Patents Assigned to The Penn State Research Foundation
  • Patent number: 11980502
    Abstract: A method of performing shear wave elastography in tissue includes transmitting successively a series of ultrasound push pulses in the tissue in a region of interest (ROI) using a single array transducer. The acoustic intensities of the push pulses are sinusoidally modulated with a modulation frequency, Each push pulse generates an acoustic radiation force that pushes the tissue and creates an individual shear wave propagating through the tissue. The amplitudes of the shear waves, and therefore, the displacements produced by the push pulses, are positively proportionally to the intensities of the push pulses. The successively created individual shear waves with different amplitudes sum together to form a continuous, harmonic summed shear wave with a single frequency the same as the modulation frequency of the push pulses.
    Type: Grant
    Filed: November 25, 2019
    Date of Patent: May 14, 2024
    Assignee: The Penn State Research Foundation
    Inventors: Daniel Humberto Cortes Correales, Che-Yu Lin, Seyedali Sadeghi
  • Patent number: 11971377
    Abstract: The present invention describes a versatile, robust and environmentally controlled platform with a linear temperature gradient for massively parallel chemical or biochemical processing. This apparatus is capable of probing the phase transition behavior of macromolecules in solution, both thermodynamically and kinetically. This includes—but is not limited to—liquid/liquid phase transition behavior of antibody solutions and in situ gelation of thermo-responsive polymers. The device can be operated in a multiplex fashion using a controlled temperature gradient architecture and visualized by dark field microscopy or by other optical intensity measurements.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: April 30, 2024
    Assignees: The Penn State Research Foundation, MEDIMMUNE LLC
    Inventors: Tinglu Yang, Bradley Rogers, Jifeng Zhang, Paul S. Cremer
  • Patent number: 11958038
    Abstract: A group of reductive 2D materials (R2D) with extended reactive vacancies and a method for making the R2D with extended reactive vacancies are provided, especially the example of the reductive boron nitride (RBN). To create defects such as vacancies, boron nitride (BN) powders are milled at cryogenic temperatures. Vacancies are produced by milling, and the vacancies can be used to reduce various metal nanostructures on RBN. Due to the thermal stability of the RBN and the enhanced catalytic performance of metal nanostructures, RBN-metals can be used for different catalysts, including electrochemical catalysts and high temperature catalysts.
    Type: Grant
    Filed: June 11, 2021
    Date of Patent: April 16, 2024
    Assignee: The Penn State Research Foundation
    Inventors: Mauricio Terrones, Yu Lei, He Liu, Kazunori Fujisawa, Ana Laura Elias Arriaga, Tianyi Zhang, Rodolfo Cruz-Silva, Morinobu Endo, Xiaoxing Wang, Cynthia Guerrero-Bermea
  • Patent number: 11959187
    Abstract: Synthetic brochosomes can be prepared by disposing a monolayer of first polymer microspheres on a substrate and forming a layer of metal on the monolayer of the first polymer microspheres. A monolayer of second polymer microspheres is then disposed on the layer of metal to form a template. The second polymer microspheres are smaller than the first polymer microspheres. A brochosome material is then electrodeposited on the template. The brochosome material is selected from the group consisting of a metal, a metal oxide, a polymer or a hybrid thereof. The first polymer microspheres and the second polymer microspheres are then removed to form a coating of synthetic brochosomes of the brochosome material on the substrate.
    Type: Grant
    Filed: January 11, 2021
    Date of Patent: April 16, 2024
    Assignee: THE PENN STATE RESEARCH FOUNDATION
    Inventors: Tak-Sing Wong, Shikuan Yang, Nan Sun, Birgitt Boschitsch
  • Patent number: 11959140
    Abstract: A method for evaluating or monitoring metabolic effects of exercise or injury by detecting and/or quantifying microR-NAs in saliva. Compositions and methods of treatment based on detection of microRNAs.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: April 16, 2024
    Assignees: QUADRANT BIOSCIENCES INC., PENN STATE RESEARCH FOUNDATION, THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Richard Uhlig, Steven D. Hicks, Frank A. Middleton
  • Patent number: 11953439
    Abstract: The present invention generally relates to the generation of tunable coloration and/or interference from, for example, surfaces, emulsion droplets and particles. Embodiments described herein may be useful for generation of tunable electromagnetic radiation such as coloration (e.g., iridescence, structural color) and/or interference patterns from, for example, surfaces (e.g., comprising a plurality of microdomes and/or microwells), emulsion droplets and/or particles. In some embodiments, the surfaces, interfaces, droplets, and/or particles produce visible color (e.g., structural color) without the need for dyes.
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: April 9, 2024
    Assignees: Massachusetts Institute of Technology, The Penn State Research Foundation
    Inventors: Lauren Dell Zarzar, Sara N. Nagelberg, Mathias Kolle, Amy Goodling
  • Patent number: 11940325
    Abstract: Embodiments of the systems can be configured to receive electromagnetic emissions of a substrate (e.g., a build material of a part being made via additive manufacturing) by a detector (e.g., a multi-spectral sensor) and generate a ratio of the electromagnetic emissions to perform spectral analysis with a reduced dependence on location and orientation of a surface of the substrate relative to the multi-spectral sensor. The additive manufacturing process can involve use of a laser to generate a laser beam for fusion of the build material into the part. The system can be configured to set the multi-spectral sensor off-axis with respect to the laser (e.g., an optical path of the multi-spectral sensor is at an angle that is different than the angle of incidence of the laser beam). This can allow the multi-spectral sensor to collect spectral data simultaneously as the laser is used to build the part.
    Type: Grant
    Filed: July 21, 2022
    Date of Patent: March 26, 2024
    Assignee: The Penn State Research Foundation
    Inventors: Abdalla R. Nassar, Alexander J. Dunbar, Edward W. Reutzel
  • Patent number: 11938476
    Abstract: A biochemical analysis system capable of sample preparation and processing can include at least one inlet channel having a non-fouling, slippery surface to autonomously transport a fluid sample to a chamber by a geometry of the at least one inlet channel. The at least one inlet channel can include a first end, which is open and exposed, and a second end connected to the chamber for mixing and reaction of the fluid sample, and the at least one inlet channel can include a converging or diverging angle.
    Type: Grant
    Filed: May 20, 2022
    Date of Patent: March 26, 2024
    Assignee: The Penn State Research Foundation
    Inventors: Pak Kin Wong, Tak-Sing Wong, Jing Wang, Hui Li, Yi Lu, Ying Wan
  • Publication number: 20240091300
    Abstract: Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via Transforming growth factor beta (TGF-?), Bone morphogenetic protein (BMP), glycogen synthase kinase 3 (GSK-3), and ?-secretase/Notch pathways. The reprogramming is demonstrated using groups of three or four compounds that are chosen from the group thiazovivin, LDN193189, SB431542, TTNPB, CHIR99021, DAPT, VPA, SAG, purmorphamine. Reprogramming is demonstrated using the group of LDN193189/CHIR99021/DAPT, the group of B431542/CHIR99021/DAPT, the group of LDN193189/DAPT/SB431542, the group of LDN193189/CHIR99021/SB431542, a three drug combination of SB431542/CHIR99021/DAPT. Reprogramming using functional analogs of the compounds is also provided, as are pharmaceutical formulations that contain the drug combinations.
    Type: Application
    Filed: November 10, 2023
    Publication date: March 21, 2024
    Applicant: THE PENN STATE RESEARCH FOUNDATION
    Inventors: Gong CHEN, Gang-Yi WU, Lei ZHANG, Jiu-Chao YIN, Hana YEH, Ning-Xin MA, Grace LEE
  • Publication number: 20240082352
    Abstract: Methods of treating the effects of disruption of normal blood flow in the CNS in an individual subject in need thereof are provided according to aspects of the present invention which include administering a therapeutically effective dose of exogenous NeuroD1 to an area where normal blood flow has been disrupted. Compositions are provided including 1) a recombinant adeno-associated adenovirus expression vector comprising a glial cell specific promoter operably linked to a nucleic acid encoding a site-specific recombinase and 2) a recombinant adeno-associated adenovirus expression vector comprising a ubiquitous promoter operably linked to a nucleic acid encoding NeuroD1, wherein the nucleic acid encoding NeuroD1 is inverted and flanked by two sets of site-specific recombinase recognition sites such that action of the recombinase irreversibly inverts the nucleic acid encoding NeuroD1 such that NeuroD1 is expressed in a mammalian cell.
    Type: Application
    Filed: August 11, 2023
    Publication date: March 14, 2024
    Applicant: The Penn State Research Foundation
    Inventor: Gong CHEN
  • Patent number: 11897479
    Abstract: A device for estimating a friction coefficient between a road surface and an automotive tire through determination of a steering torque during a steering maneuver of a slow-rolling or stationary vehicle includes a computer configured for constructing a brush model for a description of the steering torque across a contact patch between the tire and road surface. The steering torque is a torque acting on a steering axis required to overcome resistance to tire twisting on the road surface at a wheel velocity and a steering rate. The steering torque depends on a tire brush vertical load distribution and relative motion of tire brushes and the road surface. The device further includes sensors for measuring the wheel velocity and the steering rate and mechanism for measurements or estimation of the steering torque. The friction coefficient is estimated based on the measurements or estimation of the steering torque and the brush model.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: February 13, 2024
    Assignees: THE PENN STATE RESEARCH FOUNDATION, BUCKNELL UNIVERSITY
    Inventors: Craig E. Beal, Sean N. Brennan
  • Publication number: 20240025886
    Abstract: The present invention is directed to compounds and compositions comprising thereof. Further, methods of use such as for the treatment and prevention of a disorder associated with binding of IGF2BP1 to an RNA in a subject in need thereof are also provided.
    Type: Application
    Filed: November 18, 2021
    Publication date: January 25, 2024
    Applicants: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., THE PENN STATE RESEARCH FOUNDATION
    Inventors: Vladimir SPIEGELMAN, Vikash SINGH, Arun SHARMA, Amandeep SINGH, Joel YISRAELI, Nadav WALLIS, Froma OBERMAN
  • Patent number: 11866744
    Abstract: Unnatural, mutated thioesterases having an amino acid sequence that is at least 80% identical to SEQ. ID. NO: 1 and having substitutions at one or more of amino acid positions I107, R108, L109, S122, M141, E142, Y145, and L146, gene constructs encoding and configured to express the mutated thioesterases in a transformed host cell and host cells transformed to contain the gene constructs.
    Type: Grant
    Filed: May 27, 2021
    Date of Patent: January 9, 2024
    Assignees: Wisconsin Alumni Research Foundation, The Penn State Research Foundation
    Inventors: Brian F. Pfleger, Nestor Jose Hernandez-Lozada, Costas Maranas, Matthew Grisewood
  • Patent number: 11850273
    Abstract: Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via Transforming growth factor beta (TGF-?), Bone morphogenetic protein (BMP), glycogen synthase kinase 3 (GSK-3), and ?-secretase/Notch pathways. The reprogramming is demonstrated using groups of three or four compounds that are chosen from the group thiazovivin, LDN193189, SB431542, TTNPB, CHIR99021, DAPT, VPA, SAG; purmorphamine. Reprogramming is demonstrated using the group of LDN193189/CHIR99021/DAPT, the group of B431542/CHIR99021/DAPT, the group of LDN193189/DAPT/SB431542, the group of LDN193189/CHIR99021/SB431542, a three drug combination of SB431542/CHIR99021/DAPT. Reprogramming using functional analogs of the compounds is also provided, as are pharmaceutical formulations that contain the drug combinations.
    Type: Grant
    Filed: August 9, 2021
    Date of Patent: December 26, 2023
    Assignee: The Penn State Research Foundation
    Inventors: Gong Chen, Gang-Yi Wu, Lei Zhang, Jiu-Chao Yin, Hana Yeh, Ning-Xin Ma, Grace Lee
  • Publication number: 20230402589
    Abstract: To provide a cathode mixture configured to increase the discharge capacity of a lithium secondary battery. The cathode mixture is a cathode mixture for lithium secondary batteries, comprising: a cathode active material containing an S element, and diphenyl disulfide as an additive, wherein a content of the diphenyl disulfide in the cathode mixture is less than 13.0 mass % of a total mass (100 mass %) of the cathode mixture.
    Type: Application
    Filed: June 10, 2022
    Publication date: December 14, 2023
    Applicants: TOYOTA JIDOSHA KABUSHIKI KAISHA, The Penn State Research Foundation
    Inventors: Shigenori HAMA, Keisuke OMORI, Mitsutoshi OTAKI, Donghai WANG, Atif S. ALZAHRANI, Daiwei WANG
  • Patent number: 11834544
    Abstract: Described herein are cationic polymers having a plurality of quaternary amino groups, methods of making such polymers, and uses of such polymers as ion exchange membranes in electrochemical devices.
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: December 5, 2023
    Assignees: 3M Innovative Properties Company, The Penn State Research Foundation
    Inventors: Michael A. Yandrasits, Carl A. Laskowski, Timothy M. Gillard, Michael Hickner, Liang Zhu
  • Publication number: 20230363679
    Abstract: A system includes a mobile device for capturing raw video of a subject, a preprocessing system communicatively coupled to the mobile device for splitting the raw video into an image stream and an audio stream, an image processing system communicatively coupled to the preprocessing system for processing the image stream into a spatiotemporal facial frame sequence proposal, an audio processing system for processing the audio stream into a preprocessed audio component, one or more machine learning devices that analyze the facial frame sequence proposal and the preprocessed audio component according to a trained model to determine whether the subject is exhibiting signs of a neurological condition, and a user device for receiving data corresponding to a confirmed indication of neurological condition from the one or more machine learning devices and providing the confirmed indication of neurological condition to the subject and/or a clinician via a user interface.
    Type: Application
    Filed: September 17, 2021
    Publication date: November 16, 2023
    Applicants: THE PENN STATE RESEARCH FOUNDATION, THE METHODIST HOSPITAL
    Inventors: James Z. Wang, Mingli Yu, Tongan Cai, Xiaolei Huang, Kelvin Wong, John Volpi, Stephen T.C. Wong
  • Patent number: 11793893
    Abstract: A compound comprising an oligomer formed from a biocompatible multifunctional carboxylic acid comprising a hydroxyl group and at least one carboxylic acid, an polyol (e.g., an aliphatic diol), and a linker. One or more conductive oligomers (e.g., polyanilines) are covalently bonded to the oligomer. The compounds can have various forms (e.g., articles of manufacture, films, scaffolds, and the like). The compounds have various uses. For example, the compounds are used in photoacoustic imaging methods.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: October 24, 2023
    Assignee: THE PENN STATE RESEARCH FOUNDATION
    Inventors: Jian Yang, Dingying Shan
  • Patent number: 11781032
    Abstract: This document provides polymer compositions (e.g., biopolymer compositions) and coatings. For example, methods and materials related to polymer compositions (e.g., biopolymer compositions) and coatings as well as methods and materials for making and using such compositions (e.g., biopolymer compositions) and coatings are provided.
    Type: Grant
    Filed: November 5, 2020
    Date of Patent: October 10, 2023
    Assignee: The Penn State Research Foundation
    Inventors: Jeffrey M. Catchmark, Adam Ross Plucinski
  • Publication number: 20230310816
    Abstract: Methods, devices, systems, and/or kits that encompass various components for accessing cerebrospinal fluid (CSF) in a CSF containing space of a subject to drain the CSF into a dural venous sinus (DVS) of the subject via a single cranial hole are disclosed herein. The described methods, devices, systems and/or kits drain the CSF into the DVS to treat hydrocephalus in a manner that does not require penetration into the gray matter of the subject’s brain.
    Type: Application
    Filed: March 24, 2021
    Publication date: October 5, 2023
    Applicant: The Penn State Research Foundation
    Inventors: Barry M. Fell, Randy S. Haluck, Sprague W. Hazard, III, Elias B. Rizk