Patents Assigned to The Regents of the University of California
  • Publication number: 20190190033
    Abstract: An electrode material includes a catalyst support and Pt—Ni-M-M? nanostructures affixed to the catalyst support. M is a transition metal different from Pt and Ni, and M? is a transition metal different from Pt, Ni, and M.
    Type: Application
    Filed: August 3, 2017
    Publication date: June 20, 2019
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Yu HUANG, Zipeng ZHAO, Xiangfeng DUAN
  • Publication number: 20190190497
    Abstract: Active feedback is used with two electrodes of a four-electrode capacitive-gap transduced wine-glass disk resonator to enable boosting of an intrinsic resonator Q and to allow independent control of insertion loss across the two other electrodes. Two such Q-boosted resonators configured as parallel micromechanical filters may achieve a tiny 0.001% bandwidth passband centered around 61 MHz with only 2.7 dB of insertion loss, boosting the intrinsic resonator Q from 57,000, to an active Q of 670,000. The split capacitive coupling electrode design removes amplifier feedback from the signal path, allowing independent control of input-output coupling, Q, and frequency. Controllable resonator Q allows creation of narrow channel-select filters with insertion losses lower than otherwise achievable, and allows maximizing the dynamic range of a communication front-end without the need for a variable gain low noise amplifier.
    Type: Application
    Filed: December 4, 2018
    Publication date: June 20, 2019
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Clark T.-C. Nguyen, Thura Lin Naing, Tristan O. Rocheleau
  • Publication number: 20190185938
    Abstract: A method for determining the epigenetic age acceleration of an individual comprising measuring a methylation level of a set of methylation markers in genomic DNA of an individual. An epigenetic age of the individual is determined based on the measured methylation level. An epigenetic age of the individual is further determined based on a methylation derived weighted average cell count of naive cytotoxic T cells and exhausted cytotoxic T cells in the individual. The determined epigenetic age is then compared to a chronological age of the individual to determine an epigenetic age acceleration of the individual. Instances wherein the epigenetic age is greater than the chronological age of the individual is an indication of an increased risk of all-cause mortality.
    Type: Application
    Filed: August 7, 2017
    Publication date: June 20, 2019
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: Stefan Horvath
  • Publication number: 20190185581
    Abstract: Certain embodiments of the invention provide an antibody, or a fragment thereof, comprising a heavy chain complementarity-determining region 3 (CDR-H3) having at least about 80% sequence identity to a sequence described herein, as well as methods of use thereof.
    Type: Application
    Filed: December 18, 2018
    Publication date: June 20, 2019
    Applicant: The Regents of the University of California
    Inventors: Xin Ge, Dong Hyun Nam, Tyler Lopez
  • Publication number: 20190184805
    Abstract: A hybrid vehicle powertrain with a flywheel-based short-term energy storage system (SESS), including control and design optimization for a hybrid electric vehicle with the flywheel as a third energy storage system. The powertrain comprises three different propulsion systems including: an internal combustion engine (ICE); an electric motor (EM) with battery; and a flywheel and continuously variable transmission (CVT) that comprise the SESS.
    Type: Application
    Filed: December 20, 2018
    Publication date: June 20, 2019
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jifei Yan, Andrew Frank
  • Publication number: 20190187040
    Abstract: Systems and methods of fabricating and functionalizing patterned nanowire probes that are stable under fluid reservoir conditions and have imageable patterns are provided. Additional embodiments possess functionalized molecular groups to collect content data of desired chemical species from a fluid reservoir in order to detect even highly dilute quantities of the desire chemical species in the reservoir. Optical imaging and deconstruction methods and systems are also provided that are capable of determining the distribution of nanowires of a particular pattern to determine the mixing between or leakage from fluid reservoirs.
    Type: Application
    Filed: February 25, 2019
    Publication date: June 20, 2019
    Applicant: The Regents of the University of California
    Inventors: Paul S. Weiss, Anne M. Andrews, Andrea L. Bertozzi, Stanley J. Osher
  • Publication number: 20190183429
    Abstract: An automatic classification method for distinguishing between indolent and clinically significant carcinoma using multiparametric MRI (mp-MRI) imaging is provided. By utilizing a convolutional neural network (CNN), which automatically extracts deep features, the hierarchical classification framework avoids deficiencies in current schemes in the art such as the need to provide handcrafted features predefined by a domain expert and the precise delineation of lesion boundaries by a human or computerized algorithm. This hierarchical classification framework is trained using previously acquired mp-MRI data with known cancer classification characteristics and the framework is applied to mp-MRI images of new patients to provide identification and computerized cancer classification results of a suspicious lesion.
    Type: Application
    Filed: August 16, 2018
    Publication date: June 20, 2019
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Kyung Hyun Sung, William Hsu, Shiwen Shen, Xinran Zhong
  • Publication number: 20190184172
    Abstract: Modulation, preferably inhibition, of neurosignaling of a cardiac-related sympathetic nerve in the extracardiac intrathoracic neural circuit is effective in stabilizing cardiac electrical and/or mechanical function, thereby providing ways of treating or preventing cardiac dysfunction such as arrhythmias.
    Type: Application
    Filed: August 25, 2017
    Publication date: June 20, 2019
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, GALVANI BIOELECTRONICS LIMITED
    Inventors: Jeffrey Laurence ARDELL, Kalyanam SHIVKUMAR, Arun SRIDHAR
  • Publication number: 20190184041
    Abstract: Siderocalin-metal chelator combinations that bind metallic radioisotopes used in nuclear medicine with high affinity are described. The high affinity siderocalin-metal chelator combinations include a number of chelator backbone arrangements with functional groups that coordinate with metals. The siderocalin-metal chelator combinations can be used to deliver radionuclides for imaging and therapeutic purposes.
    Type: Application
    Filed: August 28, 2017
    Publication date: June 20, 2019
    Applicants: Fred Hutchinson Cancer Research Center, The Regents of the University of California
    Inventors: Roland K. Strong, Peter Rupert, Rebecca J. Abergel, Ilya Captain, Gauthier JP Deblonde
  • Patent number: 10322283
    Abstract: The present disclosure relates to methods, devices and systems used for the treatment of mood, anxiety, post traumatic stress disorder, and cognitive and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: June 18, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Christopher DeGiorgio, Ian A. Cook, Alejandro Covalin, Patrick R. Miller, Lara Schrader
  • Patent number: 10321684
    Abstract: Described are compositions and methods to increase bud break in order to increase aspects of one or both of plant vegetative and reproductive growth, by use of a natural metabolite. In particular, the present disclosure provides a natural metabolite either alone or as part of a fertilizer blend to increase crop production. Additionally the present disclosure provides a natural metabolite in combination with one or both of a plant growth regulator and a biostimulant to increase crop production.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: June 18, 2019
    Assignee: The Regents of the University of California
    Inventor: Carol J. Lovatt
  • Patent number: 10324018
    Abstract: Microfluidic devices, systems and techniques in connection with particle sorting in liquid, including cytometry devices and techniques and applications in chemical or biological testing and diagnostic measurements.
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: June 18, 2019
    Assignee: The Regents of the University of California
    Inventors: Yu-Hwa Lo, Chun Hao Randy Chen, Sung Hwan Cho, Shang-Feng Tsai
  • Patent number: 10322948
    Abstract: The disclosure provides relates to compositions and methods for water treatment. It also addresses a method for synthesizing TiO2 (and other metal oxides) with or without dopants. This method enables control over size, phase, morphology and porosity and specific surface area of these materials. The disclosure also provides metal oxide composites that can be used in photocatalysts, photovoltaics, and solar hydrogen applications.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: June 18, 2019
    Assignee: The Regents of the University of California
    Inventors: David Kisailus, Nichola Kinsinger
  • Patent number: 10324099
    Abstract: Provided herein are novel assays for the measurement of androgens such as testosterone in a sample. The assays utilize sensitive androgen receptor mutants and have much greater sensitivity than assays based on wild-type androgen receptors. The assays of the invention can detect androgens at concentrations as low as 1 ng/dl in serum, urine, environmental samples and other samples. The invention encompasses novel assay methods as well as nucleic acid sequences, proteins, and cells. Advantageously, the assays provide a measure of physiologically relevant androgen concentrations in a sample, taking into account the presence of androgen-binding factors or anti-androgen drugs in serum.
    Type: Grant
    Filed: March 24, 2015
    Date of Patent: June 18, 2019
    Assignee: The Regents of the University of California
    Inventor: Fred Schaufele
  • Publication number: 20190178449
    Abstract: A particle focusing system includes an inlet; an inertial focusing microchannel disposed in a substrate and connected to the inlet; and a pressure/flow source configured to drive a particle-containing fluid through the inertial focusing microchannel, where the inertial focusing microchannel includes a side wall having an irregular surface. The side wall includes a first irregularity protruding from a baseline surface away from a longitudinal axis of the inertial focusing microchannel. Alternatively or additionally, the first irregularity and the baseline surface form an angle more than or equal to 135 degrees. The inertial focusing microchannel may have a substantially rectangular cross-section having a height and a width, and a ratio of height to width is approximately 5:4 to 4:1. The system may also include a downstream expanding region having a side wall, where the side wall has a stepped surface.
    Type: Application
    Filed: February 15, 2019
    Publication date: June 13, 2019
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Dino Di Carlo, Wonhee Lee
  • Publication number: 20190175611
    Abstract: The invention comprises the administration of a remyelinating agent to treat a demyelinating condition, such as MS. Disclosed are various remyelinating compositions which promote remyelination, oligodendrocyte differentiation, and the treatment of demyelinating conditions such as MS. In one aspect, the remyelinating compositions are selective estrogen receptor modulators with remyelinating properties. In one aspect, the remyelinating compositions are agonists of GPR56, a G-protein coupled receptor which has not previously been identified as an effector of remyelination.
    Type: Application
    Filed: August 11, 2017
    Publication date: June 13, 2019
    Applicant: The Regents of the University of California
    Inventors: Riley Bove, Jonah Chan, Ari Green, Yun-An Shen, Kelsey Rankin
  • Publication number: 20190178698
    Abstract: A wireless remote monitoring system for biomedical fluid management that uses one or more sensors to detect changes in fluid or air in any container attached to a patient in order to monitor pre-surgical or post-surgical progress or complications. The sensors may be configured to monitor any type of container used to collect fluid or air from the human body, to transmit the sensor signals wirelessly to any number of devices including, but not limited to, cell phones or devices which in turn can send data to a functional repository where it can be analyzed and potentially acted upon by either a central or distributed network of providers.
    Type: Application
    Filed: November 30, 2018
    Publication date: June 13, 2019
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Dieter R. Enzmann, William J. Kaiser, Jay M. Lee
  • Publication number: 20190175532
    Abstract: The inventors have unexpectedly discovered that shock and/or potential multi-organ failure due to shock can be effectively treated by administration of liquid high-dose protease inhibitor formulations to a location upstream of where pancreatic proteases are introduced into the gastrointestinal tract. Most preferably, administration is directly to the stomach, for example, via nasogastric tube under a protocol effective to treat shock by such administration without the need of providing significant quantities of the protease inhibitor to the jejunum and/or ileum.
    Type: Application
    Filed: November 21, 2018
    Publication date: June 13, 2019
    Applicants: InflammaGen, LLC, The Regents of the University of California
    Inventors: Geert W. Schmid-Schonbein, Yung-Tsai (Andrew) Lee, Jeng Wei
  • Publication number: 20190181521
    Abstract: This disclosure provides systems, methods, and apparatus related to a vapor phase photo-electrochemical cell. In one aspect, a device includes a photovoltaic cell, a cathode disposed on the photovoltaic cell, an ionomer membrane disposed on the cathode, and an anode disposed on the ionomer membrane. The cathode includes a cathode catalyst. The ionomer membrane is in contact with the cathode catalyst. The anode includes an anode catalyst. The anode catalyst is in contact with the ionomer membrane. The anode, the ionomer membrane, and the cathode are transmissive to the solar radiation spectrum.
    Type: Application
    Filed: December 5, 2018
    Publication date: June 13, 2019
    Applicant: The Regents of the University of California
    Inventors: David M. Larson, Karl A. Walczak
  • Publication number: 20190177677
    Abstract: A microfluidic device for processing cells for the intracellular delivery of molecules or other cargo includes a plurality of microchannels disposed in a substrate or chip and fluidically coupled to an inlet configured to receive a solution containing the cells and the molecules or other cargo to be delivered intracellularly to the cells. Each of the plurality of microchannels has one or more constriction regions therein, wherein the constriction regions comprise an omniphobic, superhydrophilic, or superhydrophobic surface. In some embodiments, multiple microfluidic devices operating in parallel are used to process large numbers of cells. The device and method has particularly applicability to delivering gene-editing molecules intracellularly to cells.
    Type: Application
    Filed: August 19, 2017
    Publication date: June 13, 2019
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, PRESIDENT AND FELLOWS OF HARVARD COLLEGE, BRIGHAM AND WOMEN'S HOSPITAL
    Inventors: Steven J. Jonas, Paul S. Weiss, Xu Hou, Joanna Aizenberg, Alireza Khademhosseini