Patents Assigned to The Regents of the University of California
  • Patent number: 11041023
    Abstract: The present disclosure generally relate to chimeric antigen receptors (CARs) that bind an engulfment receptor expressed on the surface of a phagocytic cell and activate the endogenous phagocytic signaling pathway. Also disclosed are compositions and methods useful for producing such CARs, nucleic acids encoding same, phagocytic cells that have been modified to include a targeted effector activity directed towards a cell of interest such as, e.g., a cancer cell, as well as for modifying a cell and/or for the treatment of various health disorders such as cancer, including solid tumor and hematologic malignancy.
    Type: Grant
    Filed: March 17, 2020
    Date of Patent: June 22, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Ronald D. Vale, Meghan A. Morrissey, Adam P. Williamson
  • Patent number: 11041850
    Abstract: Methods are provided for detecting a glycosylated target protein in a sample. Aspects of the methods include: (a) contacting a sample comprising a probe-labeled glycosylated target protein with: (i) a first conjugate comprising a first nucleic acid tag linked to a first capture agent that specifically binds the target protein; (ii) a second conjugate comprising a second nucleic acid tag linked to a second capture agent that specifically binds the probe; and (iii) a bridging nucleic acid that hybridizes to the first and second nucleic acid tags; under conditions sufficient to specifically bind the first and second capture agents to the probe-labeled target protein and to hybridize the bridging nucleic acid to the first and second nucleic acid tags to produce a nucleic acid complex; and (b) detecting the nucleic acid complex. Also provided are compositions and kits useful in practicing various embodiments of the subject methods.
    Type: Grant
    Filed: July 6, 2016
    Date of Patent: June 22, 2021
    Assignee: The Regents of the University of California
    Inventors: Carolyn R. Bertozzi, Peter V. Robinson, Cheng-Ting Tsai
  • Patent number: 11042982
    Abstract: An ultra-dense electrode-based brain imaging system with high spatial and temporal resolution. A Sparsity and Smoothness enhanced Method Of Optimized electrical TomograpHy (s-SMOOTH) based reconstruction technique to improve the spatial resolution and localization accuracy of reconstructed brain images is described. Also described is a graph Fractional-Order Total Variation (gFOTV) based reconstruction technique to improve the spatial resolution and localization accuracy of reconstructed brain images.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: June 22, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Wentai Liu, Ying Li, Jing Qin, Chi-Wei Chang, Yi-Kai Lo
  • Patent number: 11043843
    Abstract: Many embodiments provide an implant power management unit (IPMU) that includes a reconfigurable active rectifier (AR) for wireless power transfer (WPT), where the AR is configurable to operate in a plurality of different modes of operation, an adaptive load control (ALC) unit that accommodates power delivery with load requirements, where the ALC unit is configured to control AR voltage based upon a desired value, control circuitry that is configured to enable a full bridge rectifier in a regular mode of operation of the AR, a feedback circuit that adaptively generates offset current to compensate for switch delays in at least one active NMOS diode, and a feedback circuit that adaptively generates offset current to compensate switch delays in at least one active PMOS diode.
    Type: Grant
    Filed: January 22, 2018
    Date of Patent: June 22, 2021
    Assignee: The Regents of the University of California
    Inventors: Dejan Rozgic, Dejan Markovic
  • Patent number: 11040091
    Abstract: The invention provides methods for treating, ameliorating or protecting (preventing) an individual or a patient having or at risk of having heart disease or heart failure, or decreased cardiac function, comprising: providing a cyclic adenosine monophosphate-incompetent (cAMP-incompetent) adenylyl cyclase type 6 (AC6) protein or polypeptide (also called “an AC6mut”), or an AC6mut-encoding nucleic acid or a gene operatively linked to a transcriptional regulatory sequence.
    Type: Grant
    Filed: June 4, 2014
    Date of Patent: June 22, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: H. Kirk Hammond, Mei Hua Gao
  • Patent number: 11040395
    Abstract: A metal matrix nanocomposite includes: 1) a matrix including one or more metals; and 2) nanostructures uniformly dispersed and stabilized in the matrix at a volume fraction, including those greater than about 3% of the nanocomposite.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: June 22, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Xiaochun Li, Jiaquan Xu
  • Patent number: 11040898
    Abstract: A method includes: (1) using a chelating agent, extracting divalent ions from a brine solution as complexes of the chelating agent and the divalent ions; (2) using a weak acid, regenerating the chelating agent and producing a divalent ion salt solution; and (3) introducing carbon dioxide to the divalent ion salt solution to induce precipitation of the divalent ions as a carbonate salt. Another method includes: (1) combining water with carbon dioxide to produce a carbon dioxide solution; (2) introducing an ion exchanger to the carbon dioxide solution to induce exchange of alkali metal cations included in the ion exchanger with protons included in the carbon dioxide solution and to produce a bicarbonate salt solution of the alkali metal cations; and (3) introducing a brine solution to the bicarbonate salt solution to induce precipitation of divalent ions from the brine solution as a carbonate salt.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: June 22, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Gaurav Sant, Zongsu Wei, Bu Wang, Erika Callagon La Plante, Dante Simonetti
  • Patent number: 11041201
    Abstract: Provided are polynucleotides that find use, e.g., for detecting RNase activity. In certain embodiments, the polynucleotide comprises a tRNA operably linked to a pre-microRNA (pre-miRNA), and an aptamer that binds to a detectable label. According to some embodiments, the detectable label is a fluorescent dye, non-limiting examples of which include malachite green, tetramethylrosamine, sulforhodamine B, and a triphenylmethane dye. Also provided are compositions that include the polynucleotides of the present disclosure. Also provided are kits that include a polynucleotide of the present disclosure and a detectable label to which the aptamer of the polynucleotide binds.
    Type: Grant
    Filed: September 20, 2019
    Date of Patent: June 22, 2021
    Assignee: The Regents of the University of California
    Inventor: Aiming Yu
  • Publication number: 20210183493
    Abstract: Systems and methods for tracking activities from a plurality of multimodal inputs are described. Activity tracking can include receiving a plurality of multimodal inputs, synchronizing the plurality of multimodal inputs, generating segments from the synchronized multimodal inputs, recognizing activities associated with each generated segment by performing a bagged formal concept analysis (BFCA), and recording the recognized activities in a storage. Tracking of activities can include the detection of moments (e.g., eating moments), during which an activity tracking application can prompt a user for information (e.g., a food journal).
    Type: Application
    Filed: October 23, 2018
    Publication date: June 17, 2021
    Applicant: The Regents of the University of California
    Inventors: Hyungik Oh, Ramesh C. Jain, Laleh Jalali
  • Publication number: 20210181673
    Abstract: A method for lens-free imaging of a sample or objects within the sample uses multi-height iterative phase retrieval and rotational field transformations to perform wide FOV imaging of pathology samples with clinically comparable image quality to a benchtop lens-based microscope. The solution of the transport-of-intensity (TIE) equation is used as an initial guess in the phase recovery process to speed the image recovery process. The holographically reconstructed image can be digitally focused at any depth within the object FOV (after image capture) without the need for any focus adjustment, and is also digitally corrected for artifacts arising from uncontrolled tilting and height variations between the sample and sensor planes. In an alternative embodiment, a synthetic aperture approach is used with multi-angle iterative phase retrieval to perform wide FOV imaging of pathology samples and increase the effective numerical aperture of the image.
    Type: Application
    Filed: November 19, 2020
    Publication date: June 17, 2021
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Aydogan Ozcan, Alon Grinbaum, Yibo Zhang, Alborz Feizi, Wei Luo
  • Publication number: 20210177770
    Abstract: Compositions useful in the controlled delivery of therapeutic agents and their methods of preparation and use are provided. The compositions comprise an optionally oxidized porous silicon core, a layer on the surface of the porous silicon core that comprises a metal silicate, and a therapeutic agent. The compositions optionally further comprise one or more targeting agents and/or cell-penetrating agents to enable the particles to target and enter cells or tissues of interest in a treated subject.
    Type: Application
    Filed: April 14, 2017
    Publication date: June 17, 2021
    Applicants: SPINNAKER BIOSCIENCES, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Michael J. SAILOR, Jinyoung KANG, Jinmyoung JOO, Emily ANGLIN, Ester KWON, Matthew SKALAK, Sangeeta BHATIA
  • Publication number: 20210179729
    Abstract: The disclosure is related to antibodies and antibody fragments that specifically bind the CUB domain-containing protein 1 (CDCP1) and their methods and uses in treating and detecting cancers.
    Type: Application
    Filed: October 25, 2018
    Publication date: June 17, 2021
    Applicant: The Regents of the University of California
    Inventors: James A. WELLS, Alexander J. MARTINKO, Juan E. DIAZ, Michael J. HORNSBY
  • Publication number: 20210178170
    Abstract: A recharging system for recharging batteries or providing power to an implantable device includes an electric coil adapted to be coupled to the implantable device, the electric coil defining a coil interior and a coil exterior. A magnetic component is coupled to the electric coil and adapted to at least partially surround the implantable device. A mechanical actuator is attached to the magnetic component, the mechanical actuator converting compression motion into motion of the magnetic component relative to the electric coil.
    Type: Application
    Filed: December 16, 2020
    Publication date: June 17, 2021
    Applicant: The Regents of the University of California
    Inventors: William J. Agnew, William C. Tang, Zachary Siu, Brittanie Chu, Joshua Wang
  • Publication number: 20210180136
    Abstract: Compositions and methods for diagnosis or treatment of epilepsy disease with EFHC1, EFHC1 agonists, or EFHC1 analogs are provided. Compositions and methods for diagnosis or treatment of epilepsy disease with EFHC1a, EFHC1a agonists, or EFHC1a analogs are provided.
    Type: Application
    Filed: February 8, 2021
    Publication date: June 17, 2021
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, RIKEN, INSTITUTO NACIONAL DE NEUROLOGIA Y NEUROCIRUGIA MANUEL VELASCO SUAREZ, U.S. GOVERNMENT REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Antonio V. Delgado-Escueta, Kazuhiro Yamakawa, Toshimitsu Suzuki, Marco Tulio Medina-Hernandez, Maria Elisa Alonso Vilatela
  • Patent number: 11033760
    Abstract: A radiotherapy system and method for delivering radiotherapy are provided. In some aspects, the radiotherapy system includes beam director comprising a radiation source configured to generate radiation for irradiating a patient, the beam director having at least four degrees of freedom of movement. The radiotherapy system also includes a controller configured to operate the beam director to irradiate the patient in accordance with a radiation treatment plan, wherein the radiation treatment plan is generated based on a solution space determined by the at least four degrees of freedom of movement of the beam director.
    Type: Grant
    Filed: March 24, 2018
    Date of Patent: June 15, 2021
    Assignees: The Regents of the University of California, Radiabeam Systems, LLC
    Inventors: Ke Sheng, Salime M. Boucher
  • Patent number: 11033640
    Abstract: The present invention provides particulate contrast media for use in CT imaging. In an exemplary embodiment, the invention provides an enteric contrast medium formulation based on particles of low-Z elements selected from microparticles and nanoparticles. In various embodiments, the particles are coated with a material compatible with enteric administration of the formulation to a subject in need of such administration. The invention also provides methods for imaging of body parts simultaneously enhanced with contrast media of the invention and with other contrast media of a different type using CT imaging, including dual energy or spectral CT imaging. The invention also provides methods for the digital separation of CT signal produced by the contrast media of the invention from the CT signal produced by other contrast media or bodily tissues, to generate multiple resultant CT images with individual contrast materials subtracted or highlighted.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: June 15, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Benjamin M. Yeh, Yanjun Fu, Tejal Desai
  • Patent number: 11033321
    Abstract: A new method for the ablation of undesirable tissue such as cells of a cancerous or non-cancerous tumor is disclosed. It involves the placement of electrodes into or near the vicinity of the undesirable tissue through the application of electrical pulses causing irreversible electroporation of the cells throughout the entire area of the undesirable tissue. The electric pulses irreversibly permeate the cell membranes, thereby invoking cell death. The irreversibly permeabilized cells are left in situ and are removed by the body immune system. The amount of tissue ablation achievable through the use of irreversible electroporation without inducing thermal damage is considerable.
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: June 15, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Rafael Davalos, Boris Rubinsky
  • Patent number: 11033588
    Abstract: Provided herein are, inter alia, microbial compositions and methods of using the same. The microbial compositions provided include, inter alia, therapeutically effective amounts of Lactobacillus johnsonii, Faecalibacterium prausnitzii, Akkermansia muciniphila, Myxococcus xanthus and Pediococcus pentosaceus and are particularly useful for methods of treating and preventing inflammatory diseases.
    Type: Grant
    Filed: August 26, 2019
    Date of Patent: June 15, 2021
    Assignee: The Regents of the University of California
    Inventors: Susan Lynch, Nikole Kimes, Din Lin, Ricardo Valladares, Kei Fujimura
  • Patent number: 11033584
    Abstract: Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-? chain and a heterologous TCR-? chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: June 15, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Theodore Lee Roth, Eric Shifrut, Alexander Marson, Cristina Puig Saus, Antoni Ribas
  • Patent number: 11033736
    Abstract: In one example embodiment, a neuromodulation system for inducing locomotor activity in a mammal, in cooperation with a signal generator and an electrode, delivers a signal with an overlapping high frequency pulse to a mammal.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: June 15, 2021
    Assignee: The Regents of the University of California
    Inventors: Victor Reggie Edgerton, Yuri P. Gerasimenko, Nicholas A. Terrafranca, Daniel C. Lu