Patents Assigned to The Ohio State University
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Patent number: 12119008Abstract: Systems, computer-implemented methods, and computer program products to facilitate end to end integration of dialogue history for spoken language understanding are provided. According to an embodiment, a system can comprise a processor that executes components stored in memory. The computer executable components comprise a conversation component that encodes speech-based content of an utterance and text-based content of the utterance into a uniform representation.Type: GrantFiled: March 18, 2022Date of Patent: October 15, 2024Assignees: International Business Machines Corporation, The Ohio State UniversityInventors: Samuel Thomas, Vishal Sunder, Hong-Kwang Kuo, Jatin Ganhotra, Brian E. D. Kingsbury, Eric Fosler-Lussier
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Patent number: 11679157Abstract: Formulations for chemoprevention of oral cancer and precancerous lesions, and for methods for preparing the formulations are described.Type: GrantFiled: August 31, 2020Date of Patent: June 20, 2023Assignees: THE OHIO STATE UNIVERSITY, THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Susan R. Mallery, Peter E. Larsen, Gary D. Stoner, Steven P. Schwendeman, Kashappa-Goud Desai
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Patent number: 11583511Abstract: The present invention relates to maresins, preferably maresin-1, for use in the treatment of CNS injuries preferably selected from spinal cord injury and traumatic brain injury.Type: GrantFiled: July 20, 2017Date of Patent: February 21, 2023Assignees: UNIVERSITAT AUTONOMA DE BARCELONA, OHIO STATE UNIVERSITY, THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITYInventors: Ruben Lopez Vales, Isaac Francos Quijorna, Jan Markus Schwab, Samuel David
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Patent number: 11524061Abstract: The present disclosure relates to nanoparticle compositions for use as vaccines against Clostridium perfringens in poultry which causes necrotic enteritis in poultry. Such compositions include one or more Clostridium perfringens extracellular proteins entrapped in a polyanhydride or chitosan nanoparticle. The one or more Clostridium perfringens extracellular proteins may include one or more Clostridium perfringens toxins, such as, for example, alpha toxin (CPA), beta toxin (CPB), epsilon toxin (ETX), iota toxin (ITX), perfringolysin O (PFO), enterotoxin (CPE), beta2 toxin (CPB2), or NetB toxin. In some aspects, the composition further includes a Salmonella enteritidis flagellar protein. The present invention also includes methods for the oral delivery of one or more Clostridium perfringens extracellular proteins to the mucosal membrane of the intestinal tract of a bird of the order Galliformes.Type: GrantFiled: February 4, 2021Date of Patent: December 13, 2022Assignees: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC, THE OHIO STATE UNIVERSITYInventors: Ramesh Kumar Selvaraj, Gabriel Akerele, Sankar Renu, Renukaradhya J. Gourapura
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Patent number: 11390848Abstract: This disclosure provides miRNA/mRNA pairs that can be used to increase the efficacy of T cells or to down-modulate T cell efficacy and restore equilibrium.Type: GrantFiled: June 28, 2017Date of Patent: July 19, 2022Assignees: Regents of the University of Minnesota, Regents of the University of Michigan, The Ohio State UniversityInventors: Bruce R. Blazar, Keli Hippen, Pavan Reddy, Yaping Sun, Ramiro Garzon
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Patent number: 11377436Abstract: The present application provides pyridine, pyrimidine, and pyrazine derivatives that activate excitatory amino acid transporter 2 (EAAT2), and methods of using the derivatives for treating or preventing diseases, disorders, and conditions associated with glutamate excitotoxicity.Type: GrantFiled: July 12, 2018Date of Patent: July 5, 2022Assignees: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., OHIO STATE UNIVERSITYInventors: Kevin Hodgetts, Chien-Liang Glenn Lin
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Publication number: 20220033783Abstract: The current disclosure relates to methods, compositions and kits for detecting modified adenosine in a target RNA molecule. Aspects relate to a method for detecting modified adenosine in a target ribonucleic acid (RNA) comprising contacting the target RNA with an adenosine deaminase enzyme (adenosine deaminase, RNA-specific) to generate a target RNA with deaminated adenosines and sequencing the target RNA with deaminated adenosines; wherein the modified adenosine is detected when the nucleotide sequence includes adenosine within a m6A motif.Type: ApplicationFiled: October 18, 2019Publication date: February 3, 2022Applicants: The University of Chicago, Nationwide Children's Hospital, The Ohio State UniversityInventors: Jianrong LI, Mark E. PEEPLES, Chuan HE, Stefan NIEWIESK, Mijia LU, Miaoge XUE, Zijie ZHANG, Boxuan ZHAO
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Patent number: 11193913Abstract: A method of detecting sub-surface voids in a sample comprises positioning a probe adjacent to a first point on the sample, emitting an ultrasonic wave from the probe towards the sample, moving the probe towards the sample, measuring a shear force amplitude of a reflection of the ultrasonic wave at the probe as the probe moves towards the sample, creating an approach curve by plotting the measured shear force amplitude of the reflection of the ultrasonic wave as a function of a distance between the probe and the sample, and determining whether a sub-surface void exists at the first point on the sample based on a slope of the approach curve.Type: GrantFiled: January 31, 2020Date of Patent: December 7, 2021Assignees: TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC., THE OHIO STATE UNIVERSITYInventors: Shailesh N. Joshi, Vishnu Baba Sundaresan, Vijay Venkatesh
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Patent number: 11191773Abstract: This invention features new compositions and methods that are useful in treating a host with a Gram-negative bacterial infection. Combination therapies comprising an aminocoumarin compound and a polymyxin compound are disclosed, including certain combinations that exhibit synergistic effects. Furthermore, aminocoumarin compounds are described having altered inhibition of DNA gyrase in Gram-negative bacteria and/or the ability to target the transport proteins responsible for assembling lipopolysaccharide in the outer membrane of Gram-negative bacteria.Type: GrantFiled: July 16, 2018Date of Patent: December 7, 2021Assignees: President and Fellows of Harvard College, The Ohio State UniversityInventors: Daniel E. Kahne, Michael D. Mandler, Vadim Baidin, Natividad Ruiz
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Publication number: 20210338593Abstract: Multistage delivery vehicles are disclosed which include a first stage particle and a second stage particle. The first stage particle is a micro or nanoparticle that contains the second stage particle. The second stage particle includes an active agent, such as a therapeutic agent or an imaging agent. The multistage delivery vehicle allows sequential overcoming or bypassing of biological barriers. The multistage delivery vehicle is administered as a part of a composition that includes a plurality of the vehicles. Methods of making the multistage delivery vehicles are also provided.Type: ApplicationFiled: July 6, 2021Publication date: November 4, 2021Applicants: Board of Regents of the University of Texas System, The Ohio State University Research FoundationInventors: Mauro Ferrari, Ennio Tasciotti, Jason Sakamoto
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Publication number: 20210239653Abstract: A method of detecting sub-surface voids in a sample comprises positioning a probe adjacent to a first point on the sample, emitting an ultrasonic wave from the probe towards the sample, moving the probe towards the sample, measuring a shear force amplitude of a reflection of the ultrasonic wave at the probe as the probe moves towards the sample, creating an approach curve by plotting the measured shear force amplitude of the reflection of the ultrasonic wave as a function of a distance between the probe and the sample, and determining whether a sub-surface void exists at the first point on the sample based on a slope of the approach curve.Type: ApplicationFiled: January 31, 2020Publication date: August 5, 2021Applicants: Toyota Motor Engineering & Manufacturing North America, Inc., The Ohio State UniversityInventors: Shailesh N. Joshi, Vishnu Baba Sundaresan, Vijay Venkatesh
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Publication number: 20210133952Abstract: An electronics system may include a substrate, an electronic device bonded to the substrate, a plurality of photoluminescent particles disposed on the electronic device, an illuminator, a sensor, and a control module. The illuminator can illuminate the electronic device. The sensor can capture a first set of positions of the photoluminescent particles on the electronic device when the electronic device is not operating under a load and a second set of positions of the photoluminescent particles when the electronic device is operating under a load. The control module can determine thermomechanical stress on the electronic device based at least in part on a difference between the first set of positions and the second set of positions.Type: ApplicationFiled: October 30, 2019Publication date: May 6, 2021Applicants: Toyota Motor Engineering & Manufacturing North America, Inc., The Ohio State UniversityInventors: Shailesh N. Joshi, Umesh Gandhi, Vishnu Sundaresan, Vijay Venkatesh, Srivatsava Krishnan
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Publication number: 20210052732Abstract: Formulations for chemoprevention of oral cancer and precancerous lesions, and for methods for preparing the formulations are described.Type: ApplicationFiled: August 31, 2020Publication date: February 25, 2021Applicants: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION, THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Susan R. Mallery, Peter E. Larsen, Gary D. Stoner, Steven P. Schwendeman, Kashappa-Goud Desai
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Patent number: 10925697Abstract: The present invention relates to an integrated hybrid dental implant, and more particularly, to an integrated hybrid dental implant in which an opening portion formed at a screw body to enable a drug to be injected into an implantation site of the implant, and the mechanical stability is excellent despite the presence of the opening portion. The integrated hybrid dental implant according to the present invention enables a drug to be supplied to the area around the implantation site so as to induce bone regeneration into the implant after the implant has been placed at a bone-deficient site, has an additional mechanical strength when bone grows into the side openings and hollow inner channel, and allows the screw body to be integrally formed with the prosthesis section (i.e., one piece) to exhibit more excellent mechanical strength so that the implant can be useful as a dental implant.Type: GrantFiled: December 13, 2016Date of Patent: February 23, 2021Assignees: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, THE OHIO STATE UNIVERSITYInventors: Jung-Suk Han, Do-Gyoon Kim
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Patent number: 10787433Abstract: Pyradizine derivatives that activity the excitatory amino acid transporter 2 (EAAT2) of the formula: and methods of use thereof for treating or preventing diseases, disorders, and conditions with glutamate toxicity.Type: GrantFiled: January 13, 2017Date of Patent: September 29, 2020Assignees: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., OHIO STATE UNIVERSITYInventors: Kevin Hodgetts, Chien-Liang Glenn Lin
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Publication number: 20200281994Abstract: The present disclosure relates to synthetic oncolytic viruses comprising a lipid nanoparticle comprising one or more types of lipid and a self-amplifying replicon RNA comprising a sequence that encodes an immunomodulatory molecule.Type: ApplicationFiled: January 10, 2020Publication date: September 10, 2020Applicants: Massachusetts Institute of Technology, The Ohio State UniversityInventors: Darrell J. Irvine, Karl Dane Wittrup, Ron Weiss, Yingzhong Li, Noor Momin, Yizhou Dong
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Patent number: 10758619Abstract: Formulations for chemoprevention of oral cancer and precancerous lesions, and for methods for preparing the formulations are described.Type: GrantFiled: November 15, 2011Date of Patent: September 1, 2020Assignees: THE OHIO STATE UNIVERSITY, THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Susan R. Mallery, Peter E. Larsen, Gary D. Stoner, Steven P. Schwendeman, Kashappa-Goud Desai
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Patent number: 10725040Abstract: The invention provides for a proteomic approach for identification of specific bacterial protein profiles that may be used in the development of methods for the diagnosis of bacterial chronic sinusitis. The invention provides for methods for determining the presence of pathogenic bacteria in the upper respiratory tract of a subject using protein profiles of the pathogenic bacteria. The invention also provides for methods of diagnosing a bacterial infection of the upper respiratory tract of a subject using protein profiles of a pathogenic bacteria. In addition, the invention provides for devices, immunoassays and kits for identifying pathogenic bacteria in the upper respiratory tract.Type: GrantFiled: June 24, 2019Date of Patent: July 28, 2020Assignees: NATIONWIDE CHILDREN'S HOSPITAL, INC., THE OHIO STATE UNIVERSITYInventors: Subinoy Das, Lauren O. Bakaletz
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Patent number: 10723698Abstract: The disclosure relates to PRMT5 inhibitors, including optionally substituted N-alkyl-9H-carbazole analogs, derivatives thereof, and related compounds; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation and benign hematologic diseases using the compounds and compositions.Type: GrantFiled: July 19, 2018Date of Patent: July 28, 2020Assignee: The Ohio State UniversityInventors: Robert A. Baiocchi, Chenglong Li, Hongshan Lai, Said Sif
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Publication number: 20200163923Abstract: The present invention relates to maresins, preferably maresin-1, for use in the treatment of CNS injuries preferably selected from spinal cord injury and traumatic brain injury.Type: ApplicationFiled: July 20, 2017Publication date: May 28, 2020Applicants: UNIVERSITAT AUTONOMA DE BARCELONA, OHIO STATE UNIVERSITY, MCGILL UNIVERSITYInventors: Ruben LOPEZ VALES, Isaac FRANCOS QUIJORNA, Jan Markus SCHWAB, David SAMUEL