Patents Assigned to The Regents of the University of California
  • Publication number: 20220199966
    Abstract: A method for direct recycling of degraded lithium-ion battery (LIB) cathodes includes relithiating degraded lithium nickel cobalt manganese oxide (NCM) by mixing the cathode particles with a eutectic molten-salt solution and heating the mixture at ambient pressure over a period of time, followed by a short-time thermal annealing. Combining low-temperature relithiation using the eutectic molten-salt solution with thermal annealing provides successful regeneration and full recovery of the LIB to its original storage capacity, cycling stability and rate capability to the levels of the pristine materials. The method is useful to recycle and remanufacture degraded cathode materials for LIB or sodium-ion batteries.
    Type: Application
    Filed: March 11, 2020
    Publication date: June 23, 2022
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Zheng CHEN, Yang SHI
  • Publication number: 20220193437
    Abstract: A transcutaneous magnetic stimulation (tMS) device is provided for modulating nerve function and chronic pain management, and includes a tMS stimulator, a control module in wired and powered communication with the tMS stimulator, and a portable electronic device in wireless communication with the control module to receive, generate and transmit feedback and control settings relating to a treatment session. The tMS stimulator may be a flexible figure-of-eight coil configured in different sizes and shapes to provide varying pulse and magnetic field strengths for mobile, home, or clinical uses, and also include guidance tools and measurement sensors to aid in positioning and directing the tMS stimulator to a target area for treatment.
    Type: Application
    Filed: March 14, 2022
    Publication date: June 23, 2022
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Albert LEUNG, Shiv SHUKLA
  • Publication number: 20220192974
    Abstract: Systems and methods of using and imaging shear-thinning biomaterial compositions are provided. More particularly, systems and methods of providing reversible birth control and/or for delivering therapeutics to reproductive organs are provided. A method includes administering a biomaterial into fallopian tubes, uterus, or vas deferens of the subject, where the biomaterial is a shear-thinning nanocomposite.
    Type: Application
    Filed: March 26, 2020
    Publication date: June 23, 2022
    Applicants: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH, The Regents of the University of California, OBSIDIO, INC.
    Inventors: Rahmi Oklu, Hassan Albadawi, Amir Sheikhi, Ali Khademhosseini, Ehsan Jabbarzadeh
  • Publication number: 20220200705
    Abstract: A system and method for ultrashort signal detection adds an optical weighting element upstream of a detector within a direct detection receiver. The optical weighting element is configured to generate an optical pulse that closely matches at least one ultrashort pulse within the input signal so that portions of the input signal that are nonoverlapping with the at least one ultrashort pulse are rejected.
    Type: Application
    Filed: December 27, 2021
    Publication date: June 23, 2022
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Ana PEJKIC, Stojan RADIC
  • Publication number: 20220193891
    Abstract: This disclosure relates to apparatus a multi-legged robot including at least one pair of actuators. Each actuator includes a pliable body. The pliable body includes a first portion having a first chamber, a second portion having a second chamber, where the second portion coupled to a distal end of the first portion. The pliable body includes a first inlet coupled to the first chamber, where the first portion is configured to bend upon receiving a first fluid via the first inlet and a second inlet coupled to the second chamber, where the second portion is configured to extend upon receiving a second fluid via the second inlet. The multi-legged robot includes a frame coupled to a proximate end of the first portion of each actuator.
    Type: Application
    Filed: December 22, 2021
    Publication date: June 23, 2022
    Applicant: The Regents of the University of California
    Inventors: Konstantinos KARYDIS, Zhichao LIU
  • Publication number: 20220195392
    Abstract: Embodiments of the invention describe a cultured meat or food product with more desirable flavor and texture, as well as methods and compositions for producing the same. Certain embodiments are directed to methods of producing a stiffer, structured surfaces or scaffolds that mimic the extracellular matrix (ECM) and support the growth of myotubes that are interspersed with a scaffold component supporting fat cells (adipocytes) in vitro.
    Type: Application
    Filed: April 23, 2020
    Publication date: June 23, 2022
    Applicant: The Regents of the University of California
    Inventors: Amy ROWAT, Nora Stephanie KAWECKI, Siobhan Ariel BROOK, Sam NORRIS
  • Patent number: 11368020
    Abstract: Systems and methods for optimizing energy distribution are disclosed. Exemplary embodiment may: receive a request for separating a grid sub-network from a greater grid network at a grid point of common coupling, and wherein the greater grid network comprises a first set of premises, a first set of energy resources, and a first set of premise points of common coupling; separate the grid sub-network, wherein the grid sub-network comprises a second set of premises, a second set of energy resources, and a second set of premise points of common coupling; distribute energy from the second set of energy resources to the second set of premises of the grid sub-network; receive a request to reintegrate the grid sub-network to the greater grid network; reintegrate the grid sub-network; and distribute energy from the first set of energy resources to the first set of premises of the greater grid network.
    Type: Grant
    Filed: February 7, 2018
    Date of Patent: June 21, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Abdulelah Habib, Raymond de Callafon, Vahid Rasouli Disfani, Jan Kleissl, John Holmes, Elizabeth Ratnam
  • Patent number: 11364003
    Abstract: A device and methods for performing a simulated CT biopsy on a region of interest on a patient. The device comprises a gantry (22) configured to mount an x-ray emitter (24) and CT detector (26) on opposing sides of the gantry, a motor (28) rotatably coupled to the gantry such that the gantry rotates horizontally about the region of interest, and a rotation of source high resolution x-ray detector (172) positioned adjacent the CT detector in between the CT detector and the x-ray emitter.
    Type: Grant
    Filed: February 19, 2021
    Date of Patent: June 21, 2022
    Assignee: The Regents of the University of California
    Inventors: John M. Boone, Thomas R. Yellen-Nelson
  • Patent number: 11363979
    Abstract: A nanowire probe sensor array including a substrate with a metal pattern thereon. An array of semiconductor vertical nanowire probes extends away from the substrate, and at least some of probes, and preferably all, are individually electrically addressed through the metal pattern. The metal pattern is insulated with dielectric, and base and stem portions of the nanowires are also preferably insulated. A fabrication process patterns metal connections on a substrate. A semiconductor substrate is bonded to the metal pattern. The semiconductor substrate is etched to form the neural nanowire probes that are bonded to the metal pattern. Dielectric is then deposited to insulate the metal pattern.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: June 21, 2022
    Assignee: The Regents of the University of California
    Inventors: Shadi A. Dayeh, Renjie Chen, Sang Heon Lee, Ren Liu, Yun Goo Ro, Atsunori Tanaka, Yoontae Hwang
  • Patent number: 11365431
    Abstract: The present invention provides for a genetically modified yeast cell comprising at least six or more of the following modifications: increased expression of Mus musculus fatty acid reductase, acetyl-CoA carboxylase, fatty acid synthase 1, fatty acid synthase 2, a mutant of the bottleneck enzyme encoded by ACC1 insensitive to post-transcriptional and post-translational repression, and/or a desaturase encoded by OLE1, and reduced expression of DGA1, HFD1, ADH6, and/or GDH1. The present invention provides a method for constructing the genetically modified yeast cell, and a method for producing a fatty alcohol from the genetically modified yeast cell.
    Type: Grant
    Filed: February 10, 2020
    Date of Patent: June 21, 2022
    Assignee: The Regents of the University of California
    Inventors: Leopold D'Espaux, Jay D. Keasling
  • Patent number: 11364118
    Abstract: Some embodiments relate to Some embodiments relate to an integrated ultrasound guided delivery system for positioning or repositioning of a transcatheter heart valve including: a delivery catheter coupled to the transcatheter heart valve, and an intravascular ultrasound (IVUS) catheter operably coupled to the delivery catheter, wherein the IVUS catheter includes an ultrasound transducer tip that is aligned with a base of leaflets of the transcatheter heart valve. Also disclosed is a method for positioning or repositioning a transcatheter heart valve at a target site in a subject including: providing an integrated ultrasound guided delivery system as disclosed herein; advancing the transcatheter heart valve in the vicinity of a native valve, viewing the native valve and the target site in real-time with the IVUS catheter, and deploying the transcatheter heart valve at the target site aiming to maintain a conformal placement within the native valve annulus, thereby avoiding or minimizing paravalvular leak.
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: June 21, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: Arash Kheradvar
  • Patent number: 11367869
    Abstract: Various embodiments provide glass bottle-based silicon electrode materials. A battery electrode includes silicon made from magnesiothermic reduction of silicon oxide derived from glass bottles and a conformal carbon coating thereon. A method of making the electrode material includes crushing glass bottles to produce crushed glass containing silicon oxide particles, mixing the silicon oxide particles with a heat scavenger to produce a mixture, magnesiothermically reducing the mixture to produce silicon, and applying a carbon coat to the silicon to produce an electrode material.
    Type: Grant
    Filed: April 18, 2019
    Date of Patent: June 21, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Cengiz S Ozkan, Mihrimah Ozkan, Chueh Liu, Changling Li, Wei Wang
  • Patent number: 11365435
    Abstract: Methods, systems, and devices are disclosed for providing a portable enzymatic-ink dispensing system. The system includes an enzymatic-ink including one or more biocompatible binders, one or more biocompatible mediators, an enzyme, an enzyme stabilizer, and a conductive material. The system includes a dispenser including a chamber to hold the enzymatic-ink and an applicator to apply the enzymatic ink dispensed from the chamber onto a target substrate.
    Type: Grant
    Filed: December 9, 2019
    Date of Patent: June 21, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Joseph Wang, Amay Jairaj Bandodkar
  • Patent number: 11366122
    Abstract: Disclosed herein include systems, devices, and methods for droplet deposition for mass spectrometry. In some embodiments, a microfluidic device comprising wells is reversibly sealed to a mass spectrometry surface and used to deposit contents of droplets (e.g., enzymes and substrates), or products thereof, onto the mass spectrometry surface. The contents of droplets can be analyzed by laser desorption/ionization to, for example, identify a substrate of an enzyme or an enzyme capable of catalyzing a substrate to a product.
    Type: Grant
    Filed: October 4, 2020
    Date of Patent: June 21, 2022
    Assignee: The Regents of the University of California
    Inventors: Noel Ha, Markus de Raad, Trent R. Northen
  • Patent number: 11367264
    Abstract: A computer implemented method or system including a map conversion toolkit and a map Population toolkit. The map conversion toolkit allows one to quickly trace the layout of a floor plan, generating a file (e.g., GeoJSON file) that can be rendered in two dimensions (2D) or three dimensions (3D) using web tools such as Mapbox. The map population toolkit takes the scan (e.g., 3D scan) of a room in the building (taken from an RGB-D camera), and, through a semi- automatic process, generates individual objects, which are correctly dimensioned and positioned in the (e.g., GeoJSON) representation of the building. In another example, a computer implemented method for diagraming a space comprises obtaining a layout of the space; and annotating or decorating the layout with meaningful labels that are translatable to glanceable visual signals or audio signals.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: June 21, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Viet Trinh, Roberto Manduchi
  • Patent number: 11366121
    Abstract: Research tool assay for identifying a specific modulator of GNAI, compositions and methods of use. The assay includes combining a drug candidate with GNAI and a C-terminal GIV peptide and determining if the drug candidate inhibits GNAI interaction with the C-terminal GIV peptide; and combining the drug candidate with GNAI and a DAPLE peptide and determining if the drug candidate inhibits GNAI interaction with DAPLE peptide. Also provided are compositions and methods of treatment relating to the same.
    Type: Grant
    Filed: February 22, 2018
    Date of Patent: June 21, 2022
    Assignee: The Regents of the University of California
    Inventor: Pradipta Ghosh
  • Patent number: 11368336
    Abstract: An apparatus for interfacing with a circuit switched network may be configured to detect when a data carrier signal from a circuit switched network is offline. While the data carrier signal from the circuit switched network is offline, the apparatus may send, to a network element coupled with the circuit switched network via the apparatus, control packets indicating that the data carrier signal is offline. The apparatus may further maintain an active data carrier signal between the apparatus and the network device by sending, to the network element, protocol idle frames. The apparatus may buffer, at the apparatus, packets sent from the network element to the circuit switched network. Once the data carrier signal is restored, the apparatus may send, to the circuit switched network, control packets indicating that the data carrier signal is online and the packet buffered at the apparatus while the data carrier signal is offline.
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: June 21, 2022
    Assignee: The Regents of the University of California
    Inventors: George Porter, William Mellette
  • Patent number: 11366236
    Abstract: A signal of opportunity (SOP)-aided inertial navigation system (INS) framework provides various technical solutions to technical problems facing GNSS implementations. A mobile receiver, whether handheld or vehicle-mounted, has access to Global Navigation Satellite System (GNSS) signals, multiple unknown terrestrial SOPs, and IMU measurements, which are used to estimate receiver states. When GNSS signals become unreliable, the mobile receiver continues to navigate using the SOP-aided INS. The SOP-aided INS produces bounded estimation errors in the absence of GNSS signals, and the bounds are dependent on the quantity and quality of exploited SOPs.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: June 21, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Zak M. Kassas, Joshua J. Morales
  • Publication number: 20220184172
    Abstract: The present disclosure provides a method of preventing and/or treating hepatocellular apoptosis and liver damage in a liver disease, particularly NASH, by targeting the AMPK/caspase-6 axis to inhibit caspase-6 activity and/or activate AMPK activity. Also disclosed is the pharmaceutical composition for preventing and/or treating a liver disease comprising one or more caspase-6 inhibitor and/or AMPK activator of the present disclosure. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
    Type: Application
    Filed: April 18, 2020
    Publication date: June 16, 2022
    Applicant: The Regents of the University of California
    Inventors: Alan Salitiel, Peng Zhao
  • Publication number: 20220184121
    Abstract: Aspects of the present disclosure provide methods and compositions for immune cell activation. Disclosed are antibody-coated microparticles and methods for use. In some cases, immune cell activation methods comprising mechanical stimulation are disclosed. Embodiments are directed to activation of cytotoxic T cells. Additional aspects include generation and activation of regulatory T cells.
    Type: Application
    Filed: March 18, 2020
    Publication date: June 16, 2022
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Manish BUTTE, Fatemeh MAJEDI, Mohammad Mahdi HASANI-SADRABADI