Abstract: Methods for producing new neurons in the brain in vivo are provided according to aspects of the present invention which include introducing NeuroD1 into a glial cell, particularly into a reactive astrocyte or NG2 cell, thereby “converting” the reactive glial cell to a neuron. Methods of producing a neuronal phenotype in a glial cell are provided according to aspects of the present invention which include expressing exogenous NeuroD1 in the glial cell, wherein expressing exogenous NeuroD1 includes delivering an expression vector, such as a viral expression vector, including a nucleic acid encoding the exogenous NeuroD1 to the glial cell.

Abstract: A laser beam apparatus can include a set of pulsed lasers (e.g. solid state fiber lasers), a controllable beam deflector, and an electric power supply and controller connected to the beam deflector. The laser pulses from the different pulsed lasers can be configured to hit the beam deflector at different angles and different times. The electric power supply and controller can be configured to control and synchronize the timing and angle at which the different lasers pulses hit the beam deflector with an adjustment of the deflection property of the beam deflector so that the laser pulses from different input directions propagate in the same direction after passing through the beam deflector. The laser pulses from the lasers can be combined together via this control and synchronization.

Abstract: The present disclosure describes membrane compositions and methods for preparing membrane compositions. In particular, the methods employ a layer-by-layer approach to membrane preparation. The membrane compositions provide significantly enhanced membrane performance over existing commercial membranes, particularly in terms of permeability and selectivity.

Abstract: Systems, methods, and other techniques for monitoring, including non-invasive monitoring, of biological markers based on the interaction, temporal association, or coincidence of brain activity and periphery activity in a mammal are provided. Systems and methods for generating a behavioral state-independent representation of cardiac activity and for identifying cardiac events and/or brain-periphery, e.g., brain-cardiac, temporal associations useful as biomarkers of disease such as, e.g., neurologic disease, in a mammal are also provided.

Abstract: Provided are methods for prophylaxis or treatment of SARS-CoV-2 by administering a composition comprising one or more iminosugars to an individual in need thereof. The compositions may be administered to an individual who is at risk of becoming infected by SARS-CoV-2, or has been diagnosed with a SARS-CoV-2 infection. The iminosugars can inhibit SARS-CoV-2 cell entry and replication. The iminosugars potentiate co-administered antiviral agents, such as nucleoside analogs.

Abstract: Unnatural, mutated thioesterases having an amino acid sequence that is at least 80% identical to SEQ. ID. NO: 1 and having substitutions at one or more of amino acid positions I107, R108, L109, S122, M141, E142, Y145, and L146, gene constructs encoding and configured to express the mutated thioesterases in a transformed host cell, and host cells transformed to contain the gene constructs.

Abstract: Provided are processes and materials for solving biological or structural information about proteins or other organic molecules. The processes capitalize on a rigid multimeric nanocage formed from self-assembling substructure proteins. The processes and materials allow for recognition and tight, optionally covalent, bonding of any protein molecule with a tag complementary to a capture sequence on the nanocage. The processes and materials may be used to obtain biological or structural information by cryo-electron microscopy and overcome prior limitations of target protein size or salt concentration.

Abstract: Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via Transforming growth factor beta (TGF-?), Bone morphogenetic protein (BMP), glycogen synthase kinase 3 (GSK-3), and ?-secretase/Notch pathways. The reprogramming is demonstrated using groups of three or four compounds that are chosen from the group thiazovivin, LDN193189, SB431542, TTNPB, CHIR99021, DAPT, VPA, SAG purmorphamine. Reprogramming is demonstrated using the group of LDN193189/CHIR99021/DAPT, the group of B431542/CHIR99021/DAPT, the group of LDN193189/DAPT/SB431542, the group of LDN193189/CHIR99021/SB431542, a three drug combination of SB431542/CHIR99021/DAPT. Reprogramming using functional analogs of the compounds is also provided, as are pharmaceutical formulations that contain the drug combinations.

Abstract: Clickable waterborne polymers, click crosslinking of waterborne polymers, click crosslinked waterborne polymers, clickable functional compounds, and click functionalized waterborne polymers are presented. For example, the waterborne polymers have pendant groups bearing alkyne and/or azide groups and alkyne. For example, the functionalized azide-containing functional compounds such as antimicrobial or infrared-refractive compounds. The click crosslinking of clickable waterborne polymers or polymer mixtures, and the click conjugation of clickable waterborne polymers with clickable functional compounds such as clickable antimicrobial or infrared-refractive compounds, which resulted in functional waterborne polymers with antimicrobial or infrared-refractive functions, are presented.

Abstract: A counter-directional optical network having multiple channels includes a source module connected with at least two network nodes by a fiber ribbon including an array of optical fibers. Each channel includes at least one optical fiber. The source module includes multiple signal sources, each signal source connected with one of the channels and operable to transmit a source signal in a direction in the channel. Each network node includes a modulator for processing the source signal with a data input signal forming a message signal, a switch for selecting one of the channels to transmit the message signal and a receiver connected with one of the channels for receiving a message signal from another node. The message signal is transmitted to the receiver of a receiving node in a direction opposite to the transmission direction of the source signal via the channel connected to the receiver of the receiving node.

Abstract: A bone repair system, kit and method for percutaneous repair of a bone segment containing a first bone segment and a second bone segment in a patient, each bone segment having a drill hole. The system comprises a longitudinal member configured to contact the first bone segment and the second bone segment and having at least one opening and cleats on the side adapted to contact the first bone segment and the second bone segment; a first fastener assembly configured to be disposed through the opening of the longitudinal member to hold the longitudinal member in place through the opening and the hole in the first bone segment; and a second fastener assembly configured to be disposed through the opening of the longitudinal member to hold the longitudinal member in place through the opening and the hole in the second bone segment.

Abstract: An incremental forming tool of a sheet material has a tool holder having an axis and at least one tool rod mounted in the tool holder. The at least one tool rod may have variable shapes, lengths, diameters and radii such that the rotation of the at least one tool rod about the axis of the tool holder on the sheet material simulates an up and down, in and out, and/or side-to-side vibration motion.

Abstract: A method of increasing the color gamut of a multi-emitter light emitting device when dimming includes the steps of independently driving each emitter in the device, and increasing the lumen output of at least one emitter while simultaneously decreasing the lumen output of at least one other emitter, such that total color gamut increases while total lumen output of the light emitting device decreases. A light emitting device is also disclosed.

Abstract: Systems and methods are described herein for modeling neural architecture. Regions of interest of a brain of a subject can be identified based on image data characterizing the brain of the subject. the identified regions of interest can be mapped to a connectivity matrix. The connectivity matrix can be a weighted and undirected network. A multivariate transformation can be applied to the connectivity matrix to transform the connectivity matrix into a partial correlation matrix. The multivariate transformation can maintain a positive definite constraint for the connectivity matrix. The partial correlation matrix can be transformed into a neural model indicative of the connectivity matrix.

Abstract: Systems and methods are described herein for modeling neural architecture. Regions of interest of a brain of a subject can be identified based on image data characterizing the brain of the subject. the identified regions of interest can be mapped to a connectivity matrix. The connectivity matrix can be a weighted and undirected network. A multivariate transformation can be applied to the connectivity matrix to transform the connectivity matrix into a partial correlation matrix. The multivariate transformation can maintain a positive definite constraint for the connectivity matrix. The partial correlation matrix can be transformed into a neural model indicative of the connectivity matrix.

Abstract: Unnatural, mutated thioesterases having an amino acid sequence that is at least 80% identical to SEQ. ID. NO: 1 and having substitutions at one or more of amino acid positions I107, R108, L109, S122, M141, E142, Y145, and L146, gene constructs encoding and configured to express the mutated thioesterases in a transformed host cell and host cells transformed to contain the gene constructs.

Abstract: A method of treating a subject suffering from a neurodegenerative disease characterized by insufficient autophagy is provided, the method comprising administering to the subject an effective amount of a composition that inhibits N-deacetylase N-sulfotransferase (NDST). Further provided is a method of identifying a modulator of autophagy.

Abstract: A method for improved prediction and enhancement of hydrocarbon recovery from ultra-tight/unconventional reservoirs for both the primary production and any subsequent solvent huff'n'puff periods based on facilitating the diffusion process may include steps of defining one or more initial properties of a reservoir and integrating characterization data of the reservoir; defining a wellbore trajectory for each of at least one well and one or more parameters associated with a completion/reservoir stimulation design; specifying operating conditions for a current development cycle; performing diffusion-based dynamic fracture/reservoir simulation for calculating hydrocarbon recovery and efficiency of a hydrocarbon process; and; determining whether to commence or continue enhanced oil recovery (EOR) or enhanced gas recovery (EGR) cycles.

Abstract: A battery includes an electrolyte, a metal anode and a cathode. The metal anode includes a porous material disposed thereon to protect the metal anode. The porous material has a zeta potential with a magnitude of at least above 15 mV in the electrolyte. The porous material can include a cross-linked polymer having segments with polar functional groups. Examples of polar functional groups include, but are not limited to, those comprising one or more among O, N, P, S, and B.

Abstract: The invention provides enrichment platform devices for size-based capture of particles in solution. The enrichment platform device is useful for label-free capture of any particle. The invention relates to enrichment platform devices using nanowires and vertically aligned carbon nanotubes. The invention provides methods for making the enrichment platform devices. The invention provides methods for using the enrichment platform devices for filtering particles, capturing particles, concentrating particles, and releasing viable particles.