Abstract: The use of a calcium intracellular store inactivator for inhibiting cell growth is disclosed; for example, thapsigargin or a derivative may be used to inhibit intraocular lens cell growth. Formulations include an emulsion of the compound for coating an IOL, either ex vivo or in vivo.
Type:
Grant
Filed:
June 29, 1998
Date of Patent:
July 3, 2001
Assignees:
The University of East Anglia, The Norfolk & Norwich Health Care NHS Trust
Inventors:
George Duncan, Michael Wormstone, Peter Davies, Christopher Liu