Abstract: Provided are methods for the combined use of cyclin-dependent kinase 9 (CDK9) inhibitors and bromodomain containing 4 (BRD4) inhibitors to reduce, inhibit and/or prevent cartilage degradation and systemic traumatic inflammation. A combination of CDK9 inhibitors and BRD4 inhibitors can be used to reduce, inhibit and/or prevent cartilage degradation and loss of cartilage viability during allograft storage. A combination of CDK9 inhibitors and BRD4 inhibitors can be used as a post-injury intervention treatment to reduce, inhibit and/or prevent the acute cellular responses that lead to future cartilage degradation and osteoarthritis.
Type:
Grant
Filed:
May 23, 2019
Date of Patent:
June 1, 2021
Assignee:
The Regents Of The University Of California, Davis
Abstract: A method and system for encrypting a first piece of information M to be sent by a sender [100] to a receiver [110] allows both sender and receiver to compute a secret message key using identity-based information and a bilinear map. In a one embodiment, the sender [100] computes an identity-based encryption key from an identifier ID associated with the receiver [110]. The identifier ID may include various types of information such as the receiver's e-mail address, a receiver credential, a message identifier, or a date. The sender uses a bilinear map and the encryption key to compute a secret message key gIDr, which is then used to encrypt a message M, producing ciphertext V to be sent from the sender [100] to the receiver [110] together with an element rP. An identity-based decryption key dID is computed by a private key generator [120] based on the ID associated with the receiver and a secret master key s.
Type:
Grant
Filed:
October 28, 2009
Date of Patent:
March 6, 2012
Assignees:
The Board of Trustees of the Leland Stanford Junior University, The Regents of the University of California, Davis
Abstract: A method and system for encrypting a first piece of information M to be sent by a sender [100] to a receiver [110] allows both sender and receiver to compute a secret message key using identity-based information and a bilinear map. In a one embodiment, the sender [100] computes an identity-based encryption key from an identifier ID associated with the receiver [110]. The identifier ID may include various types of information such as the receiver's e-mail address, a receiver credential, a message identifier, or a date. The sender uses a bilinear map and the encryption key to compute a secret message key gIDr, which is then used to encrypt a message M, producing ciphertext V to be sent from the sender [100] to the receiver [110] together with an element rP. An identity-based decryption key dID is computed by a private key generator [120] based on the ID associated with the receiver and a secret master key s.
Type:
Grant
Filed:
May 9, 2006
Date of Patent:
December 15, 2009
Assignees:
The Board of Trustees of the Leland Stanford Junior University, The Regents of the University of California, Davis