Patents Assigned to The President and Fellows of Harvard University
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Patent number: 10946588Abstract: A present disclosure relates to a system for automatic design and manufacturing of 3D printing units and 3D products. The system is configured to obtain specification of a target structure corresponding to a 3D product; automatically determine a design and a printing path of a 3D printing unit based on the specification of the target structure, wherein the 3D printing unit is a micronozzle unit configured to print the target structure of the 3D product; automatically determine a manufacturing procedure to print the 3D printing unit based on the specification of the target structure; and instruct a 3D printer to print the 3D printing unit according to the manufacturing procedure and the printing path of the 3D printing unit.Type: GrantFiled: March 3, 2017Date of Patent: March 16, 2021Assignee: President and Fellows of Harvard UniversityInventors: Jennifer A. Lewis, Mark Andrew Skylar-Scott, Jochen Mueller, David Kolesky
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Patent number: 8986999Abstract: Methods and apparatuses for encapsulating inorganic micro- or nanostructures within polymeric microgels are described. In various embodiments, viruses are encapsulated with microgels during microgel formation. The viruses can provide a template for in situ synthesis of the inorganic structures within the microgel. The inorganic structures can be distributed substantially homogeneously throughout the microgel, or can be distributed non-uniformly within the microgel. The inventive microgel compositions can be used for a variety of applications including electronic devices, biotechnological devices, fuel cells, display devices and optical devices.Type: GrantFiled: February 7, 2014Date of Patent: March 24, 2015Assignees: Massachusetts Institute of Technology, President and Fellows of Harvard UniversityInventors: Yoon Sung Nam, Angela Belcher, Andrew Parsons Magyar, Daeyeon Lee, Jin-Woong Kim, David Weitz
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Publication number: 20100242633Abstract: One aspect of the invention relates to the devices and methods for the collection of bioaerosols (such as viruses, bacteria, and proteins) from the exhaled breath of humans and/or animals, for the purpose of determining, for example, particle size, generation rate, diseases and interventions for particle release.Type: ApplicationFiled: March 23, 2010Publication date: September 30, 2010Applicants: The President and Fellows of Harvard University, University of Massachusetts LowellInventors: James McDevitt, Donald Milton, Petros Koutrakis, Stephen T. Ferguson, Jack M. Wolfson
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Patent number: 7737290Abstract: Metal films are deposited with uniform thickness and excellent step coverage. Copper metal films were deposited on heated substrates by the reaction of alternating doses of copper(I) NN?-diispropylacetamidinate vapor and hydrogen gas. Cobalt metal films were deposited on heated substrates be the reaction of alternating doses of cobalt(II) bis(N,N?-diispropylacetamidinate) vapor and hydrogen gas. Nitrides and oxides of these metals can be formed by replacing the hydrogen with ammonia or water vapor, respectively. The films have very uniform thickness and excellent step coverage in narrow holes. Suitable applications include electrical interconnects in microelectronics and magnetoresistant layers in magnetic information storage devices.Type: GrantFiled: July 1, 2009Date of Patent: June 15, 2010Assignee: President and Fellows of Harvard UniversityInventors: Roy Gerald Gordon, Booyong S. Lim
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Patent number: 7638645Abstract: Metal(IV) tetrakis(N,N?-dialkylamidinates) were synthesized and characterized. Exemplary metals include hafnium, zirconium, tantalum, niobium, tungsten, molybdenum, tin and uranium. These compounds are volatile, highly stable thermally, and suitable for vapor deposition of metals and their oxides, nitrides and other compounds.Type: GrantFiled: October 17, 2006Date of Patent: December 29, 2009Assignee: President and Fellows of Harvard UniversityInventors: Roy G. Gordon, Jean-Sebastien Lehn, Huazhi Li
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Patent number: 7592147Abstract: The instant invention is based, at least in part, on the dentification of a mechanism by which T-bet modulates IL2 production. The present invention pertains to methods of identifying agents that modulate the kinase-mediated interaction of T-bet with RelA, as well as methods of use therefore.Type: GrantFiled: November 7, 2006Date of Patent: September 22, 2009Assignee: President and Fellows of Harvard UniversityInventors: Laurie H. Glimcher, Eun Sook Hwang
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Patent number: 7425332Abstract: The present invention is directed to polypeptides containing at least three amino acids randomly joined in a linear array; wherein at least one of the three amino acids is an aromatic amino acid, at least one of the three amino acids is a charged amino acid and at least one amino acid is an aliphatic amino acid. In a preferred embodiment the polypeptide contains three or four of the following amino acids: tyrosine, alanine, glutamic acid or lysine. According to the present invention, the present polypeptides bind to antigen presenting cells, purified human lymphocyte antigens (HLA) and/or Copolymer 1-specific T cells. Moreover, according to the present invention, these polypeptides can be formulated into pharmaceutical compositions for treating autoimmune disease. The present invention further contemplates methods of treating an autoimmune disease in a mammal by administering a pharmaceutically effective amount of any one of the present polypeptides to the mammal.Type: GrantFiled: September 27, 2006Date of Patent: September 16, 2008Assignees: Yeda Research and Development Co., Ltd., President and Fellows of Harvard UniversityInventors: Michael Sela, Masha Fridkis-Hareli, Jack L. Strominger, Rina Aharoni, Dvora Teitelbaum, Ruth Arnon
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Publication number: 20040188721Abstract: Electrical devices comprised of nanoscopic wires are described, along with methods of their manufacture and use. The nanoscopic wires can be nanotubes, preferably single-walled carbon nanotubes. They can be arranged in crossbar arrays using chemically patterned surfaces for direction, via chemical vapor deposition. Chemical vapor deposition also can be used to form nanotubes in arrays in the presence of directing electric fields, optionally in combination with self-assembled monolayer patterns. Bistable devices are described.Type: ApplicationFiled: March 29, 2004Publication date: September 30, 2004Applicant: President and Fellows of Harvard UniversityInventors: Charles M. Lieber, Thomas Rueckes, Ernesto Joselevich, Kevin Kim
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Publication number: 20040159633Abstract: Improved methods of forming a patterned self-assembled monolayer on a surface and derivative articles are provided. According to one method, an elastomeric stamp is deformed during and/or prior to using the stamp to print a self-assembled molecular monolayer on a surface. According to another method, during monolayer printing the surface is contacted with a liquid that is immiscible with the molecular monolayer-forming species to effect controlled reactive spreading of the monolayer on the surface. Methods of printing self-assembled molecular monolayers on nonplanar surfaces and derivative articles are provided, as are methods of etching surfaces patterned with self-assembled monolayers, including methods of etching silicon. Optical elements including flexible diffraction gratings, mirrors, and lenses are provided, as are methods for forming optical devices and other articles using lithographic molding.Type: ApplicationFiled: February 11, 2004Publication date: August 19, 2004Applicant: President & Fellows of Harvard UniversityInventors: George M. Whitesides, Younan Xia, James L. Wilbur, Rebecca J. Jackman, Enoch Kim, Mara G. Prentiss, Milan Mrksich, Amit Kumar, Christopher B. Gorman, Hans Biebuyck, Karl K. Berggren
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Patent number: 6441053Abstract: A method of identifying inhibitors of glycogen synthase kinase-3 is provided. The method comprises providing a mixture comprising GSK-3, a phosphate source, and a GSK-3 substrate, incubating the mixture in the presence or absence of a test compound, and assessing the activity of GSK-3 in the mixture. A reduction of GSK-3 activity following incubation of the mixture in the presence of the test compound is an indication that the test compound is an inhibitor of GSK-3.Type: GrantFiled: June 8, 1999Date of Patent: August 27, 2002Assignees: The Trustees of the University of Pennsylvania, President and Fellows of Harvard UniversityInventors: Peter S. Klein, Douglas Melton
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Patent number: 6180379Abstract: Disclosed are novel human and clam ubiquitin carrier polypeptides involved in the ubiquitination of cyclins A and/or B. Also disclosed are inhibitors of such polypeptides, nucleic acids encoding such polypeptides and inhibitors, antibodies specific for such polypeptides, and methods of their use.Type: GrantFiled: March 31, 1997Date of Patent: January 30, 2001Assignee: President and Fellows of Harvard UniversityInventors: Joan V. Ruderman, Avram Hershko, Marc W. Kirschner, Fiona Townsley, Alexander Aristarkov, Esther Eytan, Hongtao Yu
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Patent number: 6020144Abstract: Disclosed herein are novel medical devices, particular well-suited for sustained delivery of therapeutically-significant substances. Also disclosed are methods of making and using these delivery devices. Using these devices and methods the present invention teaches sustained, targeted and reversible delivery of immunostimulating agents, as well as therapeutic agents such as enzymes, hormones and neurotransmitters, to name but a few.Type: GrantFiled: October 23, 1996Date of Patent: February 1, 2000Assignees: Symbiontics, Inc., Presidents and Fellows of Harvard UniversityInventors: Frederico J. Gueiros-Filho, Stephen M. Beverley, Dennis E. Vaccaro
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Patent number: 5980983Abstract: A liquid precursor is provided for the formation of metal oxide films comprising a mixture of two ro more types of beta-diketonate ligands bound to one or more metals. For example, a liquid mixture was formed of the mixed aluminum beta-diketonates derived from two or more of the ligands 2,6-dimethyl-3,5-heptanedione; 2,7-dimethyl-3,5-heptanedione; 2,6-dimethyl-3,5-octanedione; 2,2,6-trimethyl-3,5-heptanedione; 2,8-dimethyl-4,6-nonanedione; 2,7-dimethyl-4,6-nonanedione; 2,2,7-trimethyl-3,5-octanedione; and 2,2,6-trimethyl-3,5-octanedione. Films of metal oxides are deposited from vaporized precursor mixtures of metal beta-diketonates and, optionally, oxygen or other sources of oxygen. This process may be used to deposit high-purity, transparent metal oxide films on a substrate. The liquid mixtures may also be used for spray coating, spin coating and sol-gel deposition of materials.Type: GrantFiled: April 17, 1998Date of Patent: November 9, 1999Assignee: The President and Fellows of Harvard UniversityInventor: Roy G. Gordon
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Patent number: 5786171Abstract: An aortic-preferentially-expressed gene-1 (APEG-1) polypeptide, DNA sequences encoding and controlling the transcription of APEG-1, methods of diagnosing vascular injury, and methods of inhibiting vascular smooth muscle cell proliferation by increasing the level of APEG-1 at the site of vascular injury.Type: GrantFiled: June 22, 1995Date of Patent: July 28, 1998Assignee: President and Fellows of Harvard UniversityInventors: Mu-En Lee, Chung-Ming Hsieh
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Patent number: 5532132Abstract: The present invention is directed to a method for regulating formation of a complex of a plasminogen activator, its receptor and one of its inhibitors. More specifically, this method involves contacting a target cell having a plasminogen activator receptor with a compound which interacts with a component of the complex such that a change in target cell cytoskeletal stiffness results.Type: GrantFiled: September 28, 1993Date of Patent: July 2, 1996Assignees: President and Fellows of Harvard University, University of ParisInventors: Ning Wang, Georgia Barlovatz-Meimon, Jeffrey J. Fredberg
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Patent number: 5358959Abstract: The applicant has identified a particular class of imidazoles that inhibit endothelial cell, vascular smooth muscle cell and fibroblast proliferation. These imidazoles can be used to beneficially treat a variety of arteriosclerotic conditions.Type: GrantFiled: February 18, 1993Date of Patent: October 25, 1994Assignee: President and Fellows of Harvard UniversityInventors: Jose Halperin, Carlo Brugnara
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Patent number: 5245466Abstract: Arrays of extended crystalline and non-crystalline structures are created using light beams coupled to microscopic polarizable matter. Polarizable matter adopts the pattern of an applied, patterned light intensity distribution. Further, polarizable matter itself scatters applied light, resulting in production of a stable, bound configuration of that matter. Alternatively, polarizable matter can simultaneously adopt the pattern of an applied patterned light intensity while the incident light scattered by the matter itself acts further to organize the matter. Dielectric, semiconductor, metal, molecular, atomic and biological matter can be organized using light to fabricate numerous devices including mechanical and optical filters, self-organizing Bragg lasers, templates for epitaxy, photonic semiconductors, optical components including holograms and diffractive optical elements as well as two dimensional membranes of living biological cells.Type: GrantFiled: October 8, 1991Date of Patent: September 14, 1993Assignee: President and Fellows of Harvard University and Rowland InstituteInventors: Michael M. Burns, Jean-Marc Fournier, Jene A. Golovchenko