Abstract: The present invention relates to pyrrolo-aromatic heterocyclic compounds, a preparation method therefor and medical use thereof. Particularly, the present invention relates to a compound represented by formula I, a preparation method therefor, a pharmaceutical composition comprising the compound, and use of the compound as a BTK kinase inhibitor. The compound and the pharmaceutical composition comprising same can be used for the treating diseases associated with BTK kinase activity, such as inflammations, autoimmune disorders, and cancers. The definition of each substituent in formula I is the same as that in the description.
Type:
Grant
Filed:
December 26, 2017
Date of Patent:
March 21, 2023
Assignee:
THE NATIONAL INSTITUTES OF PHARMACEUTICAL R&D CO., LTD.
Inventors:
Huijun Yin, Xu Yan, Libin Zong, Weixue Tian, Li Zheng, Haoshuai Dou, Yan Yang
Abstract: Disclosed are a tricyclic compound as represented by general formula (I), a pharmaceutical composition containing same, and a preparation method therefor and the medical use thereof. The compound can be used for preventing and treating a variety of diseases caused by toxic aldehydes.
Type:
Application
Filed:
December 29, 2020
Publication date:
January 26, 2023
Applicant:
The National Institutes of Pharmaceutical R&D Co., Ltd.
Abstract: Medicinal composition containing ginseng secondary glycosides, its preparation method and application. The present composition contains mainly, as active ingredients, the ginsenoside with protopanoxadiol as aglucone (ginsenoside Rg3) and the ginsenoside with protopanoxatriol as aglucone (ginsenoside Rg2 and ginsenoside Rh1). It is prepared from the ginseng genus of plants through extracting, acid hydrolyzing and using macroreticular resin to separate, purify and concentrate. It is useful in the manufacture of medicaments for treating CHD, angina pectoris, myocardial ischemia, hemorrhagic shock, heart failure, and arrhythmia.
Type:
Grant
Filed:
July 5, 2006
Date of Patent:
July 5, 2011
Assignee:
National Institute of Pharmaceutical R&D Co., Ltd.
Abstract: Medicinal composition containing ginseng secondary glycosides, its preparation method and application. The present composition contains mainly, as active ingredients, the ginsenoside with protopanoxadiol as aglucone (ginsenoside Rg3) and the ginsenoside with protopanoxatriol as aglucone (ginsenoside Rg2 and ginsenoside Rh1). It is prepared from the ginseng genus of plants through extracting, acid hydrolyzing and using macroreticular resin to separate, purify and concentrate. It is useful in the manufacture of medicaments for treating CHD, angina pectoris, myocardial ischemia, hemorrhagic shock, heart failure, and arrhythmia.
Type:
Application
Filed:
July 5, 2006
Publication date:
September 25, 2008
Applicant:
National Institute of Pharmaceutical R&D Co., Ltd