Abstract: Composite media having simultaneous negative effective permittivity and permeability over a common band of frequencies. A composite media of the invention combines media, which are either themselves separately composite or continuous media, having a negative permittivity and a negative permeability over a common frequency band. Various forms of separate composite and continuous media may be relied upon in the invention. A preferred composite media includes a periodic array of conducting elements that can behave as an effective medium for electromagnetic scattering when the wavelength is much longer than both the element dimension and lattice spacing The composite media has an effective permittivity &egr;eff(&ohgr;) and permeability &mgr;eff(&ohgr;) which are simultaneously negative over a common set of frequencies. Either one or both of the negative permeability and negative permittivity media used in the invention may be modulable via external or internal stimulus.

Abstract: A method of treating or preventing post-operative ileus in a mammalian subject is disclosed. The method involves administering to the subject, a pharmaceutically effective amount of a compound that is effective in (i) preventing mast cell degranulation, (ii) inhibiting tryptase and chymase, and (iii) antagonizing PAR-2. The treatment is based on the discoveries that proteinase-activated receptor 2 is expressed in colonic muscle cells, and that activation of PAR-2 inhibits colonic motility. The PAR-2 receptor is activated, at least in part, by tryptase and chymase, produced by infiltration and degranulation of mast cells.