Patents Assigned to The Miriam Hospital
  • Selective testicular 11beta-HSD inhibitors for the treatment of hypergonadism associated disorders and modulation of fertility
    Publication number: 20070219172
    Abstract: Methods for modulating testosterone levels using selective 11?-HSD1-dehydrogenase, 11?-HSD1-reductase and 11?-HSD2 dehydrogenase modulating compounds are described.
    Type: Application
    Filed: November 10, 2006
    Publication date: September 20, 2007
    Applicants: The Miriam Hospital, The Population Council
    Inventors: David Morris, Syed Latif, Matthew Hardy, Renshan Ge
  • Selective 11beta HSD inhibitors and methods of use thereof
    Publication number: 20060148725
    Abstract: Methods for treating glucocorticoid associated states using selective 11?-HSD1-dehydrogenase, 11?-HSD1-reductase and 11?-HSD2 dehydrogenase modulating compounds are described.
    Type: Application
    Filed: April 21, 2005
    Publication date: July 6, 2006
    Applicants: The Miriam Hospital, Rhode Island Hospital
    Inventors: David Morris, Andrew Brem
  • Delivery of bioactive compounds to an organism
    Patent number: 6503504
    Abstract: Disclosed herein is a method of delivering a bioactive compound to an organism that involves growing individual cells in vitro under conditions that allow the formation of an organized tissue, at least a subset of the cells containing a foreign DNA sequence which mediates the production of the bioactive compound; and implanting the organized tissue into the organism, whereby the bioactive compound is produced and delivered to the organism.
    Type: Grant
    Filed: July 17, 1997
    Date of Patent: January 7, 2003
    Assignee: Miriam Hospital
    Inventor: Herman H. Vandenburgh
  • Non-transgenic rodent model of alzheimer's disease
    Patent number: 6172277
    Abstract: The invention features a method of inducing amyloid plaque deposition in a mammal by infusing into the brain of the mammal an amyloid peptide at a basic pH, a nontransgenic animal model for Alzheimer's disease, and methods of identifying compounds to treat Alzheimer's disease.
    Type: Grant
    Filed: October 28, 1997
    Date of Patent: January 9, 2001
    Assignee: The Miriam Hospital
    Inventors: Barbara A. Tate, Ronald Majocha, Julie L. Newton
  • Glycyrrhetinic-acid-like factor
    Patent number: 6010721
    Abstract: A human glycyrrhetinic-acid-like factor which inhibits certain enzymes in pathways of steroid hormone degradation is disclosed.
    Type: Grant
    Filed: October 15, 1996
    Date of Patent: January 4, 2000
    Assignee: The Miriam Hospital
    Inventors: David J. Morris, Syed Abdul Latif
  • Delivery of bioactive compounds to an organism
    Patent number: 5869041
    Abstract: Disclosed herein is a method of delivering a bioactive compound to an organism that involves growing individual cells in vitro under conditions that allow the formation of an organized tissue, at least a subset of the cells containing a foreign DNA sequence which mediates the production of the bioactive compound; and implanting the organized tissue into the organism, whereby the bioactive compound is produced and delivered to the organism.
    Type: Grant
    Filed: September 13, 1996
    Date of Patent: February 9, 1999
    Assignee: The Miriam Hospital
    Inventor: Herman H. Vandenburgh