Patents Assigned to The Regents of the University at California
-
Publication number: 20240166703Abstract: The present disclosure provides a novel IKK2 inhibitor that does not target the kinase domain of IKK2 molecule. The novel IKK2 inhibitor is a cell penetrating NEMOActPep comprising a small segment (residues 384-389) of human NEMO to mediate interaction with and promote activation loop phosphorylation of IKK2. The NEMOActPep is derived from the second interaction interface of NEMO:IKK2 that is dependent upon NEMO binding to linear polyubiquitin. Methods of use the novel IKK2 inhibitor, and composition thereof, for preventing and/or treating inflammation in various diseases involving IKK-NF-?B signaling pathways are also provided.Type: ApplicationFiled: March 30, 2022Publication date: May 23, 2024Applicants: The Regents of the University of California, SAN DIEGO STATE UNIVERSITY (SDSU) FOUNDATION, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Gourisankar GHOSH, Sushil MAHATA, Tom HUXFORD
-
Publication number: 20240171480Abstract: Aspects of the subject disclosure may include, for example, training a first machine learning model based on a combination of labeled training data and unlabeled training data, the first machine learning model producing augmented training data, training a second machine learning model based on a combination of the labeled training data and the augmented training data, receiving, at a client device, customer information about a service degradation at a user equipment (UE) device of a customer in a cellular network, providing the customer information to the second machine learning model, receiving, at the client device, from the second machine learning model, information identifying a root cause of the service degradation, and modifying a network component of the cellular network or the UE device, based on the information identifying a root cause of the service degradation. Other embodiments are disclosed.Type: ApplicationFiled: November 23, 2022Publication date: May 23, 2024Applicants: AT&T Intellectual Property I, L.P., The Regents of the University of CaliforniaInventors: Amit Kumar Sheoran, Xiaofeng Shi, Jia Wang, Chen Qian, Matthew Osinski
-
Publication number: 20240165154Abstract: This disclosure relates to methods and agents for modulating adoptive immunotherapy to enable bioengineered immune cells to utilize xenobiotic fuel, e.g., in a low glucose environment. The immune cells may be used, e.g., for treatment of a tumor or cancer, such as part of a therapeutic treatment of cancer or for treatment of a bacterial, fungal, or viral infection, alone or in combination with a low glucose (e.g., ketogenic) diet. They may also be used to treat a tumor, a cancer, an infection, an autoimmune disease, or an inflammatory or neuroinflammatory disease or condition in a patient on a low glucose diet. The immune cells may be used in combination with a scaffold or platform or with a microparticle or nanoparticle for localization of treatment or xenobiotic nutrients or for controlled release, as well as for other therapeutic uses.Type: ApplicationFiled: April 11, 2022Publication date: May 23, 2024Applicant: The Regents of the University of CaliforniaInventors: Manish J. BUTTE, Matthew L. MILLER
-
Publication number: 20240166695Abstract: Peptidic positive allosteric modulators of TRPV1 are provided. Methods for the design of TPRV1 allosteric modulators are also described, as well as methods for the treatment of conditions such as pain, pruritus, and cancer.Type: ApplicationFiled: March 25, 2022Publication date: May 23, 2024Applicant: The Regents of the University of CaliforniaInventors: Jie Zheng, Fan Yang
-
Patent number: 11990313Abstract: A ponderomotive phase plate, also called a laser phase plate or standing wave optical phase plate, has a first minor and a second minor that define an optical cavity. An electron beam passes through a focal spot of the optical cavity. A laser with variable polarization angle of laser light is coupled to the optical cavity. A standing wave of polarized laser light, with an anti-node at the focal spot of the optical cavity, causes variable modulation of the electron beam. The variable modulation of the electron beam is controllable by the variable polarization angle of the laser light. In a transmission electron microscope, an image plane receives the electron beam modulated by the standing wave optical phase plate. An image formed at the image plane is based on the variable polarization angle of the polarized laser light.Type: GrantFiled: September 10, 2020Date of Patent: May 21, 2024Assignee: The Regents of the University of CaliforniaInventors: Jeremy J. Axelrod, Carter Turnbaugh, Sara Campbell, Osip Schwartz, Robert M. Glaeser, Holger Mueller
-
Patent number: 11987803Abstract: In various embodiments, method and devices for delivering large cargos (e.g., organelles, chromosomes, bacteria, and the like) into cells are provided. In certain embodiments method of delivering a large cargo into eukaryotic cells, are provided that involve providing eukaryotic cells disposed on one side of a porous membrane; providing the cargo to be delivered in a solution disposed in a reservoir chamber on the opposite side of the porous membrane; and applying pressure to the reservoir chamber sufficient to pass the cargo through pores comprising said porous membrane wherein said cargo passes through cell membranes and into the cells.Type: GrantFiled: October 14, 2019Date of Patent: May 21, 2024Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Ting-Hsiang S. Wu, Pei-Yu E. Chiou, Michael A. Teitell
-
Patent number: 11988600Abstract: A gas sensor, a method of manufacturing a gas sensor, a method for fabricating a micro electro-mechanical system (MEMS) die for a heater or thermopile, and a micro electro-mechanical system (MEMS) die for a heater or thermopile. The gas sensor comprises a first micro electro-mechanical system (MEMS) die comprising a light source; a second MEMS die comprising a light detector; a sample chamber disposes in an optical path between the light source and the light detector; and a holder substrate; wherein the first and second MEMS dies are disposed on the holder substrate in a vertical orientation relative to the holder.Type: GrantFiled: December 8, 2017Date of Patent: May 21, 2024Assignees: National University of Singapore, The Regents of the University of CaliforniaInventors: Enrico Macrelli, Massimo Bruno Cristiano Alioto, Chengkuo Lee, Costas John Spanos, You Qian
-
Patent number: 11986653Abstract: A wireless implant and associated system for motor function recovery after spinal cord injury, and more particularly a multi-channel wireless implant with small package size. The wireless implant can further be used in various medical applications, such as retinal prostheses, gastrointestinal implant, vagus nerve stimulation, and cortical neuromodulation. The system also includes a method and its implementation to acquire the impedance model of the electrode-tissue interface of the implant.Type: GrantFiled: August 27, 2021Date of Patent: May 21, 2024Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Yi-Kai Lo, Wentai Liu, Victor R. Edgerton, Chih-Wei Chang
-
Patent number: 11990921Abstract: Devices, systems and methods for list decoding of polarization-adjusted convolutional (PAC) codes are described. One example method for improving error correction in a decoder for data in a communication channel includes receiving a noisy codeword, the codeword having been generated using a polarization-adjusted convolutional (PAC) code and provided to the communication channel prior to reception by the decoder, and performing PAC list decoding on the noisy codeword, wherein an encoding operation of the PAC code comprises a convolutional precoding operation that generates one or more dynamically frozen bits, and wherein the PAC list decoding comprises extending, based on the one or more dynamically frozen bits, at least two paths of a plurality of paths in the PAC list decoding differently and independently.Type: GrantFiled: March 16, 2021Date of Patent: May 21, 2024Assignee: The Regents of the University of CaliforniaInventors: Hanwen Yao, Arman Fazeli Chaghooshi, Alexander Vardy
-
Patent number: 11986442Abstract: The present invention provides methods for inhibiting respiratory complex III in a cell. The present invention also provides methods for treating cancer in a subject.Type: GrantFiled: June 4, 2021Date of Patent: May 21, 2024Assignee: The Regents of the University of CaliforniaInventors: Muhammad Hagras, Alexei Stuchebrukhov
-
Patent number: 11987600Abstract: Disclosed are systemic and intravaginal non-hormonal contraceptives comprising a spermicidal triterpenoid. The contraceptive may be in the form of a foam, cream or gel, or in unit form of a pill, vaginal contraceptive film (VCF), suppository, sponge, transdermal or hypodermal patches or a slow release intravaginal device or intrauterine device such as a drug-impregnated silicone elastomer vaginal ring or polymeric IUD.Type: GrantFiled: June 18, 2019Date of Patent: May 21, 2024Assignee: The Regents of the University of CaliforniaInventors: Polina V. Lishko, Nadja Mannowetz
-
Patent number: 11990658Abstract: Redox flow battery systems utilizing the reversible interconversion between carbon dioxide, (or bicarbonate or carbonate) and formate/formic acid. The battery system comprises an electrocatalyst that converts carbon dioxide, bicarbonate, or carbonate into formate to store electron equivalents, and oxidizes formate to release stored electrons and discharge. A non-limiting example of an electrocatalyst that can be used for reversible interconversion of carbon dioxide and formate is Pt(depe)2.Type: GrantFiled: December 17, 2020Date of Patent: May 21, 2024Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventor: Jenny Y. Yang
-
Patent number: 11990224Abstract: Methods, devices, and systems that are related to facilitating an automated, fast and accurate model for cardiac image segmentation, particularly for image data of children with complex congenital heart disease are disclosed. In one example aspect, a generative adversarial network is disclosed. The generative adversarial network includes a generator configured to generate synthetic imaging samples associated with a cardiovascular system, and a discriminator configured to receive the synthetic imaging samples from the generator and determine probabilities indicating likelihood of the synthetic imaging samples corresponding to real cardiovascular imaging sample. The discriminator is further configured to provide the probabilities determined by the discriminator to the generator and the discriminator to allow the parameters of the generator and the parameters of the discriminator to be adjusted iteratively until an equilibrium between the generator and the discriminator is established.Type: GrantFiled: March 26, 2021Date of Patent: May 21, 2024Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Hamid Jafarkhani, Saeed Karimi-Bidhendi, Arash Kheradvar
-
Patent number: 11990110Abstract: Methods and systems for estimating diffraction effects during sound propagation in a scene, which include generating, for each distance value from distance values, a subpath between a first point of the scene and a second point of the scene passing through a third point of the scene which is at a distance from a path between the first point and the second point equal to the distance value. Furthermore, for each generated subpath, a transmission value related to a degree of occlusion of the subpath by objects in the scene is determined. Also, a diffraction amplitude response is determined using a first transmission value determined for a first subpath generated for a first distance value from the distance values and a second transmission value determined for a second subpath generated for a second distance value from the distance values.Type: GrantFiled: November 9, 2021Date of Patent: May 21, 2024Assignee: The Regents of the University of CaliforniaInventors: Shahrokh Yadegari, Louis Pisha
-
Publication number: 20240157442Abstract: A method and system are disclosed of assembling metal particles into nanoparticles. The method includes electromagnetically levitating the metal particles; inductively heating the electromagnetically levitated metal particles beyond their melting point into metal droplets; and wherein an evaporation flux achieved at a surface of the metal droplets result in a supersaturation of metal atoms around the metal droplets leading to nucleation and growth of the nanoparticles.Type: ApplicationFiled: March 9, 2022Publication date: May 16, 2024Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Michael R. Zachariah, Reza Abbaschian, Pankaj Ghildiyal, Steven Herrera, Prithwish Biswas
-
Patent number: 11980447Abstract: An esophageal deflection device includes an elongate outer tube that has a natural curved deflection at a position that corresponds to a targeted esophagus region for deflection. The outer diameter of the outer tube is substantially matched to an inner diameter of the esophagus to closely contact the esophagus wall, or is at least half of the inner diameter, or is smaller and includes suction ports for drawing the esophagus wall inward. An insertion rod or tube includes a portion that is stiffer than the curved deflection, and slides into the elongate outer tube to straighten the tube and can serve to guide the deflection device into an esophagus. Subsequent withdrawal of the insertion tube or rod will allow the curved deflection to return to its natural shape and deflect the targeted region of the esophagus.Type: GrantFiled: March 8, 2018Date of Patent: May 14, 2024Assignee: The Regents of the University of CaliforniaInventors: Karcher Morris, Anay Mahesh Pandit, Thomas Savides, Young Seo, Frank Talke, Youyi Fu, Greg Feld, Scott Garner
-
Patent number: 11980645Abstract: Compositions and methods of use for modulating bile acids, including phenylalanocholic acid, tyrosocholic acid and leucocholic acid, to treat diseases, such as inflammatory bowel disease. In embodiments, the invention provides pharmaceutical compositions that modulate levels of a bile acid conjugate in a subject. In embodiments, the invention provides pharmaceutical compositions that modulate levels of a bile acid conjugate in a particular organ or bodily region of the subject.Type: GrantFiled: January 22, 2020Date of Patent: May 14, 2024Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Pieter Dorrestein, Alexey Melnik, Alexander Aksenov, Robert Quinn
-
Patent number: 11980453Abstract: The disclosed embodiments provide a system that non-invasively analyzes blood flow in a sample of living tissue. During operation, the system obtains light from a temporally coherent source, and splits the obtained light between a reference path and a sample path. Next, the system multiply scatters light from the sample path by passing the light through the sample. The system then recombines light from the reference path and the multiply scattered light from the sample path. Next, the system uses a sensor array to detect an interference pattern resulting from the recombination. Finally, the system analyzes signals from the sensor array to determine a blood flow in the sample.Type: GrantFiled: April 15, 2019Date of Patent: May 14, 2024Assignee: The Regents of the University of CaliforniaInventors: Wenjun Zhou, Oybek Kholiqov, Vivek Jay Srinivasan
-
Patent number: 11980462Abstract: Methods, systems, and devices are disclosed mouth-based biosensors and biofuel cells. In one aspect, an electrochemical sensor device for detecting analytes in saliva includes a substrate including an electrically insulative material, a first electrode disposed on the substrate at a first location, in which the first electrode includes a surface including a chemical agent (e.g., a catalyst or a reactant) corresponding to an analyte in saliva; and a second electrode disposed on the substrate at a second location separated from the first electrode by a spacing region, the first and second electrodes capable of sustaining a redox reaction involving the chemical agent and the analyte to produce an electrical signal, such that, when the device is present in the mouth of a user and electrically coupled to an electrical circuit, the device is operable to detect the analyte in the user's saliva.Type: GrantFiled: February 12, 2020Date of Patent: May 14, 2024Assignee: The Regents of the University of CaliforniaInventors: Joseph Wang, Patrick Mercier
-
Patent number: 11981571Abstract: In various embodiments functionalized graphene oxide(s) are provided that demonstrate improved antimicrobial activity, where the graphene oxide(s) are functionalized to increase carbon radical (·C) density.Type: GrantFiled: November 19, 2021Date of Patent: May 14, 2024Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NORTHWESTERN UNIVERSITYInventors: Andre E. Nel, Tian Xia, Ruibin Li, Mark C. Hersam, Nikhita D. Mansukhani, Linda Guiney