Patents Assigned to The Regents of the University of California
  • Patent number: 10735005
    Abstract: A digital fractional-N phase locked loop (PLL) with multi-rate dynamic element matching (DEM) and an adaptive mismatch-noise cancellation (MNC) is provided. The PLL includes a phase error to digital converter and a digital loop filter to suppress quantization noise of the phase error to digital converter and drive a digitally controlled oscillator. A digitally controlled oscillator (DCO) with a multi-rate DEM encoder includes an integer bank of frequency control elements (FCE) and a fractional bank of frequency control elements. Adaptive mismatch-noise cancellation logic operates to cancel DCO phase error arising from frequency control element (FCE) static and dynamic mismatch error by estimating ideal MNC coefficient values during PLL normal operation, estimating MNC coefficient errors at each sample time, and updating the MNC coefficient values to approach zero (FCE) static and dynamic mismatch error.
    Type: Grant
    Filed: August 21, 2019
    Date of Patent: August 4, 2020
    Assignee: The Regents of the University of California
    Inventors: Ian Galton, Enrique Alvarez-Fontecilla
  • Patent number: 10731236
    Abstract: A composition includes tungsten (W); at least one element selected from the group of elements consisting of boron (B), beryllium (Be) and silicon (Si); and at least one element selected from the group of elements consisting of titanium (Ti), vanadium (V), chromium (Cr), manganese (Mn), iron (Fe), cobalt (Co), nickel (Ni), copper (Cu), zinc (Zn), zirconium (Zr), niobium (Nb), molybdenum (Mo), ruthenium (Ru), hafnium (Hf), tantalum (Ta), rhenium (Re), osmium (Os), iridium (Ir), lithium (Li) and aluminum (Al). The composition satisfies the formula W1-xMxXy wherein X is one of B, Be and Si; M is at least one of Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Zr, Nb, Mo, Ru, Hf, Ta, Re, Os, Ir, Li and Al; x is at least 0.001 and less than 0.999; and y is at least 4.0. A tool is made from or coated with this composition.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: August 4, 2020
    Assignee: The Regents of the University of California
    Inventors: Richard B. Kaner, Sarah H. Tolbert, Reza Mohammadi, Andrew T. Lech, Miao Xie
  • Patent number: 10734167
    Abstract: A porous interconnected corrugated carbon-based network (ICCN) composite and methods for making the same are disclosed. The porous ICCN composite is made up of a plurality of carbon layers that are interconnected and expanded apart from one another to form a plurality of pores. Metallic nanoparticles are disposed within the plurality of pores. In one embodiment, a light exposure only based method for producing the porous ICCN composite is disclosed. In another embodiment a light exposure plus an electrodeposition method for producing the porous ICCN composite is disclosed. In yet another exemplary embodiment, a capacitor having a first electrode and a second electrode separated from the first electrode by a dielectric wherein at least one of the first electrode and the second electrode is formed from the porous ICCN composite is disclosed.
    Type: Grant
    Filed: November 18, 2015
    Date of Patent: August 4, 2020
    Assignee: The Regents of the University of California
    Inventors: Maher F. El-Kady, Richard B. Kaner, Jee Youn Hwang
  • Patent number: 10729668
    Abstract: Disclosed herein are methods for (a) treating, inhibiting, or reducing aging of a subject, (b) treating, inhibiting, or reducing an age-related symptom or an age-related disease in a subject, and/or (c) increasing the lifespan of a subject which comprise administering to the subject one or more ketobutyrate compounds and compositions thereof.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: August 4, 2020
    Assignee: The Regents of the University of California
    Inventors: Jing Huang, Randall M. Chin, Xudong Fu, Heejun Hwang, Karen Reue, Laurent Vergnes, Meisheng Jiang, Brett E. Lomenick, Xiang Yin, Mansoureh Eghbali, Jingyuan Li, Samuel Wheeler French, Ronik Khachatoorian
  • Patent number: 10734649
    Abstract: A synthetic metal dichalcogenide having a highly defected nanocrystalline layered structure, wherein layer spacing is larger than in perfect crystals of the same material, wherein the defected structure provides access to interlayer crystals of the same material, and wherein the defected structure facilitates a pseudocapacitive charge storage mechanism. The metal dichalcogenide is receptive to intercalation of ions such as Li ions, Na ions, Mg ions, and Ca ions, and does not undergo a phase transition upon intercalation of Li ions, Na ions, Mg ions, or Ca ions. The metal dichalcogenide can be used, for example, as a component of an electrode that also includes a carbon derivative, and a binder, which are intermixed to form the electrode. The resultant composite electrode is highly porous and highly electronically conductive, and is suitable for use in devices such as symmetric capacitors, asymmetric capacitors, rocking chair batteries, and other devices.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: August 4, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Sarah H. Tolbert, Bruce S. Dunn, John Cook, Hyungseok Kim, Terri Chai Lin
  • Patent number: 10730848
    Abstract: Disclosed herein inter alia are compositions and methods useful in the treatment of infectious diseases and exposure to toxins.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: August 4, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Eugene Gillespie, Robert Damoiseaux, Chi-Lee Charlie Ho, Brian T. Chamberlain, Michael E. Jung, Kenneth A. Bradley
  • Patent number: 10729895
    Abstract: Provided are active agent delivery devices configured to deliver an active agent formulation into or through a mucosal layer in a subject. The active agent delivery devices include a power reservoir configured to eject the active agent formulation at a pressure sufficient to deliver the active agent formulation into or through a mucosal layer in a subject. Methods of using the subject active agent delivery devices are also provided.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: August 4, 2020
    Assignee: The Regents of the University of California
    Inventors: Kiana Aran, Jacobo Paredes, Niren Murthy, Dorian Liepmann, Kunwoo Lee
  • Patent number: 10729788
    Abstract: In alternative embodiments, provided are methods for increasing levels of and/or upregulating the expression of ApoA-I Binding Protein (APOA1BP, AIBP, or AI-BP) to treat, ameliorate, prevent, reverse, decrease the severity or duration of: a neuropathic pain, including an inflammation-induced neuropathic pain, a nerve or CNS inflammation, a, a post nerve injury pain, a post-surgical pain, a chemotherapeutic-induced peripheral neuropathy (CIPN) (e.g., cisplatin-induced allodynia) a neurodegeneration or neurodegenerative disease or condition, a migraine, and/or a hyperalgesia.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: August 4, 2020
    Assignee: The Regents of the University of California
    Inventors: Yury Miller, Tony L. Yaksh
  • Patent number: 10730864
    Abstract: The present invention includes novel RAD51 inhibitors. The compounds of the invention may be useful in preventing or treating cancer in a subject in need thereof. The present invention also includes methods of preventing or treating cancer in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of the invention.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: August 4, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jiewen Zhu, Wen-Hwa Lee, Hongyuan Chen, Xuning Guo, Xiao-Long Qiu
  • Patent number: 10729379
    Abstract: A biosensor of the invention is a capacitive noncontact sensor with two sensor channels split into a plurality of physically interdigitated symmetrical electrodes and shield sections. Two capacitive plates are electrically connected to the two sensor channels. The capacitive noncontact sensor is sized and packaged to be worn by a person to place the capacitive plates close to the skin of the person and form first and second channel input capacitors with the skin. A signal reconstruction circuit obtains a bio signal from the first and second channel input capacitors through the electrodes by reconstructing differences in the two sensor channels. The circuit includes different parasitic input capacitance in the two channels to create channel-specific outputs that depend on input coupling capacitance.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: August 4, 2020
    Assignee: The Regents of the University of California
    Inventors: Chung-Kuan Cheng, Patrick Mercier, Shih-Hung Weng
  • Patent number: 10730892
    Abstract: Probes for formaldehyde (FA) including a homoallylamine trigger group attached to a detectable moiety are provided. Aspects of the probes include luminogenic or fluorogenic probes, such as a probe including a quencher in energy-receiving proximity to a fluorophore. Also provided are methods of using the probes for sensitive and bio orthogonal detection of FA in a sample. Aspects of the methods include selectively reacting the probe with the formaldehyde in the sample to a release (e.g., via a 2-aza-Cope rearrangement) a reporter group comprising a detectable moiety. Aspects of the methods detecting formaldehyde in a cell, tissue, organ or fluid in a subject. Also provided are compositions and kits including the subject probes that find use in practicing various embodiments of the subject methods.
    Type: Grant
    Filed: August 18, 2016
    Date of Patent: August 4, 2020
    Assignee: The Regents of the University of California
    Inventors: Christopher J. Chang, Thomas Francis Brewer, Jefferson Chan
  • Patent number: 10729387
    Abstract: A system and method for generating frequency-multiplexed synthetic sound-speech stimuli and for detecting and analyzing electrical brain activity of a subject in response to the stimuli. Frequency-multiplexing of speech copora and synthetic sounds helps the composite sound to blend into a single auditory object. The synthetic sounds are temporally aligned with the utterances of the speech corpus. Frequency multiplexing may include splitting the frequency axis into alternating bands of speech and synthetic sound to minimize the disruptive interaction between the speech and synthetic sounds along the basilar membrane and in their neural representations. The generated stimuli can be used with both traditional and advanced techniques to analyze electrical brain activity and provides a rapid, synoptic view into the functional health of the early auditory system, including how speech is processed at different levels and how these levels interact.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: August 4, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Lee Miller, Bartlett Moore, IV
  • Patent number: 10729822
    Abstract: Disclosed herein are compositions to use in biofouling-resistant coatings, biofouling-resistant coatings, methods of making biofouling-resistant coatings, biofouling-resistant devices, and methods of making biofouling-resistant devices.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: August 4, 2020
    Assignees: The Regents of the University of California, Hydrophilix, Inc.
    Inventors: Richard B. Kaner, Dayong Chen, Brian T. McVerry, Ethan Rao, Alexandra L. Polasko
  • Patent number: 10729121
    Abstract: A biodegradable bait station is disclosed that can be used with liquid baits targeting pest ants in urban, agricultural, and natural setting, which can overcome several limitations that most of other liquid bait stations currently experience. For example, instead of keeping a large quantity of liquid bait in a reservoir, a small amount, for example, 10-20 ml of sugary liquid bait with an insecticide, for example, boric acid, thiamethoxam, imidacloprid, will be contained in a biodegradable cylindrical container with one open end. The open end will be plugged with a piece of water absorbent polymer or gel, for example, polyacrylamide gel, sodium alginate. The water absorbent polymer or gel absorbs the liquid bait and expands inside of the cylindrical container so that it will function as a polymer “wick” to deliver a small amount of the liquid bait to foraging ants.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: August 4, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Dong-Hwan Choe, Michael K. Rust, Mark Hoddle, Ashok Mulchandani
  • Patent number: 10729747
    Abstract: The present invention discloses methods and compositions for treating or ameliorating a condition associated with increased or decreased myofibroblast activities and use thereof.
    Type: Grant
    Filed: May 7, 2019
    Date of Patent: August 4, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: B. Chia Soo, Kang Ting, Zhong Zheng
  • Patent number: 10729167
    Abstract: An automated apparatus for removing the tops (calyx) of strawberries as they move along a conveyor belt having a plurality of concave-shaped slotted rollers which operate to orient the calyx of each strawberry for being cut. Images are captured and processed for locating the calyx of each strawberry and determining an optimal cutting plane. In response to the image processing a control system actuates a blade in a cutting apparatus to pass through the produce item and into one of the slots in a roller, or rollers, to separate the calyx from the body of the strawberry.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: August 4, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Stavros Vougioukas, David Slaughter, Dennis Sadowski, Long He, Adrien Durand-Petiteville
  • Patent number: 10729610
    Abstract: Semi-passive control system (10) comprises a pneumatic spring actuator (16), a pressure regulator (22) in communication with the pneumatic spring actuator (16), a hydraulic locking actuator (18), a hydraulic valve (20) in communication with actuator (18), a power source (14), a pulley wheel (42), and a cable (46) having a first end in contact with pulley wheel (42), first and second side portions (50, 56) extending from opposing sides of pulley wheel (42), and a second end adapted to connect to an orthosis device (76). At least one cable clamp (62) attaches to second side portion (56) of cable (46) and interconnects cable (46) to shafts (112b, 118b) of actuators (16, 18). A central control unit (12) includes a processor (13a) and a computer readable storage medium (13b) having program instructions stored thereon for execution by the central control unit to adjust stiffness, damping or stiffness and damping parameters.
    Type: Grant
    Filed: February 18, 2016
    Date of Patent: August 4, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Robert Peter Matthew, Eric John Mica, Waiman Meinhold, Joel Alfredo Loeza, Ruzena Bajcsy, Masayoshi Tomizuka
  • Patent number: 10729344
    Abstract: A system and method to extract the timing of ECG events without reliance on ECG. The system and method are based on effects of scalp pulsation (due to blood flow) on electrode location. The electrodes in the system with the closest proximity to the facial arteries are re-referenced to create a [Mean Left-Mean Right] signal (LRM). A constrained peak detection algorithm is then used to find the BCG events. Finally, an automatic error checking and correction algorithm based on inter-beat timing is applied.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: August 4, 2020
    Assignee: The Regents of the University of California
    Inventors: Cameron Rodriguez, Mark S. Cohen, Agatha Lenartowicz
  • Patent number: 10729354
    Abstract: A system and method is provided for modeling brain dynamics in normal and diseased states.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: August 4, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: Jin Hyung Lee
  • Publication number: 20200237546
    Abstract: Systems, methods, and apparatus provide artificial knees. Artificial knees include a thigh link configured to move in unison with a thigh of the person, a shank link configured to be rotatably coupled to said thigh link, and a compression spring rotatably coupled to the thigh link and coupled to a second end of shank link with a second end of the compression spring. During a first range of motion, the compression spring is configured to provide an extension torque between the thigh link and the shank link causing said artificial knee to resist flexion. After said first range of motion, the compression spring is configured to provide a flexion torque between the thigh link and the shank link encouraging said artificial knee to flex resulting in toe clearance during the swing phase. During the swing phase, the compression spring provides no torque between the thigh link and the shank link.
    Type: Application
    Filed: November 26, 2019
    Publication date: July 30, 2020
    Applicant: The Regents of the University of California
    Inventors: Shang-Li Wu, Homayoon Kazerooni