Abstract: A durable solid and liquid repellant material is provided having an elastomeric matrix with a plurality of lubricating domains distributed therein formed by a partial crosslinking reaction between an elastomeric precursor having a first reactive functional group and a polyol having a second reactive functional group. The polyol has a limited solubility circle. The first reactive functional group is selected from the group consisting of: alkene, amine, carboxylic acid, hydroxyl, isocyanate, and combinations thereof and the second reactive group is selected from the group consisting of: amine, carboxylic acid, hydroxyl group, and combinations thereof. The partially crosslinked elastomeric matrix has a crosslink density of greater than or equal to about 200 mol/m3 and less than or equal to about 2,000 mol/m3. Methods for forming the durable solid and liquid repellant material are also provided.

Abstract: A first-dimension-guided differential scaling algorithm of the contour plot in comprehensive two-dimensional gas chromatography (2D GC) system is developed by incorporating both 1D and 2D chromatograms obtained by first and second detectors. This differential scaling method is shown to significantly improve 2D GC results in terms of retention time accuracy and consistency, peak width and hence peak capacity, and analyte quantification accuracy, which are inevitably affected by the modulation period and phase shift in modulation when the conventional contour plot reconstruction methods. Furthermore, the differential scaling method is shown to better handle the coelution and missing peak issues often encountered in the conventional methods. Finally, the differential scaling method exhibits high versatility in detector selection, which greatly broadens the 2D GC utility and can be easily adapted to other 2D chromatography systems.

Abstract: Wearable uroflowmetry systems having wearable uroflowmeters are disclosed. A disclosed example uroflowmetry system comprises a wearable uroflowmeter including: a funnel portion having an end configured to secure the funnel portion against a person, an outlet opposite the end, and a funnel configured to capture urine excreted by the person when the end is secured against the person, and to direct the captured urine into the outlet; a fluid passage portion having an opening configured to receive the urine from the outlet of the funnel portion, and a fluid channel to pass the received urine along a length of the fluid passage portion; and a measuring portion having a sensor in the fluid channel configured to collect one or more measurements of the urine as the urine passes the sensor, the measurements representative of at least one of a property of the urine, or a flow characteristic of the urine.

Abstract: The present invention provides techniques for learning Mahalanobis distance similarity metrics from data for individually fair machine learning models. In one aspect, a method for learning a fair Mahalanobis distance similarity metric includes: obtaining data with similarity annotations; selecting, based on the data obtained, a model for learning a Mahalanobis covariance matrix ?; and learning the Mahalanobis covariance matrix ? from the data using the model selected, wherein the Mahalanobis covariance matrix ? fully defines the fair Mahalanobis distance similarity metric.

Abstract: A motion sensing system uses high-voltage biasing to achieve high resolution with ultra-low power. The motion sensing system consists of a motion sensor, a readout circuit, and a high-voltage bias circuit to generate the optimized bias voltage for the motion sensor. By using the high-voltage bias, the signal from the motion sensor is raised above the readout circuit's noise floor, eliminating the power-hungry amplifier and signal-chopping used in conventional motion sensing systems. The bias circuit, while producing the programmable bias voltages for the motion sensor, also compensates for the process mismatch raised by the high voltage biases.

Abstract: Provided herein are small molecules comprising a first domain that binds to ASH1L and a second domain that facilitates ASH1L degradation. In particular, ASH1L-targeting proteolysis targeting chimeras (PROTACs) and methods of use thereof for the treatment of disease (e.g., acute leukemia, solid cancers and other diseases dependent on activity of ASH1L) are provided.

Abstract: Provided are photocurable resins comprising a poly(siloxane)-based copolymer together with a photoinitiator, and other optional ingredients such as a photocurable diluent, a photoabsorber, a photosensitizer, or a hydrophillic additive. Also provided are methods of stereolithographically printing a 3-D object from a disclosed resin. Also provided is an improved method for stereolithographically printing a 3-D object, the improvement comprising the use of a disclosed photocurable resin. Further provided is a 3-D microfluidic device such as an artificial lung prepared from a disclosed photocurable resin.

Abstract: In various aspects, methods of making a silicon carbide or silicon nitride from rice hull ash (RHA) byproduct are provided. A treated silica depleted rice hull ash product (SDRHA) comprising silicon oxide at ?about 65% by weight and carbon ?about 35% by weight may be heated in an environment free of any additional carbon sources, but in an inert atmosphere, having a temperature of ?about 1,200° C. to ?about 1,700° C. for a carbothermal reaction that forms a product (e.g., nanocomposite product) comprising at least one of silicon carbide (SiC), silicon nitride (Si3N4), and silicon oxynitride (Si2N2O or non-stoichiometric SiNxO4-x, where x ranges from greater than 0 to less than 4). A negative electroactive material is also provided that includes silicon oxynitride (Si2N2O), which may be used in a lithium ion battery.

Abstract: Protein-based nanoparticles for treating cancer, such as those characterized by intracranial tumors, and methods of forming such protein-based nanoparticles via electrohydrodynamic jetting methods are provided. The nanoparticle may comprise a water-soluble protein having an average molecular weight of ?about 8 kDa and ?about 700 kDa. In certain variations, the water-soluble protein is cross-linked (e.g., with an optional crosslinking agent) and defines a mesh structure having an average linear mesh size of ?about 1 nm to ?about 4 nm. The nanoparticle may have a transcription factor such as a therapeutic nucleic acid in the mesh structure. Methods of making such nanoparticles may include jetting a liquid comprising the water-soluble protein through a nozzle, followed by exposing the liquid to an electric field sufficient to solidify the liquid and form the protein-based nanoparticles described above.

Abstract: Systems and methods for object and material recognition are provided and include a hyperspectral infrared camera that captures a three-dimensional image of an object and black-body emissions data indicating a polarization of black-body radiation emitted from the object. An image processing device accesses a database of expected polarization signatures of black-body emissions from materials at different temperatures and determines a material of the object based on (i) the black-body emissions data indicating the polarization of the black-body radiation emitted from the object, (ii) an ambient temperature of the environment of the system, and (iii) the database of expected polarization signatures of black-body emissions from a plurality of materials for different temperatures.

Abstract: The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to ncRNAs as diagnostic markers and clinical targets for prostate, lung, breast and pancreatic cancer.

Abstract: Disclosed herein are small molecule inhibitors of platelet function, and methods of using the small molecules to treat diseases, such as platelet hemostasis and thrombosis. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.

Abstract: Disclosed are systems and methods for a supercapacitor. One form of the supercapacitor has a first electrode comprising a first active material, a second electrode comprising a second active material, and an electrolyte comprising a protic ionic liquid. The protic ionic liquid may be capable of undergoing a faradaic charge transfer with an electrode of a supercapacitor.

Abstract: A computing system includes a processor; and a memory having stored thereon an adjustment application comprising computer-executable instructions that, when executed, cause the computing system to: display a graphical user interface including a digital medical image of a patient; superimpose a bounding box; receive an adjustment of an area of interest; and provide an adjusted digital medical image. A non-transitory computer-readable medium includes computer-executable instructions that, when executed via one or more processors, cause a computer to: display a graphical user interface including a digital medical image of a patient; superimpose a bounding box; receive an adjustment of an area of interest; and provide an adjusted digital medical image. A computer-implemented method includes: displaying a graphical user interface including a digital medical image of a patient; superimposing a bounding box; receiving an adjustment of an area of interest; and providing an adjusted digital medical image.

Abstract: A stochastic Model Predictive Control approach is developed to efficiently optimize the thermal management of electric vehicles and accommodate scenarios with multiple routes. To account for the uncertainties, the cost function is constructed to minimize the expected cost across all possible routes over the prediction horizon. Thermal constraints are treated as soft constraints using slack variables. This approach allows for flexibility in satisfying the constraints while optimizing the performance. Through simulations, the performance of the proposed method is evaluated using a fleet of vehicles. In this way, the proposed method achieves a good trade-off between multiple competing performance metrics. Furthermore, an adaptation strategy is introduced, which dynamically adjusts the penalty weight value. This adaptive approach eliminates the need for offline calibration and further enhances performance.

Abstract: Traveling-wave modulation is a form of space-time modulation which has been shown to enable unique electromagnetic phenomena such as non-reciprocity, beam-steering, frequency conversion, and amplification. The capability to accurately simulate spatially-discrete traveling-wave modulated structures is critical to design. However, simulating these structures is challenging due to the complex space-time dependence of the constituent unit cells. Thus, an interpath relation is derived for spatially-discrete traveling-wave modulated structures. The interpath relation reveals that the field within a single time-modulated unit cell (rather than an entire spatial period) is sufficient to determine the field solution throughout space. It is shown that the interpath relation can be incorporated into existing periodic method of moments solvers simply by modifying the source basis functions.

Abstract: The present invention relates to nanoparticles associated with (e.g., complexed, conjugated, encapsulated, absorbed, adsorbed, admixed) biomacromolecule agents configured for treating, preventing or ameliorating various types of disorders, and methods of synthesizing the same. In particular, the present invention is directed to compositions comprising nanoparticles (e.g., synthetic high density lipoprotein (sHDL)) associated with (e.g., complexed, conjugated, encapsulated, absorbed, adsorbed, admixed) biomacromolecule agents (e.g., nucleic acid, peptides, glycolipids, etc.), methods for synthesizing such nanoparticles, as well as systems and methods utilizing such nanoparticles (e.g., in diagnostic and/or therapeutic settings).

Abstract: A method of manufacturing and assembling a sandwich flexure mechanism assembly is set forth herein. The method involves manufacture of a monolithic sandwich flexure module having a multitude of out of plane rigid inter-stage connections between at least some sets of twin stages of the monolithic sandwich flexure module. The method further involves assembling an interconnect subassembly to intermediate bodies of the monolithic sandwich flexure module. The interconnect subassembly furnishing in-plane rigid inter-stage connections between pairs of the intermediate bodies that constitute sister stages of the monolithic sandwich flexure module. The method can further involve assembling a motion body, actuators, and displacement sensors at the monolithic sandwich flexure module.

Abstract: A compact single-axis confocal endomicroscope is provided, capable of complying with 2.8 mm diameter endoscope space requirements. The single-axis confocal endomicroscope uses a folded path design achieved between a fixed mirror and a lateral plane scanning mirror thereby producing high numerical apertures that allow for diffraction-limited resolution in sub-surface scanning. The scanning mirror has a central aperture that allows for illumination beam expansion in the folded path design.

Abstract: The disclosure provides biocatalysts that halogenate complex chemical compounds in specific and predictable ways. Also disclosed are halogenated complex organic compounds. The disclosure further provides methods for the halogenation of complex chemical compounds and methods of inhibiting the contraction of smooth muscle in mammals.