Patents Assigned to The Regent of the University of Michigan
  • Patent number: 12259543
    Abstract: A compact single-axis confocal endomicroscope is provided, capable of complying with 2.8 mm diameter endoscope space requirements. The single-axis confocal endomicroscope uses a folded path design achieved between a fixed mirror and a lateral plane scanning mirror thereby producing high numerical apertures that allow for diffraction-limited resolution in sub-surface scanning. The scanning mirror has a central aperture that allows for illumination beam expansion in the folded path design.
    Type: Grant
    Filed: March 18, 2020
    Date of Patent: March 25, 2025
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Thomas D. Wang, Haijun Li, Xiyu Duan, Gaoming Li
  • Patent number: 12258263
    Abstract: A method of manufacturing and assembling a sandwich flexure mechanism assembly is set forth herein. The method involves manufacture of a monolithic sandwich flexure module having a multitude of out of plane rigid inter-stage connections between at least some sets of twin stages of the monolithic sandwich flexure module. The method further involves assembling an interconnect subassembly to intermediate bodies of the monolithic sandwich flexure module. The interconnect subassembly furnishing in-plane rigid inter-stage connections between pairs of the intermediate bodies that constitute sister stages of the monolithic sandwich flexure module. The method can further involve assembling a motion body, actuators, and displacement sensors at the monolithic sandwich flexure module.
    Type: Grant
    Filed: March 14, 2024
    Date of Patent: March 25, 2025
    Assignee: The Regents of the University of Michigan
    Inventors: Shorya Awtar, Kwun Sing Roger Ho, Siddharth Rath
  • Patent number: 12257352
    Abstract: The present invention relates to nanoparticles associated with (e.g., complexed, conjugated, encapsulated, absorbed, adsorbed, admixed) biomacromolecule agents configured for treating, preventing or ameliorating various types of disorders, and methods of synthesizing the same. In particular, the present invention is directed to compositions comprising nanoparticles (e.g., synthetic high density lipoprotein (sHDL)) associated with (e.g., complexed, conjugated, encapsulated, absorbed, adsorbed, admixed) biomacromolecule agents (e.g., nucleic acid, peptides, glycolipids, etc.), methods for synthesizing such nanoparticles, as well as systems and methods utilizing such nanoparticles (e.g., in diagnostic and/or therapeutic settings).
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: March 25, 2025
    Assignee: The Regents of the University of Michigan
    Inventors: James J. Moon, Rui Kuai, Anna A. Schwendeman, Jutaek Nam
  • Patent number: 12252714
    Abstract: The disclosure provides biocatalysts that halogenate complex chemical compounds in specific and predictable ways. Also disclosed are halogenated complex organic compounds. The disclosure further provides methods for the halogenation of complex chemical compounds and methods of inhibiting the contraction of smooth muscle in mammals.
    Type: Grant
    Filed: May 15, 2023
    Date of Patent: March 18, 2025
    Assignee: REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: David H. Sherman, Amy E. Fraley, Ashootosh Tripathi
  • Publication number: 20250085429
    Abstract: A computer includes a processor and a memory, and the memory stores instructions executable by the processor to generate a set of points from a measurement scan obtained by a lidar sensor and to generate an expected termination distance of the set of points based on a neural implicit representation of the set of points. The instructions may additionally be to compute a loss function that includes a relatively low margin correlated with the variance or standard deviation of a training distribution centered at a learned point of the set of points based on the expected termination distance of the learned point, the learned point being learned by the neural implicit representation. The instructions may additionally be to generate a keyframe from the set of points and to generate a pose of the lidar sensor based on the keyframe.
    Type: Application
    Filed: September 8, 2023
    Publication date: March 13, 2025
    Applicants: Ford Global Technologies, LLC, THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Seth Isaacson, Pou-Chun Kung, Katherine Skinner, Manikandasriram Srinivasan Ramanagopal, Ramanarayan Vasudevan
  • Patent number: 12246056
    Abstract: Provided herein are compositions and methods for generation of cysteine in microbial systems. Further provided herein are compositions and methods for reducing and eliminating biofilms.
    Type: Grant
    Filed: November 6, 2019
    Date of Patent: March 11, 2025
    Assignee: The Regents of the University of Michigan
    Inventors: Lydia Petra Freddolino, Mehdi Rahimpour
  • Publication number: 20250077068
    Abstract: Touchscreen devices, designed with an assumed range of user abilities and interaction patterns, often present challenges for individuals with diverse abilities to operate independently. Prior efforts to improve accessibility through tools or algorithms necessitated alterations to touchscreen hardware or software, making them inapplicable for the large number of existing legacy devices. This disclosure introduces a hardware interaction proxy that performs physical interactions on behalf of users while allowing them to continue utilizing accessible interfaces, such as screen readers and assistive touch on smartphones, for interface exploration and command input. The proxy maintains an interface model for accurate target localization and utilizes exchangeable actuators for physical actuation across a variety of device types, effectively reducing user workload and minimizing the risk of mistouch.
    Type: Application
    Filed: August 27, 2024
    Publication date: March 6, 2025
    Applicant: The Regents of The University of Michigan
    Inventors: Anhong GUO, Alanson SAMPLE, Ruijie GENG, Thomas KROLIKOWSKI, Yasha IRAVANTCHI, Chen LIANG
  • Patent number: 12240852
    Abstract: Disclosed herein is a method and apparatus for synthesizing co-crystals from the vapor phase without the need for liquid solvent. Also disclosed herein are co-crystals formed from the vapor phase, substrates coated with said co-crystals, pharmaceutical compositions thereof and apparatuses for producing said co-crystals.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: March 4, 2025
    Assignee: REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Max Shtein, Siddharth Borsadia, Eugene Shteyn
  • Patent number: 12241953
    Abstract: The following relates generally to accelerated magnetic resonance imaging (MRI) reconstruction. In some embodiments, a MRI machine learning algorithm is trained based on reference MRI data in non-Cartesian k-space. During the training, at each iteration of a plurality of iterations: (i) a non-Cartesian sampling trajectory ? may be optimized under the physical constraints, and/or (ii) an image reconstructor may be jointly iteratively optimized. Examples of the image reconstructor include a convolutional neural network (CNN) denoiser, a model-based deep learning (MoDL) image reconstructor, iterative image reconstructor, a regularizer, and an invertible neural network.
    Type: Grant
    Filed: January 17, 2023
    Date of Patent: March 4, 2025
    Assignee: REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Jeffrey Allen Fessler, Douglas Clair Noll, Guanhua Wang
  • Patent number: 12243185
    Abstract: Systems and methods are provided for point cloud processing with an equivariant neural network and implicit shape learning that may produce correspondence-free registration. The systems and methods may provide for feature space preservation with the same rotation operation as a Euclidean input space, due to the equivariance property, which may provide for solving the feature-space registration in a closed form.
    Type: Grant
    Filed: June 29, 2022
    Date of Patent: March 4, 2025
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Minghan Zhu, Maani Ghaffari, Huei Peng
  • Patent number: 12244151
    Abstract: A system includes a body comprising a conduction path, and first and second modules disposed along, and movable relative to, the body, each of the first and second modules including an energy storage device, a terminal, and a power management unit coupling the energy storage device and the terminal. The terminal of each of the first and second modules is capacitively coupled with the conduction path for bidirectional power transfer between the first and second modules via the conduction path.
    Type: Grant
    Filed: March 11, 2021
    Date of Patent: March 4, 2025
    Assignee: The Regents of the University of Michigan
    Inventors: Al-Thaddeus Avestruz, Akshay Sarin, Shai Revzen, Duncan Abbot
  • Publication number: 20250066658
    Abstract: Compositions suitable for reversibly storing heat in thermal energy systems (TES) include a salt hydrate represented by the formula: MXq·nH2O. M is a cation selected from Groups 1 to 14 of the IUPAC Periodic Table, X is a halide of Group 17, q ranges from 1 to 4, and n ranges from 1 to 12. The cation (M) may have an electronegativity of ? about 1.8 and a molar mass ? about 28 g/mol. The anion (X) may have an electronegativity of ?about 2.9 to ? about 3.2. A distance between a cation (M) and coordinating water molecules (H2O) is ? about 2.1 ?. Thermal energy systems (TES) incorporating such compositions are also provided that are configured to reversibly store heat in the thermal energy system (TES) via an endothermic dehydration reaction and to release heat in in the thermal energy system (TES) via an exothermic hydration reaction.
    Type: Application
    Filed: November 15, 2024
    Publication date: February 27, 2025
    Applicant: The Regents of the University of Michigan
    Inventors: Donald Jason SIEGEL, Steven KIYABU
  • Patent number: 12233189
    Abstract: An artificial lung system for a patient having a membrane lung system having an gas inlet, a blood inlet, a blood outlet, and an exhaust; a gas system operably coupled to the gas inlet of the membrane lung system; a gas phase CO2 sensor disposed downstream of the exhaust of the membrane lung system and monitoring an exhaust gas CO2 (EGCO2) level and/or an blood oxygen saturation sensor disposed upstream of the blood inlet of the membrane lung system and monitoring a blood oxygen saturation level; and a feedback controller receiving the CO2 signal and/or blood oxygen saturation signal and outputting a control signal to control gas flow and/or blood flow.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: February 25, 2025
    Assignees: The Regents of The University of Michigan, United States Government As Represented by the Department of Veterans Affairs
    Inventors: Joseph Potkay, Robert H. Bartlett, Alvaro Rojas-Pena
  • Patent number: 12233063
    Abstract: Provided herein are compositions and methods for treating eye disorders. In particular, provided herein are neuroprotective compositions and methods for treating vision loss and related disorders.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: February 25, 2025
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Cagri Giray Besirli, Thomas Wubben
  • Patent number: 12233150
    Abstract: Provided herein are star-shaped polymers and methods of use thereof. Also provided are oral compositions comprising a star-shaped polymer and an orally acceptable carrier and methods of using same. The star-shaped polymers, as provided herein, have a structure according to Formula (I).
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: February 25, 2025
    Assignees: REGENTS OF THE UNIVERSITY OF MICHIGAN, COLGATE-PALMOLIVE COMPANY
    Inventors: Kenichi Kuroda, Carl P. Myers, Guillaume A. Picquet, Lynette A. Zaidel
  • Patent number: 12234255
    Abstract: Provided herein are methods of glycosylation in the formation of disaccharides, trisaccharides, and oligosaccharides using fluoroglycosides, silyl ether glycosides and a triaryl borane catalyst.
    Type: Grant
    Filed: May 14, 2020
    Date of Patent: February 25, 2025
    Assignee: REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: John Montgomery, Girish Chandra Sati, Joshua Lane Martin
  • Patent number: 12226524
    Abstract: Implants for anti-VEGF therapy provide both stability and controlled release of bevacizumab and other structurally sensitive polypeptides while maintaining protein/peptide stability in the micronized powder; achieving near zero order and complete release (>80%). Cylindrical implants suitable for intravitreal injection.
    Type: Grant
    Filed: May 2, 2017
    Date of Patent: February 18, 2025
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Steven P. Schwendeman, Rae Sung Chang
  • Patent number: 12226491
    Abstract: The present invention provides, in some embodiments, methods, compositions, systems, and kits comprising nano-satellite complexes comprising: a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core; 3-25 satellite particles attached to, or absorbed to, said biocompatible coating; a plurality of antigenic peptides conjugated to, or absorbed to, said satellite particles; and at least one additional property. In other embodiments, provided herein are nano-satellite complexes comprising: a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core; a plurality of satellite particles attached to, or absorbed to, said biocompatible coating; a plurality of antigenic peptides conjugated to, or absorbed to, said satellite particles; and a plurality of LIGHT (TNFSF14) peptides conjugated to, or absorbed to, said satellite particles.
    Type: Grant
    Filed: April 16, 2021
    Date of Patent: February 18, 2025
    Assignee: The Regents of the University of Michigan
    Inventors: Duxin Sun, Ryan Clauson, Hongwei Chen, Chengyi Li, Wei Gao, Luke Bugada, Fei Wen, Brett Hill, Syed Monem Rizvi
  • Patent number: 12227190
    Abstract: A grip force sensing and shape-changing steering wheel configured to serve as an intuitive means of communication between a human driver and automatic driving system or driver assist system.
    Type: Grant
    Filed: May 24, 2021
    Date of Patent: February 18, 2025
    Assignee: The Regents of The University of Michigan
    Inventors: Brent Gillespie, Akshay Bhardwaj
  • Patent number: 12227831
    Abstract: Devices, systems, and techniques are provided for improved OVJP deposition using a shutter disposed within the OVJP print head, between the print head inlet and the nozzle outlets. An OVJP print head as disclosed includes an inlet for organic material entrained in a carrier gas, a micronozzle array outlet, and a shutter disposed in the gas flow path between the inlet and the micronozzle array outlet. The shutter allows for rapid cutoff of carrier gas flow through the print head with extremely low latency.
    Type: Grant
    Filed: April 20, 2021
    Date of Patent: February 18, 2025
    Assignee: The Regents of the University of Michigan, Innovation Partnerships
    Inventors: Stephen R. Forrest, Jeffrey A. Horowitz