Patents Assigned to The Ohio State University
  • Publication number: 20210133952
    Abstract: An electronics system may include a substrate, an electronic device bonded to the substrate, a plurality of photoluminescent particles disposed on the electronic device, an illuminator, a sensor, and a control module. The illuminator can illuminate the electronic device. The sensor can capture a first set of positions of the photoluminescent particles on the electronic device when the electronic device is not operating under a load and a second set of positions of the photoluminescent particles when the electronic device is operating under a load. The control module can determine thermomechanical stress on the electronic device based at least in part on a difference between the first set of positions and the second set of positions.
    Type: Application
    Filed: October 30, 2019
    Publication date: May 6, 2021
    Applicants: Toyota Motor Engineering & Manufacturing North America, Inc., The Ohio State University
    Inventors: Shailesh N. Joshi, Umesh Gandhi, Vishnu Sundaresan, Vijay Venkatesh, Srivatsava Krishnan
  • Publication number: 20210052732
    Abstract: Formulations for chemoprevention of oral cancer and precancerous lesions, and for methods for preparing the formulations are described.
    Type: Application
    Filed: August 31, 2020
    Publication date: February 25, 2021
    Applicants: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION, THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Susan R. Mallery, Peter E. Larsen, Gary D. Stoner, Steven P. Schwendeman, Kashappa-Goud Desai
  • Patent number: 10925697
    Abstract: The present invention relates to an integrated hybrid dental implant, and more particularly, to an integrated hybrid dental implant in which an opening portion formed at a screw body to enable a drug to be injected into an implantation site of the implant, and the mechanical stability is excellent despite the presence of the opening portion. The integrated hybrid dental implant according to the present invention enables a drug to be supplied to the area around the implantation site so as to induce bone regeneration into the implant after the implant has been placed at a bone-deficient site, has an additional mechanical strength when bone grows into the side openings and hollow inner channel, and allows the screw body to be integrally formed with the prosthesis section (i.e., one piece) to exhibit more excellent mechanical strength so that the implant can be useful as a dental implant.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: February 23, 2021
    Assignees: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, THE OHIO STATE UNIVERSITY
    Inventors: Jung-Suk Han, Do-Gyoon Kim
  • Patent number: 10787433
    Abstract: Pyradizine derivatives that activity the excitatory amino acid transporter 2 (EAAT2) of the formula: and methods of use thereof for treating or preventing diseases, disorders, and conditions with glutamate toxicity.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: September 29, 2020
    Assignees: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., OHIO STATE UNIVERSITY
    Inventors: Kevin Hodgetts, Chien-Liang Glenn Lin
  • Publication number: 20200281994
    Abstract: The present disclosure relates to synthetic oncolytic viruses comprising a lipid nanoparticle comprising one or more types of lipid and a self-amplifying replicon RNA comprising a sequence that encodes an immunomodulatory molecule.
    Type: Application
    Filed: January 10, 2020
    Publication date: September 10, 2020
    Applicants: Massachusetts Institute of Technology, The Ohio State University
    Inventors: Darrell J. Irvine, Karl Dane Wittrup, Ron Weiss, Yingzhong Li, Noor Momin, Yizhou Dong
  • Patent number: 10758619
    Abstract: Formulations for chemoprevention of oral cancer and precancerous lesions, and for methods for preparing the formulations are described.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: September 1, 2020
    Assignees: THE OHIO STATE UNIVERSITY, THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Susan R. Mallery, Peter E. Larsen, Gary D. Stoner, Steven P. Schwendeman, Kashappa-Goud Desai
  • Patent number: 10723698
    Abstract: The disclosure relates to PRMT5 inhibitors, including optionally substituted N-alkyl-9H-carbazole analogs, derivatives thereof, and related compounds; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation and benign hematologic diseases using the compounds and compositions.
    Type: Grant
    Filed: July 19, 2018
    Date of Patent: July 28, 2020
    Assignee: The Ohio State University
    Inventors: Robert A. Baiocchi, Chenglong Li, Hongshan Lai, Said Sif
  • Patent number: 10725040
    Abstract: The invention provides for a proteomic approach for identification of specific bacterial protein profiles that may be used in the development of methods for the diagnosis of bacterial chronic sinusitis. The invention provides for methods for determining the presence of pathogenic bacteria in the upper respiratory tract of a subject using protein profiles of the pathogenic bacteria. The invention also provides for methods of diagnosing a bacterial infection of the upper respiratory tract of a subject using protein profiles of a pathogenic bacteria. In addition, the invention provides for devices, immunoassays and kits for identifying pathogenic bacteria in the upper respiratory tract.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: July 28, 2020
    Assignees: NATIONWIDE CHILDREN'S HOSPITAL, INC., THE OHIO STATE UNIVERSITY
    Inventors: Subinoy Das, Lauren O. Bakaletz
  • Publication number: 20200163923
    Abstract: The present invention relates to maresins, preferably maresin-1, for use in the treatment of CNS injuries preferably selected from spinal cord injury and traumatic brain injury.
    Type: Application
    Filed: July 20, 2017
    Publication date: May 28, 2020
    Applicants: UNIVERSITAT AUTONOMA DE BARCELONA, OHIO STATE UNIVERSITY, MCGILL UNIVERSITY
    Inventors: Ruben LOPEZ VALES, Isaac FRANCOS QUIJORNA, Jan Markus SCHWAB, David SAMUEL
  • Patent number: 10465044
    Abstract: Method for making poly(propylene fumarate) (PPF) polymer made by ring-opening polymerization of propylene oxide and maleic anhydride in the presence of magnesium ethoxide initiator, wherein PPF is specifically designed for us in 3D manufacturing of medical devices. PPF polymers have a number average molecular weight (Mn) of from about 450 Daltons to about 3400 Daltons; a molecular mass distribution (m) of from 1.0 to 2.0; and contains less than 1% w/w of poly(maleic anhydride-co-propylene oxide) polymer chains particularly. PPF polymers are non-toxic, degradable, and resorbable and can be used in tissue scaffolds and medical devices that are implanted within a living organism.
    Type: Grant
    Filed: November 18, 2015
    Date of Patent: November 5, 2019
    Assignees: THE UNIVERSITY OF AKRON, THE OHIO STATE UNIVERSITY
    Inventors: Matthew Becker, Howard Dean, Yuanyuan Luo
  • Patent number: 10384943
    Abstract: Method and processes for synthesizing single-wall carbon nanotubes is provided. A carbon precursor gas is contacted with metal catalysts deposited on a support material. The metal catalysts are preferably nanoparticles having diameters less than about 50 nm. The reaction temperature is selected such that it is near the eutectic point of the mixture of metal catalyst particles and carbon.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: August 20, 2019
    Assignees: HONDA MOTOR CO., LTD., THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Avetik Harutyunyan, Elena Pigos, Toshio Tokune
  • Patent number: 10345300
    Abstract: The invention provides for a proteomic approach for identification of specific bacterial protein profiles that may be used in the development of methods for the diagnosis of bacterial chronic sinusitis. The invention provides for methods for determining the presence of pathogenic bacteria in the upper respiratory tract of a subject using protein profiles of the pathogenic bacteria. The invention also provides for methods of diagnosing a bacterial infection of the upper respiratory tract of a subject using protein profiles of a pathogenic bacteria. In addition, the invention provides for devices, immunoassays and kits for identifying pathogenic bacteria in the upper respiratory tract.
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: July 9, 2019
    Assignees: NATIONWIDE CHILDREN'S HOSPITAL, INC., THE OHIO STATE UNIVERSITY
    Inventors: Subinoy Das, Lauren O. Bakaletz
  • Patent number: 10307490
    Abstract: Described is a lipid nanoparticle composition that includes a macromolecule conjugated to a polymer and a targeting agent. The composition can include a therapeutic agent. The therapeutic agent can be an antisense oligonucleotide (ASO). Exemplary ASOs are targeted to a portion of a nucleic acid encoding Akt-1, and which modulates the expression of Akt-1; or targeted to a portion of a nucleic acid encoding HIF-1, and which modulates the expression of HIF-1. Also described is a lipid nanoparticle composition that includes a macromolecule conjugated to a polymer and a therapeutic agent that is an ASO such as an ASO targeted to a portion of a nucleic acid encoding Akt-1, and which modulates the expression of Akt-1 or an ASO targeted to a portion of a nucleic acid encoding HIF-1, and which modulates the expression of HIF-1. Pharmaceutical formulations, methods of making the lipid nanoparticles, and methods of using the lipid nanoparticles, for example for treating cancers, are also disclosed.
    Type: Grant
    Filed: May 23, 2013
    Date of Patent: June 4, 2019
    Assignee: The Ohio State University
    Inventors: Robert J. Lee, Young Bok Lee, Deog Joong Kim, Chang Ho Ahn
  • Publication number: 20190111000
    Abstract: Multistage delivery vehicles are disclosed which include a first stage particle and a second stage particle. The first stage particle is a micro or nanoparticle that contains the second stage particle. The second stage particle includes an active agent, such as a therapeutic agent or an imaging agent. The multistage delivery vehicle allows sequential overcoming or bypassing of biological barriers. The multistage delivery vehicle is administered as a part of a composition that includes a plurality of the vehicles. Methods of making the multistage delivery vehicles are also provided.
    Type: Application
    Filed: October 12, 2018
    Publication date: April 18, 2019
    Applicants: Board of Regents of the University of Texas System, The Ohio State University Research Foundation
    Inventors: Mauro Ferrari, Ennio Tasciotti, Jason Sakamoto
  • Patent number: 10253424
    Abstract: Provided is a particle that includes a first porous region and a second porous region that differs from the first porous region. Also provided is a particle that has a wet etched porous region and that does have a nucleation layer associated with wet etching. Methods of making porous particles are also provided.
    Type: Grant
    Filed: November 11, 2014
    Date of Patent: April 9, 2019
    Assignees: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Mauro Ferrari, Xuewu Liu, Ming-Cheng Cheng
  • Patent number: 10215755
    Abstract: A method of diagnosing a subset of Epstein Barr Virus, Myalgic Encephalomyelitis Chronic Fatigue Syndrome (ME/CFS) patients through a multi-prong clinical/serological analysis is provided wherein Epstein Barr Virus Abortive Lytic Replication (EBV) is determined as the specific causal agent through the use of serum antibodies to EBV encoded dUTPase and serum antibodies to EBV DNA Polymerase as molecular markers. A method of treating patients diagnosed with Epstein Barr Virus Abortive Lytic Replication (EBV), Myalgic Encephalomyelitis Chronic Fatigue Syndrome (ME/CFS) with specific antiviral nucleosides is also provided, to alleviate the condition.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: February 26, 2019
    Assignees: CFS, LLC, OHIO STATE UNIVERSITY
    Inventors: A. Martin Lerner, Ronald M. Glaser
  • Publication number: 20190001027
    Abstract: A Quaternary Mg—Zn—Ca-based alloy and a heat treatment process for producing bioresorbable bone fixation implants are described thereof. The mechanical and biocorrosion properties of the fabricated Mg-based alloy were improved by combining careful selection of the alloy's chemical composition and subsequent post-shaping process (heat treatments). Heat treatment process is more privileged especially after fabricating the part into its final shape such as in additive manufacturing (3D-printing) and powder metallurgy. In this way, it is possible to produce biocompatible, strong and less corrosive patient-specific bone fixation hardware. Also, such heat-treated Mg—Zn—Ca-based parts can be further coated with various types of biocompatible ceramic coatings for slower and more tailored biocorrosion rates.
    Type: Application
    Filed: December 21, 2016
    Publication date: January 3, 2019
    Applicants: The University of Toledo, Ohio State University
    Inventors: Hamdy IBRAHIM, Mohammad ELAHINIA, Howard David DEAN
  • Patent number: 10143658
    Abstract: Multistage delivery vehicles are disclosed which include a first stage particle and a second stage particle. The first stage particle is a micro or nanoparticle that contains the second stage particle. The second stage particle includes an active agent, such as a therapeutic agent or an imaging agent. The multistage delivery vehicle allows sequential overcoming or bypassing of biological barriers. The multistage delivery vehicle is administered as a part of a composition that includes a plurality of the vehicles. Methods of making the multistage delivery vehicles are also provided.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: December 4, 2018
    Assignees: Board of Regents of the University of Texas System, The Ohio State University Research Foundation
    Inventors: Mauro Ferrari, Ennio Tasciotti, Jason Sakamoto
  • Patent number: 10119029
    Abstract: The present invention is directed to a method of isolating fractions of anthocyanin molecules from anthocyanin-containing vegetable and fruit juices and extracts, or combinations thereof, at a select pH based on differences in polarity of the anthocyanin molecules in the anthocyanin-containing vegetable and fruit juices and extracts.
    Type: Grant
    Filed: February 7, 2017
    Date of Patent: November 6, 2018
    Assignees: Mars, Incorporated, The Ohio State University
    Inventors: Rebecca J. Robbins, J. Christopher Johnson, Thomas M. Collins, Neda Ahmadiani, M. Monica Giusti
  • Patent number: 10094010
    Abstract: A strain-hardenable stainless steel alloy includes hard secondary phases dispersed in an austenitic primary phase, the alloy including 0.3-0.6% nitrogen by weight.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: October 9, 2018
    Assignee: THE OHIO STATE UNIVERSITY
    Inventors: Ryan Thomas Smith, Tapasvi Lolla, Sudarsanam Suresh Babu, David Wayne Gandy, John Albert Siefert, Gregory J. Frederick, Lou Lherbier, David Novotnak