Abstract: The present invention relates to a peptide, which specifically homes to the intracranial, early stage astrocytoma model that grows as islets and harbors co-opted tumor vessels in the brain. The peptide finds its use in targeted delivery of therapeutic substances to invasive brain cancer or metastatic brain lesions as such and in combination with conventional therapies, such as surgery and radiation, and anti-angiogenic therapies, and as a tool in diagnosis of, e.g., invasive brain cancer or metastatic brain lesions.
May 8, 2009
Date of Patent:
May 29, 2012
Burnham Institute for Medical Research, The Regents of the University of California, UCSF
Pirjo Laakkonen, Erkki Ruoslahti, Gabriele Bergers