Abstract: The present invention relates to a multi-phase detergent composition of compressed particulate matter, wherein the geometric mean particle diameter of one phase differs from the geometric mean particle diameter of at least one other phase by at least 300 &mgr;m.

Abstract: The present invention is directed to a novel enteric-coated oral dosage form of a risedronate active ingredient comprised of a safe and effective amount of a pharmaceutical compostion which is comprised of a risedronate active ingredient and pharmaceutically-acceptable excipients. Said dosage forms prohibit the exposure of the risedronate active ingredient to the epithelial and mucosal tissues of the buccal cavity, pharynx, esophagus, and stomach and thereby protects said tissues from erosion, ulceration or other like irritation. Accordingly, the said dosage forms effect the delivery to the lower intestinal tract of said human or other mammal of a safe and effective amount of the risedronate active ingredient, and substantially alleviate the esophagitis or esophageal irritation which sometimes accompanies the oral administration of risedronate active ingredients.

Abstract: An absorbent article adapted to receive feces having a first waist region, a second waist region opposed to the first waist region, a crotch region disposed between the first waist region and the second waist region, the absorbent article comprising: a liquid pervious topsheet; a liquid impervious backsheet joined to at least a portion of the topsheet; an absorbent core disposed between at least a portion of the topsheet and the backsheet, and an effective amount of a feces modifying agent disposed in the article such that the feces modifying agent is available to contact at least a portion of the feces deposited in the article.

Abstract: A liquid laundry detergent having improved color care properties when used to launder colored fabrics. The composition comprises an effective amount of a chlorine scavenger, a polymeric dye transfer inhibiting agent, a detersive surfactant, and is substantially free of triazinylaminostilbene optical brightener. Methods of using such compositions for cleaning colored fabric.

Abstract: The present invention relates to compounds which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, including all enantiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, have the formula: 1

Abstract: Compounds of the following formula: 1

Abstract: The present invention relates to a method of applying oral care benefit agent to the oral tissues. More specifically, a method for treating an oral cavity is provided comprising the application of an aqueous composition comprising oral care benefit agents to a large proportion of the oral cavity, application occurring as part of the daily oral care routine shortly before retiring, and the composition remaining in contact with the oral tissues while sleeping.

Abstract: A disposable absorbent article adapted to be worn about a lower torso of a human body and having a chassis, a non-removable absorbent core component disposed in a crotch region of the chassis, and one or more replaceable absorbent core component or components disposed in capillary liquid communication with the non-removable absorbent core component. The replaceable absorbent core component may be removed and a like component may be substituted in place of the removed component without the removal of the absorbent article from the wearer. The replaceable absorbent core component may be disposed inside an openable chassis pocket, with access for its removal and replacement provided by an aperture in a garment-facing layer, an openable end of an external pocket, or an openable end of an internal pocket formed at an area of a waist end edge where the garment-facing layer and a wearer-facing layer may be separated.

Abstract: The present invention relates to a process for preparing a &agr;-hydroxyamide or &agr;-ketoamide, said process comprising the steps of: a) reacting a resin which comprises a polymer-supported isocyanide with an aldehyde in the presence of a catalyst, to form a resin-bound &agr;-hydroxyamide; b) optionally reacting said resin-bound &agr;-hydroxyamide with a reagent which is capable of oxidizing said resin-bound &agr;-hydroxyamide to a resin-bound &agr;-ketoamide; and c) reacting said resin-bound &agr;-hydroxyamide or resin-bound &agr;-ketoamide with a reagent which cleaves the nitrogen-resin bond to form a &agr;-hydroxyamide &agr;-ketoamide.

Abstract: Stable topical oral compositions comprising at least a minimally effective amount of chlorite ion are disclosed, wherein the pH of the final composition is greater than 7, the composition is essentially free of chlorine dioxide, and the composition is stable against loss of chlorite for a period of at least one year under normal storage conditions at about 25° C. or for a period of 3 months under accelerated storage conditions at about 40° C. Preferably the compositions further comprise a flavor system, which is stable against degradation by chlorite. The compositions are formulated as therapeutic rinses, especially mouth rinses, as well as toothpastes, gels, tooth powders, chewing gums, mouth sprays, lozenges (including breath mints), dental implements (such as dental floss and tape), and pet care products.

Abstract: The present invention relates to laundry detergent compositions comprising: A) from about 0.01%, preferably from about 0.

Abstract: The present invention relates to laundry detergent compositions comprising zwitterionic polyamines and a surfactant system. In addition to traditional cleaning benefits, such compositions provide enhanced hydrophilic soil removal capabilities.

Abstract: Bottle aqueous household cleaning, fabric treatment and deodorizing compositions comprising surfactant, and a perfume which contains a substantial proportion of hydrophobic perfume ingredients having a ClogP of greater than 3. The bottles are made of high density polyethylene wherein the bottles have a continuous inner surface layer of nylon, polyetheneterephthalate or fluorinated polyethylene in order to prevent migration into and/or transmission through the high density polyethylene of the hydrophobic perfume ingredients.

Abstract: Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to the following Formula (I): where R1, R2, R3, R4, R5, R6, G and Z have the meanings described in the specification. This invention also includes optical isomers, diastereomers and enantiomers of Formula I, and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. Also described are pharmaceutical compositions comprising these compounds, and methods of treating metalloprotease-related maladies using the compounds or the pharmaceutical compositions.

Abstract: The invention relates to cosmetic compositions comprising a combination of non-emulsifying and emulsifying crosslinked siloxane elastomers.

Abstract: Disclosed are dentifrice compositions comprising in a single phase: (a) from about 0.1% to about 30% of one or more linear polyphosphates having an average chain length of about 4 or more; (b) an ionic active ingredient selected from the group consisting of a fluoride ion source, a stannous ion source, a zinc ion source, a copper ion source and mixtures thereof, wherein the ionic active ingredient is present as a solid dispersion in the composition and delivers and effective amount of ionic active when solubilized; (c) a binder system comprised of (i) from about 0.05% to about 3% of a thickening agent selected from the group consisting of polysaccharides, carbomers, poloxamers, modified celluloses, and mixtures thereof; and (ii) from about 0.1% to about 70% of at least one humectant; wherein the dentifrice composition has a total water content of less than about 10%. Further disclosed are methods for stabilizing dentifrice compositions by providing such a binder system.

Abstract: A bag made of flexible sheet material having an opening defined by a periphery. Juxtaposed with the periphery is a closure zone. The closure zone has induced extensibility in a direction perpendicular to the opening of the bag so that handle ties may be conveniently formed upon extension of the closure zone material. The handle ties are bound together to form an integral closure for the bag. The closure remains bound in response to forces upon it. The induced extensibility is provided by a network of dual regions having different modes of extensibility. The dual region network also provides the advantage of an increased gripping surface for forming the handle ties.