Patents Assigned to The National Research and Development Corporation
  • Patent number: 5108758
    Abstract: Delayed release compositions comprising an active compound and glassy amylose. A variety of different types of active compound may be employed in the compositions. The compositions are particularly adapted for achieving the selective release of medicaments into the colon.
    Type: Grant
    Filed: December 19, 1989
    Date of Patent: April 28, 1992
    Assignee: National Research Development Corporation
    Inventors: Michael C. Allwood, David B. Archer, Stephen G. Ring
  • Patent number: 5109426
    Abstract: A major problem in automatic signature verification is the rejection of true signatures. One way of capturing a signature is to use a special pen 10 to write on an area 13 having horizontal lines, the pen being constructed to pass a signal to a computer 11 indicating whether the pen tip is in contact with the area 13 and when the lines in the area 13 are crossed. Signals characteristic of signatures derived in this way are analyzed and stored. To enable verification to be carried out a number of authentic signatures are analyzed and a number of measures such as means and standard deviations of signature features are determined and stored. When a trial signature is to be verified, the same features of the trial signature are measured and the results are compared with the stored measures. It has been discovered that many false rejections of true signatures are due to variations of certain types such as hesitations which occur when the pen tip is off the writing area between inked segments of the signature.
    Type: Grant
    Filed: November 8, 1990
    Date of Patent: April 28, 1992
    Assignee: National Research Development Corporation
    Inventor: John R. Parks
  • Patent number: 5108639
    Abstract: An electrorheological fluid e.g. for selectively coupling clutch members consists of silicone oil containing 30 volume % of dispersed polyaniline. The polyaniline is acidically oxidised aniline subsequently treated with base.
    Type: Grant
    Filed: April 18, 1990
    Date of Patent: April 28, 1992
    Assignee: National Research Development Corporation
    Inventors: Hermann Block, John Chapples, Timothy Watson
  • Patent number: 5106522
    Abstract: An electro-rheological fluid which comprises a solid particulate substance contained in a hydrophobic vehicle which is liquid at atmospheric pressure at least at temperatures below 50.degree. C. and which comprises a compound of the formula:(X).sub.n --Ar[Q--Z].sub.pwherein:Ar represents an aromatic nucleus;Q represents an oxygen or a sulphur atom, or a group of the formula CY.sub.1 Y.sub.2, SO, SO.sub.2, SiF.sub.2, --OSi(Y.sub.1 Y.sub.2)O-- in which Y.sub.1 and Y.sub.
    Type: Grant
    Filed: April 25, 1990
    Date of Patent: April 21, 1992
    Assignee: National Research Development Corporation
    Inventors: James E. Stangroom, Ian Harness
  • Patent number: 5106870
    Abstract: This invention relates to several thromboxane A.sub.2 inhibiting 7-[3-.alpha.-[1-[[(phenylamino)-thioxomethyl]hydrazono]ethyl]-bicyclo[2.2. 1]-heptenoic acids, pharmaceutical compositions employing them and methods of their use.
    Type: Grant
    Filed: September 10, 1990
    Date of Patent: April 21, 1992
    Assignee: National Research Development Corporation
    Inventors: Robert B. Garland, Masateru Miyano
  • Patent number: 5104865
    Abstract: Compounds in which two or more rings, being a 3-hydroxpypyrid-2-one, 3-hydroxypyrid-4-one or 1-hydroxpyrid-2-one, are linked are of value in the treatment of patients having a toxic concentration of a metal, particularly iron, in the body while the iron complexes of such compounds are of value in the treatment of iron deficiency anaemia.
    Type: Grant
    Filed: September 1, 1989
    Date of Patent: April 14, 1992
    Assignee: National Research Development Corporation
    Inventors: Robert C. Hider, George Kontoghiorghes, Jack Silver, Michael A. Stockham
  • Patent number: 5104352
    Abstract: The degree of rigor in a bird or animal carcass is measured. The carcass is carried on a carrier which runs along a rail and over a slight step or drop, which subjects the carcass to a mechanical shock. A sensor monitors the variation with time of the force exerted by the carcass on the support means which arrests its fall. Circuitry analyzes the response to determine the degree of rigor. The carcass is then subjected to appropriate treatment, e.g., by its further processing being delayed to allow rigor to develop further. This can be done by providing a switch in the rail to route the carcass along a short path or a long path. The particular feature of the response which is monitored by the circuitry may, for example, be the time of fall, the amplitude of oscillation after the carcass has been arrested by the support means, the frequency of that oscillation, the rate at which that oscillation is damped, or some combination of those features.
    Type: Grant
    Filed: December 4, 1990
    Date of Patent: April 14, 1992
    Assignee: National Research Development Corporation
    Inventor: Eric Dransfield
  • Patent number: 5102658
    Abstract: A method of preventing controlling or reducing adiposity in which an animal or human being is treated with an effective amount of an antibody to an adipocyte present respectively in said animal or human being.
    Type: Grant
    Filed: July 19, 1985
    Date of Patent: April 7, 1992
    Assignee: National Research Development Corporation
    Inventor: David J. Flint
  • Patent number: 5098921
    Abstract: A compound for treating a patient having a solid tumor in which it is known or suspected that hypoxic cells are present, which is a compound of formula (A): ##STR1## wherein X represents a nitro-substituted aromatic or hetero-aromatic group with a one-electron reduction potential at pH 7 of from -250 to -500 mV; each of R'.sub.1 to R'.sub.5 independently represents hydrogen or an alkyl, hydroxyalkyl, aryl, aralkyl or alkaryl group; m is 0 or 1; n is 1 or 2; and Z' represents a leaving group which has the potential for expulsion via an intramolecular cyclization reaction; or a physiologically acceptable acid addition salt thereof.
    Type: Grant
    Filed: December 2, 1988
    Date of Patent: March 24, 1992
    Assignee: National Research Development Corporation
    Inventors: Gerald E. Adams, Edward M. Fielden, Terence C. Jenkins, Ian J. Stratford
  • Patent number: 5096654
    Abstract: A process for the solid phase deformation of orientable, semi-crystalline, thermoplastic, polymeric material, in particular polyethylene, is provided in which an improvement of the mechanical properties of the polyethylene is achieved. The process for producing a product from linear polyethylene includes forming a workpiece which is to be extruded in the solid phase by consolidating a mass of solid particulate linear polyethylene under heat and pressure. The resulting workpiece is subjected to heat treatment under pressure to cause the polyethylene to crystallize in an extended chain morphology and to have a melting point of at least 139.5.degree. C. and a density of at least 0.98 g/cm.sup.3. Thereafter the workpiece of polyethylene is deformed in the solid phase to provide a polyethylene product by, for example, passage through a die, the workpiece being subjected to a deformation extrusion ratio of at least 3 and preferably 3 to 25.
    Type: Grant
    Filed: July 13, 1989
    Date of Patent: March 17, 1992
    Assignee: The National Research and Development Corporation
    Inventors: Gordon Craggs, Anthony K. Powell, Ian M. Ward
  • Patent number: 5096304
    Abstract: A temperature history indicator for a boiler tube or other thing can take the form of a clip fixed around the tube or thing. The indicator is made of a ferrite-containing duplex stainless steel non-structural piece of alloy having approximately 63 weight % of iron, 23-27% chromium, 5-11% nickel, and the balance comprising other components no one of which exceeds 2.0%. Preferably, the balance of the alloy includes any one or more of 0.005-0.009% carbon, 0.3-0.8% silicon, 1.0-2.0% manganese, 0.002-0.006% phosphorous, 0.003-0.007% sulphur, 0-0.002% molybdenum, and 0.006% phosphorous, 0.003-0.007% sulphur, 0-0.02% molybdenum, and 0-0.02% copper. The thing is associated beforehand with the alloy in such a way as to irreversibly alter its magnetic properties and after exposure to temperature, the time and/or temperature are deduced by the loss in magnetic permeability.
    Type: Grant
    Filed: August 15, 1990
    Date of Patent: March 17, 1992
    Assignee: National Research Development Corporation
    Inventors: Joseph K. L. Lai, Brian J. Duggan
  • Patent number: 5096706
    Abstract: A method of preventing, controlling or reducing adiposity in which an animal or human subject is treated with an immunogen which is a modified or unmodified antigenic substance obtainable from adipose tissue of an individual of the same species as the subject or of a species which is closely related phylogenetically to the species of the subject or which is a modified or unmodified antiidiotypic antibody or fragment thereof to an antibody raised against said antigenic substance whereby an immune response is elicited in the subject effective to prevent, control or reduce adiposity.
    Type: Grant
    Filed: March 25, 1986
    Date of Patent: March 17, 1992
    Assignee: National Research Development Corporation
    Inventor: David J. Flint
  • Patent number: 5096896
    Abstract: A non-crosslinked derivative formable by reacting at least one substituted or unsubstituted, saturated or unsaturated, mono-, di- or poly-carboxy, hydroxy or mercapto hydrocarbon with at least one cyclic unsaturated (thio)ether.
    Type: Grant
    Filed: January 10, 1989
    Date of Patent: March 17, 1992
    Assignee: National Research Development Corporation
    Inventors: Neil B. Graham, Robert E. Howells, David A. Wood, Koritala P. Rao
  • Patent number: 5089499
    Abstract: The invention relates to quinazoline derivatives, or pharmaceutically-acceptable salts thereof, which possess anti-tumor activity; to processes for their manufacture; and to pharmaceutical compositions containing them. The invention provides a quinazoline of the formula: ##STR1## wherein R.sup.1 is hydrogen or amino, or alkyl or alkoxy each of up to 6 carbon atoms; or R.sup.1 is substituted alkyl or alkoxy each of up to 3 carbon atoms;R.sup.2 is hydrogen, alkyl, alkenyl, alkynyl, hydroxyalkyl, halogenoalkyl or cyanoalkyl each of up to 6 carbon atoms;Ar is phenylene or heterocyclene;L is a group of the formula --CO.NH--, --NH.CO--, --CO.NR.sup.3 --, --NR.sup.3. CO--, --CH.dbd.CH--, --CH.sub.2 O--, --OCH.sub.2, --CH.sub.2 S--, --SCH.sub.2 --, --CO.CH.sub.2 --, --CH.sub.2.CO-- or --CO.O--, wherein R.sup.3 is alkyl of up to 6 carbon atoms; andY is aryl or heteroaryl or a hydrogenated derivative thereof: orY is a group of the formula --A--Y.sup.
    Type: Grant
    Filed: December 14, 1989
    Date of Patent: February 18, 1992
    Assignees: Imperial Chemical Industries PLC, National Research Development Corporation
    Inventors: Andrew J. Barker, Leslie R. Hughes, Peter R. Marsham, John Oldfield, Stephen J. Pegg
  • Patent number: 5087451
    Abstract: Periodontal disease is treated with a composition comprising a topically-retainable carrier such as an alginate gel and a non-toxic electron acceptor, such as a ferric compound or a redox organic dye, especially methylene blue or patent blue V, which does not supply molecular oxygen.
    Type: Grant
    Filed: March 7, 1988
    Date of Patent: February 11, 1992
    Assignee: National Research Development Corporation
    Inventors: Michael Wilson, Wilson Harvey
  • Patent number: 5084926
    Abstract: A pillow is of rectangular form having front and rear rolls (17,18) at its longer sides and side rolls at its shorter sides, upper and lower surfaces (15, 16) of the pillow having respective large, central recessed areas (19, 20) between the front and rear rolls, the rolls being interrupted by minor recesses (21, 22 21a, 22a30, 31) extending from respective sides of the pillow into the central recessed areas of the upper and lower surfaces respectively, the front and rear rolls forming on each surface a central main buttress and together with the side rolls forming four corner buttresses, side buttresses also being formed between pairs of adjacent corner buttresses respectively, the side buttresses tapering in width and height away from their respective associated sides of the pillow into a central recessed area (19, 20).
    Type: Grant
    Filed: July 23, 1990
    Date of Patent: February 4, 1992
    Assignee: National Research Development Corporation
    Inventors: James A. Wattie, Joanne M. Wattie
  • Patent number: 5084776
    Abstract: Replay apparatus for replaying in a second medium a hologram recorded by recording apparatus in a first medium having a refractive index different from that of said second medium wherein said replay apparatus incorporates correcting means for correcting aberrations introduced by said recording apparatus.
    Type: Grant
    Filed: December 31, 1990
    Date of Patent: January 28, 1992
    Assignee: National Research Development Corporation
    Inventor: John Watson
  • Patent number: 5084030
    Abstract: A safety device for a hypodermic needle or for a similar instrument used in the clinical puncture of the skin comprises a sheath (6, 25 or 32) adapted to be connected to the needle (5, 21 or 33) or to a support (4 or 31) for the needle. The sheath is so connected in a first position (FIG. 1A, 2A, or 3A) which permits normal use of the needle and can be placed, by movement relative to the needle (FIG. 1B or 3B) or by folding upon itself (FIGS. 2B and 2C) in a second position in which the needle is encapsulated by the sheath. The sheath is retained in that second position, for example by a projection (9, 27 or 35) extending into a slot (10 or 36) or through an aperture (28).
    Type: Grant
    Filed: October 11, 1990
    Date of Patent: January 28, 1992
    Assignee: National Research Development Corporation
    Inventors: Phillip O. Byrne, Penelope R. Sisson, Harry R. Ingham
  • Patent number: 5081282
    Abstract: Bicyclo prostaglandin analogues have been prepared.
    Type: Grant
    Filed: January 13, 1988
    Date of Patent: January 14, 1992
    Assignee: National Research Development Corporation
    Inventors: Robert L. Jones, Norman H. Wilson
  • Patent number: 5079277
    Abstract: A glass ionomer cement composition comprises poly(vinyl phosphonic acid) dissolved in its own mass of water; and (in treble the total mass of the solution) a powder, being glass or MgO or a cermet. The powder has to be deactivated so that the setting reaction with the acid is not too fast, and this is achieved either by a raised Si:Al ratio or by heat-treating.
    Type: Grant
    Filed: April 27, 1989
    Date of Patent: January 7, 1992
    Assignee: National Research Development Corporation
    Inventors: Alan D. Wilson, John Ellis