Patents Assigned to The Regent of the University of Michigan
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Publication number: 20250066658Abstract: Compositions suitable for reversibly storing heat in thermal energy systems (TES) include a salt hydrate represented by the formula: MXq·nH2O. M is a cation selected from Groups 1 to 14 of the IUPAC Periodic Table, X is a halide of Group 17, q ranges from 1 to 4, and n ranges from 1 to 12. The cation (M) may have an electronegativity of ? about 1.8 and a molar mass ? about 28 g/mol. The anion (X) may have an electronegativity of ?about 2.9 to ? about 3.2. A distance between a cation (M) and coordinating water molecules (H2O) is ? about 2.1 ?. Thermal energy systems (TES) incorporating such compositions are also provided that are configured to reversibly store heat in the thermal energy system (TES) via an endothermic dehydration reaction and to release heat in in the thermal energy system (TES) via an exothermic hydration reaction.Type: ApplicationFiled: November 15, 2024Publication date: February 27, 2025Applicant: The Regents of the University of MichiganInventors: Donald Jason SIEGEL, Steven KIYABU
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Patent number: 12233150Abstract: Provided herein are star-shaped polymers and methods of use thereof. Also provided are oral compositions comprising a star-shaped polymer and an orally acceptable carrier and methods of using same. The star-shaped polymers, as provided herein, have a structure according to Formula (I).Type: GrantFiled: May 28, 2020Date of Patent: February 25, 2025Assignees: REGENTS OF THE UNIVERSITY OF MICHIGAN, COLGATE-PALMOLIVE COMPANYInventors: Kenichi Kuroda, Carl P. Myers, Guillaume A. Picquet, Lynette A. Zaidel
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Patent number: 12234255Abstract: Provided herein are methods of glycosylation in the formation of disaccharides, trisaccharides, and oligosaccharides using fluoroglycosides, silyl ether glycosides and a triaryl borane catalyst.Type: GrantFiled: May 14, 2020Date of Patent: February 25, 2025Assignee: REGENTS OF THE UNIVERSITY OF MICHIGANInventors: John Montgomery, Girish Chandra Sati, Joshua Lane Martin
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Patent number: 12233189Abstract: An artificial lung system for a patient having a membrane lung system having an gas inlet, a blood inlet, a blood outlet, and an exhaust; a gas system operably coupled to the gas inlet of the membrane lung system; a gas phase CO2 sensor disposed downstream of the exhaust of the membrane lung system and monitoring an exhaust gas CO2 (EGCO2) level and/or an blood oxygen saturation sensor disposed upstream of the blood inlet of the membrane lung system and monitoring a blood oxygen saturation level; and a feedback controller receiving the CO2 signal and/or blood oxygen saturation signal and outputting a control signal to control gas flow and/or blood flow.Type: GrantFiled: June 18, 2019Date of Patent: February 25, 2025Assignees: The Regents of The University of Michigan, United States Government As Represented by the Department of Veterans AffairsInventors: Joseph Potkay, Robert H. Bartlett, Alvaro Rojas-Pena
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Patent number: 12233063Abstract: Provided herein are compositions and methods for treating eye disorders. In particular, provided herein are neuroprotective compositions and methods for treating vision loss and related disorders.Type: GrantFiled: October 18, 2018Date of Patent: February 25, 2025Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Cagri Giray Besirli, Thomas Wubben
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Patent number: 12227831Abstract: Devices, systems, and techniques are provided for improved OVJP deposition using a shutter disposed within the OVJP print head, between the print head inlet and the nozzle outlets. An OVJP print head as disclosed includes an inlet for organic material entrained in a carrier gas, a micronozzle array outlet, and a shutter disposed in the gas flow path between the inlet and the micronozzle array outlet. The shutter allows for rapid cutoff of carrier gas flow through the print head with extremely low latency.Type: GrantFiled: April 20, 2021Date of Patent: February 18, 2025Assignee: The Regents of the University of Michigan, Innovation PartnershipsInventors: Stephen R. Forrest, Jeffrey A. Horowitz
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Patent number: 12227190Abstract: A grip force sensing and shape-changing steering wheel configured to serve as an intuitive means of communication between a human driver and automatic driving system or driver assist system.Type: GrantFiled: May 24, 2021Date of Patent: February 18, 2025Assignee: The Regents of The University of MichiganInventors: Brent Gillespie, Akshay Bhardwaj
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Patent number: 12226524Abstract: Implants for anti-VEGF therapy provide both stability and controlled release of bevacizumab and other structurally sensitive polypeptides while maintaining protein/peptide stability in the micronized powder; achieving near zero order and complete release (>80%). Cylindrical implants suitable for intravitreal injection.Type: GrantFiled: May 2, 2017Date of Patent: February 18, 2025Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Steven P. Schwendeman, Rae Sung Chang
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Patent number: 12226491Abstract: The present invention provides, in some embodiments, methods, compositions, systems, and kits comprising nano-satellite complexes comprising: a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core; 3-25 satellite particles attached to, or absorbed to, said biocompatible coating; a plurality of antigenic peptides conjugated to, or absorbed to, said satellite particles; and at least one additional property. In other embodiments, provided herein are nano-satellite complexes comprising: a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core; a plurality of satellite particles attached to, or absorbed to, said biocompatible coating; a plurality of antigenic peptides conjugated to, or absorbed to, said satellite particles; and a plurality of LIGHT (TNFSF14) peptides conjugated to, or absorbed to, said satellite particles.Type: GrantFiled: April 16, 2021Date of Patent: February 18, 2025Assignee: The Regents of the University of MichiganInventors: Duxin Sun, Ryan Clauson, Hongwei Chen, Chengyi Li, Wei Gao, Luke Bugada, Fei Wen, Brett Hill, Syed Monem Rizvi
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Patent number: 12228487Abstract: Methods and systems for characterizing multiple parameters of viscous fluid simultaneously are provided. By imposing an oscillatory deformation profile on a filament formed of the viscous fluid between two plates, a nonlinear fit to the deformation profile captured at different times is analyzed against a filament model dependent upon the plates radius, viscous fluid density, and the oscillation frequency of the imposed deformation profile. The Reynolds number, Weber number, and the aspect ratio of the viscous fluid are thus determined, for identifying the Newtonian fluid.Type: GrantFiled: November 21, 2022Date of Patent: February 18, 2025Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: William W. Schultz, Subramaniam Balakrishna
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Patent number: 12220602Abstract: A histotripsy therapy system configured for the treatment of brain tissue is provided, which may include any number of features. In one embodiment, the system includes an ultrasound therapy transducer, a drainage catheter, and a plurality of piezoelectric sensors disposed in the drainage catheter. The ultrasound therapy is configured to transmit ultrasound pulses into the brain to generate cavitation that liquefies a target tissue in the brain. The drainage catheter is configured to detect the ultrasound pulses. An aberration correction algorithm can be executed by the system based on the ultrasound pulses measured by the drainage catheter to automatically correct for an aberration effect caused by the ultrasound pulses passing through a skullcap of the patient.Type: GrantFiled: August 20, 2021Date of Patent: February 11, 2025Assignee: The Regents of the University of MichiganInventors: Zhen Xu, Jonathan Sukovich, Aditya S. Pandey, Charles A. Cain, Hitinder S. Gurm
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Patent number: 12225044Abstract: One commonality among most vehicular security attacks reported to date is that they ultimately require write access to the CAN bus. In order to cause targeted and intentional changes in the vehicle behavior, malicious CAN injection attacks require knowledge of the CAN message format. However, since this format is proprietary to OEMs and can differ even among different models of a single make of vehicle, one must manually reverse-engineer the CAN message format of each vehicle they target. To mitigate this difficulty, an automated CAN message translator is presented.Type: GrantFiled: September 26, 2020Date of Patent: February 11, 2025Assignee: The Regents of The University of MichiganInventors: Kang G. Shin, Mert Dieter Pese
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Patent number: 12220244Abstract: A short wave infrared (SWIR) imaging system and method of using the same is provided for assessing a tissue damage depth and/or readiness for reconstruction and/or debridement. The SWIR imaging system includes a light source for illuminating the wound or burn, an image light-registering camera system having at least one narrow-band SWIR filter to image the wound or burn and output imaging information, and a detection system for receiving the imaging information and processing the imaging information to determine a tissue damage depth and/or readiness for reconstruction and/or debridement assessment.Type: GrantFiled: December 21, 2017Date of Patent: February 11, 2025Assignee: The Regents of The University of MichiganInventors: Benjamin Levi, Omer Berenfeld, Michael D. Morris
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Publication number: 20250044274Abstract: A method of operating a spa includes the following steps. Sensing a plurality of physical and chemical spa water qualities, including oxidation reduction potential (ORP), acidity (pH), and conductivity, using at least one sensor in fluid communication with spa water and in electrical communication with a spa controller. Adjusting spa chemistry in response to one or more of the plurality of fluid conditions, wherein the spa controller receives data from the at least one sensor and, based on the data received, controls one or more chemical treatment components to input chemicals into the spa water. A related apparatus is also disclosed.Type: ApplicationFiled: October 19, 2024Publication date: February 6, 2025Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Klaus Brondum, Michael McCague, Mark A. Burns, Wen-Chi Lin
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Patent number: 12215017Abstract: A sensor, such as a piezoelectric MEMS vibration sensor, includes a frame, a beam array comprising a plurality of beams, and a plurality of masses. Each beam of the plurality of beams has an anchored end and an unanchored end, with each beam being coupled to the frame at the anchored end. The unanchored end of each beam is coupled to a respective mass of the plurality of masses. Each beam of the plurality of beams can be configured to minimize a variation in a voltage output for a limited frequency range. In some implementations, the resonant frequency of each beam corresponds to a sensitivity peak in a limited frequency range.Type: GrantFiled: May 14, 2020Date of Patent: February 4, 2025Assignee: The Regents of the University of MichiganInventors: Alison Hake, Karl Grosh
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Patent number: 12216043Abstract: Methods and devices for detecting chiral properties from a sample are provided. Light may be directed towards a sample in contact with a chiral nanoparticle. Third harmonic Mie scattering (THMS) optical activity generated by the chiral nanoparticle in contact with the sample can then be detected. A device for detecting chiral properties of a sample is also contemplated that includes Nat least one microwell having a volume of ?about 1 microliter configured to hold a chiral nanoparticle capable of generating third harmonic Mie scattering (THMS) optical activity and a sample to be analyzed. The device includes a source of light configured to generate and direct light toward the at least one microwell containing the chiral nanoparticle and the sample and at least one detector configured to detect third harmonic Mie scattering (THMS) generated by the chiral nanoparticle in the microwell.Type: GrantFiled: December 1, 2022Date of Patent: February 4, 2025Assignees: The Regents of The University of Michigan, University of BathInventors: Nicholas A. Kotov, Ventsislav Valev, Lukas Ohnoutek, Ji-Young Kim
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Publication number: 20250037438Abstract: A computer that includes a processor and a memory, the memory including instructions executable by the processor to input an image to a first neural network to generate a first detected object and input the image to a second neural network to generate a reconstructed image which is input to a third neural network to generate a second detected object. The image can be divided into portions and the portions input to respective fourth neural networks to generate portions of a third detected object. The first detected object, the second detected object, the portions of the third detected object, and context data can be input to a partially observable Markov decision process to generate a high confidence detected object.Type: ApplicationFiled: July 27, 2023Publication date: January 30, 2025Applicants: Ford Global Technologies, LLC, The Regents of the University of MichiganInventors: John Moore, Subhadip Ghosh, Ziwei Zeng, Junho Hong, Jaerock Kwon, Aydin Zaboli, Kuchan Park
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Patent number: 12211955Abstract: A substrate comprising a III-N base layer comprising a first portion and a second portion, the first portion of the III-N base layer having a first natural lattice constant and a first dislocation density; and a first III-N layer having a second natural lattice constant and a second dislocation density on the III-N base layer, the first III-N layer having a thickness greater than 10 nm. An indium fractional composition of the first III-N layer is greater than 0.1; the second natural lattice constant is at least 1% greater than the first natural lattice constant; a strain-induced lattice constant of the first III-N layer is greater than 1.0055 times the first natural lattice constant; and the second dislocation density is less than 1.5 times the first dislocation density.Type: GrantFiled: January 14, 2022Date of Patent: January 28, 2025Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Kamruzzaman Khan, Elaheh Ahmadi, Stacia Keller, Christian Wurm, Umesh K. Mishra
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Patent number: 12207911Abstract: The following relates generally to motion prediction in magnetic resonance (MR) imaging. In some embodiments, a “modular” approach is taken to motion correction. That is, individual motion sources (e.g., a patient's breathing, heartbeat, stomach contractions, peristalsis, and so forth) are accounted for individually in the motion correction. In some embodiments, to correct for a particular motion source, a reference state is created from a volume of interest (VOI), and other states are created and deformably aligned to the reference state.Type: GrantFiled: June 30, 2021Date of Patent: January 28, 2025Assignee: REGENTS OF THE UNIVERSITY OF MICHIGANInventors: James Balter, Yue Cao, Lianli Liu, Adam Johansson
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Patent number: 12211601Abstract: Methods comprising an integrated, multiscale artificial intelligence-based system that reconstructs drug-specific pharmacogenomic networks and their constituent functional sub-networks are described. The system uses features of the functional topology of the three-dimensional architecture of drug-modulated spatial contacts in chromatin space. Discovery of a drug pharmacogenomic network is made through the selection of candidate SNPs by imputation, determination of the predicted causality of the SNPs using machine learning and deep learning, use of the causal SNPs to probe the spatial genome as determined by chromosome conformation capture analysis, combining targeted genes controlled by the same cell and tissue-specific enhancers, and reconstruction of the pharmacogenomic network using diverse data sources and metrics based on the results of genome-wide association studies.Type: GrantFiled: September 22, 2021Date of Patent: January 28, 2025Assignee: REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Brian D. Athey, Gerald A. Higgins, Alex Ade, Alexandr Kalinin, Narathip Reamaroon, James S. Burns