Patents Assigned to THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY
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Patent number: 7368112Abstract: The isolation of genes and proteins from Staphylococcus aureus is provided, and the nucleic acids coding for specific regions of the S. aureus CIfA protein are described. The nucleic acids encode proteins that can be useful as vaccines or in pharmaceutical compositions for application to prevent infection, promotion of wound healing, blocking adherence to indwelling medical devices, or diagnosis of infection.Type: GrantFiled: February 7, 2006Date of Patent: May 6, 2008Assignee: The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near DublinInventors: Timothy James Foster, Damien Leo McDevitt
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Publication number: 20070266892Abstract: The present invention describes a methods, uses, compositions such as adhesive, sealants and coatings, scaffold material, composite material, all comprising amyloid-like materials such as fibrils, in particular those made from fruit or vegetable proteins. The amyloid-like materials impart good mechanical strength to the materials in which it is employed. Inhibition of amyloid formation is also described.Type: ApplicationFiled: March 13, 2007Publication date: November 22, 2007Applicant: The Provost, Fellows and Scholars of the College of The Holy and Undivided Trinity of Queen ElizabeInventors: Suzanne Jarvis, Anika Mostaert
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Publication number: 20070077547Abstract: A cell based assay assembly includes a biochip assembly, a liquid delivery unit and detection and recording equipment is used for conducting an assay on a biological cell as it is delivered through the biochip assembly. The biochip assembly includes a plurality of separate biochips each comprising a microchannel with input and output ports, separate reservoir wells are provided on the biochip assembly and are periodically connected to the liquid delivery unit by removable separate disclosed transfer conduits. The input and output ports of the biochip are also periodically connected to the delivery unit by the conduit. The liquid delivery unit includes a liquid link assembly and a positive displacement pump such as a syringe pump. The liquid link assembly includes pressure compressible means which acts to smooth out pressure rises by initially contacting and then expanding to in turn dispense a steady liquid delivery output below 10? per minute.Type: ApplicationFiled: July 26, 2002Publication date: April 5, 2007Applicant: THE PROVOST FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETHInventors: Igor Shvets, Dmitri Kashanin, Dermot Kelleher, Vivienne Williams
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Patent number: 7122301Abstract: Biological assays using various constructions of biochips are disclosed to mirror in vivo situations. The biochip 50 comprises a microchannel 51 having a liquid outlet port 1, bubble release port 2 and a liquid outlet port 3 with an associated bubble release port 4. A multiplicity of tests can be performed often by coating the bore of the microchannel 50 which various adhesion mediating proteins or the use of chemoattractants. The assay assembly 60 comprises a syringe pump feeding the biochip 50. An inverted microscope 65, digital camera 66 and recorder 67 are provided. A sample liquid containing cells in suspension is injected slowly through the biochip and the effect of the assay recorded over a long period.Type: GrantFiled: October 17, 2003Date of Patent: October 17, 2006Assignee: The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near DublinInventors: Igor Shvets, Dmitriy Kashanin, Dermot Kelleher, Vivienne Williams, Yuri Volkov
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Publication number: 20060202292Abstract: A magnetoresistive medium (1) comprises a substrate (2) which has been treated to provide a miscut vicinal surface (3) in the form of terraces (4(a), 4(b)) and steps (5) of atomic and nanometer scale. A further upper film (11) provides upper nanowires (10(a), 10(b)). A thin protective layer (15) covers the upper nanowires (10(a), 10(b)) which form two separate subsets of upper nanowires with different exchange interaction with the substrate and thus a different response to an external magnetic field. The substrate (2) is so chosen that the width of the terraces 4(a) and 4(b) are significantly non-uniform. This leads to a different response depending on which terrace (4(a) or 4(b)) the upper film 11 overlies. It can utilise, for example, step-induced magnetic anisotropy between the upper nanowires (10(a), 10(b)) and the substrate (2).Type: ApplicationFiled: March 14, 2005Publication date: September 14, 2006Applicant: The Provost Fellows and Scholars of the College of The Holy and Undivided Trinity of Queen ElizabethInventors: Igor Shvets, Sunil Arora, Sumesh Sofin Ramakrishna Pillai
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Patent number: 6994855Abstract: The invention relates to the isolation of the fibrinogen binding protein gene from Staphylococcus aureus and to the use of the fibrinogen binding protein and antibodies generated against it for wound healing, blocking adherence to indwelling medical devices, immunization or diagnosis of infection.Type: GrantFiled: October 5, 2000Date of Patent: February 7, 2006Assignee: The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near DublinInventors: Timothy James Foster, Damien Leo McDevitt
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Patent number: 6978057Abstract: A laser diode (1) having an optical path (15) defined in an active layer (2) which is sandwiched between a substrate layer (3) and a top layer (4) and defined by a ridge (14) formed in the top layer (4) outputs laser light of a single predetermined wavelength. Refractive index altering grooves (21) extending transversely in the top layer (4) are provided at spaced apart locations for altering the refractive index of the active layer (2) along the optical path at partial reflecting locations (20) for causing partial longitudinal reflections of the laser light generated in the optical path (15) so that standing waves or harmonics thereof of the single predetermined wavelength are set up between the respective partial reflecting locations (20) and a first mirror facet (8) in the optical path (15).Type: GrantFiled: September 25, 2000Date of Patent: December 20, 2005Assignee: The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth near DublinInventors: James Christopher O'Gorman, Paul McEvoy, David McDonald, Frederick Paul Logue, Pascal Michel Landais
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Publication number: 20050264958Abstract: A magnetoresistive medium (1) comprises a substrate (2) which has been treated to provide a miscut vicinal surface (3) in the form of terraces (4) and steps (5) of atomic and nanometer scale. There are discrete separated spacer nanowires (7) provided by an intermediate partial spacer film on each terrace (4) against each step (5). A further main film (11) provides main nanowires (10(a), 10(b)). A thin protective layer (15) covers the main nanowires (10(a), 10(b)) which form two separate subsets of main nanowires with different exchange interaction with the substrate and thus a different response to an external magnetic field. In use, when an external magnetic field (H) is applied the response of the main nanowires (10(a), 10(b)) changes as the exchange coupling with the substrate (2) varies and the magnetisation on the main nanowires (10(a), 10(b)) change. This is shown by the arrows while prior to the application of the external magnetic field, they might, for example, be aligned.Type: ApplicationFiled: March 14, 2005Publication date: December 1, 2005Applicant: THE PROVOST FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETHInventors: Igor Shvets, Sunil Arora, Sumesh Sofin Pilli
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Patent number: 6940883Abstract: A laser diode (1) for outputting light of a single mode comprises a substrate layer (5), a cladding layer (6) and a compound light propagating layer (7) comprising first, second, third and fourth layers (9 to 12). A wave guiding region (15) of refractive index lower than its adjacent regions is defined by the third layer (11) by two quantum wells (16) positioned at the anti-node of light of a single mode which is propagating in the third layer (11) for propagating and amplifying the single mode light. A central ridge (17) locates the wave guiding region transversely of the direction of light propagation. The wave guiding region (15) can also be defined by shaping the top cladding layer (6) by forming an elongated central channel through the central ridge (17).Type: GrantFiled: March 28, 2001Date of Patent: September 6, 2005Assignee: The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth, Near DublinInventors: James Christopher O'Gorman, Frederick Paul Logue
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Patent number: 6841154Abstract: Polyclonal and monoclonal antibodies which are cross-reactive to both coagulase-positive staphylococcus bacteria, such as S. aureus and to coagulase-negative bacteria, such as S. epidermidis and S. hemolyticus, are provided which can recognize surface proteins from both coagulase-positive and coagulase negative staph bacteria. The antibodies may be generated from surface proteins that have been isolated on the basis of characteristics that may be common between S. aureus and coagulase-negative staphylococci, and these recombinant surface proteins are used to generate the antibodies of the invention. There is also provided vaccines and methods which utilize these proteins and antibodies for the treatment or protection against a wide variety of staphylococcal infections.Type: GrantFiled: June 17, 2002Date of Patent: January 11, 2005Assignees: Inhibitex, Inc., The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin, Universita'degli Studi di PaviaInventors: Timothy Foster, Fiona Roche, Mark Pallen, Joseph M. Patti, Jeff T. Hutchins, Pietro Speziale
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Patent number: 6806267Abstract: The present invention relates to pyrrolobenzoxazepines, pyrrolobenzthiazepines and related compounds having the ability to induce apoptosis, to pharmaceutical compositions comprising these compounds and to their use as anti-tumour agents.Type: GrantFiled: February 16, 2000Date of Patent: October 19, 2004Assignees: The Universita'di Siena, The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near DublinInventors: David Clive Williams, Daniela M. Zisterer, Vito Nacci, Giuseppe Campiani
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Patent number: 6805841Abstract: A liquid outlet link assembly is provided for liquid delivery output rates below 10 &mgr;l per minute so as to smooth out the flow from a positive displacement pump which has an immediate step pumping rate which is relatively substantially larger than the delivery rate required through the liquid outlet means. Essentially, this liquid link assembly has a bubble of air or some other pressure activated expansion means which initially contracts on the step pump such as a syringe pump operation and then gradually expands over time, allowing a steady output rate through the link assembly.Type: GrantFiled: May 9, 2001Date of Patent: October 19, 2004Assignee: The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near DublinInventors: Igor Shvets, Dmitri Kashanin, Vivienne Williams
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Patent number: 6804272Abstract: A semiconductor self-pulsating laser diode (1) comprises a wave guiding layer (2) sandwiched between lower and upper cladding layers (4, 5). A current blocking layer (8) defining a slot (10) through which pumping current is directed through the laser diode between upper and lower contact plates (5, 6) defines an active wave guiding region (15). The current blocking layer (8) is shaped by the formation of longitudinally extending recesses (12) for defining the active wave guiding region (15) such that a central pulse light generating region (17) is formed surrounded by an outer light propagating region (18). As the laser diode is continuously pumped, an effective step change in refractive index between the wave guiding layer (2) and the outer light propagating region (18) is formed, and the carrier density and refractive index profiles across the active wave guiding region (15) vary as each light pulse cycle progresses.Type: GrantFiled: March 14, 2003Date of Patent: October 12, 2004Assignee: The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near DublinInventors: James Christopher O'Gorman, Paul McEvoy, Stephen Anthony Lynch, Pascal Michel Landais
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Publication number: 20040198967Abstract: Methods and reagents are provided for the tissue specific, cell specific and/or inducible expression of RNAi. The invention may be used to downregulate the expression of endogenous or exogenous RNAs targeted by the RNAi in cells, animals and/or plants.Type: ApplicationFiled: September 4, 2003Publication date: October 7, 2004Applicant: Provost, Fellows and Scholars of The College of The Holy and Undivided Trinity of Queen ElizabethInventors: Danny Allen, Gwenyth Jane Farrar
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Patent number: 6770434Abstract: Biological assays using various constructions of biochips are disclosed to mirror in vivo situations. The biochip 50 comprises a microchannel 51 having a liquid outlet port 1, bubble release port 2 and a liquid outlet port 3 with an associated bubble release port 4. A multiplicity of tests can be performed often by coating the bore of the microchannel 50 which various adhesion mediating proteins or the use of chemoattractants. The assay assembly 60 comprises a syringe pump feeding the biochip 50. An inverted microscope 65, digital camera 66 and recorder 67 are provided. A sample liquid containing cells in suspension is injected slowly through the biochip and the effect of the assay recorded over a long period.Type: GrantFiled: December 29, 2000Date of Patent: August 3, 2004Assignee: The Provost, Fellows and Scholars of the College of the Holy & Undivided Trinity of Queen Elizabeth Near DublinInventors: Igor Shvets, Dmitriy Kashanin, Dermot Kelleher, Vivienne Williams, Yuri Volkov
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Publication number: 20040101445Abstract: A dispensing assembly for liquid droplets that includes a dispenser connected to a liquid carrying pipe which in turn is connected to a source of pressurized liquid. The dispenser has an elongated body member having a main bore connected to the liquid carrying pipe. At the other end, the main bore has a valve seat that is connected to a nozzle having a nozzle bore terminating in a dispensing tip. An elongated valve boss of ferromagnetic material covered with a soft polymer is mounted in the main bore and has a cross-sectional area less than that of the main bore. A separate valve boss actuating coil assembly has upper and lower coils that are separate from the main body that can be unplugged from both coils and from the liquid carrying pipe. As such, the main body can be a disposable member.Type: ApplicationFiled: September 30, 2003Publication date: May 27, 2004Applicant: Provost, Fellows & Scholars of College of Holy & Undivided Trinity of Queen Elizabeth Near DublinInventors: Igor Shvets, Sergei Makarov, Juergen Osing
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Patent number: 6713021Abstract: A dispensing assembly for liquid droplets that includes a dispenser connected to a liquid carrying pipe which in turn is connected to a source of pressurized liquid. The dispenser has an elongated body member having a main bore connected to the liquid carrying pipe. At the other end, the main bore has a valve seat that is connected to a nozzle having a nozzle bore terminating in a dispensing tip. A valve boss of ferromagnetic material covered with a soft polymer is mounted in the main bore and has a cross-sectional area less than that of the main bore. A separate valve boss actuating coil assembly has upper and lower coils that are separate from the main body that can be unplugged from both coils and from the liquid carrying pipe. As such, the main body can be a disposable member.Type: GrantFiled: November 13, 2000Date of Patent: March 30, 2004Assignee: The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near DublinInventors: Igor Shvets, Sergei Makarov, Juergen Osing
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Patent number: 6703025Abstract: Multicomponent vaccines are provided which aid in the prevention and treatment of staphylococcal infections and which include certain selected combinations of bacterial binding proteins or fragments thereof, or antibodies to those proteins or fragments. By careful selection of the proteins, fragments, or antibodies, a vaccine is provided that imparts protection against a broad spectrum of Staphylococcus bacterial strains and against proteins that are expressed at different stages of the logarithmic growth curve. In one embodiment of the invention, a composition is provided that includes at least a collagen binding protein or peptide (or an appropriate site directed mutated sequence thereof) such as CNA, or a protein or fragment with sufficiently high homology thereto, in combination with a fibrinogen binding protein, preferably Clumping factor A (“ClfA”) or Clumping factor B (“ClfB”), or a useful fragment thereof or a protein or fragment with sufficiently high homology thereto.Type: GrantFiled: August 31, 1999Date of Patent: March 9, 2004Assignees: Inhibitex, Inc., The Provost Fellows and Scholars of the College of The Holy and Undivided Trinity of Queen Elizabeth near Dublin, The Texas A&M University SystemInventors: Joseph M. Patti, Timothy J. Foster, Magnus Hook
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Patent number: 6692739Abstract: A method and composition for the passive immunization of patients infected with or susceptible to infection from Staphylococcus bacteria such as S. aureus and S. epidermidis infection is provided that includes the selection or preparation of a donor plasma pool with high antibody titers to carefully selected Staphylococcus adhesins or MSCRAMMs, or fragments or components thereof, or sequences with substantial homology thereto. The donor plasma pool can be prepared by combining individual blood or blood component samples which have higher than normal titers of antibodies to one or more of the selected adhesins or other proteins that bind to extracellular matrix proteins, or by administering carefully selected proteins or peptides to a host to induce the expression of desired antibodies, and subsequently recovering the enhanced high titer serum or plasma pool from the treated host.Type: GrantFiled: August 31, 1999Date of Patent: February 17, 2004Assignees: Inhibitex, Inc., The Provost Fellows and Scholars of The College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin, The Texas A&M University SystemInventors: Joseph M. Patti, Timothy J. Foster, Magnus Hook
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Patent number: 6635473Abstract: Isolated proteins, designated SdrF, SdrG and SdrH, and their corresponding amino acid and nucleic acid sequences are provided which are useful in the prevention and treatment of infection caused by coagulase-negative staphylococcal bacteria such as S. epidermidis. The SdrF, SdrG and SdrH proteins are cell-wall associated proteins that specifically bind host proteins and which each have a highly conserved motif of which the consensus sequence is TYTFTDYVD (SEQ ID NO:16). The proteins, antigenic portions thereof and anti-SdrF, SdrG and SdrH antibodies are also useful for the identification and diagnosis of coagulase-negative staphylococcal infections. In particular, the proteins are advantageous because they may be used as vaccine components or antibodies thereof, and they may be administered to wounds or used to coat biomaterials to act as blocking agents to prevent or inhibit the binding of coagulase-negative staphylococci to wounds or biomaterials.Type: GrantFiled: August 31, 1999Date of Patent: October 21, 2003Assignees: The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin, The Texas A&M University SystemInventors: Timothy J. Foster, Kirk McCrea, Magnus A. O. Hook, Stacy Davis, Deirdre Ni Eidhin, Orla Hartford