Patents Assigned to The Regents of the University of California
  • Publication number: 20250046069
    Abstract: A deep learning-based virtual HER2 IHC staining method uses a conditional generative adversarial network that is trained to rapidly transform autofluorescence microscopic images of unlabeled/label-free breast tissue sections into bright-field equivalent microscopic images, matching the standard HER2 IHC staining that is chemically performed on the same tissue sections. The efficacy of this staining framework was demonstrated by quantitative analysis of blindly graded HER2 scores of virtually stained and immunohistochemically stained HER2 whole slide images (WSIs). A second quantitative blinded study revealed that the virtually stained HER2 images exhibit a comparable staining quality in the level of nuclear detail, membrane clearness, and absence of staining artifacts with respect to their immunohistochemically stained counterparts.
    Type: Application
    Filed: November 30, 2022
    Publication date: February 6, 2025
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Aydogan Ozcan, Yair Rivenson, Bijie Bai, Hongda Wang
  • Publication number: 20250042956
    Abstract: The present disclosure relates to recombinant transcriptional repressor polypeptides that are capable of being targeted to specific loci, as well as methods of using these recombinant polypeptides for reducing expression of a target nucleic acid in plants.
    Type: Application
    Filed: December 2, 2022
    Publication date: February 6, 2025
    Applicant: The Regents of the University of California
    Inventors: Steve E. JACOBSEN, Ming WANG
  • Publication number: 20250042774
    Abstract: Radiative cooling enabled passive freezing desalination processes are described. High salinity water can be desalinated via radiative cooling-driven freezing desalination. The passive freezing desalination processes can be a complementary method to solar desalination to enable 24-hour, year round passive thermal desalination.
    Type: Application
    Filed: April 27, 2023
    Publication date: February 6, 2025
    Applicant: The Regents of the University of California
    Inventors: Xin Huang, Aaswath Pattabhi Raman, Jyotirmoy Mandal
  • Publication number: 20250041249
    Abstract: Compositions and methods for delivery of oleoylethanolamide (OEA) in a bioavailable formulation that reduces lipid accumulation in the liver of a subject. Described herein is a novel OEA formulation that allows for compound vehiculation to the liver parenchyma, where this natural lipid amide exerts its anti-steatosis effects. This formulation provides a significantly greater oral bioavailability than either non-formulated OEA or a different formulation of OEA (Levagen®-OEA). Moreover, oral administration of the novel OEA formulation attenuates liver steatosis produced in a mouse model of human metabolic syndrome. The composition is useful in the treatment of human non-alcoholic liver steatosis.
    Type: Application
    Filed: December 12, 2022
    Publication date: February 6, 2025
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Daniele Piomelli, Lin Lin
  • Publication number: 20250041034
    Abstract: A suction enabled dental instrument apparatus is disclosed. In at least one embodiment, the apparatus provides an elongate handpiece having a working end and an opposing interface end. A terminal face of the working end of the handpiece provides an instrument opening sized and configured for allowing an instrument end of an instrument portion positioned within the handpiece to extend a distance therethrough. A main lumen is positioned within the handpiece in fluid communication with the instrument opening and a fluid source for selectively delivering a volume of fluid from the fluid source during use of the apparatus. At least one suction lumen is also positioned within the handpiece in fluid communication with the instrument opening and a suction source for capturing fluids and dental spray generated proximal to the instrument opening during use of the apparatus for the suction source to subsequently remove.
    Type: Application
    Filed: September 19, 2022
    Publication date: February 6, 2025
    Applicant: The Regents of the University of California
    Inventors: Petra Beate Wilder Smith, Cherie Yvette Wink, Tom Milner, Scott Jenney, Thair Takesh, Peter Jang, Benjamin Emerson Dolan
  • Patent number: 12213934
    Abstract: An exoskeleton leg is wearable by a person. The exoskeleton includes a thigh link configured to move in unison with the thigh of the person, a shank link rotatably coupled to the thigh link and comprising at least one tooth, and a locking block coupled to the thigh link and comprising a locking face. Moreover, when the at least one tooth of the shank link contacts with the locking face, the shank link is prevented from flexion motion relative to the thigh link, but is allowed to extend relative to the thigh link.
    Type: Grant
    Filed: March 22, 2021
    Date of Patent: February 4, 2025
    Assignees: The Regents of the University of California, suitX, Inc.
    Inventors: Wayne Tung, Minerva V. Pillai, James Hatch, Homayoon Kazerooni, Theerapat Yangyuenthanasan, Yusuke Maruo, David Cuban
  • Patent number: 12214340
    Abstract: A method of upcycling polymers to useful hydrocarbon materials. A catalyst with nanoparticles on a substrate selectively docks and cleaves longer hydrocarbon chains over shorter hydrocarbon chains. The catalyst includes metal nanoparticles in an order array on a substrate.
    Type: Grant
    Filed: January 13, 2023
    Date of Patent: February 4, 2025
    Assignees: UCHICAGO ARGONNE, LLC, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION, CORNELL UNIVERSITY, NORTHWESTERN UNIVERSITY, AN ILLINOIS NOT-FOR-PROFIT CORPORATION, IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventors: Massimiliano Delferro, Magali S. Ferrandon, Kenneth R. Poeppelmeier, Aaron D. Sadow, Susannah Scott, Anne M. LaPointe, Geoffrey Coates
  • Patent number: 12215327
    Abstract: The present disclosure provides genetically modified host cells that produce a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative. The present disclosure provides methods of synthesizing a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative.
    Type: Grant
    Filed: November 14, 2022
    Date of Patent: February 4, 2025
    Assignee: The Regents of the University of California
    Inventors: Jay D. Keasling, Leo D'Espaux, Jeff Wong, Xiaozhou Luo, Michael Reiter, Charles Denby, Anna Lechner
  • Patent number: 12213977
    Abstract: The current methods and compositions provide for a novel therapeutic method for treating patients diagnosed with melanoma, especially those that have become resistant to certain other therapies. Accordingly, certain aspects of the disclosure relate to a method for treating melanoma in a subject, the method comprising administering a composition comprising a ferroptosis-inducing agent or other dedifferentiated melanoma-targeting agent to the subject.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: February 4, 2025
    Assignee: The Regents of the University of California
    Inventors: Thomas G. Graeber, Jennifer Tsoi, Antoni Ribas, Lidia Robert, Nicolaos Palaskas
  • Patent number: 12215377
    Abstract: The present disclosure relates to methods using CRISPR-Cas13a enzyme, complexed with HIV or HCV crRNAs to specifically and sensitively detect and quantify the presence of HIV or HCV RNA in a sample. These methods can be used to diagnose HIV or HCV infection, quantify the concentration of HIV or HCV RNA present in a sample, identify the presence of different HIV or HCV splice variants, subtypes, or mutations, and to monitor reactivation of HIV or HCV transcription.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: February 4, 2025
    Assignees: The J. David Gladstone Institute, a testamentary trust established under the Will of J. David Gladstone, The Regents of the University of California
    Inventors: Parinaz Fozouni, Melanie Ott, Jennifer A. Doudna
  • Patent number: 12214014
    Abstract: This invention describes methods for treating wound healing pathologies, inhibiting or reversing fibrotic skin disorders, including but not limited to keloids, atrophic and hypertrophic scars, and reversing skin aging via generating new dermal adipocytes (DAs). Methods described herein comprise (a) grafting of human hair follicles or (b) direct delivery of conditioned media from in vitro cultured hair follicles, or (c) delivery of purified individual factors secreted by hair follicles, or (d) delivery of small molecule agonists that mimic hair derived signaling activities, or (e) delivery of small molecule antagonists that inhibit anti-adipogenic programs, or (f) delivery of small molecule agonists of pro-adipogenic programs to convert endogenous wound or scar skin fibroblasts into new DAs.
    Type: Grant
    Filed: January 3, 2018
    Date of Patent: February 4, 2025
    Assignees: The Trustees of the University of Pennsylvania, The Regents of the University of California
    Inventors: George Cotsarelis, Christian F. Guerrero-Juarez, Maksim Plikus
  • Patent number: 12215343
    Abstract: The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
    Type: Grant
    Filed: December 22, 2021
    Date of Patent: February 4, 2025
    Assignees: The Regents of the University of California, University of Vienna
    Inventors: Jennifer A. Doudna, Martin Jinek, Krzysztof Chylinski, Emmanuelle Charpentier
  • Patent number: 12215975
    Abstract: Processes and systems for adaptive pedestrian inertial navigation are provided. Configurations can adjust to various navigation scenarios, including different floor types and different gait paces. A combination of IMU data partition, principal component analysis (PCA), and artificial neural network may be used to perform the floor type detection. Floor type results may be used in the multiple-model extended Kalman filter. In each extended Kalman filter, an adaptive threshold is used for the stance phase detection to enable the detector to adjust to gait frequency without tuning design parameters during navigation. A floor type classification of high accuracy is demonstrated, and the position error in a velocity-changing navigation system using adaptive threshold is reduced.
    Type: Grant
    Filed: August 6, 2021
    Date of Patent: February 4, 2025
    Assignee: The Regents of the University of California
    Inventors: Yusheng Wang, Andrei M. Shkel
  • Patent number: 12218344
    Abstract: Nanoporous carbon coated lithium vanadium fluorophosphate materials and cathodes for fast charging li-ion batteries are described. Formation of the materials using polymer-templating is also described.
    Type: Grant
    Filed: January 5, 2022
    Date of Patent: February 4, 2025
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Sarah H. Tolbert, Terri C. Lin
  • Patent number: 12218609
    Abstract: The present invention provides for a modified virus, such as a recombinant M13 phage, which in an array, such as a film, is capable of producing piezoelectricity. The modified virus comprises a coat protein can displays a negatively charged amino acid sequence. The present invention provides for a device comprising a piezoelectric element comprising a suitable virus, such as the modified virus, a first surface and a second surface, wherein the first surface is in contact with a first electrode and the second surface is in contact with a second electrode, wherein when pressure is applied to the film, the film is capable of generating an electric current. The present invention provides for a method of making the device, and a method for generating electricity using the device.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: February 4, 2025
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Seung-Wuk Lee, Byung Yang Lee
  • Patent number: 12213770
    Abstract: A portable device for quantitative measurement of tissue autoregulation and neurovascular coupling via portable measurement of blood flow, oxygenation, metabolism, and/or EEG signals and methods for using said device. The device may comprise a body and a plurality of legs pivotably attached to the body. The plurality of legs may comprise at least one reference electrode leg and at least one measurement electrode leg for electrical measurement, and an optical detection fiber leg and at least one optical source fiber leg for optical blood flow, oxygenation, and metabolism measurement. The present invention is additionally directed to a portable device for blood flow measurement and therapeutic photobiomodulation. The device may comprise a body and a plurality of legs. The plurality of legs may comprise at least one optical detection fiber leg and at least one optical source fiber leg, and at least one leg for therapeutic photobiomodulation.
    Type: Grant
    Filed: July 15, 2021
    Date of Patent: February 4, 2025
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Yama Akbari, Robert H. Wilson, Christian Crouzet, Thomas Milner, Bernard Choi
  • Publication number: 20250032544
    Abstract: The invention provides recombinant CD47 engager receptor proteins comprising an intracellular domain that enhances an immune response in a cell when the CD47 engager receptor protein binds to CD47 on a target cell. The invention also provides cells comprising the CD47 engager receptor proteins. The CD47 engager receptor protein may be a switched Signal Regulatory Protein Alpha (SIRP?) receptor (SIRP? switch receptors) and cells that comprise them (SIRP? switch cells). SIRP? switch receptors recognize CD47 on target tumor cells and transmit an intracellular signal within the SIRP? switch cells that upregulates natural killer cell (NK), T cell, and macrophage activity. The result is increased tumor cell killing.
    Type: Application
    Filed: December 7, 2022
    Publication date: January 30, 2025
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: Tobias Deuse
  • Patent number: 12209936
    Abstract: Interstory drift measurement systems and methods of using the same can include a laser beam source configured to emit a beam having at least a first width in a first direction and a sensor system comprising a plurality of diodes spaced apart from one another in the first direction. The plurality of diodes can include a first diode and a diode spacing width in the first direction as measured between a centerline of the first diode and a centerline of an adjacent diode of the plurality of diodes in the first direction. The beam width in the first direction is at least two times the diode spacing width.
    Type: Grant
    Filed: January 14, 2021
    Date of Patent: January 28, 2025
    Assignees: Nevada Research & Innovation Corporation, The Regents of the University of California
    Inventors: David B. McCallen, Patrick Laplace, Floriana Petrone
  • Patent number: 12208025
    Abstract: A transtibial prosthetic device comprises a pylon configured as a unitary truss structure formed of a plurality of elongated supports interconnected at nodes and having open spaces between supports of the plurality of elongated supports. The unitary truss structure comprises a polymer. A foot-ankle complex extends from a base of the pylon. The foot-ankle complex comprises an s-shaped posterior portion, an s-shaped anterior portion, and a sole portion. The s-shaped posterior portion and the s-shaped anterior portion both extend from the sole portion, have upper portions with curvatures that are concentric with each other, and are separated from each other by a gap.
    Type: Grant
    Filed: February 19, 2024
    Date of Patent: January 28, 2025
    Assignee: The Regents of The University of California
    Inventors: Joshua Pelz, Luca De Vivo, Falko Kuester, Herbert J. Barrack
  • Patent number: PP36420
    Abstract: ‘UC Surfline’ is a highly productive disease-resistant short-day cultivar that provides high yields in both the early season and late season.
    Type: Grant
    Filed: April 17, 2023
    Date of Patent: February 4, 2025
    Assignee: The Regents of the University of California
    Inventors: Steven J. Knapp, Glenn S. Cole