Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a quinazoline structure or a quinoline structure which function as dual inhibitors of EGFR proteins and PI3K proteins, and their use as therapeutics for the treatment of cancer and other diseases.

Abstract: Organic photovoltaic cells (OPVs) and their compositions are described herein. In one or more embodiments, the acceptor with an active layer of an OPV includes is a non-fullerene acceptor. Such non-fullerene acceptors may provide improved OPV performance characteristics such as improved power conversion efficiency, open circuit voltage, fill factor, short circuit current, and/or external quantum efficiency. One example of a non-fullerene acceptor is (4,4,10,10-tetrakis(4-hexylphenyl)-5,11-(2-ethylhexyloxy)-4,10-dihydro-dithienyl[1,2-b:4,5b?] benzodi-thiophene-2,8-diyl) bis(2-(3-oxo-2,3-dihydroinden-5,6-dichloro-1-ylidene) malononitrile.

Abstract: Traditional speaker verification systems are vulnerable to voice spoofing attacks, such as voice-replay attack, voice-cloning attack, and cloned-replay attack. To overcome these vulnerabilities, a secure automatic speaker verification system based on a novel sign modified acoustic local ternary pattern (sm-ALTP) features and asymmetric bagging-based classifier-ensemble with enhanced attack vector is presented. The proposed audio representation approach clusters the high and low frequency components in audio frames by normally distributing them against a convex function. Afterwards, the neighborhood statistics are applied to capture the user specific vocal tract information.

Abstract: Provided herein are compositions including peptides, pharmaceutical preparations thereof, and methods of preventing photoreceptor death therewith and protecting of retinal cells, including, but not limited to, photoreceptors and retinal pigment epithelium, from Fas- or TRAIL-mediated apoptosis.

Abstract: A method of treating a T-cell mediated disease in a subject by administering to the subject a therapeutically effective amount of an antibody or fragment thereof that specifically binds to CD6 is described. Humanized antibodies useful for the method are also described.

Abstract: An imaging system for cell-based therapies is provided. The imagining system includes one or more optical tags configured for insertion into a cell or biological tissue, an excitation light source configured to illuminate the one or more optical tags; a detector configured to measure optical emission of the one or more optical tags; an imaging subsystem configured to determine a three-dimensional location of each of the one or more optical tags in the cell or biological tissue; and a controller in electrical communication with the excitation light source, the detector, and the imaging subsystem. Each of the one or more optical tags has a contrasting feature and includes a fluorescent material. The contrasting feature may be defined by at least one of a refractive index, shape, color, and laser emission of each optical tag of the one or more optical tags.

Abstract: A hyperbranched polymer includes a hyperbranched, hydrophobic molecular core, respective low molecular weight polyethyleneimine chains attached to at least three branches of the hyperbranched, hydrophobic molecular core, and respective polyethylene glycol chains attached to at least two other branches of the hyperbranched, hydrophobic molecular core. Examples of the hyperbranched polymer may be used to form hyperbranched polyplexes, and may be included in DNA or RNA delivery systems.

Abstract: The disclosure relates to bioreactors, for example for biological treatment and, more specifically to bioreactor insert apparatus including biofilms and related methods. The bioreactor insert apparatus provides a means for circulation of reaction medium within the bioreactor, a biofilm support, and biological treatment of an inlet feed to the reactor/insert apparatus. The bioreactor insert apparatus has a high relative surface area for biofilm attachment and is capable of generating complex flow patterns and increasing treatment efficiency/biological conversion activity in a biologically-active reactor. The high surface area structure incorporates multiple biofilm support structures such as meshes at inlet and outlet portions of the structure. The biofilm support structures and biofilms thereon can increase overall reaction rate of the bioreactor and/or perform some solid/liquid separation in the treatment of the wastewater or other influent.

Abstract: A vehicle power system includes a coil that, in a first operational mode, receives power wirelessly from an external source, a first battery connected to the coil to receive power transferred from the coil while the coil is in the first operational mode, a second battery that receives power from the first battery, and a switch that switches the coil between the first operational mode and a second operational mode in which the coil receives power from the second battery and wirelessly transfers power from the second battery to an electrical load in the vehicle.

Abstract: Organic photovoltaic cells (OPVs) and their compositions are described herein. one or more embodiments, the acceptor with an active layer of an OPV includes is a non-fullerene acceptor. Such non-fullerene acceptors may provide improved OPV performance characteristics such as improved power conversion efficiency, open circuit voltage, fill factor, short circuit current, and/or external quantum efficiency.

Abstract: A method is presented for measuring motion of a moving body using an atom interferometer. The method includes: positioning at least one atom in a cavity of the atom interferometer, where the atom interferometer is attached to the moving body; splitting the at least one atom into a pair of wave-function components; guiding the pair of wave-function components along respective paths in the cavity such that the pair of wave-function components are confined spatially along the respective paths in all degrees of freedom and without interruption; coherently recombining the pair of wave-function components into the at least one atom; and measuring a property of the at least one atom after the pair of wave-function components have been recombined into the at least one atom, where the property of the at least one atom is indicative of motion of the moving body.

Abstract: A method is presented for mapping weights for kernels of a neural network onto a crossbar array. In one example, the crossbar array is comprised of an array of non-volatile memory cells arranged in columns and rows, such that memory cells in each row of the array is interconnected by a respective drive line and each column of the array is interconnected by a respective bit line; and wherein each memory cell is configured to receive an input signal indicative of a multiplier and operates to output a product of the multiplier and a weight of the given memory cell onto the corresponding bit line of the given memory cell, where the value of the multiplier is encoded in the input signal and the weight of the given memory cell is stored by the given memory cell.

Abstract: A method of predicting patient deterioration includes receiving an electronic health record data set of the patient, determining a risk score corresponding to the patient by analyzing the electronic health record data set of the patient using a trained machine learning model, determining a threshold value using an online/reinforcement learning model, comparing the risk score to the threshold value, and when the risk score exceeds the threshold value, generating an alarm. A non-transitory computer readable medium includes program instructions that when executed, cause the computer to receive a list of patients, display selectable patient information corresponding to each of the list of patients according to an ordering established by a feature importance algorithm, receive a selection, retrieve vital sign information corresponding to the selection, and display the vital sign information.

Abstract: An automated microfluidic bioreactor device and methods to rapidly detect drugs of abuse from human sweat are provided. The bioreactor can perform either single-plexed measurements (detecting only one target analyte at a time) or multiplexed measurement (detecting multiple analytes simultaneously). The bioreactor device has a cartridge comprising a capillary array that employs competitive enzyme-linked immunosorbent assay (ELISA) to detect the presence of various drugs or metabolite compounds. For example, four common drugs, methadone, methamphetamine, amphetamine, and tetrahydrocannabinol, were detected rapidly and quantitatively in about 16 minutes with a low sweat sample volume (about 4 ?L per analyte) and a large dynamic range (methadone: 0.0016 ng/mL-1 ng/mL; METH: 0.016 ng/mL-25 ng/mL; amphetamine: 0.005 ng/mL-10 ng/mL; THC: 0.02 ng/mL-1000 ng/mL).

Abstract: An integrated vascular delivery system having a frame configured to receive a catheter insertable in a patient to deliver fluid at an insertion site. The frame includes a first hub, a second hub, and a pair of flexible lateral members extending between the hubs and including a tubular lateral member. The system also includes a fluidic channel that fluidically communicates with the catheter, wherein the fluidic channel passes through the tubular lateral member and at least one of the hubs, and includes a fixed turnabout portion in which fluid flows in a direction different from that within the catheter. The first and second hubs provide anchoring points on the patient distributed around the insertion site and on opposite ends of the catheter, thereby anchoring the frame to the patient and stabilizing the catheter. A method is provided for using an integrated vascular delivery system.

Abstract: A colored visibly opaque, highly efficient NIR-transmitting optical filter displaying angle insensitivity is based on one-dimensional photonic crystals. The filter comprises a photonic crystal stack comprising at least one high refractive index layer and two low refractive index layers respectively disposed along a first side and a second side of the high refractive index layer. The photonic crystal stack may have 10 or fewer layers. The filter transmits a first portion of an electromagnetic spectrum having a first range of predetermined wavelengths in an infrared light range or near infrared light range, while reflecting a second portion of the electromagnetic spectrum having a second range of predetermined wavelengths in a visible light range to generate a reflected output. In certain aspects, a refractive index contrast between the at least one high refractive index layer and at least one of the two low refractive index layers is ? about 40%.

Abstract: Provided herein is technology relating to engineered tissues and particularly, but not exclusively, to methods, compositions, and systems for engineering a biosynthetic vascular network.

Abstract: A subsurface imaging technique using distributed sensors is introduced. Instead of monostatic transceivers employed in conventional ground penetrating radars, the proposed technique utilizes bi-static transceivers to sample the reflected signals from the ground at different positions and create a large two-dimensional aperture for high resolution subsurface imaging. The coherent processing of the samples in the proposed imaging method eliminates the need for large antenna arrays for obtaining high lateral resolution images. In addition, it eliminates the need for sampling on a grid which is a time-consuming task in imaging using ground penetration radar. Imaging results show that the method can provide high-resolution images of the buried targets using only samples of the reflected signals on a circle with the center at the transmitter location.

Abstract: A system for generating a concentrated product from a feedstock includes a feedstock chamber to which the feedstock is provided, a heat exchanger assembly in thermal communication with the feedstock chamber, the heat exchanger assembly being configured to freeze the feedstock in the feedstock chamber, an output flow arrangement configured to carry liquid from the feedstock chamber as the feedstock thaws, the output flow arrangement comprising a flow controller, a sensor disposed along the output flow arrangement or the heat exchanger assembly, the sensor being configured to measure a characteristic of the liquid, the characteristic being indicative of a solute concentration level of the liquid or the heat exchanger assembly, and a processor responsive to the characteristic and configured to control the flow controller to, based on the solute concentration level, direct the liquid passing through the output flow arrangement to define a plurality of products at different concentration levels, the plurality of p

Abstract: A method for simulating interactions between a propagating field and occluding bodies in a volume is provided. The method includes using a processor to construct a three-dimensional grid structure having a plurality of cells, the volume containing a plurality of two-dimensional triangles that intersect or reside in one or more of the cells; to iterate through a plurality of rays and trace each ray of the plurality to approximate the propagating field; to determine and account for all interactions between each ray of the plurality and the occluding bodies, where the determining includes performing ray-triangle intersection for all triangles of the plurality of triangles intersecting or residing in cells occupied by the occluding bodies, and the accounting includes adding additional rays of the plurality of rays as reflections, transmissions, and diffractions of the approximated propagating field.