Patents Assigned to The Regents of the University of Calfornia
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Publication number: 20220035215Abstract: A method of producing an electrochromic device includes providing a substrate; providing a counter electrode; immersing the substrate and the counter electrode into an electrodeposition solution; applying a negative bias voltage to a surface of the substrate so that the surface of the substrate acts a cathode in the electrodeposition solution; applying a positive bias voltage to the counter electrode so that the counter electrode acts as an anode in the electrodeposition solution; and applying a voltage of at least 0.2 V between the anode and the cathode for period of time until a tungsten-based film forms on the surface of the substrate.Type: ApplicationFiled: September 17, 2019Publication date: February 3, 2022Applicant: The Regents of the University of CalforniaInventors: Yeyue CHEN, Ruilhan GUO
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Patent number: 9902780Abstract: This invention provides antibodies that specifically bind to and typically neutralize botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/E, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.Type: GrantFiled: October 1, 2015Date of Patent: February 27, 2018Assignee: The Regents of the University of CalforniaInventors: James D. Marks, Maria Consuelo Garcia
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Publication number: 20170241946Abstract: Provided are devices that include a polymeric separation medium configured to immobilize one or more constituents of interest in the polymeric separation medium and have an increased pore size upon application of an applied stimulus. Systems including the devices, as well as methods of using the devices, are also provided. Embodiments of the present disclosure find use in a variety of different applications, including detecting whether an analyte is present in a fluid sample.Type: ApplicationFiled: June 4, 2015Publication date: August 24, 2017Applicant: The Regents of the University of CalforniaInventors: Amy E. Herr, Todd A. Duncombe
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Publication number: 20170125574Abstract: Trenched vertical power field-effect transistors with improved on-resistance and/or breakdown voltage are fabricated. In one or more embodiments, the modulation of the current flow of the transistor occurs in the lateral channel, whereas the voltage is predominantly held in the vertical direction in the off-state. When the device is in the on-state, the current is channeled through an aperture in a current-blocking region after it flows under a gate region into the drift region. In another embodiment, a novel vertical power low-loss semiconductor multi-junction device in III-nitride and non-III-nitride material system is provided. One or more multi-junction device embodiments aim at providing enhancement mode (normally-off) operation alongside ultra-low on resistance and high breakdown voltage.Type: ApplicationFiled: November 4, 2016Publication date: May 4, 2017Applicants: The Regents of the University of Calfornia, Arizona Board of Regents on Behalf of Arizona State UniversityInventors: Srabanti Chowdhury, Jeonghee Kim, Chirag Gupta, Stacia Keller, Silvia H. Chan, Umesh K. Mishra
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Publication number: 20160285504Abstract: A radio interference cancellation device that cancels self-interference from a transmitter to a receiver that includes a 2N-way RF power splitter having an input and 2N outputs, a power combiner having 2N+1 inputs and an output, and 2N adaptively controllable attenuators. Each adaptively controllable attenuator is coupled by cables between a different output of the 2N-way RF power splitter and a different input of the power combiner, each cable having a total length selected to provide a delay equal to a different one of mT(m=1,N) and mT+?(m=1,N), where T is a delay smaller than the inverse of a bandwidth of the transmitter and receiver, and ? is ¼fc, where fc is the carrier frequency of an RF signal transmitted by the transmitter.Type: ApplicationFiled: June 27, 2014Publication date: September 29, 2016Applicant: The Regents of the University of CalforniaInventor: Yingbo Hua
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Patent number: 9315821Abstract: The present invention provides methods of regulating plant stress tolerance.Type: GrantFiled: February 12, 2010Date of Patent: April 19, 2016Assignee: THE REGENTS OF THE UNIVERSITY OF CALFORNIAInventors: Sean R. Cutler, Sang-Youl Park
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Publication number: 20150099872Abstract: The disclosure provides methods of engineering plants to modulate galactan content. Specifically, the disclosure provides methods for engineering a plant to increase the galactan content in a plant tissue by inducing expression of beta-1,4-galactan synthase (GALS), modulated by a heterologous promoter. Further disclosed are the methods of modulating expression level of GALS under the regulation of a transcription factor, as well as overexpression of UDP-galactose epimerse in the same plant tissue. Tissue specific promoters and transcription factors can be used in the methods are also provided.Type: ApplicationFiled: May 10, 2013Publication date: April 9, 2015Applicant: THE REGENTS OF THE UNIVERSITY OF CALFORNIAInventors: Henrik Vibe Scheller, Joshua L. Heazlewood
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Publication number: 20140329705Abstract: Provided herein is an all-in-one saliva collection apparatus that collects saliva to allow for the filtration of saliva in order to separate saliva components, such as extracellular proteins and nucleic acids that are not present in intact cells, from the intact cells and debris remaining in the extracted sample. The filtered saliva samples can be aliquoted into two fractions for protein and/or nucleic acid analysis. The present invention further describes long term storage at ambient temperatures of filtered salivary nucleic acids, and long term storage at ambient temperatures of filtered salivary proteins added to an ethanol solution. The filtered cell-free saliva samples have diagnostic usefulness.Type: ApplicationFiled: August 6, 2012Publication date: November 6, 2014Applicant: THE REGENTS OF THE UNIVERSITY OF CALFORNIAInventors: David T. Wong, Wei Liao
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Publication number: 20120309648Abstract: A microfluidic system has a microfluidic mixer and a sample storage component that is in fluid connection with the microfluidic mixer.Type: ApplicationFiled: July 7, 2008Publication date: December 6, 2012Applicant: The Regents of the University of CalforniaInventors: Hsian-Rong Tseng, Jinyi Wang, Guodong Sui, Kym F. Faull, Yanju Wang, Wei-Yu Lin
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Patent number: 8007749Abstract: Disclosed herein is a method for removing mercury from a gas stream comprising contacting the gas stream with a getter composition comprising bromine, bromochloride, sulphur bromide, sulphur dichloride or sulphur monochloride and mixtures thereof. In one preferred embodiment the getter composition is adsorbed onto a sorbent. The sorbent may be selected from the group consisting of flyash, limestone, lime, calcium sulphate, calcium sulfite, activated carbon, charcoal, silicate, alumina and mixtures thereof. Preferred is flyash, activated carbon and silica.Type: GrantFiled: June 2, 2010Date of Patent: August 30, 2011Assignee: The Regents of the University of CalforniaInventors: Shih-Ger Chang, Shou-Heng Liu, Zhao-Rong Liu, Naiqiang Yan
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Publication number: 20090210371Abstract: In one embodiment, a method for predicting an outcome is provided. The method comprises: determining a known data set of data, the known data set of data including an input variable and an output variable; determining a plurality of candidate prediction functions, each prediction function adapted to determine a candidate predicted outcome for the output variable using a different algorithm; determining a combination of the plurality of candidate prediction functions based on the known data set; determining a second set of data, the second set of data including data for the input variable; and determining, based on the input variable, a predicted outcome for the output variable using a data adaptive prediction function, wherein the data adaptive prediction function uses the combination of candidate predicted outcomes from the plurality of candidate prediction functions determined using the data from the input variable to determine the predicted outcome.Type: ApplicationFiled: February 14, 2009Publication date: August 20, 2009Applicant: The Regents of the University of CalforniaInventor: Mark van der Laan
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Publication number: 20030216721Abstract: An ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly effected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C.Type: ApplicationFiled: January 15, 2003Publication date: November 20, 2003Applicant: THE REGENTS OF THE UNIVERSITY OF CALFORNIAInventors: Chris J. Diederich, Jeffrey C. Lotz, Will Nau, David S. Bradford, Elizabeth Wistrom, Elisa Bass
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Patent number: 6521181Abstract: A detector cell for a silicon-based or non-silicon-based sleeve type chemical reaction chamber that combines heaters, such as doped polysilicon for heating, and bulk silicon for convection cooling. The detector cell is an electrochemiluminescence cell constructed of layers of silicon with a cover layer of glass, with spaced electrodes located intermediate various layers forming the cell. The cell includes a cavity formed therein and fluid inlets for directing reaction fluid therein. The reaction chamber and detector cell may be utilized in any chemical reaction system for synthesis or processing of organic, inorganic, or biochemical reactions, such as the polymerase chain reaction (PCR) and/or other DNA reactions, such as the ligase chain reaction, which are examples of a synthetic, thermal-cycling-based reaction. The ECL cell may also be used in synthesis instruments, particularly those for DNA amplification and synthesis.Type: GrantFiled: December 26, 1996Date of Patent: February 18, 2003Assignee: The Regents of the University of CalforniaInventors: M. Allen Northrup, Yun-Tai Hsueh, Rosemary L. Smith
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Patent number: 5823938Abstract: An apparatus for occluding the upper and lower eyelids of a patient at risk of developing corneal keratopathy. A magnet is attached to or placed within a polymer base that conforms to the normal curvature of the external skin surface of the human eyelid. The conforming base is then attached to the upper eyelid using a removable adhesive such as double-sided tape. A similar conforming base and magnet is attached to the lower eyelid. The magnetic attraction from the opposing magnets pulls the upper and lower eyelids together so as to close the eye, but can be broken by gently spreading apart the conforming bases for examination of the eye or application of medicaments when necessary. Variations of the device can be made where one of the magnets is replaced by a metal plate or other magnetic, or where a pair of electromagnets are used with a control for switching polarity to the electromagnets for reversal between magnetic attractive and repulsive forces and hence opening and closing the eyelids.Type: GrantFiled: March 27, 1997Date of Patent: October 20, 1998Assignee: The Regents Of The University Of CalforniaInventor: Edward V. Hernandez
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Patent number: 5639423Abstract: An integrated microfabricated instrument for manipulation, reaction and detection of microliter to picoliter samples. The instrument is suited for biochemical reactions, particularly DNA-based reactions such as the polymerase chain reaction, that require thermal cycling since the inherently small size of the instrument facilitates rapid cycle times. The integrated nature of the instrument provides accurate, contamination-free processing. The instrument may include reagent reservoirs, agitators and mixers, heaters, pumps, and optical or electromechanical sensors. Ultrasonic Lamb-wave devices may be used as sensors, pumps and agitators.Type: GrantFiled: August 31, 1992Date of Patent: June 17, 1997Assignee: The Regents of the University of CalforniaInventors: M. Allen Northrup, Richard M. White