Patents Assigned to The Regents of the University of California
  • Publication number: 20190249172
    Abstract: The present disclosure provides methods for gene editing in stem cells. The methods generally involve modifying the stem cells by increasing the level of an apoptosis regulator in the stem cells; and introducing into the modified stem cells a genome editing composition.
    Type: Application
    Filed: February 16, 2017
    Publication date: August 15, 2019
    Applicants: The Regents of the University of California, The Regents of the University of California
    Inventors: Donald B. Kohn, Carmen Flores Bjurstroem
  • Publication number: 20190248730
    Abstract: Aspects of the present disclosure include fatty acid ?-hydroxyester compounds (e.g., fatty acid esters of ?-hydroxybutyrate), fatty acid esters of butanediol, and pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions having one or more fatty acid ?-hydroxyester compounds and/or one or more fatty acid esters of butanediol. Methods for treating a subject by administering one or more esters to the subject are also provided. Kits containing one or more of the subject esters are also described.
    Type: Application
    Filed: June 2, 2017
    Publication date: August 15, 2019
    Applicants: THE J. DAVID GLADSTONE INSTITUTES, ITHACA COLLEGE, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, ITHACA COLLEGE
    Inventors: Eric Verdin, Scott Michael Ulrich, John C. Newman
  • Publication number: 20190248239
    Abstract: The present invention provides for a genetically modified host cell capable of producing isopentenol and/or 3-methyl-3-butenol, comprising (a) an increased expression of phosphomevalonate decarboxylase (PMD) (b) an increased expression of a phosphatase capable of converting isopentenol into 3-methyl-3-butenol, (c) optionally the genetically modified host cell does not express, or has a decreased expression of one or more of NudB, phosphomevalonate kinase (PMK), and/or PMD, and (d) optionally one or more further enzymes capable of converting isopentenol and/or 3-methyl-3-butenol into a third compound, such as isoprene.
    Type: Application
    Filed: April 18, 2019
    Publication date: August 15, 2019
    Applicant: The Regents of the University of California
    Inventors: Taek Soon Lee, Aram Kang
  • Publication number: 20190250092
    Abstract: A system for deforming and analyzing a plurality of particles carried in a sample volume includes a substrate defining an inlet, configured to receive the sample volume, and an outlet; and a fluidic pathway fluidly coupled to the inlet and the outlet.
    Type: Application
    Filed: April 3, 2019
    Publication date: August 15, 2019
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Dino Di Carlo, Daniel R. Gossett, Henry T.K. Tse, Aram Chung
  • Publication number: 20190247804
    Abstract: The disclosure provides for polymer membranes which comprise metal organic frameworks, methods of making therein, and methods of use thereof, including in gas separation.
    Type: Application
    Filed: November 15, 2016
    Publication date: August 15, 2019
    Applicant: The Regents of the University of California
    Inventors: Jeffrey R. LONG, Jonathan BACHMAN, Zachary Pace SMITH
  • Publication number: 20190247539
    Abstract: The present invention provides scaffolds that include a polymer and a cyclic peptide ligand. The peptide ligand increases the attachment of endothelial cells and/or progenitor cells to the scaffold. The present invention also provides engineered tissues that include the provided scaffolds. The present invention also provides coatings that include a coating polymer and a cyclic peptide ligand. The present invention also provides methods of improving endothelialization and vascularization of endothelial cells and/or progenitor cells for tissue regeneration in a subject and of repairing bone defects in a subject, by implanting a provided scaffold.
    Type: Application
    Filed: September 7, 2018
    Publication date: August 15, 2019
    Applicant: The Regents of the University of California
    Inventors: Aijun Wang, Kit Lam
  • Publication number: 20190247838
    Abstract: Provided is a scalable delamination of a SSZ-70 framework zeolite, without the need for sonication, which has been previously made difficult by the charged nature of the imidazolium structure-directing agents that are required for zeolite synthesis. The method comprises contacting a B-SSZ-70 zeolite precursor with a zinc source such as zinc nitrate and a fluoride source.
    Type: Application
    Filed: February 14, 2019
    Publication date: August 15, 2019
    Applicants: Chevron U.S.A. Inc., The Regents of the University of California
    Inventors: Alexander KATZ, Alexander OKRUT, Martina AIGNER, Xiaoying OUYANG, Stacey Ian ZONES
  • Patent number: 10377782
    Abstract: Disclosed herein, inter alia, are acyclic nucleotide analogs and methods of using an acyclic nucleotide analog for treating and/or ameliorating a papillomavirus infection.
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: August 13, 2019
    Assignee: The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle, Nadejda Valiaeva
  • Patent number: 10376486
    Abstract: The present invention provides compositions comprising ingenol-3-angelate (PEP005) and one or more additional latency reactivation agents. The present invention also provides methods for reactivating a latent virus in a subject infected with the virus, the method comprising administering to the subject an effective amount of ingenol-3-angelate (PEP005) alone or in combination with one or more additional latency reactivation agents. In particular embodiments, the combination of compounds advantageously provides a synergistic effect at inducing reactivation of a latent virus such as HIV.
    Type: Grant
    Filed: February 7, 2017
    Date of Patent: August 13, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Guochun Jiang, Satya Dandekar
  • Patent number: 10377701
    Abstract: A method of manufacturing 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)-malononitrile ([F-18]FDDNP) utilizes a semi-automated module that is used to perform fluorination, pre-purification, separation, product extraction, and formulation. The method is able to produce [F-18]FDDNP with high yields and ready for human administration under existing FDA regulations, and without the need for hazardous organic solvents such as dichloromethane (DCM), methanol (MeOH), and tetrahydrofuran (THF). The method also improves the speed with which [F-18]FDDNP can be synthesized with the method being able to generate a final product within about 90 to 100 minutes. This synthesis method is easily adaptable to FDA registered and approved automated synthesis systems.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: August 13, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Nagichettiar Satyamurthy, Jie Liu, Jorge R. Barrio
  • Patent number: 10378021
    Abstract: The invention provides compositions and methods for manipulating the exchange of water and/or carbon dioxide (CO2) through plant stomata by controlling CO2 sensor genes. The invention provides compositions and methods for enhancing or optimizing biomass accumulation in a plant. The invention provides compositions and methods for 10 opening or closing a stomatal pore on a guard cell in the epidermis of a plant. The invention provides compositions and methods for increasing or decreasing oxygenation efficiency and/or carbon fixation in a guard cell in the epidermis of a plant by manipulating expression of a ribulose-1,5-bisphosphate carboxylase/oxygenase. The invention provides promoters for regulating expression of a nucleic acid in a plant guard cell.
    Type: Grant
    Filed: October 17, 2016
    Date of Patent: August 13, 2019
    Assignee: The Regents of the University of California
    Inventors: Julian I. Schroeder, Maria Israelsson-Nordstrom, Josef M. Kuhn, Yingzhen Yang, Honghong Hu, Aurelien Boisson-Dernier
  • Patent number: 10376567
    Abstract: This invention provides novel carbonic anhydrase (CAIX) nucleic acid and peptide sequences, as well as related methods and compositions, including anti-cancer immunogenic agent(s) (e.g. vaccines and chimeric molecules) that elicit an immune response specifically directed against cancer cells expressing a CAIX antigenic marker. The novel CAIX variant and related compositions are useful in a wide variety of treatment modalities including, but not limited to protein vaccination, DNA vaccination, and adoptive immunotherapy.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: August 13, 2019
    Assignee: The Regents of the University of California
    Inventors: Zhenhua Li, Arie S. Belldegrun
  • Patent number: 10376489
    Abstract: A method of treating a chronic wound in a subject in need of such treatment is provided. The method includes administering to the subject at least one antioxidant agent in an amount effective to treat the wound. In some versions, the antioxidant agent is ?-tocopherol or N-acetyl cysteine, or a combination of these compounds. In other versions, a method of preparing a chronic wound animal model is provided.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: August 13, 2019
    Assignee: The Regents of the University of California
    Inventors: Manuela Martins-Green, Sandeep Dhall, Danh Do, Neal Schiller
  • Patent number: 10378000
    Abstract: The present invention provides ionic liquid-tolerant cellulases and method of producing and using such cellulases. The cellulases of the invention are useful in saccharification reactions using ionic liquid treated biomass.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: August 13, 2019
    Assignees: National Technology & Engineering Solutions of Sandia, LLC, The Regents of the University of California
    Inventors: John Gladden, Joshua Park, Steven Singer, Blake Simmons, Ken Sale
  • Publication number: 20190240310
    Abstract: A method of immunizing a susceptible host against a pathogen comprising administering to the host a vaccine that comprises an attenuated recombinant live vaccine strain lacking a polynucleotide encoding CapB (LVS ?capB), wherein the LVS ?capB expresses an antigen of at least one pathogen from Table 1; or administering to the host a vaccine that comprises an attenuated Listeria monocytogenes expressing the antigen of the pathogen from Table 1; or administering to the host a prime vaccine and a heterologous booster vaccine where the prime vaccine comprises an attenuated recombinant live vaccine strain lacking a polynucleotide encoding CapB (LVS ?capB), wherein the LVS ?capB expresses an antigen of at least one pathogen from Table 1 and the heterologous booster vaccine comprises an attenuated Listeria monocytogenes expressing the antigen of the pathogen from Table 1.
    Type: Application
    Filed: July 31, 2017
    Publication date: August 8, 2019
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Marcus A. HORWITZ, Qingmei JIA
  • Publication number: 20190241727
    Abstract: The present invention relates to polymers functionalized with non-migratory internal plasticizers.
    Type: Application
    Filed: February 1, 2019
    Publication date: August 8, 2019
    Applicant: The Regents of the University of California
    Inventors: Rebecca L. BRASLAU, Chad M. HIGA
  • Publication number: 20190241613
    Abstract: This invention relates to inhibitory peptides which bind to ?-synuclein molecules and inhibit ?-synuclein amyloidogenic aggregation, ?-synuclein cytotoxicity, and spread of ?-synuclein. Methods of making and using the inhibitory peptides (e.g. to treat subjects having conditions or diseases that are mediated by ?-synuclein, such as Parkinson's disease, dementia with Lewy bodies, or MSA) are described.
    Type: Application
    Filed: June 29, 2017
    Publication date: August 8, 2019
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: David S. Eisenberg, Smriti Sangwan, Lin Jiang
  • Publication number: 20190240154
    Abstract: Hyaluronic acid-based hydrogels, solutions for preparing such, and methods pertaining thereunto are disclosed with properties that include self-resorption, extended release of biologically active agents, and/or decreased degradation, denaturation, and/or functional inactivation of biologically active agents.
    Type: Application
    Filed: April 7, 2017
    Publication date: August 8, 2019
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Michael D. ROTH, Airi HARUI
  • Publication number: 20190240666
    Abstract: Mechano-node-pore sensing (mechano-NPS), is a rapid, multi-parametric cell screening method that simultaneously quantifies cell diameter, transit time through a contraction channel, transverse deformation under constant strain, and recovery time after deformation
    Type: Application
    Filed: April 11, 2019
    Publication date: August 8, 2019
    Applicant: The Regents of the University of California
    Inventors: Lydia L. Sohn, Junghyun Kim, Sewoon Han
  • Publication number: 20190243117
    Abstract: An imaging system consisting of a cell-phone with camera as the detection part of an optical train which includes other components. Optionally, an illumination system to create controlled contrast in the sample. Uses include but are not limited to disease diagnosis, symptom analysis, and post-procedure monitoring, and other applications to humans, animals, and plants.
    Type: Application
    Filed: October 3, 2018
    Publication date: August 8, 2019
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Daniel Fletcher, Wendy Hansen, Neil Switz, David N. Breslauer, Erik Douglas, Robi Maamari, Wilbur Lam, Jesse Dill