Patents Assigned to The Queen's University of Belfast
  • Publication number: 20250163093
    Abstract: The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X?, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof, and novel crystalline forms thereof.
    Type: Application
    Filed: January 9, 2025
    Publication date: May 22, 2025
    Applicants: The Queen's University of Belfast, ChromaDex Inc.
    Inventors: Marie Eugenie Migaud, Philip Redpath, Kerri Crossey, Richard Cunningham, Aron Erickson, Richard Nygaard, Amanda Storjohann
  • Patent number: 12252506
    Abstract: Methods of preparing nicotinamide riboside and derivatives thereof.
    Type: Grant
    Filed: April 26, 2023
    Date of Patent: March 18, 2025
    Assignee: The Queen's University of Belfast
    Inventors: Marie Migaud, Philip Redpath, Kerri Crossey, Mark Doherty
  • Patent number: 12195494
    Abstract: The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X?, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof, and novel crystalline forms thereof.
    Type: Grant
    Filed: August 24, 2023
    Date of Patent: January 14, 2025
    Assignees: The Queen's University of Belfast, ChromaDex Inc.
    Inventors: Marie Eugenie Migaud, Philip Redpath, Kerri Crossey, Richard Cunningham, Aron Erickson, Richard Nygaard, Amanda Storjohann
  • Patent number: 12049519
    Abstract: Provided is a peptide including X-(Xaa1)a-(Xaa2)b-Y-(Xaa3)c-(Xaa4)d-Z, or a salt or amide thereof, in which each of X and Z is independently selected from Asn, Cys, Gln, Gly, Ser, Thr and Tyr; in which one of Xaa1 and Xaa2 is His and the other of Xaa1 and Xaa2 is Arg; in which one of Xaa3 and Xaa4 is His and the other of Xaa3 and Xaa4 is Arg; in which the amino functional group of X is, optionally, acylated; in which the carboxylate functional group of Z is, optionally, amidated; in which Y is selected from Ala and Trp; in which each of a and d is independently an integer from 2 to 4; and each of b and c is independently an integer from 2 to 4. The peptide may be used in therapeutic approaches.
    Type: Grant
    Filed: March 9, 2020
    Date of Patent: July 30, 2024
    Assignee: The Queen's University of Belfast
    Inventors: Helen McCarthy, Nicholas Dunne, Tracy Robson, Emma McErlean, Eoghan Mulholland, Grace Cole
  • Publication number: 20240239831
    Abstract: Methods of preparing nicotinamide riboside and derivatives thereof, are described. In an aspect, the invention relates to a method of making a compound of formula (II), or a salt, or solvate thereof: wherein n is 0 or 1; Y is O or S; m is 1; R1 is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted primary or secondary amino, and substituted or unsubstituted azido; and R2-R5 are each H.
    Type: Application
    Filed: March 7, 2024
    Publication date: July 18, 2024
    Applicant: The Queen's University of Belfast
    Inventors: Marie Migaud, Philip Redpath, Kerri Crossey, Mark Doherty
  • Patent number: 11981698
    Abstract: Methods of preparing nicotinamide riboside and derivatives thereof, are described. In an aspect, the invention relates to a method of making a compound of formula (II), or a salt, or solvate thereof: wherein n is 0 or 1; Y is O or S; m is 1; R1 is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted primary or secondary amino, and substituted or unsubstituted azido; and R2-R5 are each H.
    Type: Grant
    Filed: May 4, 2022
    Date of Patent: May 14, 2024
    Assignee: The Queen's University of Belfast
    Inventors: Marie Migaud, Philip Redpath, Kerri Crossey, Mark Doherty
  • Patent number: 11965893
    Abstract: This invention relates to the use of biomarker LRG1 as a biomarker for preeclampsia for use from the first trimester. Elevated levels of leucine-rich alpha 2 glycoprotein 1 (LRG1) can predict risk for the future development of preeclampsia or other hypertensive disorders of pregnancy. The predictive test will comprise the measurement of LRG1 protein, peptide fragment, DNA or RNA, from either blood, plasma, serum, urine, saliva or amniotic fluid. The invention provides a method and a test kit to assess the risk of pre-eclampsia in pregnant woman. The method or test can utilise antibodies to measure levels of LGR1 in a sample.
    Type: Grant
    Filed: July 7, 2022
    Date of Patent: April 23, 2024
    Assignee: The Queen's University of Belfast
    Inventors: Chris Watson, Timothy Lyons, Alice Cheung, Clare Kelly
  • Patent number: 11862875
    Abstract: An antenna for a body-centric wireless communication system comprises first and second radiating structures between which is located a ground plane and a feed structure. The feed structure comprises a feed line extending between the first radiating structure and the ground plane, and a slot formed in the ground plane. A pair of shorting posts connects the first radiating structure to the ground plane. The antenna is capable of simultaneously generating in-body radiation, on-body radiation and off-body radiation in the same frequency band.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: January 2, 2024
    Assignee: The Queen's University of Belfast
    Inventors: Matthew Magill, Gareth Conway
  • Publication number: 20230391815
    Abstract: The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X?, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof, and novel crystalline forms thereof.
    Type: Application
    Filed: August 24, 2023
    Publication date: December 7, 2023
    Applicants: The Queen's University of Belfast, ChromaDex Inc.
    Inventors: Marie Eugenie Migaud, Philip Redpath, Kerri Crossey, Richard Cunningham, Aron Erickson, Richard Nygaard, Amanda Storjohann
  • Publication number: 20230340617
    Abstract: The invention provides a method for detecting desired Mycobacterium species in a sample, the method comprising the steps of: a) mixing mycobacteriophage-coupled paramagnetic particles with the sample to form a reaction mixture under conditions suitable to allow the mycobacteriophage to bind to any mycobacteriophage-sensitive Mycobacterium species present in the sample; b) applying a magnetic field to the sample to collect, and separate, mycobacteriophage-coupled paramagnetic particles with bound desired Mycobacterium species; c) incubating a suspension of the separated paramagnetic particles with bound Mycobacterium species under conditions to allow the mycobacteriophage to replicate inside viable Mycobacterium species cells and to lyse the viable Mycobacterium species cells; d) recovering, from the incubated suspension, nucleotide, optionally DNA, of lysed Mycobacterium species DNA; and e) analysing the nucleotide, optionally DNA, released from the lysed Mycobacterium species to identify a signature nucleoti
    Type: Application
    Filed: September 23, 2020
    Publication date: October 26, 2023
    Applicant: The Queen's University of Belfast
    Inventors: Irene GRANT, Antonio FODDAI
  • Patent number: 11746123
    Abstract: The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X?, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof; and novel crystalline forms thereof.
    Type: Grant
    Filed: June 22, 2020
    Date of Patent: September 5, 2023
    Assignees: The Queen's University of Belfast, ChromaDex Inc.
    Inventors: Marie Eugenie Migaud, Philip Redpath, Kerri Crossey, Richard Cunningham, Aron Erickson, Richard Nygaard, Amanda Storjohann
  • Publication number: 20230203596
    Abstract: The present invention relates to a method of diagnosing ovarian cancer, including fallopian tube and/or primary peritoneal cancer. Specifically, the present invention relates to a method of diagnosing high grade serous carcinoma. The invention involves measuring the nucleic acid methylation levels of one or more biomarkers in the sample; and diagnosing ovarian cancer in the patient based on the nucleic acid methylation levels.
    Type: Application
    Filed: May 28, 2021
    Publication date: June 29, 2023
    Applicant: The Queen's University of Belfast
    Inventors: Paul Mullan, James P. Beirne, Laura Feeney, W. Glenn McCluggage, Ian JG Harley
  • Patent number: 11584770
    Abstract: Methods of preparing nicotinamide riboside and derivatives thereof.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: February 21, 2023
    Assignee: The Queen's University of Belfast
    Inventors: Marie Migaud, Philip Redpath, Kerri Crossey, Mark Doherty
  • Patent number: 11565212
    Abstract: The invention relates to dispersions of porous solids in liquids selected from deep eutectic solvents, liquid oligomers, bulky liquids, liquid polymers, silicone oils, halogenated oils, paraffin oils or triglyceride oils, as well as to their methods of preparation. In embodiments of the invention, the porous solids are metal organic framework materials (MOFs), zeolites, covalent organic frameworks (COFs), porous inorganic materials, Mobil Compositions of Matter (MCMs) or a porous carbon. The invention also relates to the use of porous materials to form dispersions, and to assemblages of such dispersions with a gas or gases. The dispersions can exhibit high gas capacities and selectivities.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: January 31, 2023
    Assignee: The Queen's University of Belfast
    Inventors: Stuart James, Min Ying Tsang, John Cahir, David Rooney
  • Publication number: 20220259250
    Abstract: Methods of preparing nicotinamide riboside and derivatives thereof, are described. In an aspect, the invention relates to a method of making a compound of formula (II), or a salt, or solvate thereof: wherein n is 0 or 1; Y is O or S; m is 1; R1 is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted primary or secondary amino, and substituted or unsubstituted azido; and R2-R5 are each H.
    Type: Application
    Filed: May 4, 2022
    Publication date: August 18, 2022
    Applicant: The Queen's University of Belfast
    Inventors: Marie Migaud, Philip Redpath, Kerri Crossey, Mark Doherty
  • Patent number: 11396684
    Abstract: A method for extracting a rare earth metal from a mixture of one or more rare earth metals, said method comprising contacting an acidic solution of the rare earth metal with a composition which comprises an ionic liquid to form an aqueous phase and a non-aqueous phase into which the rare earth metal has been selectively extracted.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: July 26, 2022
    Assignee: The Queen's University of Belfast
    Inventors: Peter Nockemann, Ruhela Ritesh
  • Patent number: 11345720
    Abstract: The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X?, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof; and novel crystalline forms thereof.
    Type: Grant
    Filed: December 15, 2021
    Date of Patent: May 31, 2022
    Assignees: The Queen's University of Belfast, ChromaDex Inc.
    Inventors: Marie Eugenie Migaud, Philip Redpath, Kerri Crossey, Richard Cunningham, Aron Erickson, Richard Nygaard, Amanda Storjohann
  • Publication number: 20220106350
    Abstract: The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X?, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof; and novel crystalline forms thereof.
    Type: Application
    Filed: December 15, 2021
    Publication date: April 7, 2022
    Applicants: The Queen's University of Belfast, ChromaDex Inc.
    Inventors: Marie Eugenie Migaud, Philip Redpath, Kerri Crossey, Richard Cunningham, Aron Erickson, Richard Nygaard, Amanda Storjohann
  • Patent number: 11274117
    Abstract: The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X?, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof; and novel crystalline forms thereof.
    Type: Grant
    Filed: April 30, 2021
    Date of Patent: March 15, 2022
    Assignees: ChromaDex Inc., The Queen's University of Belfast
    Inventors: Marie Eugenie Migaud, Philip Redpath, Kerri Crossey, Richard Cunningham, Aron Erickson, Richard Nygaard, Amanda Storjohann
  • Patent number: 11242364
    Abstract: The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X?, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof, and novel crystalline forms thereof.
    Type: Grant
    Filed: May 18, 2021
    Date of Patent: February 8, 2022
    Assignees: ChromaDex Inc., The Queen's University of Belfast
    Inventors: Marie Eugenie Migaud, Philip Redpath, Kerri Crossey, Richard Cunningham, Aron Erickson, Richard Nygaard, Amanda Storjohann