Patents Assigned to The Regents of the University of California
  • Publication number: 20240087647
    Abstract: Present implementations are directed to nonvolatile memory devices with charge trap transistor structures. Example implementations can include a method of memory storage, by programming a first data node operatively coupled to a first charge trap transistor to a first level above a threshold, decreasing, below the threshold, a first voltage at the first charge trap transistor, increasing, above the threshold, the first voltage at the first charge trap transistor, and reprogramming, the first data node to the first level, in response to an interruption of the first voltage at the first charge trap transistor caused by the decreasing and the increasing.
    Type: Application
    Filed: January 28, 2022
    Publication date: March 14, 2024
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Sepideh NOURI, Subramanian IYER
  • Publication number: 20240089001
    Abstract: Systems and methods for fabricating an optoelectronic transceiver with a tunable traveling wave modulator and an analog coherent receiver to transmit and receive wavelength-multiplexed optical signals in accordance with embodiments of the invention are disclosed. In one embodiment, a network switch includes a plurality of ports configured to transmit and receive optical signals and electrical current signals, a plurality of optoelectronic transmitters using a traveling wave modulator and driver biasing, and a plurality of analog coherent receivers.
    Type: Application
    Filed: September 13, 2023
    Publication date: March 14, 2024
    Applicant: The Regents of the University of California
    Inventors: Clint Schow, James Buckwalter, Aaron Maharry, Hector Andrade, Larry Coldren
  • Publication number: 20240082427
    Abstract: In various embodiments method are provided for generating expression cassettes and gene therapy vectors comprising those cassettes that recapitulate the spatiotemporal pattern of expression of the endogenous gene. In certain embodiments the methods comprise (i) selecting a target gene; (ii) identifying putative regulatory elements associated with the target gene; (iii) determining if the regulatory element is a key regulatory element and (iv) providing a list of the key regulatory elements identified in step (iii).
    Type: Application
    Filed: January 28, 2022
    Publication date: March 14, 2024
    Applicant: The Regents of the University of California
    Inventors: Donald B. Kohn, Ryan L. Wong, Roger Paul Hollis, Richard A. Morgan, Aaron Ross Cooper
  • Publication number: 20240084345
    Abstract: Methods for converting mixtures of anthocyanins occurring in fruit or vegetable juice or extract into particular anthocyanin molecules having desirable colorant properties are provided herein. The method of the present disclosure can be employed to increase the amount of particular anthocyanin molecules, while lowering the total number of anthocyanin molecules present in the natural juice and/or extract. The disclosure is also directed to anthocyanin molecules prepared by the methods of present disclosure and to enzymes capable of catalyzing reactions that provide such effects.
    Type: Application
    Filed: July 21, 2023
    Publication date: March 14, 2024
    Applicants: MARS, INCORPORATED, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Thomas M. Collins, Rebecca J. Robbins, Randall Powers, Justin Siegel, Pamela Ruth Denish, Kathryn Gwendolyn Guggenheim
  • Publication number: 20240085432
    Abstract: Described herein are methods, materials, kits, devices, and assays for use in screening, detection, and treatment of diabetes, including diabetes mellitus and gestational diabetes mellitus (GDM). The amount of a plurality of metabolic markers present in a test sample obtained from the subject is measured, followed by comparing the amount of the metabolic markers present in the test sample to reference levels of the markers; and identifying a subject as susceptible to, or as having, diabetes when the amount of each of the measured markers present in the test sample is increased or decreased relative to the reference levels. Also provided is a method of treating diabetes in a subject when the amount of each of the measured markers present in the test sample is increased or decreased relative to the reference levels.
    Type: Application
    Filed: October 9, 2020
    Publication date: March 14, 2024
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: Brian J. Koos
  • Publication number: 20240085328
    Abstract: Systems and methods are provided for excitation spectral microscopy using frame-synchronized acousto-optic scanning of fluorescent excitation wavelengths. Linear unmixing of the images of targets of components that are individually labeled with different fluorophores can be simultaneously imaged with high temporal resolution and low crosstalk and the local abundance of each fluorophore at each pixel can be quantified. Fluorophore decomposed micrographs of the sample can be obtained by rendering the abundance in each pixel as an image.
    Type: Application
    Filed: October 11, 2023
    Publication date: March 14, 2024
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Ke Xu, Kun Chen, Rui Yan, Limin Xiang
  • Patent number: 11929459
    Abstract: Slurry compositions, tape casting binder systems and fabrication methods for the fabrication of lithium-garnet electrolyte scaffolds for use in solid state batteries and other devices are provided. Slurry compositions may be optimized mixtures of LLZO powder, a dispersant, a lithium salt, a wetting agent a binder, a plasticizer and at least one solvent. The optimized ceramic slurry compositions may include MgO as a sintering additive to improve density and ionic conductivity of the doped-LLZO sheets and produce a fine-grained microstructure. Sintering protocols for cast slurries of commercially available doped LLZO powders eliminate the requirement of mother-powder coverings or externally applied pressure. An environmentally friendly water-based system using methylcellulose as a binder is also provided producing green tape and final properties comparable to those obtained with organic solvent-based systems.
    Type: Grant
    Filed: September 21, 2021
    Date of Patent: March 12, 2024
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Robert Jonson, Michael Tucker
  • Patent number: 11926826
    Abstract: The present invention relates to compositions comprising TWIST signaling inhibitors and optionally one or more anti-cancer agents, and methods of using the compositions for the treatment of cancer.
    Type: Grant
    Filed: June 24, 2022
    Date of Patent: March 12, 2024
    Assignees: City of Hope, The Regents of the University of California
    Inventors: Carlotta A. Glackin, John Rossi, Jeffrey I. Zink, Fuyuhiko Tamanoi, Cai M. Roberts, James Finlay
  • Patent number: 11925679
    Abstract: Peptides that generate an immune response to glioma-related H3.3 proteins and methods of their use are provided.
    Type: Grant
    Filed: October 22, 2020
    Date of Patent: March 12, 2024
    Assignee: The Regents of the University of California
    Inventors: Hideho Okada, Yafei Hou
  • Patent number: 11926819
    Abstract: Provided are methods of adding a polymer of non-canonical nucleotides to the 3? end of a ribonucleic acid (RNA). In certain embodiments, the methods comprise combining an RNA, a polynucleotide-3? nucleotidyl transferase, and non-canonical nucleotides, in a reaction mixture under conditions in which the polynucleotide-3? nucleotidyl transferase adds a polymer of the non-canonical nucleotides to the 3? end of the RNA. Such methods may further include analyzing the RNA using a nanopore. According to some embodiments, the methods include identifying the polymer of non-canonical nucleotides added to the 3? end of the RNA, and determining the junction between the 3? end of the RNA and the polymer of non-canonical nucleotides to identify the 3? end of the RNA. Kits that find use, e.g., in practicing the methods of the present disclosure are also provided.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: March 12, 2024
    Assignee: The Regents of the University of California
    Inventors: Manuel Ares, Logan Mulroney, Jenny Vo, Mark Akeson
  • Patent number: 11926868
    Abstract: This present disclosure provides methods and compositions that can be used to quantify cfDNA in biofluids using a hybridization approach.
    Type: Grant
    Filed: July 15, 2021
    Date of Patent: March 12, 2024
    Assignee: The Regents of the University of California
    Inventors: Minnie M. Sarwal, Tara K. Sigdel, Joshua Y. Yang
  • Patent number: 11926047
    Abstract: A surgical practice system including a box that defines an inner compartment, and multiple articulable arms mounted to the box within the inner compartment, each arm including a gripping element provided at its distal end that is configured to grip an object.
    Type: Grant
    Filed: June 26, 2021
    Date of Patent: March 12, 2024
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: Neil Cambronero
  • Publication number: 20240076623
    Abstract: Methods for the efficient isolation and use of pluripotent adipose-derived stem cells (PASCs) are provided. In certain embodiments the methods involve providing an adipose tissue sample from which the stromal vascular fraction is co-cultured with the adipocyte fraction. PASCs can be isolated with a high degree of purification without requiring an additional cell enrichment process (e.g. cell sorting). PASCs and their conditioned media can be used for tissue regeneration within hours of harvesting the adipose tissue, and without requiring cell expansion. PASCs can grow as floating individual cells, as clusters of cells, or attached to surface(s) of the culture vessel. PASCs do not produce teratomas in vivo, nor do they induce immunorejection upon transplantation, and they achieve a high efficiency in grafting. The cells and compositions can be used for cell therapy and to screen new drugs.
    Type: Application
    Filed: November 15, 2023
    Publication date: March 7, 2024
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: Gregorio CHAZENBALK
  • Publication number: 20240079856
    Abstract: A method for fabricating a quality and manufacturable aperture for light emitting elements, such as vertical cavity surface emitting lasers (VCSELs), using epitaxial later overgrowth (ELO). A bar comprised of island-like III-nitride semiconductor layers is grown on a substrate using a growth restrict mask, and the island-like III-nitride semiconductor layers are fabricated into light-emitting resonating cavities across a smallest length of the bar. Apertures for the resonating cavities are also fabricated along the smallest length of the bar on wing regions of the epitaxial lateral overgrowth. Distributed Bragg reflectors (DBRs) are fabricated as mirrors for the resonant cavities on the bottom and top of the wing regions of the epitaxial lateral overgrowth.
    Type: Application
    Filed: October 23, 2020
    Publication date: March 7, 2024
    Applicant: The Regents of the University of California
    Inventors: Gandrothula Srinlvas, Takeshi Kamikawa, Masahiro Araki
  • Publication number: 20240076213
    Abstract: A microporous wick and a method for non-thermal solar desalination is disclosed, which includes placing a capillary wick in a brine containing sodium chloride (NaCl), the capillary wick comprising a plurality of bonded aluminum nitride (Al—N) microparticles and illuminating the capillary wick with a light source.
    Type: Application
    Filed: September 7, 2023
    Publication date: March 7, 2024
    Applicant: The Regents of the University of California
    Inventors: Luat T. VUONG, James Li-Guo LEUNG, Navindra D. SINGH
  • Patent number: 11918770
    Abstract: Provided herein is an implant for delivering a hydrophobic active agent to a target tissue. The implant may include a scaffold defining a first surface and a second surface opposite the first surface, wherein the scaffold is substantially impermeable to a hydrophobic active agent, and a silicone tubing having a wall permeable to the active agent, wherein a first length of the silicone tubing is affixed to the first surface of the scaffold, wherein the two ends of the silicone tubing extend from the first surface, and wherein a path outlined by a second length of the tubing within the first length is circuitous. Also provided is a method of using the implant to locally deliver a hydrophobic active agent to a target tissue, and kits that find use in performing the present method.
    Type: Grant
    Filed: February 7, 2022
    Date of Patent: March 5, 2024
    Assignee: The Regents of the University of California
    Inventors: Pamela Munster, Jim Kiriakis, Hani Sbitany, Scott Thomas
  • Patent number: 11918686
    Abstract: A submicron structure comprising a silica body defining a plurality of pores that are suitable to receive molecules therein, and having a surface, and a phospholipid bilayer coating the surface, wherein said submicron structure has a maximum dimension of less than one micron, and wherein the phospholipid bilayer stably seals the plurality of pores; and wherein the submicron structure is a member of a monodisperse population of submicron structures.
    Type: Grant
    Filed: September 21, 2020
    Date of Patent: March 5, 2024
    Assignee: The Regents of the University of California
    Inventors: Andre E. Nel, Jeffrey I. Zink, Huan Meng
  • Patent number: 11921522
    Abstract: This disclosure is directed to sub-meter level navigation accuracy for Unmanned Aerial Vehicles (UAVs) using broadband communication signals, such as cellular long-term evolution (LTE) signals. A framework and methods are provided using a receiver and controller to produce at least one of carrier phase, code phase, and Doppler frequency measurements from received LTE signals. Single difference measurements may be used to remove clock bias. LTE ENodeB clock biases are initialized using the known initial position of the UAV. The measurements are fused via an extended Kalman filter (EKF) to estimate the UAV position and integer ambiguities of the carrier phase single difference measurements. LTE signals can have different carrier frequencies and conventional algorithms do not estimate the integer ambiguities. Processes are described to detect cycle slip, where the carrier phase measurements from the LTE eNodeB multiple antenna ports are used to detect cycle slip.
    Type: Grant
    Filed: November 3, 2020
    Date of Patent: March 5, 2024
    Assignee: The Regents of the University of California
    Inventors: Zak Kassas, Kimia Shamaei
  • Patent number: 11923784
    Abstract: A pyramid-type multilevel converter for converting DC voltage to AC voltage waveforms, and vice versa. An example device can use modular building blocks to form a selector stage, a converter stage, and at least one intermediate stage if the number of converters within the converter stage is greater than or equal to 3, with the converter stage switching at high-frequency PWM to chop the DC voltages. The modular building blocks are connected in a symmetric or asymmetric pyramid configuration having a base of using the converter stage and an apex of the selector stage.
    Type: Grant
    Filed: January 26, 2022
    Date of Patent: March 5, 2024
    Assignee: The Regents of the University of California
    Inventors: Vahid Dargahi, Keith A. Corzine
  • Patent number: PP35677
    Abstract: A new male pistachio cultivar (Pistacia vera L.) designated as ‘UC Westside’, to be used advantageously as a pollenizer for commercial female pistachio varieties. ‘UC Westside’ blooms later in the spring than most existing male pistachio cultivars and is particularly characterized by a reduced juvenility period, dense blooms in years with low chill, good pollen viability, and improved bloom synchrony with standard female pistachio varieties, especially ‘Kerman’. It may be used as a replacement for the male cultivar ‘Peters’.
    Type: Grant
    Filed: February 3, 2023
    Date of Patent: March 12, 2024
    Assignee: The Regents of the University of California
    Inventors: Craig E. Kallsen, Dan E. Parfitt