Patents Assigned to The Regents of the University of California
-
Publication number: 20250046069Abstract: A deep learning-based virtual HER2 IHC staining method uses a conditional generative adversarial network that is trained to rapidly transform autofluorescence microscopic images of unlabeled/label-free breast tissue sections into bright-field equivalent microscopic images, matching the standard HER2 IHC staining that is chemically performed on the same tissue sections. The efficacy of this staining framework was demonstrated by quantitative analysis of blindly graded HER2 scores of virtually stained and immunohistochemically stained HER2 whole slide images (WSIs). A second quantitative blinded study revealed that the virtually stained HER2 images exhibit a comparable staining quality in the level of nuclear detail, membrane clearness, and absence of staining artifacts with respect to their immunohistochemically stained counterparts.Type: ApplicationFiled: November 30, 2022Publication date: February 6, 2025Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Aydogan Ozcan, Yair Rivenson, Bijie Bai, Hongda Wang
-
Publication number: 20250042956Abstract: The present disclosure relates to recombinant transcriptional repressor polypeptides that are capable of being targeted to specific loci, as well as methods of using these recombinant polypeptides for reducing expression of a target nucleic acid in plants.Type: ApplicationFiled: December 2, 2022Publication date: February 6, 2025Applicant: The Regents of the University of CaliforniaInventors: Steve E. JACOBSEN, Ming WANG
-
Publication number: 20250042774Abstract: Radiative cooling enabled passive freezing desalination processes are described. High salinity water can be desalinated via radiative cooling-driven freezing desalination. The passive freezing desalination processes can be a complementary method to solar desalination to enable 24-hour, year round passive thermal desalination.Type: ApplicationFiled: April 27, 2023Publication date: February 6, 2025Applicant: The Regents of the University of CaliforniaInventors: Xin Huang, Aaswath Pattabhi Raman, Jyotirmoy Mandal
-
Publication number: 20250041249Abstract: Compositions and methods for delivery of oleoylethanolamide (OEA) in a bioavailable formulation that reduces lipid accumulation in the liver of a subject. Described herein is a novel OEA formulation that allows for compound vehiculation to the liver parenchyma, where this natural lipid amide exerts its anti-steatosis effects. This formulation provides a significantly greater oral bioavailability than either non-formulated OEA or a different formulation of OEA (Levagen®-OEA). Moreover, oral administration of the novel OEA formulation attenuates liver steatosis produced in a mouse model of human metabolic syndrome. The composition is useful in the treatment of human non-alcoholic liver steatosis.Type: ApplicationFiled: December 12, 2022Publication date: February 6, 2025Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Daniele Piomelli, Lin Lin
-
Publication number: 20250041034Abstract: A suction enabled dental instrument apparatus is disclosed. In at least one embodiment, the apparatus provides an elongate handpiece having a working end and an opposing interface end. A terminal face of the working end of the handpiece provides an instrument opening sized and configured for allowing an instrument end of an instrument portion positioned within the handpiece to extend a distance therethrough. A main lumen is positioned within the handpiece in fluid communication with the instrument opening and a fluid source for selectively delivering a volume of fluid from the fluid source during use of the apparatus. At least one suction lumen is also positioned within the handpiece in fluid communication with the instrument opening and a suction source for capturing fluids and dental spray generated proximal to the instrument opening during use of the apparatus for the suction source to subsequently remove.Type: ApplicationFiled: September 19, 2022Publication date: February 6, 2025Applicant: The Regents of the University of CaliforniaInventors: Petra Beate Wilder Smith, Cherie Yvette Wink, Tom Milner, Scott Jenney, Thair Takesh, Peter Jang, Benjamin Emerson Dolan
-
Patent number: 12213934Abstract: An exoskeleton leg is wearable by a person. The exoskeleton includes a thigh link configured to move in unison with the thigh of the person, a shank link rotatably coupled to the thigh link and comprising at least one tooth, and a locking block coupled to the thigh link and comprising a locking face. Moreover, when the at least one tooth of the shank link contacts with the locking face, the shank link is prevented from flexion motion relative to the thigh link, but is allowed to extend relative to the thigh link.Type: GrantFiled: March 22, 2021Date of Patent: February 4, 2025Assignees: The Regents of the University of California, suitX, Inc.Inventors: Wayne Tung, Minerva V. Pillai, James Hatch, Homayoon Kazerooni, Theerapat Yangyuenthanasan, Yusuke Maruo, David Cuban
-
Patent number: 12214340Abstract: A method of upcycling polymers to useful hydrocarbon materials. A catalyst with nanoparticles on a substrate selectively docks and cleaves longer hydrocarbon chains over shorter hydrocarbon chains. The catalyst includes metal nanoparticles in an order array on a substrate.Type: GrantFiled: January 13, 2023Date of Patent: February 4, 2025Assignees: UCHICAGO ARGONNE, LLC, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION, CORNELL UNIVERSITY, NORTHWESTERN UNIVERSITY, AN ILLINOIS NOT-FOR-PROFIT CORPORATION, IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.Inventors: Massimiliano Delferro, Magali S. Ferrandon, Kenneth R. Poeppelmeier, Aaron D. Sadow, Susannah Scott, Anne M. LaPointe, Geoffrey Coates
-
Patent number: 12215327Abstract: The present disclosure provides genetically modified host cells that produce a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative. The present disclosure provides methods of synthesizing a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative.Type: GrantFiled: November 14, 2022Date of Patent: February 4, 2025Assignee: The Regents of the University of CaliforniaInventors: Jay D. Keasling, Leo D'Espaux, Jeff Wong, Xiaozhou Luo, Michael Reiter, Charles Denby, Anna Lechner
-
Patent number: 12213977Abstract: The current methods and compositions provide for a novel therapeutic method for treating patients diagnosed with melanoma, especially those that have become resistant to certain other therapies. Accordingly, certain aspects of the disclosure relate to a method for treating melanoma in a subject, the method comprising administering a composition comprising a ferroptosis-inducing agent or other dedifferentiated melanoma-targeting agent to the subject.Type: GrantFiled: June 27, 2018Date of Patent: February 4, 2025Assignee: The Regents of the University of CaliforniaInventors: Thomas G. Graeber, Jennifer Tsoi, Antoni Ribas, Lidia Robert, Nicolaos Palaskas
-
Patent number: 12215377Abstract: The present disclosure relates to methods using CRISPR-Cas13a enzyme, complexed with HIV or HCV crRNAs to specifically and sensitively detect and quantify the presence of HIV or HCV RNA in a sample. These methods can be used to diagnose HIV or HCV infection, quantify the concentration of HIV or HCV RNA present in a sample, identify the presence of different HIV or HCV splice variants, subtypes, or mutations, and to monitor reactivation of HIV or HCV transcription.Type: GrantFiled: September 6, 2019Date of Patent: February 4, 2025Assignees: The J. David Gladstone Institute, a testamentary trust established under the Will of J. David Gladstone, The Regents of the University of CaliforniaInventors: Parinaz Fozouni, Melanie Ott, Jennifer A. Doudna
-
Patent number: 12214014Abstract: This invention describes methods for treating wound healing pathologies, inhibiting or reversing fibrotic skin disorders, including but not limited to keloids, atrophic and hypertrophic scars, and reversing skin aging via generating new dermal adipocytes (DAs). Methods described herein comprise (a) grafting of human hair follicles or (b) direct delivery of conditioned media from in vitro cultured hair follicles, or (c) delivery of purified individual factors secreted by hair follicles, or (d) delivery of small molecule agonists that mimic hair derived signaling activities, or (e) delivery of small molecule antagonists that inhibit anti-adipogenic programs, or (f) delivery of small molecule agonists of pro-adipogenic programs to convert endogenous wound or scar skin fibroblasts into new DAs.Type: GrantFiled: January 3, 2018Date of Patent: February 4, 2025Assignees: The Trustees of the University of Pennsylvania, The Regents of the University of CaliforniaInventors: George Cotsarelis, Christian F. Guerrero-Juarez, Maksim Plikus
-
Patent number: 12215343Abstract: The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.Type: GrantFiled: December 22, 2021Date of Patent: February 4, 2025Assignees: The Regents of the University of California, University of ViennaInventors: Jennifer A. Doudna, Martin Jinek, Krzysztof Chylinski, Emmanuelle Charpentier
-
Patent number: 12215975Abstract: Processes and systems for adaptive pedestrian inertial navigation are provided. Configurations can adjust to various navigation scenarios, including different floor types and different gait paces. A combination of IMU data partition, principal component analysis (PCA), and artificial neural network may be used to perform the floor type detection. Floor type results may be used in the multiple-model extended Kalman filter. In each extended Kalman filter, an adaptive threshold is used for the stance phase detection to enable the detector to adjust to gait frequency without tuning design parameters during navigation. A floor type classification of high accuracy is demonstrated, and the position error in a velocity-changing navigation system using adaptive threshold is reduced.Type: GrantFiled: August 6, 2021Date of Patent: February 4, 2025Assignee: The Regents of the University of CaliforniaInventors: Yusheng Wang, Andrei M. Shkel
-
Patent number: 12218344Abstract: Nanoporous carbon coated lithium vanadium fluorophosphate materials and cathodes for fast charging li-ion batteries are described. Formation of the materials using polymer-templating is also described.Type: GrantFiled: January 5, 2022Date of Patent: February 4, 2025Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Sarah H. Tolbert, Terri C. Lin
-
Patent number: 12218609Abstract: The present invention provides for a modified virus, such as a recombinant M13 phage, which in an array, such as a film, is capable of producing piezoelectricity. The modified virus comprises a coat protein can displays a negatively charged amino acid sequence. The present invention provides for a device comprising a piezoelectric element comprising a suitable virus, such as the modified virus, a first surface and a second surface, wherein the first surface is in contact with a first electrode and the second surface is in contact with a second electrode, wherein when pressure is applied to the film, the film is capable of generating an electric current. The present invention provides for a method of making the device, and a method for generating electricity using the device.Type: GrantFiled: May 10, 2013Date of Patent: February 4, 2025Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Seung-Wuk Lee, Byung Yang Lee
-
Patent number: 12213770Abstract: A portable device for quantitative measurement of tissue autoregulation and neurovascular coupling via portable measurement of blood flow, oxygenation, metabolism, and/or EEG signals and methods for using said device. The device may comprise a body and a plurality of legs pivotably attached to the body. The plurality of legs may comprise at least one reference electrode leg and at least one measurement electrode leg for electrical measurement, and an optical detection fiber leg and at least one optical source fiber leg for optical blood flow, oxygenation, and metabolism measurement. The present invention is additionally directed to a portable device for blood flow measurement and therapeutic photobiomodulation. The device may comprise a body and a plurality of legs. The plurality of legs may comprise at least one optical detection fiber leg and at least one optical source fiber leg, and at least one leg for therapeutic photobiomodulation.Type: GrantFiled: July 15, 2021Date of Patent: February 4, 2025Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Yama Akbari, Robert H. Wilson, Christian Crouzet, Thomas Milner, Bernard Choi
-
Publication number: 20250032544Abstract: The invention provides recombinant CD47 engager receptor proteins comprising an intracellular domain that enhances an immune response in a cell when the CD47 engager receptor protein binds to CD47 on a target cell. The invention also provides cells comprising the CD47 engager receptor proteins. The CD47 engager receptor protein may be a switched Signal Regulatory Protein Alpha (SIRP?) receptor (SIRP? switch receptors) and cells that comprise them (SIRP? switch cells). SIRP? switch receptors recognize CD47 on target tumor cells and transmit an intracellular signal within the SIRP? switch cells that upregulates natural killer cell (NK), T cell, and macrophage activity. The result is increased tumor cell killing.Type: ApplicationFiled: December 7, 2022Publication date: January 30, 2025Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventor: Tobias Deuse
-
Patent number: 12209936Abstract: Interstory drift measurement systems and methods of using the same can include a laser beam source configured to emit a beam having at least a first width in a first direction and a sensor system comprising a plurality of diodes spaced apart from one another in the first direction. The plurality of diodes can include a first diode and a diode spacing width in the first direction as measured between a centerline of the first diode and a centerline of an adjacent diode of the plurality of diodes in the first direction. The beam width in the first direction is at least two times the diode spacing width.Type: GrantFiled: January 14, 2021Date of Patent: January 28, 2025Assignees: Nevada Research & Innovation Corporation, The Regents of the University of CaliforniaInventors: David B. McCallen, Patrick Laplace, Floriana Petrone
-
Patent number: 12208025Abstract: A transtibial prosthetic device comprises a pylon configured as a unitary truss structure formed of a plurality of elongated supports interconnected at nodes and having open spaces between supports of the plurality of elongated supports. The unitary truss structure comprises a polymer. A foot-ankle complex extends from a base of the pylon. The foot-ankle complex comprises an s-shaped posterior portion, an s-shaped anterior portion, and a sole portion. The s-shaped posterior portion and the s-shaped anterior portion both extend from the sole portion, have upper portions with curvatures that are concentric with each other, and are separated from each other by a gap.Type: GrantFiled: February 19, 2024Date of Patent: January 28, 2025Assignee: The Regents of The University of CaliforniaInventors: Joshua Pelz, Luca De Vivo, Falko Kuester, Herbert J. Barrack
-
Patent number: PP36420Abstract: ‘UC Surfline’ is a highly productive disease-resistant short-day cultivar that provides high yields in both the early season and late season.Type: GrantFiled: April 17, 2023Date of Patent: February 4, 2025Assignee: The Regents of the University of CaliforniaInventors: Steven J. Knapp, Glenn S. Cole