Abstract: The present disclosure relates, inter alia, to methods and systems for providing diagnosis and/or prognosis of a disease or disorder affecting movement of a subject, such as Parkinson's disease (PD), as well as determining treatment efficacy for said disorder. More particularly, the present disclosure relates, according to some embodiments, to diagnosis and/or prognosis of Parkinson's disease and/or monitoring of the disease state and/or determining or assessing treatment efficacy, using values extrapolated and/or calculated from continuous signals received by at least one Body Fixed Sensor (BFS).