Abstract: Disclosed are systems biology-based methods for repositioning known pharmaceutical compounds to new indications, through the identification of network-based signatures. In particular, the invention provides new and useful methods for selecting drugs or combinations of drugs (and preferably previously-approved drugs) for use in new therapeutic indications. Also disclosed are methods for identifying anti-breast tumor initiating cell (TIC)-based therapeutics from within populations of target compounds. In illustrative embodiments, the invention provides methods and computer programs for the repositioning of FDA-approved pharmaceutical compounds to new indications using network-based signature analysis coupled with conventional in vitro and in vivo testing of identified drug candidates. The invention also allows identification of drugs or drug combinations for treating unmet medical needs including, for example, “orphan” diseases.

Abstract: Disclosed are molecular diagnostic compositions and methods for predicting brain metastasis of breast cancer, as well as methods for drug repositioning to identify existing and new therapeutics for use in developing individualized, patient-specific treatment regimens for improving diagnoses and patient outcomes in individuals at risk for brain metastasis of breast cancer.

Abstract: Disclosed are compositions and methods for targeted drug delivery using image-guided energy deposition to help localize active compounds to particular sites within the body of an animal. Also provided are compounds and formulations thereof for use in the targeted administration of therapeutically, prophylactically, and/or diagnostically effective amounts of such agents to a population of cells or tissues of a mammal in need thereof.

Abstract: Disclosed are vascular access devices, implantable dialysis grafts, and systems including them useful for improved access to implanted medical devices. Also disclosed are implantable hemodialysis vascular access graft devices that facilitate easy, accurate and reproducible cannulation or needle entry into the implanted device by magnetically-locating a portion of the graft that includes one or more paramagnetic materials operably defining the physical boundaries of the target cannulation site/entry port.

Abstract: Disclosed are methods for reconstructing a three-dimensional image of an object's volume of interest using computed tomography that employs conical-beam, intensity-modulated projections of this object. In one embodiment, a plurality of collimating devices serves to modulate the aperture of the radiation source thereby acting to modulate the intensity of the source upon the object. Also provided are image processing devices, examination apparatus, as well as a computer-readable medium and a program element adapted and configured to perform aspects of the methods disclosed herein.

Abstract: A system, method, and computer-readable medium for magnetic resonance diffusion anisotropy image processing are provided.

Abstract: Disclosed are a system and methods for identifying JAK2-specific polynucleotide sequences in a biological sample. Also disclosed are oligonucleotide primer and probe comopositions for detecting mutations in a JAK2 polynucleotides, and the JAK2V617F mutation in specific, as well as systems, diagnostic kits and articles of manufacture comprising JAK2-specific primer and probe compositions.