Patents Assigned to The National Institutes of Pharmaceutical R&D Co., Ltd.
  • Patent number: 11608334
    Abstract: The present invention relates to pyrrolo-aromatic heterocyclic compounds, a preparation method therefor and medical use thereof. Particularly, the present invention relates to a compound represented by formula I, a preparation method therefor, a pharmaceutical composition comprising the compound, and use of the compound as a BTK kinase inhibitor. The compound and the pharmaceutical composition comprising same can be used for the treating diseases associated with BTK kinase activity, such as inflammations, autoimmune disorders, and cancers. The definition of each substituent in formula I is the same as that in the description.
    Type: Grant
    Filed: December 26, 2017
    Date of Patent: March 21, 2023
    Assignee: THE NATIONAL INSTITUTES OF PHARMACEUTICAL R&D CO., LTD.
    Inventors: Huijun Yin, Xu Yan, Libin Zong, Weixue Tian, Li Zheng, Haoshuai Dou, Yan Yang
  • Publication number: 20230021669
    Abstract: Disclosed are a tricyclic compound as represented by general formula (I), a pharmaceutical composition containing same, and a preparation method therefor and the medical use thereof. The compound can be used for preventing and treating a variety of diseases caused by toxic aldehydes.
    Type: Application
    Filed: December 29, 2020
    Publication date: January 26, 2023
    Applicant: The National Institutes of Pharmaceutical R&D Co., Ltd.
    Inventors: Huijun YIN, Xu YAN, Guobiao LIU, Jianxin SHI, Shizhu CHEN, Siyang REN, Yadong FENG
  • Patent number: 7973014
    Abstract: Medicinal composition containing ginseng secondary glycosides, its preparation method and application. The present composition contains mainly, as active ingredients, the ginsenoside with protopanoxadiol as aglucone (ginsenoside Rg3) and the ginsenoside with protopanoxatriol as aglucone (ginsenoside Rg2 and ginsenoside Rh1). It is prepared from the ginseng genus of plants through extracting, acid hydrolyzing and using macroreticular resin to separate, purify and concentrate. It is useful in the manufacture of medicaments for treating CHD, angina pectoris, myocardial ischemia, hemorrhagic shock, heart failure, and arrhythmia.
    Type: Grant
    Filed: July 5, 2006
    Date of Patent: July 5, 2011
    Assignee: National Institute of Pharmaceutical R&D Co., Ltd.
    Inventors: Congxin Sun, Hesheng Luo, Yongli Zhao
  • Publication number: 20080234208
    Abstract: Medicinal composition containing ginseng secondary glycosides, its preparation method and application. The present composition contains mainly, as active ingredients, the ginsenoside with protopanoxadiol as aglucone (ginsenoside Rg3) and the ginsenoside with protopanoxatriol as aglucone (ginsenoside Rg2 and ginsenoside Rh1). It is prepared from the ginseng genus of plants through extracting, acid hydrolyzing and using macroreticular resin to separate, purify and concentrate. It is useful in the manufacture of medicaments for treating CHD, angina pectoris, myocardial ischemia, hemorrhagic shock, heart failure, and arrhythmia.
    Type: Application
    Filed: July 5, 2006
    Publication date: September 25, 2008
    Applicant: National Institute of Pharmaceutical R&D Co., Ltd
    Inventors: Congxin Sun, Hesheng Luo, Yongli Zhao