Patents Assigned to The Queen's Medical Center
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Patent number: 10869611Abstract: This invention relates to a system that adaptively compensates for subject motion in real-time in an imaging system. An object orientation marker (30), preferably a retro-grate reflector (RGR), is placed on the head or other body organ of interest of a patient (P) during a scan, such as an MRI scan. The marker (30) makes it possible to measure the six degrees of freedom (x, y, and z-translations, and pitch, yaw, and roll), or “pose”, required to track motion of the organ of interest. A detector, preferably a camera (40), observes the marker (30) and continuously extracts its pose. The pose from the camera (40) is sent to the scanner (120) via an RGR processing computer (50) and a scanner control and processing computer (100), allowing for continuous correction of scan planes and position (in real-time) for motion of the patient (P).Type: GrantFiled: December 11, 2017Date of Patent: December 22, 2020Assignees: The Queen's Medical Center, The University of Hawaii, The Medical Collene of Wisconsin, Inc., UWM Research Foundation, Inc.Inventors: Thomas Michael Ernst, Thomas Edmund Prieto, Brian Stewart Randall Armstrong
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Patent number: 10660541Abstract: The systems, methods, and devices described herein generally relate to achieving accurate and robust motion correction by detecting and accounting for false movements in motion correction systems used in conjunction with medical imaging and/or therapeutic systems. In other words, in some embodiments of the systems, methods, and devices described herein can be configured to detect false movements for motion correction during a medical imaging scan and/or therapeutic procedure, and thereby ensure that such false movements are not accounted for in the motion correction process. Upon detection of false movements, the imaging or therapeutic system can be configured to transiently suppress and/or subsequently repeat acquisitions.Type: GrantFiled: March 13, 2018Date of Patent: May 26, 2020Assignees: The University of Hawai'i, The Queen's Medical CenterInventors: Thomas Michael Ernst, Brian Keating, Aditya Singh, Maxim Zaitsev, Michael Herbst
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Patent number: 10653381Abstract: The disclosure herein provides methods, systems, and devices for tracking motion of a patient or object of interest during biomedical imaging and for compensating for that motion in the biomedical imaging scanner and/or the resulting images to reduce or eliminate motion artifacts. In an embodiment, a motion tracking system is configured to overlay tracking data over biomedical imaging data in order to display the tracking data along with its associated image data. In an embodiment, a motion tracking system is configured to overlay tracking data over biomedical imaging data in order to display the tracking data along with its associated image data. In an embodiment, one or more detectors are configured to detect images of a patient, and a detector processing interface is configured to analyze the images to estimate motion or movement of the patient and to generate tracking data describing the patient's motion.Type: GrantFiled: September 6, 2017Date of Patent: May 19, 2020Assignees: Kineticor, Inc., The University of Hawaii, The Queen's Medical CenterInventors: Jeffrey N. Yu, Thomas Michael Ernst
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Patent number: 10004462Abstract: The disclosure herein provides methods, systems, and devices for removing prospective motion correction from medical imaging scans.Type: GrantFiled: March 23, 2015Date of Patent: June 26, 2018Assignees: KinetiCor, Inc., The University of Hawai'i, The Queen's Medical CenterInventors: Thomas Michael Ernst, Benjamin Anton Zahneisen, Jeffrey N. Yu
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Patent number: 9943247Abstract: The systems, methods, and devices described herein generally relate to achieving accurate and robust motion correction by detecting and accounting for false movements in motion correction systems used in conjunction with medical imaging and/or therapeutic systems. In other words, in some embodiments of the systems, methods, and devices described herein can be configured to detect false movements for motion correction during a medical imaging scan and/or therapeutic procedure, and thereby ensure that such false movements are not accounted for in the motion correction process. Upon detection of false movements, the imaging or therapeutic system can be configured to transiently suppress and/or subsequently repeat acquisitions.Type: GrantFiled: July 28, 2016Date of Patent: April 17, 2018Assignees: The University of Hawai'i, The Queen's Medical CenterInventors: Thomas Michael Ernst, Brian Keating, Aditya Singh, Maxim Zaitsev, Michael Herbst
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Patent number: 9867549Abstract: This invention relates to a system that adaptively compensates for subject motion in real-time in an imaging system. An object orientation marker (30), preferably a retro-grate reflector (RGR), is placed on the head or other body organ of interest of a patient (P) during a scan, such as an MRI scan. The marker (30) makes it possible to measure the six degrees of freedom (x, y, and z-translations, and pitch, yaw, and roll), or “pose”, required to track motion of the organ of interest. A detector, preferably a camera (40), observes the marker (30) and continuously extracts its pose. The pose from the camera (40) is sent to the scanner (120) via an RGR processing computer (50) and a scanner control and processing computer (100), allowing for continuous correction of scan planes and position (in real-time) for motion of the patient (P).Type: GrantFiled: August 17, 2015Date of Patent: January 16, 2018Assignees: The Queen's Medical Center, The University of Hawaii, The Medical College of Wisconsin, Inc., UWM Research Foundation, Inc.Inventors: Thomas Michael Ernst, Thomas Edmund Prieto, Brian Stewart Randall Armstrong
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Patent number: 9782141Abstract: The disclosure herein provides methods, systems, and devices for tracking motion of a patient or object of interest during biomedical imaging and for compensating for that motion in the biomedical imaging scanner and/or the resulting images to reduce or eliminate motion artifacts. In an embodiment, a motion tracking system is configured to overlay tracking data over biomedical imaging data in order to display the tracking data along with its associated image data. In an embodiment, a motion tracking system is configured to overlay tracking data over biomedical imaging data in order to display the tracking data along with its associated image data. In an embodiment, one or more detectors are configured to detect images of a patient, and a detector processing interface is configured to analyze the images to estimate motion or movement of the patient and to generate tracking data describing the patient's motion.Type: GrantFiled: January 29, 2014Date of Patent: October 10, 2017Assignees: KINETICOR, INC., THE UNIVERSITY OF HAWAII, THE QUEEN'S MEDICAL CENTERInventors: Jeffrey N. Yu, Thomas Michael Ernst
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Patent number: 9504806Abstract: Disclosed herein is a removable cap for connection to an input port of a catheter, comprising a proximal end having a lumen configured to house a guidewire therethrough; a distal end configured to reversibly mate with a luer lock of the input port of a catheter, the distal end having a lumen configured to house the guidewire therethrough; and a tubular body between the proximal end and the distal end, wherein the tubular body comprises an anti-migration feature transformable between a first configuration to allow slidable movement of the guidewire within the cap in a first direction toward the patient, and a second configuration to prevent slidable movement of the guidewire within the cap in the first direction toward the patient. Systems and methods are also disclosed.Type: GrantFiled: February 25, 2015Date of Patent: November 29, 2016Assignee: The Queen's Medical CenterInventors: Thomas Scott Gallacher, Jeffrey N. Yu
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Patent number: 9164102Abstract: The invention relates, in part, to methods useful in identifying molecules, that bind TRPM4b, which modulate TRPM4b ion channel activity, and/or which alter expression of TRPM4b within cells. The TRPM4b channels as described herein contain TRPM4b polypeptides, which are in turn encoded by TRPM4b nucleic acids. The ion channels described herein are preferably formed in HEK-293 cells from one or more novel TRPM4b polypeptides, which exhibit one or more of the unique TRPM4b properties described herein.Type: GrantFiled: October 30, 2007Date of Patent: October 20, 2015Assignee: The Queen's Medical CenterInventor: Reinhold Penner
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Patent number: 9138175Abstract: This invention relates to a system that adaptively compensates for subject motion in real-time in an imaging system. An object orientation marker (30), preferably a retro-grate reflector (RGR), is placed on the head or other body organ of interest of a patient (P) during a scan, such as an MRI scan. The marker (30) makes it possible to measure the six degrees of freedom (x, y, and z-translations, and pitch, yaw, and roll), or “pose”, required to track motion of the organ of interest. A detector, preferably a camera (40), observes the marker (30) and continuously extracts its pose. The pose from the camera (40) is sent to the scanner (120) via an RGR processing computer (50) and a scanner control and processing computer (100), allowing for continuous correction of scan planes and position (in real-time) for motion of the patient (P).Type: GrantFiled: April 28, 2015Date of Patent: September 22, 2015Assignees: The Queen's Medical Center, The University of Hawaii, The Medical College of Wisconsin, Inc., UWM Research Foundation, Inc.Inventors: Thomas Michael Ernst, Thomas Edmund Prieto, Brian Stewart Randall Armstrong
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Patent number: 9076212Abstract: This invention relates to a system that adaptively compensates for subject motion in real-time in an imaging system. An object orientation marker (30), preferably a retro-grate reflector (RGR), is placed on the head or other body organ of interest of a patient (P) during a scan, such as an MRI scan. The marker (30) makes it possible to measure the six degrees of freedom (x, y, and z-translations, and pitch, yaw, and roll), or “pose”, required to track motion of the organ of interest. A detector, preferably a camera (40), observes the marker (30) and continuously extracts its pose. The pose from the camera (40) is sent to the scanner (120) via an RGR processing computer (50) and a scanner control and processing computer (100), allowing for continuous correction of scan planes and position (in real-time) for motion of the patient (P).Type: GrantFiled: September 23, 2013Date of Patent: July 7, 2015Assignees: The Queen's Medical Center, The University of Hawaii, The Medical College of Wisconsin, Inc., UWM Research Foundation, Inc.Inventors: Thomas Michael Ernst, Thomas Edmund Prieto, Brian Stewart Randall Armstrong
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Patent number: 8992480Abstract: Disclosed herein is a removable cap for connection to an input port of a catheter, comprising a proximal end having a lumen configured to house a guidewire therethrough; a distal end configured to reversibly mate with a luer lock of the input port of a catheter, the distal end having a lumen configured to house the guidewire therethrough; and a tubular body between the proximal end and the distal end, wherein the tubular body comprises an anti-migration feature transformable between a first configuration to allow slidable movement of the guidewire within the cap in a first direction toward the patient, and a second configuration to prevent slidable movement of the guidewire within the cap in the first direction toward the patient. Systems and methods are also disclosed.Type: GrantFiled: October 2, 2013Date of Patent: March 31, 2015Assignee: The Queen's Medical CenterInventors: Thomas Scott Gallacher, Jeffrey N. Yu
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Patent number: 8828674Abstract: The invention provides methods and compositions for determining the identity of CRACM homologs underlying Icrac activity in cells.Type: GrantFiled: March 21, 2008Date of Patent: September 9, 2014Assignee: The Queen's Medical CenterInventors: Reinhold Penner, Andrea Fleig
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Publication number: 20140100552Abstract: Disclosed herein is a removable cap for connection to an input port of a catheter, comprising a proximal end having a lumen configured to house a guidewire therethrough; a distal end configured to reversibly mate with a luer lock of the input port of a catheter, the distal end having a lumen configured to house the guidewire therethrough; and a tubular body between the proximal end and the distal end, wherein the tubular body comprises an anti-migration feature transformable between a first configuration to allow slidable movement of the guidewire within the cap in a first direction toward the patient, and a second configuration to prevent slidable movement of the guidewire within the cap in the first direction toward the patient. Systems and methods are also disclosed.Type: ApplicationFiled: October 2, 2013Publication date: April 10, 2014Applicant: The Queen's Medical CenterInventors: Thomas Scott Gallacher, Jeffrey N. Yu
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Publication number: 20140037174Abstract: This invention relates to a system that adaptively compensates for subject motion in real-time in an imaging system. An object orientation marker (30), preferably a retro-grate reflector (RGR), is placed on the head or other body organ of interest of a patient (P) during a scan, such as an MRI scan. The marker (30) makes it possible to measure the six degrees of freedom (x, y, and z-translations, and pitch, yaw, and roll), or “pose”, required to track motion of the organ of interest. A detector, preferably a camera (40), observes the marker (30) and continuously extracts its pose. The pose from the camera (40) is sent to the scanner (120) via an RGR processing computer (50) and a scanner control and processing computer (100), allowing for continuous correction of scan planes and position (in real-time) for motion of the patient (P).Type: ApplicationFiled: September 23, 2013Publication date: February 6, 2014Applicants: THE QUEEN'S MEDICAL CENTER, UWM RESEARCH FOUNDATION, INC., THE MEDICAL COLLEGE OF WISCONSIN, INC., THE UNIVERSITY OF HAWAIIInventors: Thomas Michael Ernst, Thomas Edmund Prieto, Brian Stewart Randall Armstrong
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Patent number: 8580525Abstract: The present invention relates to the identification and isolation of a novel family of ATP regulated calcium transmembrane channel polypeptides designated herein as “LTRPC7” (Long Transient Receptor Potential Channel). Channels comprising these polypeptides close in response to concentrations of cytoplasmic ATP in the millimolar range, are subject to inhibition by high intracellular levels of calcium and/or magnesium, and do not respond to depletion or reduction in intracellular calcium stores. The invention further relates to the methods of utilizing LTRPC7 for binding, and the methods for modulating LTRPC7 activity and for measuring LTRPC2 permeability. The invention further relates to the methods of modulating expression of LTRPC7.Type: GrantFiled: May 28, 2008Date of Patent: November 12, 2013Assignee: The Queen's Medical CenterInventors: Reinhold Penner, Andrea Fleig
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Patent number: 8571293Abstract: This invention relates to a system that adaptively compensates for subject motion in real-time in an imaging system. An object orientation marker (30), preferably a retro-grate reflector (RGR), is placed on the head or other body organ of interest of a patient (P) during a scan, such as an MRI scan. The marker (30) makes it possible to measure the six degrees of freedom (x, y, and z-translations, and pitch, yaw, and roll), or “pose”, required to track motion of the organ of interest. A detector, preferably a camera (40), observes the marker (30) and continuously extracts its pose. The pose from the camera (40) is sent to the scanner (120) via an RGR processing computer (50) and a scanner control and processing computer (100), allowing for continuous correction of scan planes and position (in real-time) for motion of the patient (P).Type: GrantFiled: January 7, 2013Date of Patent: October 29, 2013Assignees: The Queen's Medical Center, The University of Hawaii, The Medical College of Wisconsin, Inc., UWM Research Foundation, Inc.Inventors: Thomas Michael Ernst, Thomas Edmund Prieto, Brian Stewart Randall Armstrong
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Patent number: 8554373Abstract: The present disclosure provides methods of synthesizing alkylating agents and methods of use.Type: GrantFiled: December 21, 2007Date of Patent: October 8, 2013Assignee: The Queen's Medical CenterInventor: John Lim
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Patent number: 8551445Abstract: Methods of alkylating target compounds are disclosed. The alkylating agent can be radiolabeled. In some instances, the alkylating agent is synthesized and then reacted with a target compound without an intervening purification step. The method comprises synthesizing an alkylating agent having the formula: X—(CR1R2)aCR3R4-LG wherein, a is 0, 1, 2 or 3, R1, R2, R3 and R4 are independently H, X or alkyl, X is a halogen or a label, with the proviso that at least one X is a halogen, LG is a leaving group; and directly reacting said alkylating agent with a target compound comprising an alkylation reactive group under conditions suitable for the alkylation of said target compound.Type: GrantFiled: August 17, 2010Date of Patent: October 8, 2013Assignee: The Queen's Medical CenterInventor: John Lim
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Publication number: 20130188830Abstract: This invention relates to a system that adaptively compensates for subject motion in real-time in an imaging system. An object orientation marker (30), preferably a retro-grate reflector (RGR), is placed on the head or other body organ of interest of a patient (P) during a scan, such as an MRI scan. The marker (30) makes it possible to measure the six degrees of freedom (x, y, and z-translations, and pitch, yaw, and roll), or “pose”, required to track motion of the organ of interest. A detector, preferably a camera (40), observes the marker (30) and continuously extracts its pose. The pose from the camera (40) is sent to the scanner (120) via an RGR processing computer (50) and a scanner control and processing computer (100), allowing for continuous correction of scan planes and position (in real-time) for motion of the patient (P).Type: ApplicationFiled: January 7, 2013Publication date: July 25, 2013Applicants: THE QUEEN'S MEDICAL CENTER, UWM RESEARCH FOUNDATION, INC., THE MEDICAL COLLEGE OF WISCONSIN, INC., THE UNIVERSITY OF HAWAIIInventors: THE QUEEN'S MEDICAL CENTER, THE UNIVERSITY OF HAWAII, THE MEDICAL COLLEGE OF WISCONSIN, INC., UWM RESEARCH FOUNDATION, INC.