Abstract: The present invention relates to methods, compositions and systems for detecting perchlorate in a sample. Compositions useful for detecting perchlorate in a sample include those comprising a perchlorate reductase, a reductant and an electron shuttle. In an exemplary embodiment, the composition comprises perchlorate reductase from Dechloromonas agitata, reduced nicotinamide adenine dinucleotide and N-methylphenazinium methylsulfate. The present invention also provides for methods of using the compositions disclosed herein, as well as systems thereof. In some exemplary embodiments, the methods comprise a concentration step, in which, for example, the sample is contacted with a cationic solid phase extraction column. Employing this step provides certain advantages such as a lowered detection limit and the removal of contaminants.
Type:
Application
Filed:
September 1, 2009
Publication date:
October 27, 2011
Applicant:
The Regents of the University of California The Office of the President
Abstract: A RF coil for use with a resonance imaging device, the RF coil comprises a conductor comprising a first conductive region, a second conductive region substantially isolated from the first portion along its length, and at least one coupling portion adjacent to ends of the first and second portions and configured to electrically couple the first and second portions at a first predetermined frequency. The coil further includes a dielectric substrate supporting the conductor. The RF coil is configured to perform one of excitation, detection, reception, or a combination thereof. A method of using one or more RF coil is further disclosed.
Type:
Application
Filed:
April 29, 2009
Publication date:
March 31, 2011
Applicant:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA THE OFFICE OF THE PRESIDENT
Abstract: The invention provides methods and compositions for screening for modulators of EGFR activity. In particular, an assay for such modulators is provided, which includes methods of screening for modulators using models of the three dimensional structure of EGFR kinase domains.
Type:
Application
Filed:
November 19, 2008
Publication date:
December 23, 2010
Applicant:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA THE OFFICE OF THE PRESIDENT
Inventors:
John Kuriyan, Xuewu Zhang, Natalia Jura
Abstract: The invention provides methods and compositions for the modulation of EGFR activity, in particular, inhibition of EGFR activation through an allosteric mechanism is discloses, as is a method for targeted drug discovery and design based on models of the three dimensional structure of the kinase domains of the protein dimers.
Type:
Application
Filed:
October 15, 2007
Publication date:
May 13, 2010
Applicant:
The Regents of the University of California The Office of the President
Abstract: This invention relates to a new and distinctive male asparagus hybrid called ‘M256’. ‘M256’ has the ability to confer desirable traits on its progeny, such as early spear emergence, and produces offspring that have a higher proportion of marketable spears.
Type:
Application
Filed:
April 2, 2007
Publication date:
October 2, 2008
Applicant:
The Regents of the University of California Office of the President
Inventors:
Mikeal Roose, Neil Stone, Laverne Lippert, Janice Gish
Abstract: The present invention provides a transcription amplification system, comprising an effector nucleic acid molecule and a reporter molecule, which work together to produce a heterologous gene product in a cell-type, specific manner. The present invention also relates to methods for producing, detecting, imaging, and monitoring the heterologous gene product in a cell or in a subject.
Type:
Application
Filed:
February 7, 2003
Publication date:
October 5, 2006
Applicant:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OFFICE OF THE PRESIDENT)
Abstract: The present invention provides methods for stimulating Toll-like receptors (TLR) to activate IRF (e.g., an IRF3) and signaling pathway, and thereby directing an antimicrobial activity. The present invention also provides methods for identifying agents that bind and/or stimulate TLR and mediate induction of an IRF3 pathway, thereby directing an antimicrobial activity. Additionally, the invention provides methods and agents for suppressing stimulation of TLR, thereby directing an anti-inflammatory response.
Type:
Application
Filed:
April 24, 2003
Publication date:
March 16, 2006
Applicant:
THE Regents of the University of California Office of the President
Inventors:
Genhong Cheng, Robert Modlin, Sagar Vaidya, Sean Doyle