Patents Assigned to The Population Council, Inc.
-
Publication number: 20160339076Abstract: Disclosed are compositions for inhibiting transmission of a sexually transmitted infection that contain one or more polyanionic microbicides, such as carrageenans, including lambda carrageenan, as well as water-soluble metal salts and specified lectins. Also disclosed are methods for making and using the compositions.Type: ApplicationFiled: January 13, 2015Publication date: November 24, 2016Applicants: The Population Council, Inc., The United States of AmericaInventors: Barry R. O'Keefe, Melissa Robbiani, José A. Fernández Romero
-
Patent number: 9446051Abstract: Methods for treating neurodegeneration and/or myelination in patients are disclosed comprising treating the patient with a progestin compound which exerts binding to progesterone receptors and elicits progesterone-receptor-induced biological responses without interacting with the androgen receptor and without inducing androgen or glucocorticoid biological responses at a dosage sufficient to prevent or reduce neurodegeneration. The progestin compound preferably comprises 16-methylene-17?-acetoxy-19-norpregn-4-ene-3,20-dione, and the methods include combining the progestin compound with an estrogen compound to provide both contraception and treatment for myelin repair and neurodegeneration, and include effects on stroke and TBI.Type: GrantFiled: December 21, 2012Date of Patent: September 20, 2016Assignee: The Population Council, Inc.Inventors: Regine Sitruk-Ware, Michael Maria Helmut Schumacher, Roberta Brinton, Martine El-Etr, Abdelmouman Ghoumari, Rachida Guennoun
-
Patent number: 9364488Abstract: Methods for effective remyelination in patients are disclosed comprising treating the patient with an androgen receptor ligand which exerts binding to androgen receptors and elicits androgen-receptor-induced biological responses at a dosage sufficient to induce remyelination. The androgen compound preferably comprises MENT in an androgen targeting both androgen and estrogen receptors, and the methods include combining the androgen compound with a progestin compound in order to provide both contraception in men and treatment for neurodegeneration.Type: GrantFiled: March 22, 2012Date of Patent: June 14, 2016Assignee: The Population Council, Inc.Inventors: Regine Sitruk-Ware, Michael Maria Helmut Schumacher, Abdelmouman Ghoumari, Said Ghandour, Rashad Hussain, Bartosz Bielecki
-
Patent number: 9296780Abstract: A process ethynylates 16-methylene-17-keto steroids to the corresponding 16-methylene-17?-ethynyl-17?-hydroxy steroids by treatment with silyl-protected lithium acetylides followed by further desilylation. The resulting products are useful intermediates in the preparation of several pharmaceutically active agents, such as e.g. Nestorone® or melengestrol acetate.Type: GrantFiled: December 19, 2012Date of Patent: March 29, 2016Assignees: Crystal Pharma, S.A.U., Population Council Inc.Inventors: Luis Gerardo Gutiérrez Fuentes, Celso Miguel Sandoval Rodriguez
-
Publication number: 20150005518Abstract: A process ethynylates 16-methylene-17-keto steroids to the corresponding 16-methylene-17?-ethynyl-17?-hydroxy steroids by treatment with silyl-protected lithium acetylides followed by further desilylation. The resulting products are useful intermediates in the preparation of several pharmaceutically active agents, such as e.g. Nestorone® or melengestrol acetate.Type: ApplicationFiled: December 19, 2012Publication date: January 1, 2015Applicants: CRYSTAL PHARMA, S.A.U., THE POPULATION COUNCIL INC.Inventors: Luis Gerardo Gutiérrez Fuentes, Celso Miguel Sandoval Rodríguez
-
Patent number: 8753667Abstract: Multi-layered vaginal rings 2 comprising silicone elastomers and pharmaceutically active ingredients are disclosed. The rings comprise a number of layers, at least one of which contains a pharmaceutically active ingredient, and each of which is a silicone elastomer. The multiple layers preferably are produced from these layers of different compositions, including an inner layer 4, a middle layer 5, and an outer layer 6. After extrusion and simultaneous curing, however, the ring 2 includes a contiguous body which comprises a continuous silicone body providing unimpeded diffusion of the pharmaceutically active ingredient from the inner layer (s) 4 to the outer layer (s) 6. Methods of producing these vaginal rings and of using them are also disclosed.Type: GrantFiled: April 7, 2010Date of Patent: June 17, 2014Assignee: The Population Council, Inc.Inventors: Bruce Variano, Jeffrey Speck, Maria Teresa Sallent, Simone Evans
-
Publication number: 20140011791Abstract: Methods for effective remyelination in patients are disclosed comprising treating the patient with an androgen receptor ligand which exerts binding to androgen receptors and elicits androgen-receptor-induced biological responses at a dosage sufficient to induce remyelination. The androgen compound preferably comprises MENT in an androgen targeting both androgen and estrogen receptors, and the methods include combining the androgen compound with a progestin compound in order to provide both contraception in men and treatment for neurodegeneration.Type: ApplicationFiled: March 22, 2012Publication date: January 9, 2014Applicant: THE POPULATION COUNCIL, INC.Inventors: Regine Sitruk-Ware, Michael Maria Helmut Schumacher, Abdelmouman Ghoumari, Said Ghandour, Rashad Hussain, Bartosz Bielecki
-
Publication number: 20130150810Abstract: Disclosed are compositions for inhibiting transmission of a sexually transmitted infection that contain one or more polyanionic microbicides, such as carrageenans, including lambda carrageenan, as well as water-soluble metal salts and specified antiretroviral agents comprising NNRTIs and NRTIs. Also disclosed are methods for making and using the compositions. Also disclosed are intravaginal rings for delivering water-soluble compounds, and preferably high molecular weight water-soluble polymers at essentially a zero order rate. The rings include an outer layer of non-water-swellable elastomer, and preferably high molecular weight water-soluble polymer and an inner layer of the water-soluble polymer, which is imbedded in the outer layer, and an aperture through the outer layer for release thereof only through that aperture.Type: ApplicationFiled: February 5, 2013Publication date: June 13, 2013Applicant: THE POPULATION COUNCIL, INC.Inventor: The Population Council, Inc.
-
Publication number: 20130116217Abstract: Methods for treating neurodegeneration and/or myelination in patients are disclosed comprising treating the patient with a progestin compound which exerts binding to progesterone receptors and elicits progesterone-receptor-induced biological responses without interacting with the androgen receptor and without inducing androgen or glucocorticoid biological responses at a dosage sufficient to prevent or reduce neurodegeneration. The progestin compound preferably comprises 16-methylene-17?-acetoxy-19-norpregn-4-ene-3,20-dione, and the methods include combining the progestin compound with an estrogen compound to provide both contraception and treatment for myelin repair and neurodegeneration, and include effects on stroke and TBI.Type: ApplicationFiled: December 21, 2012Publication date: May 9, 2013Applicant: THE POPULATION COUNCIL, INC.Inventor: The Population Council, Inc.
-
Publication number: 20130045953Abstract: The invention discloses compositions and methods for ensuring in both women of fertile age where it ensures also a contraception with additional health benefits and in postmenopausal women where it offers a hormonal therapy with additional medical benefits such as the potential for lower risk of thrombosis. The aforementioned compositions comprising NES as a potent progestational and antiovulatory agent with no androgenic nor estrogenic nor glucocorticoid effect, and combined with estradiol formulated for non-oral transdermal administration as specific daily doses.Type: ApplicationFiled: December 17, 2010Publication date: February 21, 2013Applicants: ANTARES PHARMA IPL AG, THE POPULATION COUNCIL, INC.Inventors: Regine Sitruk-Ware, Dario Norberto Ramon Carrara, Arnaud Grenier
-
Patent number: 8367098Abstract: Disclosed are compositions for inhibiting transmission of a sexually transmitted infection that contain one or more polyanionic microbicides, such as carrageenans, including lambda carrageenan, as well as water-soluble metal salts and specified antiretroviral agents comprising NNRTIs and NRTIs. Also disclosed are methods for making and using the compositions.Type: GrantFiled: October 6, 2009Date of Patent: February 5, 2013Assignee: The Population Council, Inc.Inventors: Mitchell Thorn, Naomi Rutenberg
-
Publication number: 20120231052Abstract: Methods for treating neurodegeneration and/or myelination in patients are disclosed comprising treating the patient with a progestin compound which exerts binding to progesterone receptors and elicits progesterone-receptor-induced biological responses without interacting with the androgen receptor and without inducing androgen or glucocorticoid biological responses at a dosage sufficient to prevent or reduce neurodegeneration. The progestin compound preferably comprises 16-methylene-17?-acetoxy-19-norpregn-4-ene-3,20-dione, and the methods include combining the progestin compound with an estrogen compound to provide both contraception and treatment for myelin repair and neurodegeneration.Type: ApplicationFiled: October 19, 2010Publication date: September 13, 2012Applicant: THE POPULATION COUNCIL, INC.Inventors: Regine Sitruk-Ware, Michael Maria Helmut Schumacher, Roberta Brinton, Martine El-Etr, Abdelmouman Ghoumari, Rachida Guennoun
-
Publication number: 20120148655Abstract: Multi-layered vaginal rings 2 comprising silicone elastomers and pharmaceutically active ingredients are disclosed. The rings comprise a number of layers, at least one of which contains a pharmaceutically active ingredient, and each of which is a silicone elastomer. The multiple layers preferably are produced from these layers of different compositions, including an inner layer 4, a middle layer 5, and an outer layer 6. After extrusion and simultaneous curing, however, the ring 2 includes a contiguous body which comprises a continuous silicone body providing unimpeded diffusion of the pharmaceutically active ingredient from the inner layer (s) 4 to the outer layer (s) 6. Methods of producing these vaginal rings and of using them are also disclosed.Type: ApplicationFiled: April 7, 2010Publication date: June 14, 2012Applicant: THE POPULATION COUNCIL, INC.Inventors: Bruce Variano, Jeffrey Speck, Maria Teresa Sallent, Simone Evans
-
Patent number: 8173593Abstract: Disclosed are methods and compositions containing endothelin receptor antagonists for emergency contraception.Type: GrantFiled: July 19, 2006Date of Patent: May 8, 2012Assignee: The Population Council, Inc.Inventors: Indrani C. Bagchi, Regine Sitruk-Ware
-
Publication number: 20100256089Abstract: Disclosed are compositions for inhibiting transmission of a sexually transmitted infection that contain one or more polyanionic microbicides, such as carrageenans, including lambda carrageenan, as well as water-soluble metal salts and specified antiretroviral agents comprising NNRTIs and NRTIs. Also disclosed are methods for making and using the compositions.Type: ApplicationFiled: October 6, 2009Publication date: October 7, 2010Applicant: The Population Council, Inc.Inventors: Robin A. Maguire, Mitchell Thorn, David M. Phillips
-
Publication number: 20100015247Abstract: Disclosed are compositions for inhibiting transmission of a sexually transmitted infection that contain one or more carrageenans, including lambda carrageenan. Also disclosed are methods for making and using the compositions.Type: ApplicationFiled: September 18, 2009Publication date: January 21, 2010Applicant: The Population Council, Inc.Inventors: Robin A. Maguire, Mitchell Thorn, David M. Phillips
-
Publication number: 20090203591Abstract: Disclosed are methods and compositions containing endothelin receptor antagonists for emergency contraception.Type: ApplicationFiled: July 19, 2006Publication date: August 13, 2009Applicant: The Population Council, Inc.Inventors: Indrani C. Bagchi, Regine Sitruk-Ware
-
Publication number: 20050261240Abstract: Disclosed are compositions for inhibiting transmission of a sexually transmitted infection that contain one or more carrageenans, including lambda carrageenan. Also disclosed are methods for making and using the compositions.Type: ApplicationFiled: October 29, 2004Publication date: November 24, 2005Applicant: The Population Council, Inc.Inventors: Robin Maguire, Mitchell Thorn, David Phillips
-
Publication number: 20050256051Abstract: Disclosed are compositions and methods for introducing Peptide Nucleic Acids (PNAs) into cell nuclei. The PNAs are linked to a ligand that binds a nuclear receptor. The methods have therapeutic and diagnostic applications.Type: ApplicationFiled: June 27, 2005Publication date: November 17, 2005Applicant: The Population Council, Inc.Inventor: Patricia Morris
-
Publication number: 20040242476Abstract: Disclosed are male contraceptives containing a peptide and analogs thereof having an amino acid sequence corresponding to the second extracellular domain of a mammalian occludin. The peptides may be linked to a carrier targeting testicular cells, preferably to a modified follicle stimulating hormone. Methods of producing such a contraceptive, and a method of use are also disclosed.Type: ApplicationFiled: July 7, 2004Publication date: December 2, 2004Applicant: The Population Council, IncInventor: C Yan Cheng