Patents Assigned to THE PROVOST FELLOWS FOUNDATION SCHOLARS AND THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH
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Patent number: 11092550Abstract: The present invention provides a method of using Raman spectroscopy for identification of low grade cervical cytology cases likely to progress to high grade/cancer. The Applicant has found that high quality Raman spectra can be successfully acquired from morphologically normal appearing cells from negative, LSIL and HSIL Thinprep® specimens and different grades of cervical pre-cancer can be separated with good sensitivities and specificities. Raman spectroscopy can further identify different categories of the LSIL cases i.e., whether they are likely to regress to negative or progress to HSIL cytology.Type: GrantFiled: December 20, 2017Date of Patent: August 17, 2021Assignees: Technological University Dublin, The Provost, Fellows, Foundation Scholars, and the Other Members of Board, of the College of the Holy and Undivided Trinity of Queen Elizabeth Near DublinInventors: Shiyamala Duraipandian, Fiona Lyng, Damien Traynor, John O'Leary, Cara Martin, Padraig Kearney
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Patent number: 10987220Abstract: A heart valve therapeutic device (1) has an elongate anchor (7) wherein the anchor has a stiffness to hold its shape and location to support the valve element. The anchor may have a stylet or a shaped or stiff collar (70) arranged to provide a desired shape to the anchor (7) and it may be lockable. A prosthetic valve element (15) has leaflets (17) and is supported on the anchor by coupler (16, 50) at a desired location. There is an actuator for changing relative axial position of the proximal and distal couplers (16, 50) on the anchor. The anchor stiffness may be sufficient to provide sufficient support to resist axial forces from the ventricle in use without necessarily having a fixing element engaging heart tissue. The prosthetic leaflets (240) may extend proximally and radially outwardly, so that there is excellent co-apting of the native leaflets (NL) against the prosthetic leaflets (240).Type: GrantFiled: June 12, 2020Date of Patent: April 27, 2021Assignee: The Provost, Fellows Foundation Scholars, and the Other Members of the Board, Of The College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin (TCD)Inventor: Martin Quinn
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Patent number: 10952854Abstract: A heart valve therapeutic device (1) comprises a coaptation assist valve (20) comprising a conduit (2) with an outer surface (3) for coaption with the native leaflets, and a prosthetic flow valve (5) mounted within the conduit (2) to allow one-way flow through the conduit (2). Support for the coaptation assist valve (20) is provided by a support (10) for positioning the conduit (2) across the native leaflets, and connectors (15) attaching the conduit (2) to the support (10).Type: GrantFiled: July 30, 2020Date of Patent: March 23, 2021Assignee: The Provost, Fellows, Foundation Scholars and the Other Members Of Board, of the College of the Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin (TCD)Inventors: Paul Heneghan, Bruce Murphy, Lucy O'Keeffe, Martin Quinn, Conor Quinn
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Patent number: 10793572Abstract: Disclosed are novel compounds useful in the treatment of multiple sclerosis and other autoimmune diseases. The present invention describes compounds of formula (I) wherein: R1 is selected from H and CH3 R2 is selected from H, C4H9 alkyl, C6H13 alkyl and C3H6-phenyl, said phenyl optionally substituted by OH or OCH3, (1R,2S,5S)-5-methylcyclopent-3-ene-1,2-diol X is O or S Y is C, N or S.Type: GrantFiled: September 29, 2015Date of Patent: October 6, 2020Assignee: THE PROVOST FELLOWS FOUNDATION SCHOLARS AND THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETHInventors: John Michael Southern, Stephen J. Connon
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Patent number: 10765084Abstract: A seed coating composition comprising a mixture of a fungal root endophyte isolated from a root of the plant found in low-nutrient, drought-stressed or multiply-stressed conditions and a carrier medium for application of said composition to a target seed, wherein the endophyte is characterised in having a nuclear ribosomal internal transcribed spacer (nr ITS) with at least a 90% sequence identity to any one of SEQ ID NOs: 3 to 15.Type: GrantFiled: August 29, 2015Date of Patent: September 8, 2020Assignees: The Provost, Fellows, Foundation Scholars & the Other Members of Board, of the College of the Holy & Undivided Trinity of Queen Elizabeth, Near Dublin, University College Dublin, National University of Ireland, DublinInventors: Brian Murphy, Trevor Hodkinson, Fiona Doohan
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Patent number: 10682231Abstract: A heart valve therapeutic device (1) has an elongate anchor (7) wherein the anchor has a stiffness to hold its shape and location to support the valve element. The anchor may have a stylet or a shaped or stiff collar (70) arranged to provide a desired shape to the anchor (7) and it may be lockable. A prosthetic valve element (15) has leaflets (17) and is supported on the anchor by coupler (16, 50) at a desired location. There is an actuator for changing relative axial position of the proximal and distal couplers (16, 50) on the anchor. The anchor stiffness may be sufficient to provide sufficient support to resist axial forces from the ventricle in use without necessarily having a fixing element engaging heart tissue. The prosthetic leaflets (240) may extend proximally and radially outwardly, so that there is excellent co-apting of the native leaflets (NL) against the prosthetic leaflets (240).Type: GrantFiled: June 17, 2019Date of Patent: June 16, 2020Assignee: The Provost, Fellows Foundation Scholars, And The Other Members of the Board, Of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin (TCD)Inventor: Martin Quinn
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Patent number: 10538487Abstract: The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in the treatment of a wide range of disorders in which the inflammation process, or more specifically the NLRP3 inflammasome, have been implicated as being a key factor.Type: GrantFiled: February 16, 2016Date of Patent: January 21, 2020Assignees: THE UNIVERSITY OF QUEENSLAND, THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLINInventors: Luke O'Neill, Rebecca Coll, Matthew Cooper, Avril Robertson, Kate Schroder
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Cell suspension medium and cell suspension medium additive for the three dimensional growth of cells
Patent number: 10526575Abstract: The present invention relates to a cell culture medium additive comprising a xanthan polysaccharide and a mannan polysaccharide, such as a glucomannan or a galactomannan, that supports the growth of cells in suspension, and to a cell culture medium containing the additive. More particularly, but not exclusively, the present invention relates to a cell culture medium additive that supports the formation of multicellular bodies such as spheroids, and prevents sedimentation of cells without adversely affecting the physical properties of the cell culture medium.Type: GrantFiled: April 2, 2013Date of Patent: January 7, 2020Assignee: The Provost, Fellows, Foundation Scholars, and the other Members of the Board of the College of the Holy and Undivided Trinity of Queen ElizabethInventor: Anthony Davies -
Patent number: 10383729Abstract: A heart valve therapeutic device has an elongate anchor wherein the anchor has a stiffness to hold its shape and location to support the valve element. The anchor may have a stylet or a shaped or stiff collar arranged to provide a desired shape to the anchor and it may be lockable. A prosthetic valve element has leaflets and is supported on the anchor by coupler at a desired location. There is an actuator for changing relative axial position of the proximal and distal couplers on the anchor. The anchor stiffness may be sufficient to provide sufficient support to resist axial forces from the ventricle in use without necessarily having a fixing element engaging heart tissue. The prosthetic leaflets may extend proximally and radially outwardly, so that there is excellent co-apting of the native leaflets (NL) against the prosthetic leaflets.Type: GrantFiled: September 29, 2015Date of Patent: August 20, 2019Assignee: The Provost, Fellows Foundation Scholars, and The Other Members of the Board, of the College of The Holy and Undivided Trinity of Queen Elizabeth Near Dublin (TCD)Inventor: Martin Quinn
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Patent number: 10362488Abstract: Provided a method and system for computing a bandwidth requirement for a cellular operator from shared spectrum in a cellular network, the shared spectrum comprising at least one shared spectrum class which is accessible by multiple entities, the method comprising: computing an average user throughput in the cellular network; comparing the average user throughput to a target minimum average user throughput, taking into account an average percentage of users within coverage and a coverage probability threshold; and based on the comparison, computing an additional bandwidth requirement from the at least one shared spectrum class.Type: GrantFiled: September 28, 2016Date of Patent: July 23, 2019Assignee: THE PROVOST, FELLOWS, FOUNDATION SCHOLARS AND THE OTHER MEMBERS OF THE BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLINInventors: Jasmina McMenamy, Irene Macaluso, Linda Doyle
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Patent number: 10304937Abstract: A process for exfoliating untreated 3-dimensional material to produce a 2-dimensional material, said process comprising the steps of mixing the untreated 3-dimensional material in a liquid to provide a mixture; applying shear force to said mixture to exfoliate the 3-dimensional material and produce dispersed exfoliated 2-dimensional material in solution; and removing the shear force applied to said mixture, such that the dispersed exfoliated 2-dimensional material remains free and unaggregated in solution.Type: GrantFiled: March 14, 2014Date of Patent: May 28, 2019Assignee: The Provost, Fellows, Foundation Scholars, and the Other Members of Board, of the College of the Holy and Undivided Trinity of Queen Elizabeth Near DublinInventors: Jonathan Coleman, Keith Paton
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Patent number: 10251604Abstract: A process for producing conductive composites, the process comprising the steps of soaking a polymer in an organic solvent and applying energy; soaking the polymer in a solution of conductive nano-material dispersed in an organic solvent:water mixture and applying energy, so that conductive nano-material is incorporated into the polymer structure; washing the conductive nano-material-incorporated polymer in deionized water and applying energy; and drying the washed conductive nano-material-incorporated polymer to produce the conductive composite, wherein the conductive composite incorporates conductive nano-material throughout the structure of the polymer without affecting the integrity of the properties of the polymer.Type: GrantFiled: March 14, 2014Date of Patent: April 9, 2019Assignee: The Provost, Fellows, Foundation Scholars, and the other Members of Board, of the College of the Holy and Undivided Trinity of Queen Elizabeth, near DublinInventors: Jonathan Coleman, Conor Boland, Umar Khan
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Patent number: 10106519Abstract: Provided herein are 3-phenyl-7-hydroxy-isocoumarin compounds which are MIF inhibitors; compositions comprising said inhibitors and methods for treating or preventing diseases associated with MIF.Type: GrantFiled: March 27, 2015Date of Patent: October 23, 2018Assignee: The Provost, Fellows, Foundation Scholars, and the Other Members of Board, of the College of the Holy and Undivided Trinity of Queen Elizabeth, Near DublinInventors: Seamas Donnelly, David Lloyd, Ciaran O'Reilly, Darren Fayne
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Patent number: 10039488Abstract: The invention describes a system and method how tissue compression can be measured continuously in a non-contact way to provide a low cost, patient/user specific measurement system. The method may be used to inform existing and future pressure relief mattress systems. The invention may also be used for any application either in conjunction with another system or on its own to measure tissue compression. In another embodiment the invention can be used for measuring any type of compression of a compressible material, for example compression of viscoelastic foam or other materials. The invention may also be used to make inferences about the changes of blood flow at site of measurement.Type: GrantFiled: September 10, 2012Date of Patent: August 7, 2018Assignee: Provost, Fellows, Foundation Scholars and the other members of the Board of the College of the Holy and Undivided Trinity of Queen Elizabeth, near DublinInventors: Sonja Hermann, Richard Reilly
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Patent number: 10029056Abstract: A system and method suitable for monitoring user technique of an inhaler device configured for delivery of a medicament is provided. The system may include a microphone adapted for sensing sound made during operation of the inhaler device and processing circuitry operable to process a data signal obtained from the microphone, wherein the data signal includes acoustic information sensed. The processing circuitry is adapted to determine inhalation and exhalation breath characteristics that occur during use, by analyzing the temporal and spectral components of the acoustic information sensed and processed to differentiate between an inhalation and an exhalation, based on both the temporal and spectral components. This information can be processed to determine user technique adherence to inhaler or respiratory device protocol. The analysis of temporal and spectral components can determine the impact of user technique errors on the quantity and the deposition of medicament delivered into the user's airways.Type: GrantFiled: August 29, 2013Date of Patent: July 24, 2018Assignees: The Provost, Fellows, Foundation Scholars, & The Other Members of Board, of the College of the Holy & Undivided Trinity of Queen Elizabeth near Dublin, Royal College of Surgeons in IrelandInventors: Richard Reilly, Richard Costello, Cian Hughes, Ehsan Chah, Isabelle Killane
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Patent number: 9975860Abstract: Compounds and compositions are described which are useful especially for treatment of angiogenesis-related diseases or disorders such as neovascularisation of the eye, age-related macular degeneration, diabetic retinopathy or cancer.Type: GrantFiled: January 15, 2015Date of Patent: May 22, 2018Assignees: University College Dublin, National University of Ireland, Dublin, The Provost Fellows Foundation Scholars and the other members of the Board of the College of the Holy and Undivided Trinity of Queen Elizabeth, near DublinInventors: Breandan Kennedy, Alison Reynolds, Jacintha O'Sullivan, Andrew Douglas Baxter
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Patent number: 9873717Abstract: The invention relates to a novel thyrotropin releasing hormone (TRH) receptor subtype in human central nervous system (CNS) that is pharmacologically distinct from the TRH receptor subtype in human pituitary. The invention provides a means to understand how the central actions of TRH are mediated and to isolate and characterize the novel receptor, as well as methods applicable to research and development of diagnostic and therapeutic applications in human CNS disorders.Type: GrantFiled: December 18, 2013Date of Patent: January 23, 2018Assignee: THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLINInventor: Julie Kelly
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Patent number: 9815788Abstract: (E)-2-(2-Quinolin-2-yl-propenyl)-phenol, 2-Quinolin-2-yl-ylethynyl-phenol and salts thereof are useful as medicaments, especially for treatment of an angiogenesis-related disease or disorder.Type: GrantFiled: June 28, 2016Date of Patent: November 14, 2017Assignees: THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN, UNIVERSITY COLLEGE DUBLIN NATIONAL UNIVERSITY OF IRELAND, DUBLINInventors: Breandan Noel Kennedy, Alison Reynolds, Claire Kilty, Jacintha O'Sullivan, Andrew Douglas Baxter
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Patent number: 9751760Abstract: The invention provides a process for exfoliating a 3-dimensional layered material to produce a 2-dimensional material, said process comprising the steps of mixing the layered material in a solvent to provide a mixture; applying energy, for example ultrasound, to said mixture, and removing the energy applied to the mixture, such that sedimentation of the 2-dimensional material out of solution as a weakly re-aggregated, exfoliated 2-dimensional material is produced. The invention provides a fast, simple and high yielding process for separating 3-dimensional layered materials into individual 2-dimensional layers or flakes, which do not strongly re-aggregate, without utilising hazardous solvents.Type: GrantFiled: June 28, 2013Date of Patent: September 5, 2017Assignee: The Provost, Fellows, Foundation Scholars, and the Other Members of Board of the College of the Holy and Undivided Trinity of Queen Elizabeth Near DublinInventors: Jonathan Coleman, Umar Khan
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Patent number: D818020Type: GrantFiled: June 6, 2017Date of Patent: May 15, 2018Assignee: THE PROVOST, FELLOWS, FOUNDATION SCHOLARS AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLINInventor: Conor McGinn