Patents Assigned to The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth
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Patent number: 8257969Abstract: The invention relates to gene suppression and replacement. In particular, the invention relates to enhanced expression of suppression agents for suppressing gene expression in a cell and in vivo and replacement nucleic acids that are not inhibited by the suppression agent. Regulatory elements are included in expression vectors to optimize expression of the suppression agent and/or replacement nucleic acid.Type: GrantFiled: April 14, 2008Date of Patent: September 4, 2012Assignee: The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen ElizabethInventors: Gwyneth Jane Farrar, Sophia Millington-Ward, Naomi Chadderton, Arpad Palfi, Mary O'Reilly, Paul Kenna, Peter Humphries
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Patent number: 8238388Abstract: A tunable laser device (1) comprises integrally formed first and second ridge waveguides (5, 6). A longitudinally extending ridge (12) defines first and second light guiding regions (19, 20) of the first and second waveguides (5, 6) A plurality of first and second slots (27, 28) extending laterally in the ridge (12) adjacent the first and second waveguides (5, 6), produce first and second mirror loss spectra of the respective first and second waveguides (5, 6) with minimum peak values at respective first and second wavelength values. The spacing between the second slots (28) is different to that between the first slots (27) so that with one exception the minimum peak values of the first and second mirror loss spectrum occur at different wavelength values. The first and second waveguides (5, 6) are independently pumped with variable currents to selectively vary the common wavelength at which the minimum peak values of the first and second mirror loss spectra occur to produce Vernier tuning of the device.Type: GrantFiled: September 20, 2007Date of Patent: August 7, 2012Assignees: The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin, University College Cork, National University of Ireland, CorkInventors: John F. Donegan, Richard Phelan, Wei-Hua Guo, Qiao-Yin Lu, Brian Corbett, Paul Martin Lambkin, Brendan John Roycroft
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Patent number: 8119771Abstract: Products for altering IL-33 activity including antibodies that specifically bind to an epitope with the polypeptide sequence of IL-33 such as antibodies that specifically bind to a protease cleavage region of IL-33 comprising the amino acid sequence of SEQ ID No. 17, or SEQ ID NO. 16, or SEQ ID NO. 10; isolated IL-33 polypeptide(s); and compositions comprising a soluble IL-33 receptor linked to an enzyme capable of cleaving IL-33 or an antibody that binds to IL-33 linked to an enzyme capable of cleaving IL-33. The invention also relates to methods of altering IL-33 activity using the products described herein.Type: GrantFiled: April 28, 2008Date of Patent: February 21, 2012Assignee: The Provost, Fellow and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth, Near DublinInventor: Seamus J. Martin
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Patent number: 8105601Abstract: The present invention provides a composition for suppressing an inflammatory immune response comprising the excretory/secretory (ES) component of Fasciola hepatica or a fraction thereof. The composition has particular utility in the treatment or prophylaxis of T cell mediated inflammatory immune responses, and in particular autoimmune disease. The invention further extends to methods for modulating a T cell mediated immune response wherein a therapeutically effective amount of the excretory/secretory (ES) component from Fasciola hepatica is administered to a subject in need of such treatment in order to suppress the development of the response.Type: GrantFiled: December 5, 2006Date of Patent: January 31, 2012Assignee: The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near DublinInventors: Kingston Mills, Miriam Brady
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Patent number: 8090155Abstract: A hand washing monitoring system (1) comprising a camera (2), a processor (4), the processor being adapted to receive from the camera images of hand washing activity. The processor analyses mutual motion of hands to determine if the hands mutually move in desired poses, and if so, the durations of the patterns; and generates a hand washing quality indication according to the analysis. The processor extracts information features from the images and generates feature vectors based on the features, including bimanual hand and arm shape vectors, and executes a classifier with the vectors to determine the poses. The processor uses edge segmentation and pixel spatio-temporal measurements to form at least some of the feature vectors.Type: GrantFiled: May 4, 2007Date of Patent: January 3, 2012Assignee: Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near DublinInventors: Gerard Lacey, David Fernandez Llorca
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Patent number: 8017133Abstract: Multicomponent vaccines are provided which aid in the prevention and treatment of staphylococcal infections and which include certain selected combinations of bacterial binding proteins or fragments thereof, or antibodies to those proteins or fragments. By careful selection of the proteins, fragments, or antibodies, a vaccine is provided that imparts protection against a broad spectrum of Staphylococcus and other bacterial strains and against proteins that are expressed at different stages of the logarithmic growth curve. In one embodiment of the invention, a composition is provided that includes a fibrinogen binding domain of a fibrinogen binding protein and a bacterial component such as a capsular polysaccharide, and both active and passive vaccines based on these components are also provided, along with methods of treating infection using these compositions and vaccines.Type: GrantFiled: February 23, 2010Date of Patent: September 13, 2011Assignees: Inhibitex, The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin, The Texas A & M University SystemInventors: Joseph M. Patti, Timothy J. Foster, Magnus Hook
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Publication number: 20110177958Abstract: The invention is directed to materials and methods associated with polymorphic variants in two enzymes involved in folate-dependent and one-carbon metabolic pathways: MTHFD1 (5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase) and methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (MTHFD1L). Diagnostic and therapeutic methods are provided involving the correlation of polymorphic variants in MTHFD1, MTHFD1, and other genes with relative susceptibility for various pregnancy-related and other complications.Type: ApplicationFiled: January 18, 2011Publication date: July 21, 2011Applicants: The United States of America, as represented by Secretary, Department of Health and Human Services, The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth, The Health Research BoardInventors: Lawrence C. BRODY, Anne PARLE-MCDERMOTT, John SCOTT, Peadar KIRKE, James MILLS, Faith PANGILINAN, Anne MOLLOY
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Patent number: 7968100Abstract: Surface proteins are provided which generate polyclonal and monoclonal antibodies which are cross-reactive to both coagulase-positive staphylococcus bacteria, such as S. aureus and to coagulase-negative bacteria, such as S. epidermidis and S. hemolyticus. The antibodies may be generated from surface proteins that have been isolated on the basis of characteristics that may be common between S. aureus and coagulase-negative staphylococci, or the A domains of those surface proteins, and these recombinant surface proteins are used to generate the cross-reactive antibodies. Vaccines comprising an immunologically effective amount of the proteins are also provided, and these vaccines are used in methods for the treatment or protection against a wide variety of staphylococcal infections.Type: GrantFiled: February 4, 2009Date of Patent: June 28, 2011Assignees: Universita'Degli Studi Di Pavia, Inhibitex, Inc., Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near DublinInventors: Timothy Foster, Fiona Roche, Mark Pallen, Joseph M. Patti, Jeff T. Hutchins, Pietro Speziale
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Patent number: 7956108Abstract: Composite materials comprise nanotubes and a polymer. The nanotubes and polymer interact in an ordered fashion at an interfacial region. The interface is crystalline or semi crystalline.Type: GrantFiled: September 25, 2006Date of Patent: June 7, 2011Assignee: The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth, Near DublinInventors: Jonathan Coleman, Werner Blau, Martin Cadek
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Patent number: 7901907Abstract: A nucleic acid sequence encoding all or part of an 18-19 kDa Helicobater pylori protein is described to which immunoreactivity is detected in H. pylori negative individuals. A process for the production of a recombinant form of this protein and its use, particularly as a vaccine to provide immunological protection against H. pylori infection are also described.Type: GrantFiled: August 25, 2006Date of Patent: March 8, 2011Assignee: The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth near DublinInventors: William Byrne, Dermot P. Kelleher, Henry Windle, Ross McManus
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Patent number: 7879551Abstract: The invention is directed to materials and methods associated with polymorphic variants in two enzymes involved in folate-dependent and one-carbon metabolic pathways: MTHFD1 (5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase) and methylenetetrahydrofolate dehydrogenase (NADP+dependent) 1-like (MTHFD1L). Diagnostic and therapeutic methods are provided involving the correlation of polymorphic variants in MTHFD1, MTHFD1, and other genes with relative susceptibility for various pregnancy-related and other complications.Type: GrantFiled: December 17, 2007Date of Patent: February 1, 2011Assignees: The United States of America as represented by the Department of Health and Human Services, The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin, The Health Research BoardInventors: Lawrence C. Brody, Anne Parle-McDermott, John Scott, Peadar Kirke, James Mills, Faith Pangilinan, Anne Molloy
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Patent number: 7851434Abstract: The present invention describes a methods, uses, compositions such as adhesive, sealants and coatings, scaffold material, composite material, all comprising amyloid-like materials such as fibrils, in particular those made from fruit or vegetable proteins. The amyloid-like materials impart good mechanical strength to the materials in which it is employed. Inhibition of amyloid formation is also described.Type: GrantFiled: March 13, 2007Date of Patent: December 14, 2010Assignee: The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near DublinInventors: Suzanne P. Jarvis, Anika S. Mostaert
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Patent number: 7838012Abstract: The isolation of genes and proteins from Staphylococcus aureus is provided, and the nucleic acids coding for specific regions of the S. aureus protein are described. The nucleic acids encode proteins that can be useful as vaccines or in pharmaceutical compositions for application to prevent infection, promotion of wound healing, blocking adherence to indwelling medical devices, or diagnosis of infection.Type: GrantFiled: May 6, 2008Date of Patent: November 23, 2010Assignee: The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near DublinInventors: Timothy James Foster, Damien Leo McDevitt
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Patent number: 7713935Abstract: The invention relates to compounds that inhibit thyrotropin-releasing hormone (TRH) degrading ectoenzyme and/or enhance, and/or mimic the biological actions of TRH. The compounds find therapeutic application, particularly in conditions involving neuronal cell injury and disturbances in neurobiological function.Type: GrantFiled: October 3, 2005Date of Patent: May 11, 2010Assignee: The Provost, Fellows and Scholars of The College of The Holy and Undivided Trinity of Queen Elizabeth Near DublinInventor: Julie Kelly
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Patent number: 7709008Abstract: Methods for treating or preventing infections from coagulase-negative staphylococci using proteins and polypeptides from coagulase-negative staphylococcal bacteria such as S. epidermidis, including proteins designated SdrF, SdrG and SdrH, and their effective fragments such as their respective A domains, are provided. Methods are also provided wherein antibodies that recognize the SdrG protein or its ligand binding A region are used to treat or prevent staphylococcal infection, and these methods can also be utilized to prevent the formation of infections on indwelling medical devices.Type: GrantFiled: April 4, 2006Date of Patent: May 4, 2010Assignees: The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin, The Texas A & M University SystemInventors: Timothy J. Foster, Kirk McCrea, Magnus A. O. Hook, Stacey Davis, Deirdre Ni Eidhin, Orla Hartford
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Patent number: 7632088Abstract: Systems and methods for forming patterns and structures in target materials are described. The method produces a pattern or structure in a target material by contacting a stamp including one or more features with a target material using a normal load sufficient for keeping the one or more features in contact with the target material, and providing a cyclic shear force in an amount sufficient to extrude the target material and form a negative relief of the one more features in the target material. The systems and methods can be used to produce a variety of articles including, but not limited to, semiconductor integrated electrical circuits, integrated optical, magnetic, mechanical circuits and microdevices.Type: GrantFiled: October 19, 2007Date of Patent: December 15, 2009Assignee: Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth near DublinInventors: John B. Pethica, Graham Lawrence William Cross, Hakan Ozgur Ozer, Barry S. O'Connell
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Patent number: 7569470Abstract: A method of preparing an array of conducting or semi-conducting nanowires may include forming a vicinal surface of stepped atomic terraces on a substrate, and depositing a fractional layer of dopant material to form nanostripes having a width less than the width of the atomic terraces. Diffusion of the atoms of the dopant nanostripes into the substrate may form the nanowires.Type: GrantFiled: May 26, 2006Date of Patent: August 4, 2009Assignee: The Provost Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near DublinInventors: Sergio Fernandez-Ceballos, Giuseppe Manai, Igor Vasilievich Shvets
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Publication number: 20090176696Abstract: The present invention provides compositions and methods for the suppression of Th2-mediated immune response. Tracheal cytotoxin is shown to mediate a selective suppression of T helper cell type 2 (Th2)-mediated immune responses. The methods and compositions of the invention are useful for the treatment of Th2-mediated diseases and conditions due to their utility in suppressing Th2-mediated immune responses. The invention further extends to methods for suppressing the production of cytokines, such as IL-4 and IL-5 which contribute to the development of Th2-mediated immune responses.Type: ApplicationFiled: April 18, 2007Publication date: July 9, 2009Applicant: The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen ElizabethInventors: Kingston Mills, Ed Lavelle, Sarah Higgins
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Patent number: 7557368Abstract: A semiconductor photodetector (1) for detecting short duration laser light pulses of predetermined wavelength in a light signal (2) comprises a micro-resonator (3) of vertical Fabry-Perot construction having a Bragg mirror pair, namely, a front mirror (5) and a rear mirror (6) with an active region (8) located between the front and rear mirrors (5,6). An N-type substrate (11) supports the rear mirror (6). The light signal (2) is directed into the active region (8) through the front mirror (5) while a pump beam (17) is directed into the active region (8) at an end (18) thereof. The spacing between the front and rear mirrors (5,6) is such as to cause light of the predetermined wavelength to resonate between the mirrors (5,6).Type: GrantFiled: March 3, 2003Date of Patent: July 7, 2009Assignee: The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near DublinInventors: John Hegarty, Liam Paul Barry, Herve Armel Francois Folliot, James Christopher O'Gorman
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Patent number: 7473762Abstract: Proteins and polypeptides from coagulase-negative staphylococcal bacteria such as S. epidermidis, including proteins designated SdrF, SdrG and SdrH, and their effective fragments such as their respective A domains, are provided which are useful in the prevention and treatment of infection caused by coagulase-negative staphylococcal bacteria such as S. epidermidis. The SdrF, SdrG and SdrH proteins are cell-wall associated proteins that specifically bind host proteins and which each have a highly conserved motif of which the consensus sequence is TYTFTDYVD (SEQ ID NO: 16). The proteins and polypetides may be useful in generating antibodies for the diagnosis and treatment of coagulase-negative staphylococcal infections.Type: GrantFiled: October 21, 2003Date of Patent: January 6, 2009Assignees: The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin, The Texas A&M University SystemInventors: Timothy J. Foster, Kirk McCrea, Magnus A. O. Hook, Stacy Davis, Deirdre Nieidhin, Orla Hartford