Filed: April 29, 2017
    Publication date: May 23, 2019
    Applicant: The Medical College of Wisconsin, Inc.
    Inventors: Aoy Tomita Mitchell, Karl Stamm