Abstract: Apparatus for implanting closable locking clips to effect the percutaneous occlusion of target vessels or tissue is disclosed, including a pair of pivotable jaws defining a clip retaining cavity, a clip moving slide for sliding a locking clip from a retracted position remote from the clip retaining cavity to an actuated position with the clip retaining cavity, and a camming surface operatively disposed within the clip retaining cavity so that upon slidable movement of the locking clip from the retracted position to the actuated position the camming surface causes at least partial closure of the locking clip therein.