Patents Assigned to The Pirbright Institute
  • PEPTIDE
    Publication number: 20140219918
    Abstract: The present invention provides a foot-and-mouth diseases virus (FMDV) VP1 capsid protein which comprises an entity of interest (EOI). The EOI sequence may, for example, be an epitope tag, an immunomodulatory molecule or a target molecule. The present invention also provides an FMDV vaccine which comprises such a VP1 capsid protein and its use to prevent FMD.
    Type: Application
    Filed: June 26, 2012
    Publication date: August 7, 2014
    Applicant: THE PIRBRIGHT INSTITUTE
    Inventors: Julian Seago, Nicholas Juleff
  • RESISTANCE TO BACTERIAL INFECTION
    Publication number: 20140189898
    Abstract: The present invention provides a method of identifying an animal having a genotype associated with resistance to bacterial infection comprising the steps of: (a) providing a sample from said animal; (b) determining the alleles at one or more markers of the SAL1 locus to identify the genotype of the marker, wherein said SAL1 locus lies between 54.0 MB to 54.8 MB of chicken Chromosome 5 or an equivalent thereof; and (c) determining whether the genotype is a genotype associated with resistance to bacterial infection.
    Type: Application
    Filed: March 6, 2014
    Publication date: July 3, 2014
    Applicant: The Pirbright Institute
    Inventors: Mark Fife, Peter Kaiser, Nigel Salmon
  • FOOT AND MOUTH DISEASE VIRUS WITH INCREASED STABILITY AND ITS USE AS VACCINE
    Publication number: 20130230549
    Abstract: The present invention provides a foot and mouth disease (FMD) virus having improved stability compared to the field isolate of the same subtype, wherein the virus comprises one or more amino acid mutations along a line of symmetry of the capsid structure. The present invention also relates to a vaccine comprising such an FMD virus and its use to prevent foot and mouth disease.
    Type: Application
    Filed: September 8, 2011
    Publication date: September 5, 2013
    Applicant: THE PIRBRIGHT INSTITUTE
    Inventors: Veronica Fowler, Nick Knowles, Paul Barnett
  • VACCINE
    Publication number: 20130216569
    Abstract: The present invention provides a polypeptide comprising the amino acid sequence as shown as SEQ ID No. 1 or a homologue or fragment thereof, a nucleic acid capable of encoding such a polypeptide and a vaccine comprising such a polypeptide/nucleic acid. The vaccine may be used for the treatment and/or prevention of a disease associated with an apicomplexan parasite.
    Type: Application
    Filed: August 2, 2011
    Publication date: August 22, 2013
    Applicant: THE PIRBRIGHT INSTITUTE
    Inventors: Damer Blake, Adrian Smith, Martin Shirley
  • Vector
    Patent number: 8501466
    Abstract: The present invention relates to a herpes virus vector which comprises a modified genomic sequence encoding a microRNA (miRNA) against a target sequence. The herpes virus vector may be used as or in a vaccine to prevent and/or treat a disease.
    Type: Grant
    Filed: June 11, 2009
    Date of Patent: August 6, 2013
    Assignee: The Pirbright Institute
    Inventors: Venugopal Nair, Luke Lambeth
  • Diagnose of mycobacterial infections by determination of IFN-gamma
    Patent number: 8455201
    Abstract: The present invention provides a method for diagnosing a mycobacterial infection in a subject, involving the following steps: (i) collection of a sample from the subject; (ii) incubation of the sample from (i) with an antigen preparation for 12 hours or less; and (iii) analysis of ?-IFN in the sample from (ii). The invention also provides a diagnostic kit for use in such a method.
    Type: Grant
    Filed: August 14, 2007
    Date of Patent: June 4, 2013
    Assignee: The Pirbright Institute
    Inventors: Jayne Hope, Paul Sopp, Chris Howard