Abstract: Siderocalin-metal chelator combinations that bind metallic radioisotopes used in nuclear medicine with high affinity are described. The high affinity siderocalin-metal chelator combinations include a number of chelator backbone arrangements with functional groups that coordinate with metals. The siderocalin-metal chelator combinations can be used to deliver radionuclides for imaging and therapeutic purposes.
Type:
Grant
Filed:
August 28, 2017
Date of Patent:
February 1, 2022
Assignees:
Fred Hutchinson Cancer Research Center, The Regents of the Universitv of California
Inventors:
Roland K. Strong, Peter Rupert, Rebecca J. Abergel, Ilya Captain, Gauthier J P Deblonde
Abstract: A model-based control scheme consisting of either a proportional-integral-derivative (IMC-PID) controller or a model predictive controller (MPC), with an insulin feedback (IFB) scheme personalized based on a priori subject characteristics and comprising a lower order control-relevant model to obtain PID or MPC controller for artificial pancreas (AP) applications.
Type:
Grant
Filed:
September 17, 2019
Date of Patent:
December 14, 2021
Assignee:
The Regents of the Universitv of California
Inventors:
Francis J. Doyle, III, Eyal Dassau, Dale E. Seborg, Joon Bok Lee