Patents Assigned to The Regents of the University of Calif.
  • Patent number: 7754491
    Abstract: An assembly and method for gas analysis. The assembly comprises a catalyst compartment for catalytically reacting a component of a gas sample, producing one or more gas species as products. A product compartment receives the gas species, and a sensing element within the compartment senses the amount of one or more of the gas species. This amount is compared to the amount of the same gas species present in a reference compartment containing a non-catalyzed gas sample, providing the amount of the gas species produced by catalysis. Using this value, the content of the gas component in the gas sample is calculated based upon the stoichiometry of the catalyzed reaction. In preferred embodiments, the gas for analysis is a process gas for fuel production, and the catalyst is a high temperature shift catalyst that catalyzes the reaction of carbon monoxide and water into hydrogen and carbon dioxide.
    Type: Grant
    Filed: December 9, 2005
    Date of Patent: July 13, 2010
    Assignee: The Regents of the University of Calif.
    Inventors: Chan Seung Park, Colin E. Hackett, Nora A. Hackett, legal representative, Joseph M. Norbeck
  • Patent number: 6278040
    Abstract: In accordance with the present invention, there are provided targeted loss of function mutant mice which express less than endogenous levels of at least one member of the steroid/thyroid superfamily of receptors in at least one specific tissue type. For example, mutations in the RXR&agr; gene in mouse germlines are lethal in the embryonic stage between E13.5 and E16.5 when bred to homozygosity. The major defect responsible for this lethal effect is hypoplastic development of the ventricular chambers of the heart, which is manifest as a grossly thinned ventricular wall with concurrent defects in ventricular septation. This phenotype is identical to a subset of the effects of embryonic vitamin A deficiency, and therefore establishes RXR&agr; as a genetic component of the vitamin A signaling pathway in cardiac morphogenesis.
    Type: Grant
    Filed: February 19, 1997
    Date of Patent: August 21, 2001
    Assignees: The Salk Institute for Biological Studies, The Regents of the University of Calif.
    Inventors: Henry M. Sucov, Ronald M. Evans, Kenneth R. Chien
  • Patent number: 5925818
    Abstract: A method and apparatus of magnetic force control for a scanning probe, wherein a first magnetic source having a magnetic moment is provided on the scanning probe and a second magnetic source is disposed external to the scanning probe to apply a magnetic field in a direction other than parallel, and preferably perpendicular, to the orientation of the magnetic moment, from the second magnetic source to the first magnetic source to produce a torque related to the amplitude of the applied magnetic field acting on the probe. By controlling the amplitude of the applied magnetic field, the deflection of the scanning probe is maintained constant during scanning by the scanning probe. An output signal related to the amplitude of the magnetic field applied by the second magnetic source is produced and is indicative of a surface force applied to the probe. The invention can also be used to apply large forces during scanning for applications such as nanolithography or elasticity mapping.
    Type: Grant
    Filed: July 1, 1997
    Date of Patent: July 20, 1999
    Assignee: The Regents of the University of Calif.
    Inventors: Jason Cleveland, Paul Hansma, William Ducker
  • Patent number: 5916127
    Abstract: A method and device for reducing the amount of noise generated by a supersonic jet engine is provided. The method creates an envelope of air around the supersonic jet exhaust. The temperature and velocity of this envelope is controlled to eliminate or reduce the formation of noise making Mach waves.
    Type: Grant
    Filed: July 30, 1996
    Date of Patent: June 29, 1999
    Assignee: The Regents of the University of Calif.
    Inventor: Dimitri Papamoschou
  • Patent number: 5802937
    Abstract: There is provided an apparatus for machining surfaces to accuracies within the nanometer range by use of electrical current flow through the contact of the cutting tool with the workpiece as a feedback signal to control depth of cut.
    Type: Grant
    Filed: July 26, 1995
    Date of Patent: September 8, 1998
    Assignee: The Regents of The University of Calif.
    Inventors: Robert Dean Day, Larry R. Foreman, Douglas J. Hatch, Mark S. Meadows
  • Patent number: 5760365
    Abstract: A laser welding process including: (a) using optical ray tracing to make a model of a laser beam and the geometry of a joint to be welded; (b) adjusting variables in the model to choose variables for use in making a laser weld; and (c) laser welding the joint to be welded using the chosen variables.
    Type: Grant
    Filed: November 6, 1995
    Date of Patent: June 2, 1998
    Assignee: The Regents of the University of Calif.
    Inventors: John O. Milewski, Edward Sklar
  • Patent number: 5757001
    Abstract: A method of detecting counterfeit currency by contacting the currency to be tested with near infrared beams in the spectrum below 1250 namometers, measuring reflectance of the near infrared beams and comparing the reflectance values with those from genuine currency.
    Type: Grant
    Filed: May 1, 1996
    Date of Patent: May 26, 1998
    Assignee: The Regents of the University of Calif.
    Inventor: Donald A. Burns
  • Patent number: 5595834
    Abstract: A stack of polymer electrolyte fuel cells is formed from a plurality of unit cells where each unit cell includes fuel cell components defining a periphery and distributed along a common axis, where the fuel cell components include a polymer electrolyte membrane, an anode and a cathode contacting opposite sides of the membrane, and fuel and oxygen flow fields contacting the anode and the cathode, respectively, wherein the components define an annular region therethrough along the axis. A fuel distribution manifold within the annular region is connected to deliver fuel to the fuel flow field in each of the unit cells. The fuel distribution manifold is formed from a hydrophilic-like material to redistribute water produced by fuel and oxygen reacting at the cathode. In a particular embodiment, a single bolt through the annular region clamps the unit cells together.
    Type: Grant
    Filed: January 17, 1996
    Date of Patent: January 21, 1997
    Assignee: The Regents of the University of Calif.
    Inventors: Mahlon S. Wilson, Jay K. Neutzler
  • Patent number: 5470668
    Abstract: A structure including a thin film of a conductive alkaline earth metal oxide selected from the group consisting of strontium ruthenium trioxide, calcium ruthenium trioxide, barium ruthenium trioxide, lanthanum-strontium cobalt oxide or mixed alkaline earth ruthenium trioxides thereof upon a thin film of a noble metal such as platinum is provided.
    Type: Grant
    Filed: March 31, 1994
    Date of Patent: November 28, 1995
    Assignee: The Regents of the University of Calif.
    Inventors: Xin D. Wu, Prabhat Tiwari
  • Patent number: 5375595
    Abstract: Apparatus and method for measuring intraocular pressure changes in an eye under investigation by detection of vibrational resonances therein. An ultrasonic transducer operating at its resonant frequency is amplitude modulated and swept over a range of audio frequencies in which human eyes will resonate. The output therefrom is focused onto the eye under investigation, and the resonant vibrations of the eye observed using a fiber-optic reflection vibration sensor. Since the resonant frequency of the eye is dependent on the pressure therein, changes in intraocular pressure may readily be determined after a baseline pressure is established.
    Type: Grant
    Filed: March 17, 1993
    Date of Patent: December 27, 1994
    Assignee: The Regents of the University of Calif.
    Inventors: Dipen N. Sinha, William O. Wray
  • Patent number: 5256636
    Abstract: A microelectronic component comprising a crossover is provided comprising a substrate, a first high T.sub.c superconductor thin film, a second insulating thin film comprising SrTiO.sub.3 ; and a third high T.sub.c superconducting film which has strips which crossover one or more areas of the first superconductor film. An insitu method for depositing all three films on a substrate is provided which does not require annealing steps. The photolithographic process is used to separately pattern the high T.sub.c superconductor thin films.
    Type: Grant
    Filed: September 21, 1990
    Date of Patent: October 26, 1993
    Assignee: The Regents of the University of Calif.
    Inventors: Frederick C. Wellstood, John J. Kingston, John Clarke
  • Patent number: 5182524
    Abstract: Phase and amplitude variations at the output of a high power pulsed microwave amplifier arising from instabilities of the driving electron beam are suppressed with a feed-forward system that can stabilize pulses which are too brief for regulation by conventional feedback techniques. Such variations tend to be similar during successive pulses. The variations are detected during each pulse by comparing the amplifier output with the low power input signal to obtain phase and amplitude error signals. This enables storage of phase and amplitude correction signals which are used to make compensating changes in the low power input signal during the following amplifier output pulse which suppress the variations. In the preferred form of the invention, successive increments of the correction signals for each pulse are stored in separate channels of a multi-channel storage.
    Type: Grant
    Filed: March 10, 1992
    Date of Patent: January 26, 1993
    Assignee: The Regents of the University of Calif.
    Inventor: Donald B. Hopkins
  • Patent number: 5171610
    Abstract: Method and apparatus for formation of an alloy thin film, or a mixed metal oxide thin film, on a substrate at relatively low temperatures. Precursor vapor(s) containing the desired thin film constituents is positioned adjacent to the substrate and irradiated by light having wavelengths in a selected wavelength range, to dissociate the gas(es) and provide atoms or molecules containing only the desired constituents. These gases then deposit at relatively low temperatures as a thin film on the substrate. The precursor vapor(s) is formed by vaporization of one or more precursor materials, where the vaporization temperature(s) is selected to control the ratio of concentration of metals present in the precursor vapor(s) and/or the total precursor vapor pressure.
    Type: Grant
    Filed: August 28, 1990
    Date of Patent: December 15, 1992
    Assignee: The Regents of the University of Calif.
    Inventor: David K. Liu
  • Patent number: 5164809
    Abstract: Hydrogenated amorphous silicon radiation detector devices having enhanced signal are disclosed. Specifically provided are transversely oriented electrode layers and layered detector configurations of amorphous silicon, the structure of which allow high electric fields upon application of a bias thereby beneficially resulting in a reduction in noise from contact injection and an increase in signal including avalanche multiplication and gain of the signal produced by incoming high energy radiation. These enhanced radiation sensitive devices can be used as measuring and detection means for visible light, low energy photons and high energy ionizing particles such as electrons, x-rays, alpha particles, beta particles and gamma radiation. Particular utility of the device is disclosed for precision powder crystallography and biological identification.
    Type: Grant
    Filed: April 21, 1989
    Date of Patent: November 17, 1992
    Assignee: The Regents of the University of Calif.
    Inventors: Robert A. Street, Victor Perez-Mendez, Selig N. Kaplan
  • Patent number: 5047335
    Abstract: A process for controlling the glycosylation of protein in a cell wherein the cell is genetically engineered to produce one or more enzymes which provide internal control of the cell's glycosylation mechanism. A Chinese hamster ovary (CHO) cell line is genetically engineered to produce a sialyltransferase. This supplemental sialyltransferase modifies the CHO glycosylation machinery to produce glycoproteins having carbohydrate structures which more closely resemble naturally occurring human glycoproteins.
    Type: Grant
    Filed: December 21, 1988
    Date of Patent: September 10, 1991
    Assignee: The Regents of the University of Calif.
    Inventors: James Paulson, Eryn Ujita-Lee, Jasminder Weinstein
  • Patent number: 4748674
    Abstract: A pattern learning and recognition device. The device includes a parallel processing network for receiving and processing an N-dimensional vector input, and a control system for calculating, and storing output signal correlation information during the learning mode of the device, and for distributing the learned information to the network, in the form of feedback gain, during the pattern-recognition mode of the device. The network is preferably composed of an array of N oscillatory units designed to bifurcate from a rest to an active state when stimulated with a threshold input voltage surge.
    Type: Grant
    Filed: October 7, 1986
    Date of Patent: May 31, 1988
    Assignee: The Regents of the University of Calif.
    Inventor: Walter J. Freeman
  • Patent number: 4644304
    Abstract: A switched capacitor pseudo-N-path filter stage includes an analog integrator circuit having an input, an output, and a feedback capacitor connected between the input and the output. A plurality of storage capacitors are connected across the feedback capacitor and an input capacitor is provided. The feedback capacitor and storage capacitors form an analog random access memory. A switching circuit selectively connects the input capacitor across electrical ground and between an input signal and the input of the integrator circuit, and also selectively connects the feedback capacitor and the storage capacitors between electrical ground and the output of the integrator circuit. In this manner, the input signal is filtered as the input capacitor samples the input signal and the charge on the input capacitor is circulated through the feedback capacitor and the storage capacitors.
    Type: Grant
    Filed: August 17, 1981
    Date of Patent: February 17, 1987
    Assignee: The Regents of the University of Calif.
    Inventor: Gabor C. Temes
  • Patent number: 4618710
    Abstract: An optically active alpha-amino acid derivative having the formula: ##STR1## wherein: X is OH, Cl, Br, I, or OCOR.sub.3 ;Y is a radical selected to stabilize the alpha carbon atom of the alpha-amino acid derivative sufficiently to prevent significant change in symmetry thereof during replacement of X with an alkyl, aryl, alkenyl, alkynyl, alkaryl, aralkyl, alkenaryl or alkynaryl radical, or such radical having one or more chemical constituents thereon; andR.sub.1 and R.sub.2 are different from one another and are each hydrogen or an alkyl, aryl, alkenyl, alkynyl, alkaryl, aralkyl, alkenaryl, or alkynaryl radical, or such radical having one or more non-protic chemical constituents thereon is conventionally synthesized from the corresponding alpha-amino acid. The ##STR2## portion of the above derivative is converted to a ketone functionality without racemization.
    Type: Grant
    Filed: September 13, 1982
    Date of Patent: October 21, 1986
    Assignee: The Regents of the University of Calif.
    Inventors: Henry Rapoport, Thomas F. Buckley, III
  • Patent number: 4599565
    Abstract: An imaging NMR scanner generates multi-dimensional NMR spin echo responses from selected sub-volumes of an object. 90.degree. and 180.degree. r.f. nutation pulses are used together with a variable amplitude gradient between these nutation pulses to phase encode a second dimension in the spin echo response which is already phase-encoded in a first dimension by use of a magnetic gradient during signal readout. Two-dimensional Fourier transforms or multiple angle projection reconstruction processes are then used to generate an array of pixel value data signals representing a visual image of the point-by-point spatial distribution of nutated nuclei within the object. Image artifacts potentially caused by relatively moving elements of the object are avoided by selecting the spin echo generating sub-volumes to avoid the moving elements. High resolution images of sub-volumes of interest can be obtained by selection of a sub-volume of interest in conjunction with these reconstruction techniques.
    Type: Grant
    Filed: July 19, 1983
    Date of Patent: July 8, 1986
    Assignee: The Regents of the University of Calif.
    Inventors: John C. Hoenninger, III, Lawrence E. Crooks, Mitsuaki Arakawa, Jerome R. Singer
  • Patent number: 4594325
    Abstract: Human lymphoblastoid cell line capable of acting as a fusion partner in the preparation of hybridomas is grown and selected under conditions whereby a cell line is obtained having greatly enhanced fusion efficiency over the parent cell line. The cell line is derived from UC 729 by growing in Iscove's modified serum-free medium with plating at relatively high densities, followed by cloning at limiting dilutions and selecting for high frequency fusion.The subject cell line referred to as WI-L2-729 HF.sub.2 has the A.T.C.C. designation number CRL 8062, having been deposited on Apr. 2, 1981.
    Type: Grant
    Filed: March 26, 1981
    Date of Patent: June 10, 1986
    Assignee: The Regents of the University of Calif.
    Inventor: Robert L. Lundak