Patents Assigned to The Midland Certified Reagent Company
  • Biotinylated oligonucleotides and reagents for preparing the same
    Patent number: 5128476
    Abstract: Reagents of the formula I ##STR1## wherein A is --CH.sub.2 --.sub.m O-- (m=2 to 20) or --C.sub.n H.sub.2n --O--.sub.t (n=2 to 6; t=2 to 10) and B is selected from the group consisting of ##STR2## and salts thereof are useful for the preparation of 5'-biotinylated oligonucleotides.
    Type: Grant
    Filed: February 20, 1991
    Date of Patent: July 7, 1992
    Assignee: The Midland Certified Reagent Company
    Inventors: Guangrong Zhang, Richard V. Case
  • Method of making lyophilized terminal deoxynucleotidyl transferase
    Patent number: 4448883
    Abstract: Heat sensitive terminal deoxynucleotidyl transferase is stabilized by lyophilizing a solution of the enzyme, said solution prior to freeze-drying having a carefully controlled pH, an ionic concentration of at least 0.05 mole/liter and a protein concentration of greater than 0.3 gram/liter.
    Type: Grant
    Filed: July 26, 1982
    Date of Patent: May 15, 1984
    Assignee: The Midland Certified Reagent Company
    Inventor: Richard V. Case