Patents Assigned to The Regents of the University of California, a California Corporation
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Publication number: 20230305066Abstract: Disclosed is an analytic sensitivity expression for parameters of a battery electrochemical model, based on model reduction and reformulation techniques such as the single particle assumption, Padé approximation, and Laplace transform. The analytic expressions of sensitivity are in a compact form with explicit relationship to the current input, which enables the direct optimization of the input-dependent sensitivity. The current optimization with maximum sensitivity may be performed for several critical battery electrochemical parameters, namely a solid-phase lithium diffusion coefficient, a volume fraction of the electrode active material, and a reaction rate constant. The electrochemical parameter may be reliably identified using the optimal current profile.Type: ApplicationFiled: August 4, 2021Publication date: September 28, 2023Applicants: LG ENERGY SOLUTION, LTD., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATIONInventors: Geum-Bee KIM, Hyoung Jun AHN, Won-Tae JOE, Qingzhi LAI, Xinfan LIN
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Patent number: 11527667Abstract: Tunnel junctions for multijunction solar cells are provided. According to an aspect of the invention, a tunnel junction includes a first layer including p-type AlGaAs, a second layer including n-type GaAs, wherein the second layer is a quantum well, and a third layer including n-type AlGaAs or n-type lattice matched AlGaInP. The quantum well can be GaAs or AlxGaAs with x being more than about 40%, and lattice matched GaInAsNSb in the Eg range of from about 0.8 to about 1.4 eV.Type: GrantFiled: April 27, 2018Date of Patent: December 13, 2022Assignees: Alliance for Sustainable Energy, LLC, The Regents of the University of California, A California CorporationInventors: Nikhil Jain, Myles Aaron Steiner, John Franz Geisz, Emmett Edward Perl, Ryan Matthew France
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Patent number: 11136301Abstract: Disclosed herein, inter alia, are agents having antiviral activity and methods of use thereof.Type: GrantFiled: August 31, 2016Date of Patent: October 5, 2021Assignee: The Regents of the University of California, A California Corporation et al.Inventors: Tariq M. Rana, Mario Stevenson
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Patent number: 10881853Abstract: Neuromodulation systems are described comprising a signal generator and at least one electrode. The at least one electrode can be configured to deliver a stimulation to a mammal, wherein the stimulation includes a biphasic signal and an overlapping high frequency pulse thereby inducing voluntary movement in the individual. Methods of administering the stimulation are also described.Type: GrantFiled: October 5, 2018Date of Patent: January 5, 2021Assignee: The Regents of the University of California, A California CorporationInventors: Victor Reggie Edgerton, Yury P. Gerasimenko, Nicholas A. Terrafranca, Parag Gad
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Patent number: 10654916Abstract: The present invention is directed to antibodies binding to aquaporin 4 (AQP4) and methods of using such antibodies to treat neuromyelitis optica (NMO) either as a monotherapy or in combination with standard NMO therapies such as immunosuppressives or plasmaphersis.Type: GrantFiled: April 23, 2012Date of Patent: May 19, 2020Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION, THE REGENTS OF THE UNIVERSITY OF COLORADO A BODY CORPORATEInventors: Jeffrey L. Bennett, Gregory P. Owens, Alan S. Verkman
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Patent number: 9802962Abstract: Tricyclic pyrone compounds having high oral bioavailability, excellent blood-brain barrier permeability, and low toxicity are presented. Administration of the compounds to Alzheimer's Disease transgenic models resulted in substantially reduced soluble and insoluble A? species in the brain without affecting general behavior and motor coordination. Furthermore, in addition to blocking the toxicity and formation of both intraneuronal and extracellular A? aggregates, the compounds also increase cellular cholesterol efflux, restore axonal trafficking, and enhance hippocampal synaptic plasticity.Type: GrantFiled: September 30, 2014Date of Patent: October 31, 2017Assignees: KANSAS STATE UNIVERSITY RESEARCH FOUNDATION, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION, AFASCI, INC.Inventors: Duy H Hua, Lee-way Jin, Izumi Maezawa, Xinmin Xie
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Patent number: 9233973Abstract: Pharmaceutical compositions that bind to a predicted FK506 Binding Protein 52 (FKBP52) interaction surface on the androgen receptor hormone binding domain, otherwise known as FKBP52 Targeting Agents (FTAs) are provided. These compositions of the present invention are found to specifically recognize the FKBP52 regulatory surface on the androgen receptor and inhibit FKBP52 from functionally interacting with the androgen receptor. Compositions comprising the pharmaceutical composition, as well as methods of use, treatment and screening are also provided.Type: GrantFiled: July 21, 2014Date of Patent: January 12, 2016Assignees: The United States of America, as represented by The Secretary, Department of Health and Human Services, The Regents of the University of California, a California Corporation, Board of Regents, The University of Texas SystemInventors: Leonard M. Neckers, Marc B. Cox, Jane B. Neckers, Yeong Sang Kim, Aki Iwai, Yangmin Ning, Johanny Kugelman-Tonos, Heather A. Balsiger, Robert Fletterick
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Patent number: 9227014Abstract: Techniques for controlling an insulin pump include determining values for parameters selected from a group including a first prediction time horizon, a predicted glucose threshold (Goff) for turning the insulin pump off, a maximum shut off time within a time window, and duration of the time window. A safety rule is determined based on the maximum shut off time within the duration. Glucose readings are collected up to a current time. An expected current glucose value G and glucose temporal rate of change are determined based only on the glucose readings and a Kalman filter configured for noisy glucose readings. A glucose level (Gh1) is predicted for a future time that is the prediction time horizon after the current time. A command is issued to shut off the insulin pump if it is determined both that Gh1 is less than Goff and that the safety rule is satisfied.Type: GrantFiled: February 7, 2014Date of Patent: January 5, 2016Assignees: The Board of Trustees of the Laland Stanford Junior University, The Regents of the University of California, a California Corporation, The Regents of the University of Colorado, a body corporate, Rensselaer Polytechnic InstituteInventors: Bruce A. Buckingham, B. Wayne Bequette, Fraser Cameron, Darrell M. Wilson, H. Peter Chase, Francis J. Doyle, III, Matthew Stenerson
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Patent number: 9162101Abstract: In one embodiment, an exercise apparatus for exercising an arm includes a lever adapted to attach to a wheel of a wheelchair, a forearm support pivotally mounted to the lever that is adapted to support a forearm of a wheelchair user during exercise, and a resilient member attached to the lever that is adapted to resist movement of the lever by the user.Type: GrantFiled: March 15, 2013Date of Patent: October 20, 2015Assignee: The Regents of the University of California, A California CorporationInventors: Daniel Zondervan, David Reinkensmeyer
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Patent number: 9121852Abstract: The present invention provides methods and kits a) for predicting colorectal cancer patient survival, as well as the survival of patients harboring other invasive cancers where cellular proliferation and carcinogenesis is linked, in part, to high levels of ODC activity and increased cellular polyamine contents, and b) for selecting the corresponding treatment options for such patients based on the allelic nucleotide sequence or SNP at position +316 of the ODC1 promoter gene as well as cancer treatment methods, in each case, which include the determination of the ODC1 promoter +316 position genotype, as a means to guide treatment selection.Type: GrantFiled: December 10, 2012Date of Patent: September 1, 2015Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF UNIVERSITY OF ARIZONA, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATIONInventors: Eugene W. Gerner, Jason A. Zell, Christine E. McLaren, Frank L. Meyskens, Jr., Hoda Anton-Culver, Patricia A. Thompson
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Publication number: 20140274959Abstract: The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Applicant: The Regents of the University of California, a California corporationInventors: Karl Y. Hostetler, James R. Beadle, Nadejda Valiaeva
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Publication number: 20140275532Abstract: The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Applicant: The Regents of the University of California, a California CorporationInventors: Karl Y. Hostetler, James R. Beadle, Nadejda Valiaeva
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Patent number: 8835630Abstract: The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.Type: GrantFiled: March 14, 2014Date of Patent: September 16, 2014Assignee: The Regents of the University of California, a California corporationInventors: Karl Y. Hostetler, James R. Beadle, Nadejda Valiaeva
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Publication number: 20140221966Abstract: Techniques for controlling an insulin pump include determining values for parameters selected from a group including a first prediction time horizon, a predicted glucose threshold (Goff) for turning the insulin pump off, a maximum shut off time within a time window, and duration of the time window. A safety rule is determined based on the maximum shut off time within the duration. Glucose readings are collected up to a current time. An expected current glucose value G and glucose temporal rate of change are determined based only on the glucose readings and a Kalman filter configured for noisy glucose readings. A glucose level (Gh1) is predicted for a future time that is the prediction time horizon after the current time. A command is issued to shut off the insulin pump if it is determined both that Gh1 is less than Goff and that the safety rule is satisfied.Type: ApplicationFiled: February 7, 2014Publication date: August 7, 2014Applicants: The Board of Trustees of the Leland Stanford Junior University, Rensselaer Polytechnic Institute, The Regents of the University of Colorado, a body corporate, The Regents of the University of California, a California CorporationInventors: Bruce A. Buckingham, B. Wayne Bequette, Fraser Cameron, Darrell M. Wilson, H. Peter Chase, Francis J. Doyle, III, Matthew Stenerson
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Publication number: 20140170140Abstract: The present invention is directed to antibodies binding to aquaporin 4 (AQP4) and methods of using such antibodies to treat neuromyelitis optica (NMO) either as a monotherapy or in combination with standard NMO therapies such as immunosuppressives or plasmaphersis.Type: ApplicationFiled: April 23, 2012Publication date: June 19, 2014Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION, THE REGENTS OF THE UNIVERSITY OF COLORADO A BODY CORPORATEInventors: Jeffrey L. Bennett, Gregory P. Owens, Alan S. Verkman
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Publication number: 20130217743Abstract: Controlling exogenous polyamines may be used, in some aspects, as an adjunctive strategy to chemoprevention with polyamine inhibitory agents, for example, anti-carcinoma combination therapies comprising ornithine decarboxylase (ODC) inhibitor and a spermidine/spermine N1-acetyltransferase expression agonist, optionally based on a patient's ODC1 promoter genotype. Assessing a tissue polyamine level or tissue polyamine flux may be used in some aspects, for predicting the efficacy of an anti-carcinoma combination therapy comprising, for example, an ornithine decarboxylase (ODC) inhibitor and an agent that modulates the polyamine pathway to reduce overall cellular polyamine content.Type: ApplicationFiled: May 13, 2011Publication date: August 22, 2013Applicants: CANCER PREVENTION PHARMACEUTICALS, INC., CANCER PREVENTION PHARMACEUTICAL, INC, THE REGENT OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATIONInventors: Kavitha P. Raj, Jason A. Zell, Christine E. Mclaren, Eugene W. Gerner, Frank L. Meyskens, JR., Jeffrey Jacob
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Publication number: 20130164751Abstract: The present invention provides methods and kits a) for predicting colorectal cancer patient survival, as well as the survival of patients harboring other invasive cancers where cellular proliferation and carcinogenesis is linked, in part, to high levels of ODC activity and increased cellular polyamine contents, and b) for selecting the corresponding treatment options for such patients based on the allelic nucleotide sequence or SNP at position +316 of the ODC1 promoter gene as well as cancer treatment methods, in each case, which include the determination of the ODC1 promoter +316 position genotype, as a means to guide treatment selection.Type: ApplicationFiled: December 10, 2012Publication date: June 27, 2013Applicants: The Regents of the University of California, a California Corporation, Arizona Board of Regents on Behalf of University of ArizonaInventors: Arizona Board of Regents on Behalf of University o, The Regents of the University of California, a Cal
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Publication number: 20130152933Abstract: An automated fluid delivery system and method are disclosed. The system includes distensible tubing, a flow controller, and a fluid flow adjustment module. The fluid flow adjustment module may be configured to detect differential pressure in the tubing and adjust the flow controller to provide an amount of fluid through the tubing during inhalation.Type: ApplicationFiled: August 9, 2011Publication date: June 20, 2013Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATIONInventors: David William Lischer, Stephen Winston Roberts
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Publication number: 20130076789Abstract: An augmented reality scene may be registered onto an arbitrary surface. A camera may capture an image of the arbitrary surface. The camera may analyze the surface geometry of the arbitrary surface. In some embodiments, a processing computing device may analyze data captured by the camera and an adjacent camera to reconstruct the surface geometry of the arbitrary surface. A scene may be registered to a three dimensional coordinate system corresponding to the arbitrary surface. A projector may project the scene onto the arbitrary surface according to the registration so that the scene may not display as being distorted.Type: ApplicationFiled: September 24, 2012Publication date: March 28, 2013Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATIONInventor: THE REGENTS OF THE UNIVERSITY
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Publication number: 20130070094Abstract: Automatic registration of projectors and their images on a curved surface may be performed using non-linear optimization techniques. A camera may capture images on the curved surface. The camera may be un-calibrated. The camera parameters may be estimated using a non-linear optimization of data in the images of the curved surface. The images may be from multiple projectors. In some embodiments, registration may be view independent.Type: ApplicationFiled: September 20, 2012Publication date: March 21, 2013Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATIONInventor: THE REGENTS OF THE UNIVERSITY OF CALIF