Patents Assigned to The Regents of the University of California
  • Method and device for digital high resolution melt
    Patent number: 11915795
    Abstract: Methods are provided for nucleic acid analysis via a platform which incorporates a digital sample partitioning platform such as a microfluidic chip or digital droplet platform and instrumentation to accomplish universal amplification, High Resolution Melting (HRM), and machine learning within reactions simultaneously.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: February 27, 2024
    Assignee: The Regents of the University of California
    Inventors: Stephanie I. Fraley, Sinead Charpentier, Daniel Ortiz Velez, Mridu Sinha, Benjamin Albert Yang
  • LEAF DETECTION AND EXTRACTION SYSTEM
    Publication number: 20240057527
    Abstract: Disclosed herein is a system and methods for leaf detection and extraction. The extracted leaf may be used for leaf water potential analysis. In some embodiments, the method comprises identifying the leaf from a point cloud based on an image, determining a pose of the leaf based on the point cloud, and cutting and storing the leaf based on the pose of the leaf.
    Type: Application
    Filed: August 22, 2023
    Publication date: February 22, 2024
    Applicant: The Regents of the University of California
    Inventors: Konstantinos KARYDIS, Merrick CAMPBELL, Amel DECHEMI
  • METHOD FOR RELAXING SEMICONDUCTOR FILMS INCLUDING THE FABRICATION OF PSEUDO-SUBSTRATES AND FORMATION OF COMPOSITES ALLOWING THE ADDITION OF PREVIOUSLY UN-ACCESSIBLE FUNCTIONALITY OF GROUP lll-NITRIDES
    Publication number: 20240063340
    Abstract: The present disclosure describes porous GaN layers and/or compliant substrates used to enable relaxation of previously strained top layers and the deposition of relaxed or partially relaxed on top. Relaxed In GaN layers are fabricated without generation of crystal defects, which can serve as base layers for high performance long wavelength light emitting devices (LEDs, lasers) solar cells, or strain engineered transistors. Similarly, relaxed AlGaN layers can serve as base layers for high performance short wavelength UV light emitting devices (LEDs, lasers) solar cells, or wide bandgap transistors.
    Type: Application
    Filed: September 10, 2020
    Publication date: February 22, 2024
    Applicants: The Regents of the University of California, The Regents of the University of California
    Inventors: Stacia Keller, Umesh K. Mishra, Shubhra Pasayat, Chirag Gupta
  • COMBINATION THERAPY WITH FOR46 FOR CANCER
    Publication number: 20240058464
    Abstract: Disclosed herein are methods of treating cancer. Some such methods include administration of a first anti-cancer agent that increases CD46 expression on the surface of a cancer cell. Some embodiments include administration of a second anti-cancer agent that binds CD46. The second anti-cancer agent may include an immunoconjugate comprising a CD46 binding domain and effector agent.
    Type: Application
    Filed: January 6, 2022
    Publication date: February 22, 2024
    Applicants: Fortis Therapeutics, Inc., The Regents of the University of California
    Inventors: Bin LIU, Andrew DORR, Jay LICHTER, Marc NASOFF, Leonard POST
  • Method for identifying chemical and structural variations through terahertz time-domain spectroscopy
    Patent number: 11906424
    Abstract: A terahertz scanner for detecting irregularities, such as chemical or structural variations, in a sample and methods of use thereof are described. The described terahertz scanner and algorithms allow for direct, high-sensitivity, high-throughput, and non-invasive detection of irregularities that range from chemical contaminant to material defects in a variety of substrates and settings.
    Type: Grant
    Filed: October 1, 2020
    Date of Patent: February 20, 2024
    Assignee: The Regents of the University of California
    Inventors: Mona Jarrahi, Nezih Tolga Yardimci
  • Sealable, mesoporous silica shell nanoreactor
    Patent number: 11906674
    Abstract: The present technology relates to nanomaterials and methods of their use, and more specifically to methods and structures using nanomaterials to fiducially measure radiation dosing.
    Type: Grant
    Filed: March 4, 2021
    Date of Patent: February 20, 2024
    Assignee: REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: Ting Guo
  • Surround vehicle tracking and motion prediction
    Patent number: 11906625
    Abstract: A surround multi-object tracking and surround vehicle motion prediction framework is provided. A full-surround camera array and LiDAR sensor based approach provides for multi-object tracking for autonomous vehicles. The multi-object tracking incorporates a fusion scheme to handle object proposals from the different sensors within the calibrated camera array. A motion prediction framework leverages the instantaneous motion of vehicles, an understanding of motion patterns of freeway traffic, and the effect of inter-vehicle interactions. The motion prediction framework incorporates probabilistic modeling of surround vehicle trajectories. Additionally, subcategorizing trajectories based on maneuver classes leads to better modeling of motion patterns. A model takes into account interactions between surround vehicles for simultaneously predicting each of their motion.
    Type: Grant
    Filed: January 8, 2019
    Date of Patent: February 20, 2024
    Assignee: The Regents of the University of California
    Inventors: Akshay Rangesh, Mohan M. Trivedi, Nachiket Deo
  • Heat exchange module, system and method
    Patent number: 11903872
    Abstract: A heat exchange module alone or part of a system including a control console. The HEM can include a channel enclosure assembly, a thermoelectric cooler (TEC) assembly and a heat transfer (cover) assembly. The enclosure assembly includes a channel for a heat-transfer liquid. The module can be constructed to provide for flexibility to better conform and fit on rounded and/or angular body parts and to efficiently transfer heat between the adjacent body part and the heat-transfer liquid via the TECs of the TEC assembly.
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: February 20, 2024
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, HYPOTHERM DEVICES, INC.
    Inventors: Julio L. Vergara, Daniel M. Estrada, Mayank Kalra, Andrew Padula, Ryan Cohn
  • Immobilized RNPs for sequence-specific nucleic acid capture and digital detection
    Patent number: 11905552
    Abstract: A digital biosensor for assaying a target nucleic acid and methods of using the biosensor for digitally detecting the target nucleic acid are disclosed wherein the biosensor includes a substrate having a substrate surface and at least two electrodes, a linker molecule having a first moiety conjugated to the substrate surface, a ribonucleoprotein (RNP) conjugated to a second moiety of the linker molecule, and a guide ribonucleic acid (gRNA) having a first sequence capable of binding to the inactive RNP and a second sequence capable of binding to the target nucleic acid.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: February 20, 2024
    Assignees: KECK GRADUATE INSTITUTE OF APPLIED LIFE SCIENCES, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Kiana Aran, Tara deBoer, Irina Conboy
  • Therapeutic Supernatant from Cell-Seeded Substrates and Related Methods
    Publication number: 20240049701
    Abstract: Disclosed herein are methods and compositions for the identification of viability enhancing cell features and substrate features as they relate to post-cryopreservation survival of substrate seeded cells. Embodiments of the present invention further involve identification of cell features to manufacture a supernatant that is useful for cell culturing and treatment of various diseases.
    Type: Application
    Filed: October 10, 2023
    Publication date: February 15, 2024
    Applicants: University of Southern California, The Regents of the University of California
    Inventors: Britney O. Pennington, Jeffrey K. Bailey, Mohamed A. Faynus, Cassidy Arnold, Lincoln V. Johnson, Dennis O. Clegg, Mark S. Humayun, David R. Hinton, Danhong Zhu, Debbie Mitra
  • CHEMICAL RECYLING OF PLASTICS USING IONIC LIQUIDS OR DEEP EUTECTIC SOLVENTS
    Publication number: 20240052133
    Abstract: A method for depolymerizing a mixture of plastics is described. The method comprises (a) providing a composition comprising two of more plastics, (b) introducing a solvent comprising an ionic liquid (IL) or deep eutectic solvents (DES) and optionally water to the composition to form a solvent-plastic composition, such as an aqueous solvent-plastic composition, and (c) incubating the solvent-plastic composition for a period of time to produce a depolymerized composition such that at least portions of the two of more plastics are depolymerized into monomers. The produced monomers can be used as a carbon source for microbes to produce bioproducts.
    Type: Application
    Filed: August 5, 2023
    Publication date: February 15, 2024
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, National Technology and Engineering Solutions of Sandia, LLC
    Inventors: Chang Dou, Hemant Choudhary, Ning Sun, Blake A. Simmons
  • FACILITATING CONTROLLED MOLECULAR ASSEMBLY OF NANOSCALE STRUCTURES VIA DYNAMIC CONFINEMENT OF SOLVENT
    Publication number: 20240051218
    Abstract: The disclosed embodiments provide a system that performs molecular assembly. During operation, the system delivers one or more droplets of a fluid onto a surface using a nanofluidic delivery probe and an associated high-precision positioning device, wherein the solution comprises a solvent and one or more solute molecules, and wherein delivery of the droplets onto the surface facilitates evaporation-driven assembly of one or more structures on the surface. Moreover, while delivering a droplet onto the surface, the system controls a size of the droplet and a shape of the droplet during evaporation to produce a variety of shapes in resulting structures.
    Type: Application
    Filed: October 6, 2020
    Publication date: February 15, 2024
    Applicants: The Regents of the University of California, IBM Almaden Research Center
    Inventors: Jiali Zhang, Victoria A. Puinova, Yang Liu, Jane Frommer, Gang-Yu Liu
  • FLEXIBLE THERMAL INTERFACE BASED ON SELF-ASSEMBLED BORON ARSENIDE FOR HIGH-PERFORMANCE THERMAL MANAGEMENT
    Publication number: 20240055320
    Abstract: A thermal interface comprising a polymer composite comprising a polymer and a self-assembled boron arsenide.
    Type: Application
    Filed: February 4, 2022
    Publication date: February 15, 2024
    Applicant: The Regents of the University of California
    Inventors: Yongjie HU, Ying CUI
  • SELF-ASSEMBLED CONCENTRIC NANOPARTICLE RINGS TO GENERATE ORBITAL ANGULAR MOMENTUM
    Publication number: 20240052111
    Abstract: Methods for generating patterned nanoparticle assemblies in thin films of supramolecular nanocomposites are provided that allow control over microdomain morphology, periodicity, and orientation by tuning the assembly kinetics and pathways of the system. Directed self-assembly (DSA) of block copolymers (BCPs) with nanoparticles formed on lithographically-patterned templates produce patterned supramolecular nanocomposite films and patterns of nanoparticles. DSA may be used to guide the formation of concentric rings with radii spanning approximately 150 nm to 1150 nm and ring widths spanning about 30 nm to 60 nm, for example. When plasmonic nanoparticles are used, ring nanodevice arrays can be fabricated in one step, and the completed devices produce high-quality orbital angular momentum (OAM).
    Type: Application
    Filed: August 15, 2023
    Publication date: February 15, 2024
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Ting Xu, Jie Yao, Katherine Evans, Qingjun Wang, Emma Vargo
  • Inhibition of oxidation-specific epitopes to treat ischemic reperfusion injury
    Patent number: 11897969
    Abstract: The disclosure provides for methods and treatments of ischemic injury, reperfusion injury, stroke and myocardial infarctions by administering within minutes to hours an antibody or antibody fragment that bind to and inhibits the biological activity of OxPL in an affected tissue.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: February 13, 2024
    Assignee: The Regents of the University of California
    Inventors: Sotirios Tsimikas, Joseph L. Witztum, Xuchu Que
  • Microfluidic pressure regulator for robust hydrogel loading without bursting
    Patent number: 11898129
    Abstract: A pressure regulator module for a chip-based microfluidic platform is provided. The module includes a microfluidic channel for passing flowable material from the inlet region through the outlet region and into a downstream compartment; one or more microvalves fluidly connected to the microfluidic channel and upstream of the outlet region; and one or more reservoirs fluidly connected to the microvalves, for receiving flowable material diverted by the microvalves, where a flow of flowable material passing from the inlet region toward the downstream compartment is at least partially diverted by the microvalves into the reservoirs as a result of a pressure increase in the microfluidic channel. In some versions, the microvalves are capillary burst valves. A microfluidic chip containing the module and a method of using the module are provided.
    Type: Grant
    Filed: October 1, 2021
    Date of Patent: February 13, 2024
    Assignee: The Regents of the University of California
    Inventors: Abraham P. Lee, Xiaolin Wang, Duc Phan, Christopher C. W. Hughes, Steven C. George
  • Reversible stencils for fabricating micro-tissues
    Patent number: 11898167
    Abstract: The invention relates to devices, methods, kits, and compositions for in vitro generation of three-dimensional micro-tissues that are accurate models of heart, skeletal muscle, neuronal, and other tissues.
    Type: Grant
    Filed: October 26, 2020
    Date of Patent: February 13, 2024
    Assignees: The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Gladstone, The Regents of the University of California
    Inventors: Nathaniel Huebsch, Bruce Conklin, Kevin E. Healy, Peter Loskill
  • Shotgun proteomic antigen identification
    Patent number: 11899020
    Abstract: This invention provides methods for the screening and identification of antigenic components in a tissue or organ of interest.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: February 13, 2024
    Assignee: The Regents of the University of California
    Inventors: Leigh G. Griffiths, Katherine Y. Gates, Ailsa J. Dalgliesh, Maelene L. Wong
  • Receptors for ligand-dependent transcriptional regulation
    Patent number: 11897932
    Abstract: The present disclosure generally relates to, among other things, a new class of receptors engineered to modulate transcriptional regulation in a ligand-dependent manner. Particularly, the new receptors, even though derived from Notch, do not require the Notch negative regulatory regions previously believed to be essential for the functioning of the receptors. The disclosure also provides compositions and methods useful for producing such receptors, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various health conditions or diseases, such as cancers.
    Type: Grant
    Filed: March 30, 2021
    Date of Patent: February 13, 2024
    Assignee: The Regents of the University of California
    Inventors: Kole T. Roybal, Raymond Liu, Iowis Zhu
  • Biomimetic electrically conductive hyaluronic acid-based hydrogels
    Patent number: 11896738
    Abstract: An electrically conductive hyaluronic acid-based hydrogel is disclosed that is a crosslinked porous scaffold having a graphene-based material encapsulated or in contact within the porous scaffold. The graphene-based material includes one or more of graphene oxide foam, reduced graphene oxide foam, nanoplatelets, nanoparticles, or fibers. The porous scaffold may be formed over an implanted bioelectronic device such as a microelectrode array having a plurality of electrodes. The porous scaffold may also be used to control the differentiation of cells including Neural Stem/Progenitor Cells (NS/PCs).
    Type: Grant
    Filed: March 10, 2021
    Date of Patent: February 13, 2024
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: Rebecca Bierman