Patents Assigned to The Regent of the University of Michigan
  • Publication number: 20250044274
    Abstract: A method of operating a spa includes the following steps. Sensing a plurality of physical and chemical spa water qualities, including oxidation reduction potential (ORP), acidity (pH), and conductivity, using at least one sensor in fluid communication with spa water and in electrical communication with a spa controller. Adjusting spa chemistry in response to one or more of the plurality of fluid conditions, wherein the spa controller receives data from the at least one sensor and, based on the data received, controls one or more chemical treatment components to input chemicals into the spa water. A related apparatus is also disclosed.
    Type: Application
    Filed: October 19, 2024
    Publication date: February 6, 2025
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Klaus Brondum, Michael McCague, Mark A. Burns, Wen-Chi Lin
  • Patent number: 12216043
    Abstract: Methods and devices for detecting chiral properties from a sample are provided. Light may be directed towards a sample in contact with a chiral nanoparticle. Third harmonic Mie scattering (THMS) optical activity generated by the chiral nanoparticle in contact with the sample can then be detected. A device for detecting chiral properties of a sample is also contemplated that includes Nat least one microwell having a volume of ?about 1 microliter configured to hold a chiral nanoparticle capable of generating third harmonic Mie scattering (THMS) optical activity and a sample to be analyzed. The device includes a source of light configured to generate and direct light toward the at least one microwell containing the chiral nanoparticle and the sample and at least one detector configured to detect third harmonic Mie scattering (THMS) generated by the chiral nanoparticle in the microwell.
    Type: Grant
    Filed: December 1, 2022
    Date of Patent: February 4, 2025
    Assignees: The Regents of The University of Michigan, University of Bath
    Inventors: Nicholas A. Kotov, Ventsislav Valev, Lukas Ohnoutek, Ji-Young Kim
  • Patent number: 12215017
    Abstract: A sensor, such as a piezoelectric MEMS vibration sensor, includes a frame, a beam array comprising a plurality of beams, and a plurality of masses. Each beam of the plurality of beams has an anchored end and an unanchored end, with each beam being coupled to the frame at the anchored end. The unanchored end of each beam is coupled to a respective mass of the plurality of masses. Each beam of the plurality of beams can be configured to minimize a variation in a voltage output for a limited frequency range. In some implementations, the resonant frequency of each beam corresponds to a sensitivity peak in a limited frequency range.
    Type: Grant
    Filed: May 14, 2020
    Date of Patent: February 4, 2025
    Assignee: The Regents of the University of Michigan
    Inventors: Alison Hake, Karl Grosh
  • Publication number: 20250037438
    Abstract: A computer that includes a processor and a memory, the memory including instructions executable by the processor to input an image to a first neural network to generate a first detected object and input the image to a second neural network to generate a reconstructed image which is input to a third neural network to generate a second detected object. The image can be divided into portions and the portions input to respective fourth neural networks to generate portions of a third detected object. The first detected object, the second detected object, the portions of the third detected object, and context data can be input to a partially observable Markov decision process to generate a high confidence detected object.
    Type: Application
    Filed: July 27, 2023
    Publication date: January 30, 2025
    Applicants: Ford Global Technologies, LLC, The Regents of the University of Michigan
    Inventors: John Moore, Subhadip Ghosh, Ziwei Zeng, Junho Hong, Jaerock Kwon, Aydin Zaboli, Kuchan Park
  • Patent number: 12208227
    Abstract: A solid film structure formed of multiple solid film insert layers each having different functionality is provided. The solid film structure forms a bio-chemotronic structure having an actuator thin film layer with one or more low molecular weight organic active agents that may be activated, a sensor thin film layer that includes one or more sensors for measuring a direct or indirect response from a target to the one or more active agents, and a control thin film layer configured to individually control activation of the active agents in the actuator layer, e.g., according to a protocol.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: January 28, 2025
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Max Shtein, Olga Shalev, Y. Eugene Shteyn
  • Patent number: 12207911
    Abstract: The following relates generally to motion prediction in magnetic resonance (MR) imaging. In some embodiments, a “modular” approach is taken to motion correction. That is, individual motion sources (e.g., a patient's breathing, heartbeat, stomach contractions, peristalsis, and so forth) are accounted for individually in the motion correction. In some embodiments, to correct for a particular motion source, a reference state is created from a volume of interest (VOI), and other states are created and deformably aligned to the reference state.
    Type: Grant
    Filed: June 30, 2021
    Date of Patent: January 28, 2025
    Assignee: REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: James Balter, Yue Cao, Lianli Liu, Adam Johansson
  • Patent number: 12211955
    Abstract: A substrate comprising a III-N base layer comprising a first portion and a second portion, the first portion of the III-N base layer having a first natural lattice constant and a first dislocation density; and a first III-N layer having a second natural lattice constant and a second dislocation density on the III-N base layer, the first III-N layer having a thickness greater than 10 nm. An indium fractional composition of the first III-N layer is greater than 0.1; the second natural lattice constant is at least 1% greater than the first natural lattice constant; a strain-induced lattice constant of the first III-N layer is greater than 1.0055 times the first natural lattice constant; and the second dislocation density is less than 1.5 times the first dislocation density.
    Type: Grant
    Filed: January 14, 2022
    Date of Patent: January 28, 2025
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Kamruzzaman Khan, Elaheh Ahmadi, Stacia Keller, Christian Wurm, Umesh K. Mishra
  • Patent number: 12213331
    Abstract: An organic electronic optoelectronic device comprises a substrate, a first electrode positioned over the substrate, a first organic buffer layer positioned over the first electrode, and a first inorganic emissive layer positioned over the first organic buffer layer. A method of fabricating an organic optoelectronic device is also disclosed.
    Type: Grant
    Filed: January 26, 2022
    Date of Patent: January 28, 2025
    Assignee: The Regents of the University of Michigan
    Inventors: Byungjun Lee, Jongchan Kim, Stephen R. Forrest
  • Patent number: 12211601
    Abstract: Methods comprising an integrated, multiscale artificial intelligence-based system that reconstructs drug-specific pharmacogenomic networks and their constituent functional sub-networks are described. The system uses features of the functional topology of the three-dimensional architecture of drug-modulated spatial contacts in chromatin space. Discovery of a drug pharmacogenomic network is made through the selection of candidate SNPs by imputation, determination of the predicted causality of the SNPs using machine learning and deep learning, use of the causal SNPs to probe the spatial genome as determined by chromosome conformation capture analysis, combining targeted genes controlled by the same cell and tissue-specific enhancers, and reconstruction of the pharmacogenomic network using diverse data sources and metrics based on the results of genome-wide association studies.
    Type: Grant
    Filed: September 22, 2021
    Date of Patent: January 28, 2025
    Assignee: REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Brian D. Athey, Gerald A. Higgins, Alex Ade, Alexandr Kalinin, Narathip Reamaroon, James S. Burns
  • Publication number: 20250028563
    Abstract: An accelerator architecture is presented for a Transformer machine learning model. The accelerator is comprised of: one or more memory devices, each memory device has a random access memory and is configured for processing in memory, where a key matrix, a value matrix, a query weight matrix, a key weight matrix, and a value weight matrix for an attention mechanism of the Transformer machine learning model are stored in the one or more memory devices; and a control device interfaced with each of the one or more memory devices, the control device is used to coordinate the vector matrix multiplication operations performed on the memory devices, perform other arithmetic and logic operations used in attention blocks that are not suited for the memory devices, and coordinate the updates of the key and value matrices in the one or more memory devices.
    Type: Application
    Filed: July 19, 2024
    Publication date: January 23, 2025
    Applicant: The Regents of The University of Michigan
    Inventors: Wei Lu, Yuting Wu, Ziyu Wang
  • Patent number: 12206388
    Abstract: Bulk acoustic wave resonators are presented. Such resonators typically operate based on a dynamic nonuniform effective piezoelectricity in composite multilayer ferroelectrics with large electrostriction coefficients, like barium strontium titanate (BST). Harmonic resonance modes of a multilayer bulk acoustic wave resonator can be selectively excited with an electromechanical coupling coefficient equal to the fundament mode, which is contrary to the trend K2?1/n2 exhibited by conventional piezoelectric bulk acoustic resonators. Such a resonator allows for the design of a new class of band-switching filters.
    Type: Grant
    Filed: April 22, 2021
    Date of Patent: January 21, 2025
    Assignee: The Regents of The University of Michigan
    Inventors: Amir Mortazawi, Milad Zolfagharloo Koohi
  • Patent number: 12207535
    Abstract: A method of fabricating an organic optoelectronic device comprises positioning a patterning layer over a substrate, etching the patterning layer using a photolithographic process to create an etched patterning layer, positioning a layer of an organic material over the etched patterning layer, and removing at least a portion of the etched patterning layer and at least a portion of the layer of the organic material to create a patterned organic layer over the substrate.
    Type: Grant
    Filed: March 1, 2022
    Date of Patent: January 21, 2025
    Assignee: The Regents of the University of Michigan
    Inventors: Stephen R. Forrest, Xinjing Huang, Dejiu Fan
  • Patent number: 12196558
    Abstract: A sensor package and associated method provides roadside sensor-based data. The sensor package includes a controller, a network access device for remote communications, GNSS receiver, an inertial measurement unit (IMU), and environment sensors. The controller operates under software control and communicates with the other sensor package devices to: collect environment sensor data using the sensors; receive GNSS signals indicating current sensor package location; obtain IMU data; determine position/orientation data that includes position data and orientation data based on the orientation data is based on the IMU data; and send the environment sensor data and the position/orientation data of the sensor package to an external device using the network access device. The environment sensor data includes at least one sensor data frame, and the sensor data frame is matched with position/orientation data based on a time associated with collecting the sensor data frame and the position/orientation data.
    Type: Grant
    Filed: February 14, 2022
    Date of Patent: January 14, 2025
    Assignee: The Regents of the University of Michigan
    Inventors: Tyler S. Worman, Gregory J. McGuire
  • Patent number: 12196831
    Abstract: Methods and systems perform magnetic resonance fingerprinting (MRF) by obtaining magnetic resonance data over a main field-of-view (FOV) and resulting from providing a magnetic resonance fingerprinting pulse sequence to a sample. The pulse sequence includes gradient waveforms and radio frequency (RF) pulses that have pulse sequence parameters specifically tailored for scanning, not the entire main FOV but rather a reduced portion of that main FOV. The methods and systems further include comparing the magnetic resonance data from the sample to a fingerprint dictionary of signal profiles that specifically correspond to the reduced portion of the main FOV and generating tissue property maps that correspond only to that reduced portion.
    Type: Grant
    Filed: November 18, 2022
    Date of Patent: January 14, 2025
    Assignee: REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Vikas Gulani, Nicole Seiberlich, Jon-Fredrik Nielsen, Yun Jiang
  • Patent number: 12194661
    Abstract: A method of and apparatus for sinter forging a precursor powder to form a film may reduce or eliminate the stress in the film and may facilitate processing of continuous length of films such as ceramic films for use in batteries. The precursor powder can be provided on a substrate and is simultaneously heated and pressed in a pressing direction parallel to a thickness of the film so as to sinter and densify the precursor powder to form the film in a sinter forging area. Notably, in a plane perpendicular to the pressing direction, there are no lateral constraints on the sinter forging area or the material received therein.
    Type: Grant
    Filed: February 1, 2021
    Date of Patent: January 14, 2025
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Jeffrey Sakamoto, Michael Wang, Nathan Taylor
  • Patent number: 12198309
    Abstract: A computer-implemented method includes receiving a raw data set representing an image of a sample, identifying a first set of extremum by analyzing the raw data set using a metric algorithm, identifying a second set of extremum by analyzing the first set of extremum, and generating, based on the second set of extremum, a reconstructed image of the sample. A phase correcting scanner includes one or more processors, one or more scanner adapted to sequentially sample an object to generate a vector of raw data representing the object in a Lissajous pattern, and memory storing instructions that, when executed by the one or more processors, cause the computing system to receive the vector of raw data, identify a first set of extremum by analyzing the raw data set using a metric algorithm, and identify a second set of extremum by analyzing the first set of extremum.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: January 14, 2025
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Kenn Oldham, Thomas D. Wang, Mayur Bhushan Birla, Xiyu Duan
  • Patent number: 12196828
    Abstract: Methods and systems perform magnetic resonance fingerprinting (MRF) that provides tissue characterization through simultaneous quantification of water tissue properties and proton density fat fraction (PDFF), by using water-only and fat-only images from MRF. MRF is performed using rosette trajectories scanning k-space to effectively isolate water tissue and fat tissue, by separating these rosette trajectories into individual segments that are then analyzed to enable signals from fat tissue to be distinguished from water.
    Type: Grant
    Filed: November 18, 2022
    Date of Patent: January 14, 2025
    Assignee: REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Nicole Seiberlich, Yun Jiang, Jesse Hamilton, Yuchi Liu
  • Patent number: 12195083
    Abstract: A method in a data processing system including at least one processor and at least one memory including instructions executed by the at least one processor to implement a lane change system is provided by the present disclosure. The method includes receiving, from at least one of a plurality of sensors coupled to a vehicle, information associated with a location of an object longitudinally ahead of the vehicle, determining a sequence of control inputs associated with a time horizon to avoid a collision between the vehicle and the object based on a constraint and the location of the object, and the determining the sequence of control inputs including minimizing a maximum tire slip angle of the vehicle during the time horizon subject to the constraint, and causing a vehicle control system of the vehicle to perform a vehicle maneuver based on the sequence of control inputs.
    Type: Grant
    Filed: June 26, 2019
    Date of Patent: January 14, 2025
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Tulga Ersal, Jeffrey L. Stein, John B. Wurts
  • Publication number: 20250012757
    Abstract: Nearly all existing direct current (DC) chemical vapor sensing methodologies are based on charge transfer between sensor and adsorbed molecules. However, the high binding energy at the charge-trapped sites, which is critical for high sensitivity, significantly slows sensors' response and makes the detection of non-polar molecules difficult. By exploiting the incomplete screening effect of graphene, this disclosure demonstrates a DC graphene electronic sensor for rapid (sub-second) and sensitive (ppb) detection of a broad range of vapor analytes, including polar, non-polar, organic and inorganic molecules. Molecular adsorption induced capacitance change in the graphene transistor is revealed to be the main sensing mechanism. This work provides an avenue for a broad spectrum real-time gas sensing technology and serves as an ideal testbed for probing molecular physisorption on graphene.
    Type: Application
    Filed: November 15, 2022
    Publication date: January 9, 2025
    Applicant: The Regents of The University of Michigan
    Inventors: Zhaohui ZHONG, Xudong FAN, Wenzhe ZANG, Zhe LIU, Girish S. KULKARNI, Hongbo ZHU, You WU
  • Patent number: 12188051
    Abstract: The invention disclosed herein generally relates to methods and systems for converting stem cells into specific tissue(s) or organ(s) through directed differentiation. In particular, the invention disclosed herein relates to methods and systems for promoting vascularized human intestinal organoid tissue having an intestine-specific EC transcriptional signature from hindgut spheroid tissue produced in vitro from the described methods.
    Type: Grant
    Filed: May 27, 2021
    Date of Patent: January 7, 2025
    Assignee: The Regents of the University of Michigan
    Inventors: Emily Holloway, Jason Spence