Patents Assigned to The Regents of the Univ. of California
  • Patent number: 6872817
    Abstract: Methods and compositions for chromosome-specific staining are provided. Compositions comprise heterogeneous mixtures of labeled nucleic acid fragments having substantially complementary base sequences to unique sequence regions of the chromosomal DNA for which their associated staining reagent is specific. Methods include methods for making the chromosome-specific staining compositions of the invention, and methods for applying the staining compositions to chromosomes.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: March 29, 2005
    Assignee: The Regents of the Univ. of California
    Inventors: Joe W. Gray, Daniel Pinkel
  • Publication number: 20040167014
    Abstract: A novel proton exchange membrane fuel cell with nanostructured components with higher precious metal utilization rate at the electrodes, higher power density, and lower cost. Aligned arrays of carbon nanotubes, either single wall or multiwall, are prepared by catalyzed chemical vapor deposition (CVD), or plasma assisted CVD and used as support for catalyst. Solubilized perfluorosulfonate ionomer membrane is incorporated into the spare space between nanotubes to form a 4-phase boundary of gas, metal, proton conductor, and electron conductor. By assembling the as-prepared electrodes with perfluorosulfonate ionomer membrane, backing layers and electron collectors, proton exchange membrane fuel cells are developed.
    Type: Application
    Filed: November 13, 2003
    Publication date: August 26, 2004
    Applicant: The Regents of the Univ. of California, Office of Technology Transfer, University of California
    Inventors: Yushan Yan, Cheng Wang
  • Patent number: 6274119
    Abstract: A method for labeling &bgr;-amyloid plaques and neurofibrillary tangles in vivo and in vitro, comprises contacting a compound of formula (I): with mammalian tissue.
    Type: Grant
    Filed: August 20, 1999
    Date of Patent: August 14, 2001
    Assignee: The Regents of the Univ. of California
    Inventors: Jorge R. Barrio, Andrej Petric, Nagichettiar Satyamurthy, Gary W. Small, Gregory M. Cole, Sung-Cheng Huang
  • Patent number: 5589881
    Abstract: A low-noise FET amplifier is connected to amplify output charge from a che coupled device (CCD). The FET has its gate connected to the CCD in common source configuration for receiving the output charge signal from the CCD and output an intermediate signal at a drain of the FET. An intermediate amplifier is connected to the drain of the FET for receiving the intermediate signal and outputting a low-noise signal functionally related to the output charge signal from the CCD. The amplifier is preferably connected as a virtual ground to the FET drain. The inherent shunt capacitance of the FET is selected to be at least equal to the sum of the remaining capacitances.
    Type: Grant
    Filed: November 9, 1994
    Date of Patent: December 31, 1996
    Assignee: The Regents of the Univ. of California Office of Technology Transfer
    Inventors: Mark E. Dunham, David W. Morley
  • Patent number: 5581566
    Abstract: A system of sending and receiving gateways interconnects high speed data interfaces, e.g., HIPPI interfaces, through fiber optic links, e.g., a SONET network. An electronic stripe distributor distributes bytes of data from a first interface at the sending gateway onto parallel fiber optics of the fiber optic link to form transmitted data. An electronic stripe collector receives the transmitted data on the parallel fiber optics and reforms the data into a format effective for input to a second interface at the receiving gateway. Preferably, an error correcting syndrome is constructed at the sending gateway and sent with a data frame so that transmission errors can be detected and corrected in a real-time basis. Since the high speed data interface operates faster than any of the fiber optic links the transmission rate must be adapted to match the available number of fiber optic links so the sending and receiving gateways monitor the availability of fiber links and adjust the data throughput accordingly.
    Type: Grant
    Filed: January 6, 1995
    Date of Patent: December 3, 1996
    Assignee: The Regents of the Univ. of California Office of Technology Transfer
    Inventors: Wallace B. St. John, David H. DuBois
  • Patent number: 5578909
    Abstract: A coupled-cavity drift-tube linac (CCDTL) combines features of the Alvarez drift-tube linac (DTL) and the .pi.-mode coupled-cavity linac (CCL). In one embodiment, each accelerating cavity is a two-cell, 0-mode DTL. The center-to-center distance between accelerating gaps is .beta..lambda., where .lambda. is the free-space wavelength of the resonant mode. Adjacent accelerating cavities have oppositely directed electric fields, alternating in phase by 180 degrees. The chain of cavities operates in a .pi./2 structure mode so the coupling cavities are nominally unexcited. The CCDTL configuration provides an rf structure with high shunt impedance for intermediate velocity charged particles, i.e., particles with energies in the 20-200 MeV range.
    Type: Grant
    Filed: July 15, 1994
    Date of Patent: November 26, 1996
    Assignee: The Regents of the Univ. of California
    Inventor: James H. Billen
  • Patent number: 5558998
    Abstract: A method is provided for sizing DNA fragments using high speed detection systems, such as flow cytometry to determine unique characteristics of DNA pieces from a sample. In one characterization the DNA piece is fragmented at preselected sites to produce a plurality of DNA fragments. The DNA piece or the resulting DNA fragments are treated with a dye effective to stain stoichiometrically the DNA piece or the DNA fragments. The fluorescence from the dye in the stained fragments is then examined to generate an output functionally related to the number of nucleotides in each one of the DNA fragments. In one embodiment, the intensity of the fluorescence emissions from each fragment is linearly related to the fragment length. The distribution of DNA fragment sizes forms a characterization of the DNA piece for use in forensic and research applications.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: September 24, 1996
    Assignee: The Regents of the Univ. of California
    Inventors: Mark L. Hammond, James H. Jett, Richard A. Keller, Babetta L. Marrone, John C. Martin
  • Patent number: 5447841
    Abstract: Methods and compositions for chromosome-specific staining are provided. Compositions comprise heterogenous mixtures of labeled nucleic acid fragments having substantially complementary base sequences to unique sequence regions of the chromosomal DNA for which their associated staining reagent is specific. Methods include methods for making the chromosome-specific staining compositions of the invention, and methods for applying the staining compositions to chromosomes.
    Type: Grant
    Filed: December 14, 1990
    Date of Patent: September 5, 1995
    Assignee: The Regents Of The Univ. Of California
    Inventors: Joe W. Gray, Daniel Pinkel
  • Patent number: 5404762
    Abstract: A quick-change filter cartridge. In sampling systems for measurement of airborne materials, a filter element is introduced into the sampled airstream such that the aerosol constituents are removed and deposited on the filter. Fragile sampling media often require support in order to prevent rupture during sampling, and careful mounting and sealing to prevent misalignment, tearing, or creasing which would allow the sampled air to bypass the filter. Additionally, handling of filter elements may introduce cross-contamination or exposure of operators to toxic materials. Moreover, it is desirable to enable the preloading of filter media into quick-change cartridges in clean laboratory environments, thereby simplifying and expediting the filter-changing process in the field. The quick-change filter cartridge of the present invention permits the application of a variety of filter media in many types of instruments and may also be used in automated systems.
    Type: Grant
    Filed: January 15, 1993
    Date of Patent: April 11, 1995
    Assignee: The Regents of the Univ. of California Office of Technology Transfer
    Inventors: John C. Rodgers, Andrew R. McFarland, Carlos A. Ortiz
  • Patent number: 5347541
    Abstract: A Bayesian blind equalizer which approximates the optimum symbol-by-symbol detector for an unknown intersymbol interference pattern in a communication channel is provided in a plurality of parallel processors. Each processor operates in parallel from a common data bus with each of the other processors. Each of the processors in turn generates an estimated signal and updated metric for the communication channel for a corresponding one of each of the possible data subsequences which could cause intersymbol interference. The estimated signals or innovations are then combined with the updated metrics in a supervisory processor to generate unconditional channel coefficients for the next received data sample. Using the estimated channel coefficients and received data samples, the transmitted data sample is reliably decoded notwithstanding intersymbol interference without the use of data preambles or training data and notwithstanding that the channel coefficients may be rapidly varying.
    Type: Grant
    Filed: November 2, 1992
    Date of Patent: September 13, 1994
    Assignee: The Regents of the Univ. of California
    Inventors: Ronald A. Iltis, John J. Shynk
  • Patent number: 5252461
    Abstract: Assays are provided for detecting the existence of active rheumatoid arthritis by detecting rheumatoid factor as a blood component which cross-links human IgG with sheep IgG. Particularly, an enzyme labelled assay is provided using biotin-avidin to link the enzyme to the immunoglobulin. The binding peptide of the rheumatoid factor is also provided.
    Type: Grant
    Filed: January 28, 1992
    Date of Patent: October 12, 1993
    Assignee: The Regents of the Univ. of California
    Inventor: Richard Weisbart
  • Patent number: 5250295
    Abstract: A factor (NKEF) for use in enhancing the activity of natural killer cells both in vivo and in vitro. NKEF is a soluble red blood cell cytosol protein having a molecular mass of between about 300 and 400 kilodaltons as determined by gel filtration high pressure liquid chromatography and an apparent molecular weight of about 48 kilodaltons as determined by non-reducing SDS-PAGE.
    Type: Grant
    Filed: November 4, 1991
    Date of Patent: October 5, 1993
    Assignee: The Regents of the Univ. of California
    Inventors: Hungyi Shau, Sidney H. Golub
  • Patent number: 5238851
    Abstract: Assays are provided for detecting the existence of active rheumatoid arthritis by detecting rheumatoid factor as a blood component which cross-links human IgG with sheep IgG. Particularly, an enzyme labelled assay is provided using biotin-avidin to link the enzyme to the immunoglobulin.
    Type: Grant
    Filed: October 7, 1991
    Date of Patent: August 24, 1993
    Assignee: The Regents of the Univ. of California
    Inventor: Richard Weisbart
  • Patent number: 5092948
    Abstract: The present invention relates to an article having improved physical properties as compared to the individual components, which article comprises:a laminated ceramic fiber composite of alternating layers of discrete thin solid sheets of ceramic A having a substantially large upper and lower surface bonded to discrete thin sheets B comprising fibers and having large upper and lower surfaces using a suitable bonding agent.
    Type: Grant
    Filed: January 3, 1989
    Date of Patent: March 3, 1992
    Assignee: The Regents of the Univ, of California
    Inventors: Frederick F. Lange, David B. Marshall, Craig A. Folsom
  • Patent number: 5066479
    Abstract: Metallacarborane chelate-antibody compounds which are useful for radioimmunodetection and radiotherapy. The compounds have the formula ##STR1## wherein X is a metal or radioisotope of said metal, Y is a rotation resistant organic chelate bridge moiety, Z is an antibody linkage moiety and AB is an antibody. Metallacarborane chelate and carborane chelate compounds are also disclosed which are useful in preparing the final metallacarborane chelate-antibody compound which is used for radioimmunodetection and radiotherapy.
    Type: Grant
    Filed: May 31, 1988
    Date of Patent: November 19, 1991
    Assignee: The Regents of the Univ. of California
    Inventor: M. Frederick Hawthorne
  • Patent number: 5032519
    Abstract: A method for genetically engineering cells to produce soluble and secretable Golgi processing enzymes instead of naturally occurring membrane-bound enzymes. Cells are genetically engineered to express glycosyltransferases which lack both a membrane anchor and a rThis invention was made with government support under Grant Contract Nos. GM-27904 and GM-11557 awarded by the National Institute of Health. The government has certain rights in this invention. The publications and other reference materials referred to herein to describe the background of the invention and to provide additional detail regarding its practice are hereby incorporated by reference. For convenience, the reference materials are numerically referenced and grouped in the appended bibliography.
    Type: Grant
    Filed: October 24, 1989
    Date of Patent: July 16, 1991
    Assignee: The Regents of the Univ. of California
    Inventors: James C. Paulson, Eryn Ujita-Lee, Karen J. Colley, Beverly Adler, Jeffrey K. Browne
  • Patent number: 5000735
    Abstract: A hyperdermic syringe having a plunger which separates from a piston inside a barrel of the syringe after a downward stroke of the plunger preventing reuse of the syringe. The plunger breaks breakaway portions mounted inside the piston when pushed downward to unload the syringe effectively separating the plunger from the piston and destroying the syringe, preventing the piston from being withdrawn for the purpose of reloading the syringe. In another embodiment, a connector is used to releasably engage a plunger to a piston. Downward movement of the plunger causes upward extensions of the connector to move toward each other and lock together. The plunger disengages from the connector and piston after the extension lock together. A modified tip portion of a barrel containing a valve ball and valve flaps may be used to prevent the syringe from being used after a single use discharging medicinal fluid from the syringe. The valve ball blocks flow of medicinal fluid into the syringe after use of the syringe.
    Type: Grant
    Filed: January 5, 1989
    Date of Patent: March 19, 1991
    Assignee: The Regents of the Univ. of California
    Inventor: James P. Whelan
  • Patent number: 4943589
    Abstract: This invention is directed to a method for treating helminthiasis which comprises administering to an animal in need thereof an anthelmintically effective amount of a compound of Formula (I): ##STR1## where R.sup.1 is hydrogen or --SR.sup.2,whereinR.sup.2 is hydrogen, --C(O)--CH.sub.3, or ##STR2## or a pharmaceutically acceptable salt thereof. This invention is also directed to a composition for treating helminthiasis in an animal which comprises a pharmaceutically acceptable excipient and an anthelmintically effective amount of a compound of Formula (I). This invention is also directed to novel compounds of Formula (I) wherein R.sup.
    Type: Grant
    Filed: October 27, 1988
    Date of Patent: July 24, 1990
    Assignees: Syntex (U.S.A.) Inc., The Regents of the Univ. of California
    Inventors: Phillip Crews, Thomas R. Matthews, Paul Horton
  • Patent number: 4909252
    Abstract: A balloon catheter utilizing a perfusion balloon at one end thereof is described. The perfusion balloon has a donut shaped cross section having a central opening formed therethrough. The central opening provides a blood flow passage even when the balloon is fully inflated. When inflated, the perfusion balloon is used to dilate a stenotic region of a blood vessel or heart valve to restore blood flow. After deflation, if the blood vessel collapses, the balloon catheter of the present invention can be reinflated and kept in place while the patient is prepared for surgery. In this manner, acceptable blood flow is provided regardless of the length of time required for surgical preparation. In an alternate embodiment, a one-way valve is formed integrally with the perfusion balloon so that the present invention may be better applied to valvuloplasty. In this application, the balloon is inflated at a stenotic region of a heart valve to expand the valve and restore acceptable blood flow.
    Type: Grant
    Filed: May 26, 1988
    Date of Patent: March 20, 1990
    Assignee: The Regents of the Univ. of California
    Inventor: Jeffrey Goldberger
  • Patent number: 4715387
    Abstract: A method and an apparatus and composition used in the reduction of the incidence of tobacco smoking and which comprises an aerosol for application to the oral cavity and respiratory tract of an individual. The aerosol contains a food acid, such as citric acid, which is present in non-toxic amounts and capable of being inhaled. The aerosol may be in the form of a liquid spray or a finely divided solid. The droplets or particles contained in the aerosol are of proper size and have the food acid sufficient in content to simulate the sensations in the upper respiratory tract caused by tobacco smoke. In this way, the oral cavity sensations and the respiratory tract sensations simulate those created by tobacco smoke to replace the need for tobacco smoke. In another embodiment of the invention the food acid aerosol contains tobacco smoke of proper particle size so that the food acid particles migrate to the respiratory tract and the tobacco smoke remains in the oral cavity.
    Type: Grant
    Filed: August 23, 1985
    Date of Patent: December 29, 1987
    Assignee: The Regents of the Univ. of California
    Inventor: Jed E. Rose