Abstract: Disclosed herein are compounds, compositions, and methods for treating infections by bacteria and for killing bacteria. In particular, the disclosed compounds, compositions, and methods are useful for treating infections by bacteria and for killing persister bacteria that survive antibiotic treatment and then reconstitute infections.

Abstract: A method of increasing the color gamut of a multi-emitter light emitting device when dimming includes the steps of independently driving each emitter in the device, and increasing the lumen output of at least one emitter while simultaneously decreasing the lumen output of at least one other emitter, such that total color gamut increases while total lumen output of the light emitting device decreases. A light emitting device is also disclosed.

Abstract: A method of improving quality of crowdsourced affective data based on agreement relationship between a plurality of annotators include receiving, by a processor, a collection of stimuli previously given affective labels by the plurality of annotators, executing, by a processor, an algorithm operative to perform the steps including constructing an agreement multigraph as a probabilistic model including a pair-wise status of agreement between the affective labels given by different ones of the plurality of annotators, learning the probabilistic model computationally using the crowdsourced affective data, identifying a reliability of each of the plurality of annotators based on the learned model, and adjusting the crowdsourced affective data by calculating the affective labels of each stimuli based on the identified reliability of each of the plurality of annotators, thereby improving the quality of the crowdsourced affective data.

Abstract: Embodiments relate to a Gaussian synapse device configured so that its transfer characteristics resemble a Gaussian distribution. Embodiments of the Gaussian synapse device include an n-type field-effect transistor (FET) and p-type FET with a common contact so that the two FETs are connected in series. Some embodiments include a global back-gate contact and separate top-gate contact to obtain dual-gated FETs. Some embodiments include two different 2D materials used in the channel to generate the two FETs, while some embodiments use a single ambipolar transport material. In some embodiments, the dual-gated structure is used to dynamically control the amplitude, mean and standard deviation of the Gaussian synapse. In some embodiments, the Gaussian synapse device can be used as a probabilistic computational device (e.g., used to form a probabilistic neural network).

Abstract: The present invention is related to the development of therapeutics and prophylactics for the treatment and/or prevention of bacterial infections in humans and other mammals. A new class of small molecules is disclosed that inhibits the bacterial trans-translation/ribosome rescue mechanism and thus blocks infection of host cells by bacteria. Also disclosed are methods of using the small molecule inhibitors in the treatment/prevention of bacterial infections.

Abstract: Embodiments relate to use of graphite nanoplatelets (GnP) to enhance the mechanical and durability characteristics of cement that may be used as cement sheaths in wellbores of oil and gas wells. Generally, undesired permeability of cement is caused by diffusion of trapped oil and/or natural gas through the cementitious matrix of the cement, leading to material degradation of the cement. Methods disclosed involve using modified GnPs (having physically modified surfaces or chemically modified surfaces energies) to generate a cementitious nanocomposite with uniformly dispersed GnPs, which can effectively arrest the undesired diffusion mechanism. Modified GnPs can also increase the strength of interfacial adhesion (e.g., interfacial bonds and interfacial energies) between the GnP and the cement matrix (e.g., hydrations of the cement). Physical modification of GnP can involve non-covalent treatment techniques. Chemical modification of GnP can involve covalent treatment techniques.

Abstract: Embodiments relate to a computing device that may be configured as a biomimetic audiomorphic device. The device can include a field effect transistor (FET) having a split-gate architecture with different spacing between the split-gates. Embodiments of the device can include multiple split-gates. Some embodiments include the integration of delay elements and tunable resistor-capacitance (RC) circuits for imitating the interaural time delay neurons. Some embodiments include global back-gating structural features to provide neuroplasticity aspects so as to provide adaptation related changes.

Abstract: Alkylresorcinols (ARs) are a homologous series of natural phenolipids extracted from rye bran which have shown antioxidant activity in bulk oils and oil-in-water emulsions. This application is directed to their use in low-moisture foods using crackers as a model system. ARs (153 ?mol) inhibited lipid oxidation reactions based on delayed formation of primary and secondary products of lipid oxidation compared to a control treatment, and were more effective than ?-tocopherol. The antioxidant activity of ARs of compound of Formula (I) increased as alkyl chain length increased, with optimum activity at alkyl chain length C23:0. There was no effect of alkyl chain length on rate of AR loss. ARs are effective antioxidants in low-moisture foods likely due to their hydrophobic nature, which allowed them to localize in the lipid phase, the purported site of lipid oxidation in the model cracker system.

Abstract: A composite material is formed by combining an expandable polymer having a charge with another polymer having an opposite charge to produce. In particular, the composite material can be prepared by combining the polymers with a medium such as and water, and expanding the mixture using a treatment that expands the mixture to produce, for example, insoluble porous foam-like composites.

Abstract: Devices and methods for assisting breathing in a subject are described. In one embodiment, a device includes a splint that can be used to apply negative distending pressure, i.e., outward pull, to one or both of the chest walls and/or the abdomen of a subject. The splint may include an air bladder that can be attached to the skin of the subject's chest and/or abdomen. When the air bladder is inflated, negative distending pressure is applied to the subject's chest and/or abdomen, thereby assisting or promoting respiration. The inflated air bladder may also apply a compressive force on the chest to facilitate expiration, and the removal of secretions in the airways.

Abstract: A free standing liquid membrane is disclosed that can selectively separate objects based on the kinetic energy value of the objects such that either an object having a first kinetic energy value can pass through the free standing liquid membrane while retaining the membrane and/or an object having a second kinetic energy value is prevented from passing through the membrane while retaining the membrane. Advantageously, the free standing liquid membrane can remain intact for seconds to hours with multiple objects passing through the membrane.

Abstract: Provided is a method for treating cancer by administering to an individual who has the cancer a MAD1 peptide. The peptide can enhance the effect of a chemotherapeutic agent that is administered to the individual in combination with the peptide.

Abstract: Embodiments of the systems can be configured to receive electromagnetic emissions of a substrate (e.g., a build material of a part being made via additive manufacturing) by a detector (e.g., a multi-spectral sensor) and generate a ratio of the electromagnetic emissions to perform spectral analysis with a reduced dependence on location and orientation of a surface of the substrate relative to the multi-spectral sensor. The additive manufacturing process can involve use of a laser to generate a laser beam for fusion of the build material into the part. The system can be configured to set the multi-spectral sensor off-axis with respect to the laser (e.g., an optical path of the multi-spectral sensor is at an angle that is different than the angle of incidence of the laser beam). This can allow the multi-spectral sensor to collect spectral data simultaneously as the laser is used to build the part.

Abstract: The present invention provides a prosthetic wrist implant comprising: a radial implant component having an elongated radial stem extending proximally adapted for attachment to radius, a carpal implant component having a distal surface adapted for attachment to one or more carpal bones, and a interposed component between the radial implant component and the carpal implant component that is flexible and allows for changes in orientation between the radial component and the carpal components relative to each other component.

Abstract: Methods and compositions for tissue regeneration of the present invention include a biocompatible porous composite of a decellularized tissue and an aptamer-functionalized hydrogel, wherein the aptamers of the aptamer-functionalized hydrogel specifically and reversibly bind to an active agent.

Abstract: In one aspect, compositions are described herein. A composition described herein comprises a nanoparticle, a therapeutic species, and a linker joining the nanoparticle to the therapeutic species. The linker joining the nanoparticle to the therapeutic species comprises a Diels-Alder cyclo-addition reaction product. Additionally, in some embodiments, the nanoparticle is a magnetic nanoparticle.

Abstract: A bone repair system and method for percutaneously fixing a first bone segment to a second bone segment, such as rib bone segments, in a body of a patient include drilling a first hole through the first bone segment and a second hole through the second bone segment, and feeding a first tether through the first hole and a second tether through the second hole, each tether having a proximal end and a distal end. The first and second tether distal ends are withdrawn from the body while the first and second tether proximal ends have not passed through the first and second bone segments, respectively. A reinforcing member, such as a bone plate, having first and second openings, is passed onto the first and second tether distal ends, and the reinforcing member is pulled into engagement with the first and second bone segments guided by the tethers.

Abstract: Methods and compositions for treating cancer are provided. Compositions comprising ceramide nanoliposomes are administered to a subject in need of such treatment. The composition administration also enhances immunotherapy. Further administering compositions in combination with tumor antigen specific T-cells, and/or compositions in combination with tumor antigen expressing cells, and/or said compositions in combination with antagonists of PD-1 provides for enhanced results. Administration of the compositions provides for effective treatment of tumors including regression and eradication of established tumors.

Abstract: A distension/compression device for assisting breathing in a subject according to one embodiment includes a first tube having a flexible and elastic material that forms a first tube lumen extending from a proximal end to a distal end of the first tube. Longitudinal expansion of the first tube is restricted less than radial expansion of the first tube. A connection element including a first air supply port is in fluid communication with an open proximal end of the first tube lumen and attached to a proximal end of the first tube. A method for assisting breathing of a patient and a method for assisting the clearing of secretions is also included.

Abstract: A method for monitoring a flame cutting process includes a preheating phase, a piercing phase following the preheating phase and a cutting phase following the piercing phase, wherein a cutting torch applies a flame generated by combustion of a gas mixture to an electrically conductive workpiece and wherein an electric current flowing between an electrically conductive part of the cutting torch and the workpiece is measured by a current measuring device during a measuring period. An ignition point at which piercing of a hole through the workpiece using the flame starts due to oxidation of the workpiece is detected by a change in the measured current.