Abstract: Compounds of the formulae, (I), wherein each variable is as defined herein are provided which are useful in (i) diagnostic methods for detecting and/or identifying cells presenting PSMA; (2) compositions comprising a compound of the invention together with a pharmaceutically acceptable carrier, excipient, and/or diluent; (3) methods for inhibiting or treating prostrate cancer; and (4) methods for blocking or destabilizing neovasculature of a tumor.
Type:
Application
Filed:
November 10, 2011
Publication date:
January 9, 2014
Applicants:
THE REGEANTS OF THE UNIVERSITY OF CALIFORNIA, WASHINGTON STATE UNIVERSITY
Inventors:
Clifford E. Berkmam, Henry F. Vanbrocklin
Abstract: Provided are methods of using humanin and humanin analogs to treat a mammal exhibiting or at risk for insulin resistance, increase insulin sensitivity in a mammal exhibiting or at risk for insulin resistance, treat type-2 diabetes mellitus, metabolic syndrome, and neurodegeneration, treat and prevent myocardial injury, and determine longevity.
Type:
Application
Filed:
October 9, 2012
Publication date:
February 21, 2013
Applicants:
The Regeants of the University of California, Albert Einstein College of Medicine of Yeshiva University
Inventors:
Nir Barzilai, Pinchas Cohen, Radhika Muzumdar, David Lefer
Abstract: Selective thyroid hormone agonists are disclosed that are highly selective for the TR.beta. subtype with high binding affinity. Methods of using such agonists and pharmaceutical compositions containing them are also disclosed, as are novel procedures for their preparation.
Type:
Grant
Filed:
June 18, 1997
Date of Patent:
March 16, 1999
Assignee:
The Regeants of the University of California
Inventors:
Thomas S. Scanlan, Grazia Chiellini, Hikari Yoshihara, James Apriletti, John D. Baxter, Ralff C. J. Ribeiro
Abstract: A biologically active composition made up of biodegradable core particles which are coated with a layer that is designed to allow attachment of biologically active agents without denaturing them. The composition may further include an exterior targeting membrane which provides selective targeting to specific receptors.
Type:
Grant
Filed:
November 1, 1993
Date of Patent:
October 31, 1995
Assignee:
The Regeants of the University of California
Inventors:
Nir Kossovsky, H. James Hnatyszyn, Andrew Gelman
Abstract: A semiactive control apparatus for damping motion of a body. According to the sensed position and velocity of the body, a voltage is applied or removed from the electrorheological fluid contained in an elastic body and coupled to the body, thus damping the body's motion.
Type:
Grant
Filed:
January 11, 1993
Date of Patent:
March 21, 1995
Assignee:
Regeants of the University of California
Abstract: A digital filter having a recursive portion and a non-recursive portion. The digital filter is implemented using pipelining techniques and parallel arithmetic and parallel arithmetic in both portions.
Type:
Grant
Filed:
March 26, 1984
Date of Patent:
January 22, 1985
Assignee:
The Regeants of the University of California