Abstract: The present invention relates to specific antibodies and use thereof, such as for identifying and/or quantifying liraglutide fibrils and/or semaglutide fibrils.

Abstract: Systems and methods for predicting and/or detecting cardiac events based on real-time biomedical signals are discussed herein. In various embodiments, a machine learning algorithm may be utilized to predict and/or detect one or more medical conditions based on obtained biomedical signals. For example, the systems and methods described herein may utilize ECG signals to predict and detect cardiac events. In various embodiments, patterns identified within a signal may be assigned letters (i.e., encoded as distributions of letters). Based on the known morphology of a signal, states within the signal may be identified based on the distribution of letters in the signal. When applied in the in-vehicle environment, drivers or passengers within the vehicle may be alerted when an individual within the vehicle is, or is about to, experience a cardiac event.

Abstract: N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.

Abstract: An autonomous vehicle can plan a path of the autonomous vehicle at an intersection where cyclists are also present. The autonomous vehicle includes an imaging device and processing circuitry configured to receive information from the imaging device and then identify a position of a cyclist in a traffic intersection based on the information from the imaging device. Additionally, a future path of the cyclist is predicted based on the position of the cyclist in the traffic intersection and a path of the autonomous vehicle is planned based on the predicted future path of the cyclist. Further, it can be determine if the cyclist followed the predicted future path, and the planned path of the autonomous vehicle is updated in response to the cyclist not following the predicted future path.

Abstract: There is disclosed squaraine compounds of formula I: wherein each of Y1 and Y2 is independently chosen from an optionally substituted amino group and an optionally substituted aryl group. Also described are organic optoelectronic devices comprising a Donor-Acceptor heterojunction that is formed from one or more of the squaraine compounds. A method of making the disclosed device, which may include one or more sublimation step for depositing said squaraine compound, is also disclosed.

Abstract: A method is presented for controlling power output by a battery in a vehicle. The method includes: measuring voltage of the battery during a sequence of vehicle events to form a time series, where each vehicle event is powered by the battery; constructing an unknown fingerprint from the voltage measurements made during the sequence of vehicle events, where the unknown fingerprint is indicative of a sequence of vehicle events; comparing the unknown fingerprint to the at least one fingerprint; receiving a start signal, where the start signal is a request to start the engine of the vehicle; and, in response to receiving the start signal and based on the comparison of the unknown fingerprint to the at least one fingerprint, outputting electric power from the battery to an electric starter motor of the vehicle.

Abstract: A railway tie being constructed of an engineered cementitious composite (ECC) material having: (1) a minimum of 2% tensile ductility of ECC, (2) complete absence of alkali-silica reaction (ASR), (3) high fatigue resistance of ECC at least five times that of normal concrete, (4) self-healing ability of ECC requiring only water and air, and (5) customization of ECC for lower stiffness in the tie (60% that of normal concrete) and higher abrasion resistance in the seat (three times that of normal concrete).

Abstract: Apparatus and methods are provided for applying ultrasound pulses into tissue or a medium in which the peak negative pressure (P?) of one or more negative half cycle(s) of the ultrasound pulses exceed(s) an intrinsic threshold of the tissue or medium, to directly form a dense bubble cloud in the tissue or medium without shock-scattering. In one embodiment, a microtripsy method of Histotripsy therapy comprises delivering an ultrasound pulse from an ultrasound therapy transducer into tissue, the ultrasound pulse having at least a portion of a peak negative pressure half-cycle that exceeds an intrinsic threshold in the tissue to produce a bubble cloud of at least one bubble in the tissue, and generating a lesion in the tissue with the bubble cloud. The intrinsic threshold can vary depending on the type of tissue to be treated. In some embodiments, the intrinsic threshold in tissue can range from 15-30 MPa.

Abstract: The present disclosure provides compounds represented by Formula (I), and the pharmaceutically acceptable salts and solvates thereof wherein R1a, R1b, R2a, R2b, R3, R4, R5, R6, R7, E and (B) are as defined as set forth in the specification. The present disclosure also provides compounds of Formula (I) for use to treat a condition or disorder responsive to inhibition of ALK such as cancer.

Abstract: A nonlinear resonator is presented that enhances the bandwidth while providing high resonance amplitude. The nonlinear resonance circuit is comprised of an inductor electrically coupled to a capacitor, where either the inductor or capacitor is nonlinear. Response of the nonlinear resonance circuit to an excitation signal is described by a family of second-order differential equations with cubic-order nonlinearity, known as Duffing equations. In one aspect, the nonlinear resonator is implemented by a nonlinear dielectric resonator.

Abstract: The present disclosure provides methods and systems for receiving, with processing circuitry of an implant device, an electrical signal from a free tissue graft attached to a portion of a nerve (e.g., a nerve branch or fascicle) through an electrical conductor in electrical communication with the free tissue graft (e.g., muscle graft), the nerve having reinnervated the free tissue graft. The electrical signal from the free tissue graft has a voltage amplitude of greater than or equal to about 150 microvolts. The processing circuitry stores signal data corresponding to the electrical signal from the free tissue graft in a memory accessible to the processing circuitry.

Abstract: A magnetic beacon and inertial sensor system for precise indoor localization is provided using active magnetic beacons, magnetometers and inertial measurement units. The system is designed to work in environments that are not conducive to radio frequency (RF) (such as GPS, cell, Wi-Fi, or Bluetooth) or optical techniques (CCTV, IR), such as inside heavy industrial plant settings, underground or underwater.

Abstract: The present disclosure provides compounds of Formula (II-A), which inhibit the interaction of menin with one or more of MLL1, MLL2 and MLL-fusion oncoproteins. Also disclosed are methods for the treatment of leukemia, solid cancers, diabetes and other diseases dependent on activity of MLL1, MLL2, MLL fusion proteins, and/or menin.

Abstract: An environmental logging system that includes a housing and an electronic logging circuit sealed within the housing. The logging circuit includes an energy source, transducer, charging circuit, trigger circuit, electronic control unit (ECU), and transmitter. The energy source is charged by the charging circuit using electricity from the transducer in response to external energy applied to the transducer. Commands may also be received by the circuit via the transducer. The ECU includes a processor, memory, and one or more sensors, and it operates under power from the energy source to store data from the sensor(s). The transmitter is coupled to the ECU and transmits the data via electromagnetic radiation outside the housing. The trigger circuit supplies operating power to the processor only when the voltage level of the energy source is above a minimum threshold. The housing may be a tubular shell filled with a polymeric material.

Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a quinazolinedione structure which function as reactive oxygen species (ROS) inducers and inhibitors of mitochondrial activity within cancer cells (e.g., pancreatic cancer cells), and their use as therapeutics for the treatment of cancer (e.g., pancreatic cancer) and other diseases.

Abstract: A mechanotransductive bowel extender device that can be used to correct short bowel syndrome by applying tension to the bowel tissue which, via the process of mechanotransduction, grows in length in response to the applied tension. Such a device is placed within the small bowel and applies tension over a period of several days or weeks by attaching to the lumen of the bowel at two different locations and moving those two points apart, stretching the tissue between. The extender device further capable of localized application and/or evacuation of medically relevant liquid and other material within the bowel.

Abstract: A method is presented for generating a data set from a database. The method involves iterative data manipulation that stochastically identifies candidate entries from the cases (subjects, participants) and variables (data elements) and subsequently selects, nullifies, and imputes the information. This process heavily relies on statistical multivariate imputation to preserve the joint distributions of the complex structured data archive. At each step, the algorithm generates a complete dataset that in aggregate closely resembles the intrinsic characteristics of the original data set, however, on an individual level the rows of data are substantially altered. This procedure drastically reduces the risk for subject reidentification by stratification, as meta-data for all subjects is repeatedly and lossily encoded.

Abstract: Systems and methods provide containers instantiated for each user equipment (UE), or on “per-UE” bases, which consolidate certain network functions for processing UE traffic into an efficient, in-network, and proximate virtualization to reduce latency and increase customizability.

Abstract: A method of fabricating a photovoltaic cell having a microinverter is provided. The method may include fabricating a monolithic microinverter layer through epitaxy and operably connecting the at least one microinverter layer to at least one photovoltaic cell formed on a photovoltaic layer. A photovoltaic device is also provided. The device may have a photovoltaic layer comprising at least one photovoltaic cell and a microinverter layer comprising at least one microinverter, wherein the microinverter layer was fabricated through epitaxy, the at least one microinverter is configured to be operably connected to at least one photovoltaic cell.

Abstract: The present disclosure relates to compositions and methods for cancer therapy, including but not limited to, targeted inhibition of cancer markers. In particular, the present disclosure relates to recurrent gene fusions as clinical targets for cancer.