Patents Assigned to The Penn State Research Foundation
  • Patent number: 11141097
    Abstract: Systems, methods, and other techniques for monitoring, including non-invasive monitoring, of biological markers based on the interaction, temporal association, or coincidence of brain activity and periphery activity in a mammal are provided. Systems and methods for generating a behavioral state-independent representation of cardiac activity and for identifying cardiac events and/or brain-periphery, e.g., brain-cardiac, temporal associations useful as biomarkers of disease such as, e.g., neurologic disease, in a mammal are also provided.
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: October 12, 2021
    Assignee: The Penn State Research Foundation
    Inventors: Bruce J. Gluckman, Fatemeh Bahari, Steven J. Schiff
  • Patent number: 11141419
    Abstract: Provided are methods for prophylaxis or treatment of SARS-CoV-2 by administering a composition comprising one or more iminosugars to an individual in need thereof. The compositions may be administered to an individual who is at risk of becoming infected by SARS-CoV-2, or has been diagnosed with a SARS-CoV-2 infection. The iminosugars can inhibit SARS-CoV-2 cell entry and replication. The iminosugars potentiate co-administered antiviral agents, such as nucleoside analogs.
    Type: Grant
    Filed: April 27, 2021
    Date of Patent: October 12, 2021
    Assignee: The Penn State Research Foundation
    Inventor: Suresh Kuchipudi
  • Publication number: 20210292720
    Abstract: Unnatural, mutated thioesterases having an amino acid sequence that is at least 80% identical to SEQ. ID. NO: 1 and having substitutions at one or more of amino acid positions I107, R108, L109, S122, M141, E142, Y145, and L146, gene constructs encoding and configured to express the mutated thioesterases in a transformed host cell, and host cells transformed to contain the gene constructs.
    Type: Application
    Filed: May 27, 2021
    Publication date: September 23, 2021
    Applicants: WISCONSIN ALUMNI RESEARCH FOUNDATION, The Penn State Research Foundation
    Inventors: Brian F. Pfleger, Nestor Jose HERNANDEZ-LOZADA, Costas MARANAS, Matthew GRISEWOOD
  • Patent number: 11119054
    Abstract: Provided are processes and materials for solving biological or structural information about proteins or other organic molecules. The processes capitalize on a rigid multimeric nanocage formed from self-assembling substructure proteins. The processes and materials allow for recognition and tight, optionally covalent, bonding of any protein molecule with a tag complementary to a capture sequence on the nanocage. The processes and materials may be used to obtain biological or structural information by cryo-electron microscopy and overcome prior limitations of target protein size or salt concentration.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: September 14, 2021
    Assignee: THE PENN STATE RESEARCH FOUNDATION
    Inventors: Scott Eugene Lindner, Susan Hafenstein
  • Patent number: 11116815
    Abstract: Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via Transforming growth factor beta (TGF-?), Bone morphogenetic protein (BMP), glycogen synthase kinase 3 (GSK-3), and ?-secretase/Notch pathways. The reprogramming is demonstrated using groups of three or four compounds that are chosen from the group thiazovivin, LDN193189, SB431542, TTNPB, CHIR99021, DAPT, VPA, SAG purmorphamine. Reprogramming is demonstrated using the group of LDN193189/CHIR99021/DAPT, the group of B431542/CHIR99021/DAPT, the group of LDN193189/DAPT/SB431542, the group of LDN193189/CHIR99021/SB431542, a three drug combination of SB431542/CHIR99021/DAPT. Reprogramming using functional analogs of the compounds is also provided, as are pharmaceutical formulations that contain the drug combinations.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: September 14, 2021
    Assignee: The Penn State Research Foundation
    Inventors: Gong Chen, Gang-Yi Wu, Lei Zhang, Jiu-Chao Yin, Hana Yeh, Ning-Xin Ma, Grace Lee
  • Patent number: 11091588
    Abstract: Clickable waterborne polymers, click crosslinking of waterborne polymers, click crosslinked waterborne polymers, clickable functional compounds, and click functionalized waterborne polymers are presented. For example, the waterborne polymers have pendant groups bearing alkyne and/or azide groups and alkyne. For example, the functionalized azide-containing functional compounds such as antimicrobial or infrared-refractive compounds. The click crosslinking of clickable waterborne polymers or polymer mixtures, and the click conjugation of clickable waterborne polymers with clickable functional compounds such as clickable antimicrobial or infrared-refractive compounds, which resulted in functional waterborne polymers with antimicrobial or infrared-refractive functions, are presented.
    Type: Grant
    Filed: March 18, 2019
    Date of Patent: August 17, 2021
    Assignee: The Penn State Research Foundation
    Inventors: Jian Yang, Jianqing Hu, Jinshan Guo
  • Patent number: 11088760
    Abstract: A counter-directional optical network having multiple channels includes a source module connected with at least two network nodes by a fiber ribbon including an array of optical fibers. Each channel includes at least one optical fiber. The source module includes multiple signal sources, each signal source connected with one of the channels and operable to transmit a source signal in a direction in the channel. Each network node includes a modulator for processing the source signal with a data input signal forming a message signal, a switch for selecting one of the channels to transmit the message signal and a receiver connected with one of the channels for receiving a message signal from another node. The message signal is transmitted to the receiver of a receiving node in a direction opposite to the transmission direction of the source signal via the channel connected to the receiver of the receiving node.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: August 10, 2021
    Assignee: The Penn State Research Foundation
    Inventor: John Mazurowski
  • Patent number: 11076900
    Abstract: A bone repair system, kit and method for percutaneous repair of a bone segment containing a first bone segment and a second bone segment in a patient, each bone segment having a drill hole. The system comprises a longitudinal member configured to contact the first bone segment and the second bone segment and having at least one opening and cleats on the side adapted to contact the first bone segment and the second bone segment; a first fastener assembly configured to be disposed through the opening of the longitudinal member to hold the longitudinal member in place through the opening and the hole in the first bone segment; and a second fastener assembly configured to be disposed through the opening of the longitudinal member to hold the longitudinal member in place through the opening and the hole in the second bone segment.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: August 3, 2021
    Assignee: The Penn State Research Foundation
    Inventors: Christopher A. Campbell, Christoph A. Roth, Bryan Griffiths, Mark Grady, Barry M. Fell, Peter W. Dillon, Donald R. Mackay, Randy S. Haluck
  • Patent number: 11072015
    Abstract: An incremental forming tool of a sheet material has a tool holder having an axis and at least one tool rod mounted in the tool holder. The at least one tool rod may have variable shapes, lengths, diameters and radii such that the rotation of the at least one tool rod about the axis of the tool holder on the sheet material simulates an up and down, in and out, and/or side-to-side vibration motion.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: July 27, 2021
    Assignee: THE PENN STATE RESEARCH FOUNDATION
    Inventors: John Timothy Roth, Tyler John Grimm, Glenn Craig
  • Patent number: 11062450
    Abstract: Systems and methods are described herein for modeling neural architecture. Regions of interest of a brain of a subject can be identified based on image data characterizing the brain of the subject. the identified regions of interest can be mapped to a connectivity matrix. The connectivity matrix can be a weighted and undirected network. A multivariate transformation can be applied to the connectivity matrix to transform the connectivity matrix into a partial correlation matrix. The multivariate transformation can maintain a positive definite constraint for the connectivity matrix. The partial correlation matrix can be transformed into a neural model indicative of the connectivity matrix.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: July 13, 2021
    Assignees: Ohio State Innovation Foundation, The Penn State Research Foundation, University of North Carolina, University of San Francisco
    Inventors: Skyler Cranmer, Bruce Desmarais, Shankar Bhamidi, James Wilson, Matthew Denny, Zhong-Lin Lu, Paul Stillman
  • Patent number: 11064583
    Abstract: A method of increasing the color gamut of a multi-emitter light emitting device when dimming includes the steps of independently driving each emitter in the device, and increasing the lumen output of at least one emitter while simultaneously decreasing the lumen output of at least one other emitter, such that total color gamut increases while total lumen output of the light emitting device decreases. A light emitting device is also disclosed.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: July 13, 2021
    Assignee: The Penn State Research Foundation
    Inventor: Kevin Houser
  • Publication number: 20210209761
    Abstract: Systems and methods are described herein for modeling neural architecture. Regions of interest of a brain of a subject can be identified based on image data characterizing the brain of the subject. the identified regions of interest can be mapped to a connectivity matrix. The connectivity matrix can be a weighted and undirected network. A multivariate transformation can be applied to the connectivity matrix to transform the connectivity matrix into a partial correlation matrix. The multivariate transformation can maintain a positive definite constraint for the connectivity matrix. The partial correlation matrix can be transformed into a neural model indicative of the connectivity matrix.
    Type: Application
    Filed: March 5, 2021
    Publication date: July 8, 2021
    Applicants: Ohio State Innovation Foundation, The Penn State Research Foundation, University of North Carolina, University of San Francisco
    Inventors: Skyler Cranmer, Bruce Desmarais, Shankar Bhamidi, James Wilson, Matthew Denny, Zhong-Lin Lu, Paul Stillman
  • Patent number: 11053480
    Abstract: Unnatural, mutated thioesterases having an amino acid sequence that is at least 80% identical to SEQ. ID. NO: 1 and having substitutions at one or more of amino acid positions I107, R108, L109, S122, M141, E142, Y145, and L146, gene constructs encoding and configured to express the mutated thioesterases in a transformed host cell and host cells transformed to contain the gene constructs.
    Type: Grant
    Filed: May 12, 2020
    Date of Patent: July 6, 2021
    Assignees: WISCONSIN ALUMNI RESEARCH FOUNDATION, THE PENN STATE RESEARCH FOUNDATION
    Inventors: Brian F. Pfleger, Nestor Jose Hernandez-Lozada, Costas Maranas, Matthew Grisewood
  • Patent number: 11053501
    Abstract: A method of treating a subject suffering from a neurodegenerative disease characterized by insufficient autophagy is provided, the method comprising administering to the subject an effective amount of a composition that inhibits N-deacetylase N-sulfotransferase (NDST). Further provided is a method of identifying a modulator of autophagy.
    Type: Grant
    Filed: December 2, 2019
    Date of Patent: July 6, 2021
    Assignee: The Penn State Research Foundation
    Inventors: Scott Brian Selleck, Claire Reynolds-Peterson
  • Publication number: 20210167395
    Abstract: A battery includes an electrolyte, a metal anode and a cathode. The metal anode includes a porous material disposed thereon to protect the metal anode. The porous material has a zeta potential with a magnitude of at least above 15 mV in the electrolyte. The porous material can include a cross-linked polymer having segments with polar functional groups. Examples of polar functional groups include, but are not limited to, those comprising one or more among O, N, P, S, and B.
    Type: Application
    Filed: April 12, 2019
    Publication date: June 3, 2021
    Applicant: The Penn State Research Foundation
    Inventors: Donghai WANG, Guoxing LI
  • Publication number: 20210165126
    Abstract: A method for improved prediction and enhancement of hydrocarbon recovery from ultra-tight/unconventional reservoirs for both the primary production and any subsequent solvent huff'n'puff periods based on facilitating the diffusion process may include steps of defining one or more initial properties of a reservoir and integrating characterization data of the reservoir; defining a wellbore trajectory for each of at least one well and one or more parameters associated with a completion/reservoir stimulation design; specifying operating conditions for a current development cycle; performing diffusion-based dynamic fracture/reservoir simulation for calculating hydrocarbon recovery and efficiency of a hydrocarbon process; and; determining whether to commence or continue enhanced oil recovery (EOR) or enhanced gas recovery (EGR) cycles.
    Type: Application
    Filed: March 15, 2019
    Publication date: June 3, 2021
    Applicant: The Penn State Research Foundation
    Inventors: Russell T. JOHNS, Hamid EMAMI-MEYBODI, Michael CRONIN
  • Patent number: 11024710
    Abstract: The present invention relates to methods for fabricating vertical homogenous and heterogeneous two-dimensional structures, the fabricated vertical two-dimensional structures, and methods of using the same. The methods demonstrated herein produce structures that are free standing and electrically isolated.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: June 1, 2021
    Assignee: The Penn State Research Foundation
    Inventors: Joshua Alexander Robinson, Rafael Vila
  • Patent number: 11022529
    Abstract: The invention provides enrichment platform devices for size-based capture of particles in solution. The enrichment platform device is useful for label-free capture of any particle. The invention relates to enrichment platform devices using nanowires and vertically aligned carbon nanotubes. The invention provides methods for making the enrichment platform devices. The invention provides methods for using the enrichment platform devices for filtering particles, capturing particles, concentrating particles, and releasing viable particles.
    Type: Grant
    Filed: February 7, 2020
    Date of Patent: June 1, 2021
    Assignee: The Penn State Research Foundation
    Inventors: Siyang Zheng, Mauricio Terrones, Yin-Ting Yeh, Yi Tang, Huaguang Lu, Nestor Perea Lopez, Yiqiu Xia
  • Patent number: 11014048
    Abstract: A free standing liquid membrane is disclosed that can selectively separate objects based on the kinetic energy value of the objects such that either an object having a first kinetic energy value can pass through the free standing liquid membrane while retaining the membrane and/or an object having a second kinetic energy value is prevented from passing through the membrane while retaining the membrane. Advantageously, the free standing liquid membrane can remain intact for seconds to hours with multiple objects passing through the membrane.
    Type: Grant
    Filed: April 16, 2020
    Date of Patent: May 25, 2021
    Assignee: The Penn State Research Foundation
    Inventors: Tak-Sing Wong, Birgitt Boschitsch
  • Patent number: 11008623
    Abstract: The invention provides a method for determining the level of risk for development or progression of a hematologic neoplasia in a subject by analyzing the level of a phosphatidylinositol glycan anchor biosynthesis protein, and providing an appropriate treatment or preventive measure, on the basis of this risk.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: May 18, 2021
    Assignee: THE PENN STATE RESEARCH FOUNDATION
    Inventor: Jeffrey Pu