Patents Assigned to The Regent of the University of Michigan
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Patent number: 12259543Abstract: A compact single-axis confocal endomicroscope is provided, capable of complying with 2.8 mm diameter endoscope space requirements. The single-axis confocal endomicroscope uses a folded path design achieved between a fixed mirror and a lateral plane scanning mirror thereby producing high numerical apertures that allow for diffraction-limited resolution in sub-surface scanning. The scanning mirror has a central aperture that allows for illumination beam expansion in the folded path design.Type: GrantFiled: March 18, 2020Date of Patent: March 25, 2025Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Thomas D. Wang, Haijun Li, Xiyu Duan, Gaoming Li
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Patent number: 12258263Abstract: A method of manufacturing and assembling a sandwich flexure mechanism assembly is set forth herein. The method involves manufacture of a monolithic sandwich flexure module having a multitude of out of plane rigid inter-stage connections between at least some sets of twin stages of the monolithic sandwich flexure module. The method further involves assembling an interconnect subassembly to intermediate bodies of the monolithic sandwich flexure module. The interconnect subassembly furnishing in-plane rigid inter-stage connections between pairs of the intermediate bodies that constitute sister stages of the monolithic sandwich flexure module. The method can further involve assembling a motion body, actuators, and displacement sensors at the monolithic sandwich flexure module.Type: GrantFiled: March 14, 2024Date of Patent: March 25, 2025Assignee: The Regents of the University of MichiganInventors: Shorya Awtar, Kwun Sing Roger Ho, Siddharth Rath
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Patent number: 12257352Abstract: The present invention relates to nanoparticles associated with (e.g., complexed, conjugated, encapsulated, absorbed, adsorbed, admixed) biomacromolecule agents configured for treating, preventing or ameliorating various types of disorders, and methods of synthesizing the same. In particular, the present invention is directed to compositions comprising nanoparticles (e.g., synthetic high density lipoprotein (sHDL)) associated with (e.g., complexed, conjugated, encapsulated, absorbed, adsorbed, admixed) biomacromolecule agents (e.g., nucleic acid, peptides, glycolipids, etc.), methods for synthesizing such nanoparticles, as well as systems and methods utilizing such nanoparticles (e.g., in diagnostic and/or therapeutic settings).Type: GrantFiled: June 20, 2017Date of Patent: March 25, 2025Assignee: The Regents of the University of MichiganInventors: James J. Moon, Rui Kuai, Anna A. Schwendeman, Jutaek Nam
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Patent number: 12252714Abstract: The disclosure provides biocatalysts that halogenate complex chemical compounds in specific and predictable ways. Also disclosed are halogenated complex organic compounds. The disclosure further provides methods for the halogenation of complex chemical compounds and methods of inhibiting the contraction of smooth muscle in mammals.Type: GrantFiled: May 15, 2023Date of Patent: March 18, 2025Assignee: REGENTS OF THE UNIVERSITY OF MICHIGANInventors: David H. Sherman, Amy E. Fraley, Ashootosh Tripathi
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Publication number: 20250085429Abstract: A computer includes a processor and a memory, and the memory stores instructions executable by the processor to generate a set of points from a measurement scan obtained by a lidar sensor and to generate an expected termination distance of the set of points based on a neural implicit representation of the set of points. The instructions may additionally be to compute a loss function that includes a relatively low margin correlated with the variance or standard deviation of a training distribution centered at a learned point of the set of points based on the expected termination distance of the learned point, the learned point being learned by the neural implicit representation. The instructions may additionally be to generate a keyframe from the set of points and to generate a pose of the lidar sensor based on the keyframe.Type: ApplicationFiled: September 8, 2023Publication date: March 13, 2025Applicants: Ford Global Technologies, LLC, THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Seth Isaacson, Pou-Chun Kung, Katherine Skinner, Manikandasriram Srinivasan Ramanagopal, Ramanarayan Vasudevan
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Patent number: 12246056Abstract: Provided herein are compositions and methods for generation of cysteine in microbial systems. Further provided herein are compositions and methods for reducing and eliminating biofilms.Type: GrantFiled: November 6, 2019Date of Patent: March 11, 2025Assignee: The Regents of the University of MichiganInventors: Lydia Petra Freddolino, Mehdi Rahimpour
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Publication number: 20250077068Abstract: Touchscreen devices, designed with an assumed range of user abilities and interaction patterns, often present challenges for individuals with diverse abilities to operate independently. Prior efforts to improve accessibility through tools or algorithms necessitated alterations to touchscreen hardware or software, making them inapplicable for the large number of existing legacy devices. This disclosure introduces a hardware interaction proxy that performs physical interactions on behalf of users while allowing them to continue utilizing accessible interfaces, such as screen readers and assistive touch on smartphones, for interface exploration and command input. The proxy maintains an interface model for accurate target localization and utilizes exchangeable actuators for physical actuation across a variety of device types, effectively reducing user workload and minimizing the risk of mistouch.Type: ApplicationFiled: August 27, 2024Publication date: March 6, 2025Applicant: The Regents of The University of MichiganInventors: Anhong GUO, Alanson SAMPLE, Ruijie GENG, Thomas KROLIKOWSKI, Yasha IRAVANTCHI, Chen LIANG
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Patent number: 12240852Abstract: Disclosed herein is a method and apparatus for synthesizing co-crystals from the vapor phase without the need for liquid solvent. Also disclosed herein are co-crystals formed from the vapor phase, substrates coated with said co-crystals, pharmaceutical compositions thereof and apparatuses for producing said co-crystals.Type: GrantFiled: December 11, 2019Date of Patent: March 4, 2025Assignee: REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Max Shtein, Siddharth Borsadia, Eugene Shteyn
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Patent number: 12241953Abstract: The following relates generally to accelerated magnetic resonance imaging (MRI) reconstruction. In some embodiments, a MRI machine learning algorithm is trained based on reference MRI data in non-Cartesian k-space. During the training, at each iteration of a plurality of iterations: (i) a non-Cartesian sampling trajectory ? may be optimized under the physical constraints, and/or (ii) an image reconstructor may be jointly iteratively optimized. Examples of the image reconstructor include a convolutional neural network (CNN) denoiser, a model-based deep learning (MoDL) image reconstructor, iterative image reconstructor, a regularizer, and an invertible neural network.Type: GrantFiled: January 17, 2023Date of Patent: March 4, 2025Assignee: REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Jeffrey Allen Fessler, Douglas Clair Noll, Guanhua Wang
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Patent number: 12243185Abstract: Systems and methods are provided for point cloud processing with an equivariant neural network and implicit shape learning that may produce correspondence-free registration. The systems and methods may provide for feature space preservation with the same rotation operation as a Euclidean input space, due to the equivariance property, which may provide for solving the feature-space registration in a closed form.Type: GrantFiled: June 29, 2022Date of Patent: March 4, 2025Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Minghan Zhu, Maani Ghaffari, Huei Peng
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Patent number: 12244151Abstract: A system includes a body comprising a conduction path, and first and second modules disposed along, and movable relative to, the body, each of the first and second modules including an energy storage device, a terminal, and a power management unit coupling the energy storage device and the terminal. The terminal of each of the first and second modules is capacitively coupled with the conduction path for bidirectional power transfer between the first and second modules via the conduction path.Type: GrantFiled: March 11, 2021Date of Patent: March 4, 2025Assignee: The Regents of the University of MichiganInventors: Al-Thaddeus Avestruz, Akshay Sarin, Shai Revzen, Duncan Abbot
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Publication number: 20250066658Abstract: Compositions suitable for reversibly storing heat in thermal energy systems (TES) include a salt hydrate represented by the formula: MXq·nH2O. M is a cation selected from Groups 1 to 14 of the IUPAC Periodic Table, X is a halide of Group 17, q ranges from 1 to 4, and n ranges from 1 to 12. The cation (M) may have an electronegativity of ? about 1.8 and a molar mass ? about 28 g/mol. The anion (X) may have an electronegativity of ?about 2.9 to ? about 3.2. A distance between a cation (M) and coordinating water molecules (H2O) is ? about 2.1 ?. Thermal energy systems (TES) incorporating such compositions are also provided that are configured to reversibly store heat in the thermal energy system (TES) via an endothermic dehydration reaction and to release heat in in the thermal energy system (TES) via an exothermic hydration reaction.Type: ApplicationFiled: November 15, 2024Publication date: February 27, 2025Applicant: The Regents of the University of MichiganInventors: Donald Jason SIEGEL, Steven KIYABU
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Patent number: 12233189Abstract: An artificial lung system for a patient having a membrane lung system having an gas inlet, a blood inlet, a blood outlet, and an exhaust; a gas system operably coupled to the gas inlet of the membrane lung system; a gas phase CO2 sensor disposed downstream of the exhaust of the membrane lung system and monitoring an exhaust gas CO2 (EGCO2) level and/or an blood oxygen saturation sensor disposed upstream of the blood inlet of the membrane lung system and monitoring a blood oxygen saturation level; and a feedback controller receiving the CO2 signal and/or blood oxygen saturation signal and outputting a control signal to control gas flow and/or blood flow.Type: GrantFiled: June 18, 2019Date of Patent: February 25, 2025Assignees: The Regents of The University of Michigan, United States Government As Represented by the Department of Veterans AffairsInventors: Joseph Potkay, Robert H. Bartlett, Alvaro Rojas-Pena
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Patent number: 12233063Abstract: Provided herein are compositions and methods for treating eye disorders. In particular, provided herein are neuroprotective compositions and methods for treating vision loss and related disorders.Type: GrantFiled: October 18, 2018Date of Patent: February 25, 2025Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Cagri Giray Besirli, Thomas Wubben
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Patent number: 12233150Abstract: Provided herein are star-shaped polymers and methods of use thereof. Also provided are oral compositions comprising a star-shaped polymer and an orally acceptable carrier and methods of using same. The star-shaped polymers, as provided herein, have a structure according to Formula (I).Type: GrantFiled: May 28, 2020Date of Patent: February 25, 2025Assignees: REGENTS OF THE UNIVERSITY OF MICHIGAN, COLGATE-PALMOLIVE COMPANYInventors: Kenichi Kuroda, Carl P. Myers, Guillaume A. Picquet, Lynette A. Zaidel
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Patent number: 12234255Abstract: Provided herein are methods of glycosylation in the formation of disaccharides, trisaccharides, and oligosaccharides using fluoroglycosides, silyl ether glycosides and a triaryl borane catalyst.Type: GrantFiled: May 14, 2020Date of Patent: February 25, 2025Assignee: REGENTS OF THE UNIVERSITY OF MICHIGANInventors: John Montgomery, Girish Chandra Sati, Joshua Lane Martin
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Patent number: 12226524Abstract: Implants for anti-VEGF therapy provide both stability and controlled release of bevacizumab and other structurally sensitive polypeptides while maintaining protein/peptide stability in the micronized powder; achieving near zero order and complete release (>80%). Cylindrical implants suitable for intravitreal injection.Type: GrantFiled: May 2, 2017Date of Patent: February 18, 2025Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Steven P. Schwendeman, Rae Sung Chang
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Patent number: 12226491Abstract: The present invention provides, in some embodiments, methods, compositions, systems, and kits comprising nano-satellite complexes comprising: a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core; 3-25 satellite particles attached to, or absorbed to, said biocompatible coating; a plurality of antigenic peptides conjugated to, or absorbed to, said satellite particles; and at least one additional property. In other embodiments, provided herein are nano-satellite complexes comprising: a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core; a plurality of satellite particles attached to, or absorbed to, said biocompatible coating; a plurality of antigenic peptides conjugated to, or absorbed to, said satellite particles; and a plurality of LIGHT (TNFSF14) peptides conjugated to, or absorbed to, said satellite particles.Type: GrantFiled: April 16, 2021Date of Patent: February 18, 2025Assignee: The Regents of the University of MichiganInventors: Duxin Sun, Ryan Clauson, Hongwei Chen, Chengyi Li, Wei Gao, Luke Bugada, Fei Wen, Brett Hill, Syed Monem Rizvi
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Patent number: 12227190Abstract: A grip force sensing and shape-changing steering wheel configured to serve as an intuitive means of communication between a human driver and automatic driving system or driver assist system.Type: GrantFiled: May 24, 2021Date of Patent: February 18, 2025Assignee: The Regents of The University of MichiganInventors: Brent Gillespie, Akshay Bhardwaj
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Patent number: 12227831Abstract: Devices, systems, and techniques are provided for improved OVJP deposition using a shutter disposed within the OVJP print head, between the print head inlet and the nozzle outlets. An OVJP print head as disclosed includes an inlet for organic material entrained in a carrier gas, a micronozzle array outlet, and a shutter disposed in the gas flow path between the inlet and the micronozzle array outlet. The shutter allows for rapid cutoff of carrier gas flow through the print head with extremely low latency.Type: GrantFiled: April 20, 2021Date of Patent: February 18, 2025Assignee: The Regents of the University of Michigan, Innovation PartnershipsInventors: Stephen R. Forrest, Jeffrey A. Horowitz