Abstract: The present invention provides methods for modulating an immune response by administering a composition comprising a Toll-like receptor agonist and an immune mediator which downregufates the expression of the anti-inflammatory cytokine IL-10 and upregulates the expression of the pro-inflammatory cytokine IL-12. The methods can be used to provide therapeutic treatment for cancerous conditions and infectious diseases.
Type:
Application
Filed:
December 1, 2006
Publication date:
January 7, 2010
Applicant:
THE PROVOST, FELLOWS AND SCHOLARS OF THE COLL. OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH
Inventors:
Kingston Mills, Deirdre Toomey, Andrew Jarnicki