Patents Assigned to The Queens's University of Belfast
  • Nanocomposite drug delivery composition
    Publication number: 20060147538
    Abstract: The invention relates to a drug delivery composition comprising an active ingredient and a biologically inert material wherein the biologically inert material is a nanocomposite material. Preferably the biologically inert material is a polymer-clay nanocomposite comprising up to about 40% by weight of nano-sized (1-1000 nm) clay particles dispersed in a polymeric material. The active ingredient may be dispersed in the nanocomposite material or absorbed thereto.
    Type: Application
    Filed: November 4, 2005
    Publication date: July 6, 2006
    Applicant: THE QUEEN'S UNIVERSITY OF BELFAST
    Inventors: Duncan Q.M. Craig, John Anthony McNally
  • Aromatic sulfonation reactions
    Patent number: 7009077
    Abstract: A process for the sulfonation of an aromatic compound wherein the aromatic compound and sulfonating agent are admixed in the presence of an ionic liquid is described. The method for the sulfonation of aromatic compounds in (e.g. water stable) ionic liquids offers advantages over conventional sulfonation reactions. These are that no by-products form, the ionic liquid is not consumed, and the sulfonating agent (e.g. SO3) is relatively inexpensive.
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: March 7, 2006
    Assignee: The Queen's University of Belfast
    Inventors: Martyn John Earle, Suhas Prabhakar Katdare
  • Metal bis-triflimide compounds and methods for synthesis of metal bis-triflimide compounds
    Patent number: 6998497
    Abstract: A metal bis-triflimide compound having the formula: [Mx]n+[(N(SO2CF3)2)(nx?yz)](nx?yz)?[Ly]z? where M is a metal selected from the metals in groups 5 to 10, 12 and 14 to 16 and Cu, Au, Ca, Sr, Ba, Ra, Y, La, Ac, Hf, Rf, Ga, In, Tl, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Lu and the actinides; L is a negative or neutral ligand; n is 2,3,4,5,6,7 or 8; x is greater than or equal to 1 y is 0,1,2,3,4,5,6,7 or 8; and z is 0,1,2,3 or 4.
    Type: Grant
    Filed: March 12, 2002
    Date of Patent: February 14, 2006
    Assignee: The Queen's University of Belfast
    Inventors: Martyn J. Earle, Barry Joseph Mcauley, Alwar Ramani, Kenneth Richard Seddon, Jillian M. Thomson
  • Peptide fragments of murine epidermal growth factor as laminin receptor targets
    Patent number: 6995136
    Abstract: A peptide factor, its analogs and methods of using such peptide factor derived from murine epidermal growth factor peptide is disclosed wherein the peptide factor is modified to protect it from proteolytic degradation and the peptide binds to laminin receptors.
    Type: Grant
    Filed: April 21, 1999
    Date of Patent: February 7, 2006
    Assignee: The Queen's University of Belfast
    Inventors: John Nelson, Brian Walker, Neil McFerran, Patrick Harriott
  • Imidazole carbenes
    Patent number: 6939974
    Abstract: The disclosure herein relates to imidazole carbenes and imidazole carbene salts. The disclosure also relates to the synthesis of imidazole carbenes and imidazole carbene salts. The imidazole carbenes disclosed include those synthesized by reacting an imidazole halide with a base under reduced pressure. The imidazole carbene salts disclosed include those synthesized by reaction of imidazole carbenes with an acid or alcohol suitable for creation of a salt. The disclosure also relates to the use of imidazole carbenes and imidazole carbene salts for the synthesis of organic liquids.
    Type: Grant
    Filed: April 5, 2001
    Date of Patent: September 6, 2005
    Assignee: The Queens University of Belfast
    Inventors: John Martyn Earle, Richard Kenneth Seddon
  • Aromatic nitration reactions
    Patent number: 6906231
    Abstract: A process for the nitration of an aromatic compound, wherein the aromatic compound is admixed with a nitrating agent in the presence of an ionic liquid is described. The method for the nitration of aromatic compounds in (e.g. neutral) ionic liquids has advantages over conventional nitrations, such as the only by-product being water, the ionic liquid not being consumed and the nitrating agent being relatively inexpensive.
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: June 14, 2005
    Assignee: The Queen's University of Belfast
    Inventors: Martyn John Earle, Suhas Prabhakar Katdare
  • Sensor
    Publication number: 20050042134
    Abstract: The present invention relates to a sensor device for detecting CO2 and/or NOx, the sensor device comprising a redox material coated on a conducting substrate, the resistance of which changes in the presence of CO2 and/or NOx. The conducting substrate may also be heated to enhance functioning of the sensor device.
    Type: Application
    Filed: August 23, 2002
    Publication date: February 24, 2005
    Applicant: The Queen's University of Belfast
    Inventors: James Thomson, Wolfram Meier-Augenstein
  • Process for preparing ambient temperature ionic liquids
    Patent number: 6774240
    Abstract: A process for preparing an ionic liquid or salt, formed by reaction between an organic base and an alkylating agent, wherein the alkylating agent is a fluorinated ester or an alkyl sulfonate, is described. Suitable organic bases include imidazoles, substituted imidazoles, pyridines and substituted pyridines. The so-formed products can be subsequently transformed into different ionic liquids or salts by metathesis.
    Type: Grant
    Filed: September 9, 2002
    Date of Patent: August 10, 2004
    Assignee: The Queen's University of Belfast
    Inventors: Kenneth R. Seddon, Adrian J Carmichael, Martyn J. Earle
  • Porcine circoviruses, vaccines and diagnostic reagents
    Patent number: 6660272
    Abstract: The invention relates to new porcine circovirus strains isolated from pulmonary or ganglionic samples obtained from farms affected by the post-weaning multisystemic wasting syndrome (PMWS). It relates to purified preparations of these strains, conventional attenuated or inactivated vaccines, recombinant live vaccines, plasmid vaccines and subunit vaccines, as well as reagents and diagnostic methods. It also relates to the DNA fragments which can be used for the production of subunits in an in vitro expression vector or as sequences to be integrated into a virus or plasmid type in vivo expression vector.
    Type: Grant
    Filed: June 19, 2001
    Date of Patent: December 9, 2003
    Assignees: Merial, The Queen's University of Belfast, University of Saskatchewan
    Inventors: Gordon Allan, Brian Meehan, Edward Clark, John Ellis, Deborah Haines, Lori Hassard, John Harding, Catherine Elisabeth Charreyre, Gilles Emile Chappuis, Francis McNeilly
  • Bis-benzazoles and their use as antineoplastic agents
    Patent number: 6589971
    Abstract: “Head-to-head” bis-benzimidazoles having the following formula wherein A1, A2, X1 and X2 are as defined in the following specification, have been found to bind to specific sequences in the minor groove of duplex DNA, and to have cytotoxic effects against a range of tumor cell lines.
    Type: Grant
    Filed: April 18, 2002
    Date of Patent: July 8, 2003
    Assignees: The Queens University of Belfast, Institute of Cancer Research, The University of Reading
    Inventors: Stephen Neidle, John Monn
  • Reduction of porcine circovirus-2 viral load with inactivated PCV-2
    Patent number: 6517843
    Abstract: Porcine circovirus-2 (PCV-2) is a recently identified agent wherein the potential spectrum of PCV-2-associated disease has been expanded by evidence of vertical and sexual transmission and associated reproductive failure in swine populations. PCV-2 was isolated from a litter of aborted piglets from a farm experiencing late term abortions and stillbirths. Severe, diffuse myocarditis was present in one piglet associated with extensive immunohistochemical staining for PCV-2 antigen. Variable amounts of PCV-2 antigen were also present in liver, lung and kidney of multiple fetuses.
    Type: Grant
    Filed: May 31, 2000
    Date of Patent: February 11, 2003
    Assignees: Merial, University of Saskatchewan, The Queen's University of Belfast
    Inventors: John Albert Ellis, Gordon Allan Moore, Brian Meehan, Edward Clark, Deborah Haines, Lori Hassard, John Harding, Catherine Elisabeth Charreyre, Gilles Emile Chappuis, George Steve Krakowka, Jean-Christophe Francis Audonnet, Francis McNeilly
  • Porcine circoviruses vaccines diagnostic reagents
    Patent number: 6391314
    Abstract: The invention relates to new porcine circovirus strains isolated from pulmonary or ganglionic samples obtained from farms affected by the post-weaning multisystemic wasting syndrome (PMWS). It relates to purified preparations of these strains, conventional attenuated or inactivated vaccines, recombinant live vaccines, plasmid vaccines and subunit vaccines, as well as reagents and diagnostic methods. It also relates to the DNA fragments which can be used for the production of subunits in an in vitro expression vector or as sequences to be integrated into a virus or plasmid type in vivo expression vector.
    Type: Grant
    Filed: September 25, 1998
    Date of Patent: May 21, 2002
    Assignees: Merial, The Queen's University of Belfast, University of Saskatchewan
    Inventors: Gordon Allan, Brian Meehan, Edward Clark, John Ellis, Deborah Haines, Lori Hassard, John Harding, Catherine Elisabeth Charreyre, Gilles Emile Chappuis, Francis McNeilly
  • Porcine circovirus vaccine and diagnostics reagents
    Patent number: 6368601
    Abstract: The invention relates to new porcine circovirus strains isolated from pulmonary or ganglionic samples obtained from farms affected by the post-weaning multisystemic wasting syndrome (PMWS). It relates to purified preparations of these strains, conventional attenuated or inactivated vaccines, recombinant live vaccines, plasmid vaccines and subunit vaccines, as well as reagents and diagnostic methods. It also relates to the DNA fragments which can be used for the production of subunits in an in vitro expression vector or as sequences to be integrated into a virus or plasmid type in vivo expression vector.
    Type: Grant
    Filed: May 21, 1998
    Date of Patent: April 9, 2002
    Assignees: Merial, The Queen's University of Belfast, University of Saskatchewan
    Inventors: Gordon Allan, Brian Meehan, Edward Clark, John Ellis, Deborah Haines, Lori Hassard, John Harding, Catherine Elisabeth Charreyre, Gilles Emile Chappuis, Francis McNeilly
  • Porcine circovirus and paravovirus vaccine
    Patent number: 6217883
    Abstract: The invention relates to antigenic preparations and vaccines directed against the porcine multisystemic wasting syndrome (PMWS), comprising at least one porcine circovirus antigen, preferably type II, and at least one porcine parvovirus antigen.
    Type: Grant
    Filed: July 1, 1999
    Date of Patent: April 17, 2001
    Assignees: Merial, The Queen's University of Belfast, University of Saskatchewan
    Inventors: Gordon Moore Allan, Brian Martin Meehan, John Albert Ellis, George Steven Krakowka, Jean-ChrJistophe Francis Audonnet
  • Conductance measurements in organic solvents
    Patent number: 5472880
    Abstract: A method for quantitatively measuring an acid in a polar organic solvent involves adding a sterically hindered base, such as diisopropylentylamine, triethylamine or N-methylmorpholine to the solvent and measuring the conductance of the mixture. The method has particular relevance in monitoring the progress of preactivation, coupling and deprotection reactions in solid phase peptide synthesis (SPPS).
    Type: Grant
    Filed: October 3, 1994
    Date of Patent: December 5, 1995
    Assignee: The Queen's University of Belfast
    Inventors: Neil V. McFerran, Brian Walker, Donald T. Elmore
  • Rotational moulding apparatus and process
    Patent number: 5322654
    Abstract: A rotational moulding apparatus includes a device (5) disposed inside the mould for measuring temperature. A processor (6) forming part of a feedback tool (7) enables real time monitoring and control of the moulding process. Identifiable points on the temperature time moulding characteristic are employed to control the operation of the apparatus to optimise the properties of the mouldings obtained.
    Type: Grant
    Filed: June 4, 1992
    Date of Patent: June 21, 1994
    Assignee: The Queen's University of Belfast
    Inventors: Robert J. Crawford, Paul J. Nugent
  • Methylation of organic compounds
    Patent number: 5240836
    Abstract: A method of O-methylation of a phenol, S-methylation of a thiophenal, or methylesterification of a carboxylic acid is disclosed, which involves contacting the phenol, thiophenol, or carboxylic acid with a halomethane in the presence of a fungus selected from the group consisting of Hymenochaetaceae, Polyporaceae, and Corticiaceae.
    Type: Grant
    Filed: November 23, 1990
    Date of Patent: August 31, 1993
    Assignee: The Queens University of Belfast
    Inventor: David B. Harper
  • Fingerprint reagent
    Patent number: 5221627
    Abstract: A method of detection of amino acids comprising the application, to the material being tested, of a reagent comprising the following basic formula: ##STR1## where X, Y and/or Z may be nitrogen C--H, C-alkyl or C-aryl and wherein A, B, C and/or D may be an alkyl or aryl substituent either alone or in combination.
    Type: Grant
    Filed: May 24, 1991
    Date of Patent: June 22, 1993
    Assignee: The Queen's University of Belfast
    Inventors: Ronald E. Grigg, Charles A. Pounds, Teirevat Mongkolaussavaratana
  • Wave digital filter with fine grained pipelining
    Patent number: 5200914
    Abstract: A wave digital filter implements a pipelining strategy to significantly increase the processing speed of circuits. The implementation allows high frequency digital signals to be processed at higher speeds than were previously possible. The implementation overcomes potential hardware limitation of wave digital filters and allows pipelining to be applied without introducing delays into the feedback loops. In particular, the implementation teaches how to increase the processing speed of a two port adaptor which is commonly used in the construction of wave digital filters.
    Type: Grant
    Filed: April 2, 1991
    Date of Patent: April 6, 1993
    Assignee: Queens University of Belfast
    Inventors: John V. McCanny, Rajinder Jit Singh, Roger F. Woods
  • L-head two stroke engines
    Patent number: 5007384
    Abstract: An L-head two stroke engine comprises two pistons mounted for reciprocable movement in first and second cylinders respectively. The cranks of the two pistons are drivably connected such that the pistons are in phase. A fuel/air supply is provided for one cylinder where it is compressed and ignited causing both pistons to return to their respective bottom dead center position. The compression ratio in the one cylinder is less than in the other cylinder so as to aid retention of the air fuel mixture in the one cylinder prior to ignition.
    Type: Grant
    Filed: February 22, 1990
    Date of Patent: April 16, 1991
    Assignee: The Queen's University of Belfast
    Inventor: Gordon P. Blair