Abstract: A personal protective equipment (PPE) apparatus for patient donning during medical treatment is disclosed. The apparatus includes a portable frame and cover configured to surround the patient and mitigate the spread of airborne pathogens generated by the patient to the healthcare provider and surrounding environment.
Type:
Application
Filed:
September 16, 2021
Publication date:
August 10, 2023
Applicants:
The Regents of the University of Colorado, a body corporate, Isovac Products, LLC
Inventors:
Anne Leigh Adema, Maria Jane Mandt, Daniel Paul Connolly, Peter Michael Jenkner, Christopher Ryan Schultz, Isaac Hayden
Abstract: Various embodiments of the present technology generally relate to reflection suppressors. More specifically, some embodiments use elastomeric materials doped with optical absorbers for temporary suppression of Fresnel reflections for multiple substrates spanning wide spectral and angular bandwidth. The refractive index of the elastomer can be tuned to match a substrate and thereby minimize reflection. Some embodiments can use the addition of different absorptive dopants to allow for either broadband or wavelength-selective reflection suppression. As performance is limited only by index mismatch, both spectral and angular performance significantly exceed that of anti-reflection coatings. After use, these light traps may be removed and reused without damaging the substrate. These films have uses in spectroscopic ellipsometry, holography, and lithography.
Type:
Grant
Filed:
September 16, 2019
Date of Patent:
August 8, 2023
Assignee:
The Regents of the University of Colorado
Abstract: The present invention provides a method of treating melanoma, in a subject in need of such a treatment, a therapeutically effective amount of a compound of the formula: I or a pharmaceutically acceptable salt thereof, a solvate thereof, or a combination thereof, wherein X1 and X2 are as defined herein. Methods of the invention can further include administering other oncolytic agents and/or immunotherapy in treating a patient with melanoma.
Type:
Application
Filed:
July 23, 2021
Publication date:
August 3, 2023
Applicant:
The Regents of the University of Colorado, a body corporate
Inventors:
James Lambert, Steven K. Nordeen, Yiqun G. Shellman, M. Scott Lucia
Abstract: Systems and methods for azimuthal multiplexing using three-dimensional diffractive optics An azimuthal optical multiplexing system includes a light source. The system includes two or more at least partially transparent plates. Each plate of the two or more plates has a structured or patterned surface positioned in an optical path of the light source. The system includes means for rotating at least one plate of the two or more plates axially with respect to at least one other plate of the two or more plates. The means for rotating is operatively coupled to the at least one plate. The structured or patterned surface is configured to modulate light directed along the optical path and through the two or more plates.
Type:
Grant
Filed:
April 14, 2021
Date of Patent:
August 1, 2023
Assignee:
The Regents of the University of Colorado, a body corporate
Abstract: This invention is in the field of molecular biology, gene expression, functional genomics, and bioinformatics and relates to novel RNA and related structures and methods of use thereof that enables modulation of gene expression and preservation of particular transcriptome targets. The invention contemplates various applications of RNA sequences derived from the genomic RNA of flaviviruses (FVs) and the application of such features in combination with heterologous sequences.
Type:
Grant
Filed:
February 11, 2021
Date of Patent:
August 1, 2023
Assignee:
The Regents of the University of Colorado
Inventors:
Jeffrey S. Kieft, Erich G. Chapman, David A. Costantino, Jay R. Hesselberth, Andrea MacFadden, Benjamin Akiyama
Abstract: A bidirectional mode-locked fiber laser includes first and second passive optical fibers, a doped optical fiber, first and second polarization controllers, and first and second polarized beamsplitters that are arranged as a ring cavity with clockwise (CW) and counter-clockwise (CCW) directions. The laser imparts different nonlinear phase shifts in the CW and CCW directions, corresponding to CW and CCW repetition rates that are slightly different. When the normalized difference in repetition rates is less than approximately 10?5, both directions can be mode-locked simultaneously, thereby preventing one direction from inhibiting mode-locking of the other direction. Optical-fiber nonlinearity implements an intra-cavity bidirectional artificial saturable absorber based on nonlinear polarization rotation. The laser uses only components with normal group-velocity dispersion (GVD), thereby achieving higher pulse energies than mode-locked lasers utilizing negative GVD.
Type:
Grant
Filed:
January 29, 2021
Date of Patent:
August 1, 2023
Assignee:
The Regents of the University of Colorado, a body corporate
Abstract: A method for direct measurement of gradients of patient compliance with a medication regimen by employing a stable non-radioactive isotope taggant compound as part of, bound to, or applied to an endogenous molecule. An assay to determine patient compliance with medication regimens for HIV pre-exposure prophylaxis employing administering a taggant to a pharmacologically active compound, obtaining and collecting a patient tissue or fluid sample analyzing the collected tissue or fluid sample for the taggant concentration and interpreting data from the taggant concentration analysis as an indicator of gradients of patient compliance.
Type:
Application
Filed:
February 27, 2023
Publication date:
July 27, 2023
Applicant:
The Regents of the University of Colorado, A Body Corporate
Abstract: Apparatus and methods for forming an image of an object which involves focusing partially to fully spatially-coherent radiation onto a sample and collecting the resulting scattered radiation (the “standard data set”) on an array detector. In addition to the standard dataset, an additional measurement or plurality of measurements is made of a relatively-unscattered beam, using the array detector, which comprises the “modulus enforced probe (MEP) dataset”. This MEP dataset serves as an extra constraint, called the MEP constraint, in the phase retrieval algorithm used to reconstruct the image of the object.
Type:
Grant
Filed:
May 18, 2017
Date of Patent:
July 25, 2023
Assignee:
Regents of the University of Colorado, a body corporate
Inventors:
Michael Tanksalvala, Daniel E. Adams, Dennis Gardner, Christina L. Porter, Giulia F. Mancini, Margaret M. Murnane, Henry C. Kapteyn
Abstract: Described herein are methods and vectors for rational, multiplexed manipulation of chromosomes within open reading frames (e.g., in protein libraries) or any segment of a chromosome in a cell or population of cells, in which various CRISPR systems are used.
Type:
Grant
Filed:
August 23, 2019
Date of Patent:
July 18, 2023
Assignee:
THE REGENTS OF THE UNIVERSITY OF COLORADO
Abstract: Methods of using a phosphoinositide 3-kinase p110-delta inhibitor to treat, delay the onset, or slow the progression of an autoimmune disease or disorder in a subject, without suppressing the subject's B cell responses to exogenous antigens or rendering the subject immunocompromised, as well as pharmaceutical compositions containing phosphoinositide 3-kinase p110-delta inhibitors in amounts suitable for convenient and accurate administration within these therapeutic methods.
Type:
Grant
Filed:
January 7, 2019
Date of Patent:
July 18, 2023
Assignees:
NATIONAL INSTITUTES OF HEALTH (NCH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT NIH DIVISION OF EXTRAMURAL INVENTIONS AND TECHNOLOGY RESOURCES (DEITR), THE REGENTS OF THE UNIVERSITY OF COLORADO
Abstract: A qubit array reparation system includes a reservoir of ultra-cold particle, a detector that determines whether or not qubit sites of a qubit array include respective qubit particles, and a transport system for transporting an ultra-cold particle to a first qubit array site that has been determined by the probe system to not include a qubit particle so that the ultra-cold particle can serve as a qubit particle for the first qubit array site. A qubit array reparation process includes maintaining a reservoir of ultra-cold particles, determining whether or not qubit-array sites contain respective qubit particles, each qubit particle having a respective superposition state, and, in response to a determination that a first qubit site does not contain a respective qubit particle, transporting an ultracold particle to the first qubit site to serve as a qubit particle contained by the first qubit site.
Type:
Grant
Filed:
May 21, 2021
Date of Patent:
July 11, 2023
Assignees:
ColdQuanta, Inc., The Regents of the University of Colorado, a body corporate
Inventors:
Dana Zachary Anderson, Brad Anthony Dinardo
Abstract: A neurosurgical endoscopic training system and method for using the system to develop surgical skills and technical competency of an endoscopist. The system includes a portable part-task enclosure with a plurality of walls defining an internal chamber. One of the walls includes an access port coupling the internal chamber to an external environment and the access port can be configured to facilitate the passage of one or more endoscopic surgical tools. The system further includes a plurality of objects disposed within the internal chamber configured for manipulation by a surgical tool that extends through the access port.
Type:
Grant
Filed:
December 3, 2018
Date of Patent:
June 27, 2023
Assignee:
The Regents of the University of Colorado
Inventors:
David Ryan Ormond, Jennifer Wagner, Edin Nevzati
Abstract: The invention relates to a microfluidic poration device having narrow channels slightly smaller than the width of a target cell, wherein the channels are lined with a plurality of nanospikes in a row extending down the middle of the channel, i.e. in a row parallel to the sides of the channel. In one embodiment, one channel may have 2 nanospikes (or 2 nanolancets). Thus, in particular embodiments, the invention provides microfluidic poration devices capable of simultaneously squeezing cells while piercing holes in their membranes for allowing foreign molecules into cells. The holes in porated cells spontaneously close after exiting the channels, thus entrapping the foreign molecules inside of the target cells. This porated cell population has approximately a 95% viability with greater than 50% containing at least one foreign molecule.
Abstract: An apical cuff axial compression assembly including a ring member for coupling an apical cuff of a Ventricular Assist Device pump, to left ventricular apical tissue. Tissue anchors are employed to engage with the ring member and the apical cuff to exert direct or axial compression of the ring member to the apical cuff and to the left ventricular apical tissue. A first variant includes an axial compression ring and a plurality of openings to accommodate the tissue anchors. A second variant includes a segmented axial compression ring composed of a plurality of arcuate members, which may be contiguous or joined to each other or not. Each of the plurality of arcuate members has at least one tissue anchor opening passing there through.
Abstract: Transducer systems disclosed herein include self-sensing capabilities. In particular, electrostatic transducers include a low voltage electrode and a high voltage electrode. A low voltage sensing unit is coupled with the low voltage electrode of the electrostatic transducer. The low voltage sensing unit is configured to measure a capacitance of the electrostatic transducer, from which displacement of the electrostatic transducer may be calculated. High voltage drive signals received by the high voltage electrode during actuation may be isolated from the low voltage sensing unit. The isolation may be provided by dielectric material of the electrostatic transducer, a voltage suppression component, and/or a voltage suppression module comprising a low impedance ground path. In the event of an electrical failure of the transducer, the low voltage sensing unit may be isolated from high voltages.
Type:
Application
Filed:
May 29, 2021
Publication date:
June 22, 2023
Applicant:
The Regents of the University of Colorado, a body corporate
Inventors:
Nikolaus Correll, Khoi D. Ly, Nicholas Alexander Kellaris, Christoph Matthias Keplinger
Abstract: The present invention relates in certain aspects to the discovery of novel 2-naphthimidamide compounds that are capable of binding Type II Transmembrane Serine Proteases (TTSPs). In certain embodiments, the compounds of the invention can be used to treat or prevent Influenza A viral infection in a mammal.
Type:
Grant
Filed:
June 11, 2019
Date of Patent:
June 20, 2023
Assignee:
The Regents of the University of Colorado, a body corporate
Abstract: A bioprinter for manufacturing an organomimetic device includes at least one extruder configured to extrude a material, a three-dimensional movement assembly, and a build-plate mounted to the three-dimensional movement assembly. The build-plate may be configured to support the organomimetic device being manufactured. The bioprinter may further include a controller operably coupled to and configured to control the at least one extruder, the three-dimensional movement assembly, and the build-plate. The at least one extruder may be non-movably fixed to the cabinet.
Type:
Grant
Filed:
February 11, 2019
Date of Patent:
June 20, 2023
Assignee:
The Regents Of The University Of Colorado, A Body Corporate
Abstract: The present disclosure relates optical imaging devices and methods useful in biological and medical imaging applications. In one embodiment, an optical imaging device includes a flexible lightguide having a first end and a second end, the output of the source of pulsed infrared radiation being optically coupled to the first end of the flexible lightguide; a lens assembly attached to and optically coupled to the second end of the flexible lightguide, the lens assembly comprising a variable-focus lens element, the a variable-focus lens element having a tunable focal length; and a photodetector coupled to the flexible lightguide to detect radiation propagating from the second end toward the first end of the flexible lightguide. The optical imaging devices and methods can be used in both confocal and multi-photon techniques.
Type:
Grant
Filed:
April 20, 2020
Date of Patent:
June 13, 2023
Assignee:
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
Inventors:
Juliet T. Gopinath, Emily A. Gibson, Victor M. Bright, Richard Weir, Diego Restrepo, Baris Ozbay
Abstract: The present disclosure provides an adjustable endoscopic surgical device for illuminating a tissue surface with diffuse and oblique light. In some embodiments, light emanates from the sides of an optical fiber, which is optionally formed at least in part into a loop shape.
Type:
Grant
Filed:
December 17, 2020
Date of Patent:
June 13, 2023
Assignee:
The Regents of the University of Colorado
Abstract: This invention relates generally to characterizing bioaerosols and, more particularly, to a system for recovering, quantifying, identifying, and assessing the metabolic activities of bioaerosols based on their major biopolymer profiles (lipids, carbohydrate and protein) and more specific their genetic materials (DNA/RNA), such as airborne viruses, bacteria, fungi and pollens.
Type:
Grant
Filed:
December 27, 2018
Date of Patent:
May 30, 2023
Assignees:
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE, AEROSOL DEVICES, INC.