Patents Assigned to THE REGENTS OF TE UNIVERSITY OF CALIFORNIA
  • Compounds and methods for inhibiting Cif virulence factor
    Patent number: 10322118
    Abstract: The present invention provides a screening assay for identifying inhibitors of Pseudomonas aeruginosa CFTR Inhibitory Factor as well as compositions and methods for ameliorating or treating a respiratory disease such as cystic fibrosis or secondary infection thereof.
    Type: Grant
    Filed: December 29, 2015
    Date of Patent: June 18, 2019
    Assignees: TRUSTEES OF DARTMOUTH COLLEGE, THE REGENTS OF TE UNIVERSITY OF CALIFORNIA
    Inventors: Dean R. Madden, Christopher D. Bahl, Bruce D. Hammock, Christophe Morisseau
  • Potent and Selective Mediators of Cholesterol Efflux
    Publication number: 20120329703
    Abstract: The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABAC1 that parallels that of full-length apolipoproteins. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation.
    Type: Application
    Filed: December 13, 2007
    Publication date: December 27, 2012
    Applicant: The Regents of te University of California
    Inventors: John K. Bielicki, Jan Johansson
  • Mechanism-Based Crosslinkers
    Publication number: 20080261821
    Abstract: The present invention provides novel mechanism-based crosslinkers useful in covalently linking a kinase and an interactor.
    Type: Application
    Filed: July 21, 2005
    Publication date: October 23, 2008
    Applicant: THE REGENTS OF TE UNIVERSITY OF CALIFORNIA
    Inventors: Dustin Maly, Kevan M. Shokat