Patents Assigned to The Regents of the University of California
  • AMNIOTIC MEMBRANE FOR MYOCARDIAL REPAIR
    Publication number: 20240016979
    Abstract: A novel injectable human amniotic membrane (hAM) matrix to enhance cardiac repair and/or regeneration following myocardial injury (MI) and wound healing has been developed. The invention disclosed herein provides human amniotic membranes isolated from human placenta and engineered to be a thermo-responsible, injectable gel at temperature ranges that fall within body temperature. The ultrasound-guided injection of hAM matrix into a rodent model of myocardial infarction significantly improved cardiac contractility, as measured by ejection fraction (EF), and decreased fibrosis. The disclosure provided herein demonstrates the specific engineering injectable hAM matrices and their efficacy in attenuating degenerative changes in cardiac function following MI, which has broad applications in wound healing and tissue regeneration.
    Type: Application
    Filed: December 22, 2021
    Publication date: January 18, 2024
    Applicant: The Regents of the University of California
    Inventors: Song Li, Randall J. Lee, Jeff Henry
  • HOT FORMING OF CURVED MIRRORS WITHOUT THE NEED FOR A MANDREL
    Publication number: 20240018030
    Abstract: A method and apparatus for fabrication of mirror facesheets that uses a hot thermal forming process, or slumping. Rather than relying on an accurate negative form to slump the glass into, the glass is allowed to slump freely within a support ring that is outside the final required optical diameter of the shell. Such an approach allows for creation of shells over a variety of radii of curvature, simply by changing details of the heating process. However, to create an approximately parabolic shape, an additional force is required. The expected deformation can be modeled to show that a top weight with a given force just outside the optical diameter creates close to the desired shape. Experimental verification has been demonstrated for shells 120 mm in diameter. The forming fixtures and processes can be optimized and scaled to larger facesheets needed for upcoming ASM's.
    Type: Application
    Filed: July 14, 2023
    Publication date: January 18, 2024
    Applicant: The Regents of the University of California
    Inventors: Philip Hinz, Matthew Radovan
  • DEVICE AND METHOD FOR GAS MAINTENANCE IN MICROFEATURES ON A SUBMERGED SURFACE
    Publication number: 20240018980
    Abstract: A microstructured surface with microfeatures formed thereon and defining spaces between the microfeatures includes least one electrode of an electrode pair in the spaces, wherein electrodes of the pair are electrically connected to one another. The at least one electrode located in the space is configured to generate a gas in between the microfeatures when an electrolyte solution penetrates into the microfeatures. Importantly, the electrodes are not connected to any external power source. Because the microstructured surface is self-powered in replenishing the gas lost in a submerged condition, no additional provision to supply energy or regulate the replenishment is necessary for implementation and use.
    Type: Application
    Filed: July 21, 2023
    Publication date: January 18, 2024
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Muchen Xu, Chang-Jin Kim
  • BIOELECTRIC NEUROMODULATION FOR HEMATOPOIESIS REGULATION DURING CHEMOTHERAPY
    Publication number: 20240017070
    Abstract: A device and method are taught for stimulating sympathetic nerves toward mitigating negative impacts to hematopoiesis. An autonomic nerve actuator and stimulator system with a graphic user interface (GUI), controller circuit which converts treatment parameters into a series of Building Block Waveforms (BBW) which are output to Current/Voltage Driver Circuitry (CDC) whose electrical stimulus (ES) outputs are coupled to one or more electrodes and/or electrode arrays positioned proximal specific nerve situations. The use of this in combination with conventional chemotherapy treatments, such as use of carboplatin, was found to significantly enhance hematopoiesis, with improvements in white and red blood cell counts, platelet concentration and hemoglobin concentration, in addition to other measurable characteristics which increased survival rates in the experimental groups tested.
    Type: Application
    Filed: June 2, 2023
    Publication date: January 18, 2024
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NATIONAL CHENG KUNG UNIVERSITY
    Inventors: Wentai Liu, Meng-Ru Shen, Li-Hsien Chen, Ya-Ting Hsu
  • GABA agonists in the treatment of disorders associated with metabolic syndrome and GABA combinations in treatment or prophylaxis of type I diabetes
    Patent number: 11872200
    Abstract: In certain embodiments methods are provided for the therapeutic or prophylactic amelioration of one or more symptoms or disorders associated with metabolic syndrome. In various embodiments the methods involve administering to a subject in need thereof, a GABA receptor agonist, in an amount sufficient to ameliorate said one or more symptoms. In certain embodiments methods are provided for the prophylaxis or treatment of type I diabetes and related pathologies that involve the use of GABA or GABA agonists in combination with certain other compounds (e.g., one more antigens (e.g., GAD) that have a therapeutic effect in type I diabetes and/or an anti-CD3 antibody, an anti-CD20 antibody, exendin-4, and/or or a pro-insulin therapeutic).
    Type: Grant
    Filed: March 22, 2021
    Date of Patent: January 16, 2024
    Assignee: The Regents of the University of California
    Inventors: Daniel L Kaufman, Jide Tian
  • Solid-state lithium-ion conductor and methods of manufacture thereof
    Patent number: 11876225
    Abstract: A solid-state ion conductor including a compound of Formula 1: Li1+(4?a)yAayM1?yXO5??Formula 1 wherein, in Formula 1, A is an element of Groups 1 to 3 or 11 to 13, or a combination thereof, wherein an oxidation state a of A is 1?a?3, M is an element having an oxidation state of +4 of Groups 4 or 14, or a combination thereof, X is an element having an oxidation state of +5 of Groups 5, 15, 17, or a combination thereof, and 0<y?1.
    Type: Grant
    Filed: May 17, 2021
    Date of Patent: January 16, 2024
    Assignees: SAMSUNG ELECTRONICS CO., LTD., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, LAWRENCE BERKELEY NATIONAL LABORATORY
    Inventors: KyuJung Jun, Gerbrand Ceder, Yan Wang, Lincoln Miara, Yan Zeng, Yihan Xiao
  • High numerical aperture selective plane illumination microscopy
    Patent number: 11874451
    Abstract: In one embodiment, a microscopy system includes a first objective positioned adjacent to a sample to be imaged, the first objective being configured to both illuminate the sample with light and collect light from the sample, and a remote imaging module positioned remotely from the first objective and the sample, the remote imaging module being configured to rotate the image plane of the collected light.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: January 16, 2024
    Assignee: The Regents of the University of California
    Inventors: Bo Huang, Bin Yang
  • Inhibitors for soluble epoxide hydrolase (sEH) and fatty acid amide hydrolase (FAAH)
    Patent number: 11873288
    Abstract: The present invention provides compounds that are dual inhibitors of soluble epoxide hydrolase and fatty acid amide hydrolase. The present invention also provides methods of using the compounds to inhibit soluble epoxide hydrolase and fatty acid amide hydrolase, and to treat cancer.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: January 16, 2024
    Assignee: The Regents of the University of California
    Inventors: Bruce Hammock, Sean Kodani
  • RNA-guided nucleic acid modifying enzymes and methods of use thereof
    Patent number: 11873504
    Abstract: The present disclosure provides CasX proteins, nucleic acids encoding the CasX proteins, and modified host cells comprising the CasX proteins and/or nucleic acids encoding same. CasX proteins are useful in a variety of applications, which are provided. The present disclosure provides CasX guide RNAs that bind to and provide sequence specificity to the CasX proteins, nucleic acids encoding the CasX guide RNAs, and modified host cells comprising the CasX guide RNAs and/or nucleic acids encoding same. CasX guide RNAs are useful in a variety of applications, which are provided. The present disclosure provides archaeal Cas9 polypeptides and nucleic acids encoding same, as well as their associated archaeal Cas9 guide RNAs and nucleic acids encoding same.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: January 16, 2024
    Assignee: The Regents of the University of California
    Inventors: Jennifer A Doudna, Jillian F. Banfield, David Burstein, Lucas Benjamin Harrington, Steven C. Strutt
  • Techniques for avoiding collisions among communications packets by using shared transmission queue
    Patent number: 11876725
    Abstract: Techniques for transmitting data packets on a shared channel in a data communications network include storing, on a local node, a current number of turns in a transmitting queue and a current turn based on packets received from other nodes on the channel. For a first local data packet to transmit, a local transmit turn is obtained based on successfully transmitting the packet in a time interval following a last turn in the queue. A data link layer header includes queue fields for the current number of turns, the local transmit turn, and a request for adding the local transmit turn. While there is still a remaining packet to transmit and when the current turn is the local transmit turn, the packet is transmitted with queue fields indicating the current number of turns, the current turn, and an indication of no new turn. An acknowledgement control packet indicates successful transmission.
    Type: Grant
    Filed: February 1, 2021
    Date of Patent: January 16, 2024
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: Jose Joaquin Garcia-Luna-Aceves
  • Compositional variations of tungsten tetraboride with transition metals and light elements
    Patent number: 11873544
    Abstract: A composition includes tungsten (W); at least one element selected form the group of elements consisting of boron (B), beryllium (Be) and silicon (Si); and at least one element selected from the group of elements consisting of titanium (Ti), vanadium (V), chromium (Cr), manganese (Mn), iron (Fe), cobalt (Co), nickel (Ni), copper (Cu), zinc (Zn), zirconium (Zr), niobium (Nb), molybdenum (Mo), ruthenium (Ru), hafnium (Hf), tantalum (Ta), rhenium (Re), osmium (Os), iridium (Ir), lithium (Li) and aluminum (Al). The composition satisfies the formula W1-xMxXy wherein X is one of B, Be and Si; M is at least one of Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Zr, Nb, Mo, Ru, Hf, Ta, Re, Os, Ir, Li and Al; x is at least 0.001 and less than 0.999; and y is at least 4.0. A tool is made from or coated with this composition.
    Type: Grant
    Filed: June 25, 2020
    Date of Patent: January 16, 2024
    Assignee: The Regents of the University of California
    Inventors: Richard B. Kaner, Sarah H. Tolbert, Reza Mohammadi, Andrew T. Lech, Miao Xie
  • Tissue specific reduction of lignin
    Patent number: 11873498
    Abstract: The present invention provides an expression cassette comprising a polynucleotide that encodes a protein that diverts a monolignol precursor from a lignin biosynthesis pathway in the plant, which is operably linked to a heterologous promoter. Also provided are methods of engineering a plant having reduced lignin content, as well as plant cells, plant parts, and plant tissues from such engineered plants.
    Type: Grant
    Filed: January 25, 2021
    Date of Patent: January 16, 2024
    Assignee: The Regents of the University of California
    Inventors: Dominique Loque, Aymerick Eudes
  • Cyclic di-nucleotide induction of type I interferon
    Patent number: 11873319
    Abstract: Methods and compositions are provided for increasing the production of a type I interferon (IFN) in a cell. Aspects of the methods include increasing the level of a 2?-5? phosphodiester linkage comprising cyclic-di-nucleotide in a cell in a manner sufficient to increase production of the type I interferon (IFN) by the cell. Also provided are compositions and kits for practicing the embodiments of the methods.
    Type: Grant
    Filed: September 1, 2021
    Date of Patent: January 16, 2024
    Assignee: The Regents of the University of California
    Inventors: Russell E. Vance, Ming C. Hammond, Dara Burdette, Elie J. Diner, Stephen C. Wilson
  • ROLL-TO-ROLL BASED 3D PRINTING THROUGH COMPUTED AXIAL LITHOGRAPHY
    Publication number: 20240012330
    Abstract: A roll-to-roll computed axial lithography system includes an optical illumination system; an optical modulation system to receive light from the optical illumination system and to output an illumination pattern of light; and a web-handling system to receive and transport a web having a photosensitive material layer such that a portion of the web will be in an optical path of the modulation system. The web-handling system includes a development module to render three-dimensional structures from the layer exposed to the illumination pattern of light. The illumination pattern of light provides predetermined three-dimensional regions within a bulk of the layer that are exposed beyond a photo-responsive threshold for the photosensitive material providing volumetric patterning.
    Type: Application
    Filed: February 22, 2022
    Publication date: January 11, 2024
    Applicant: The Regents of the University of California
    Inventors: Joseph Toombs, Hayden Taylor
  • METHODS FOR PRODUCTION OF FUCOSYLATED OLIGOSACCHARIDES IN RECOMBINANT CELL CULTURE
    Publication number: 20240011064
    Abstract: Methods for producing oligosaccharide products such as difucosylated oligosaccharides are disclosed. The methods include culturing recombinant cells in a cell culture medium comprising L-fucose, an oligosaccharide acceptor, and a carbon source. The cells are cultured under conditions in which a first fucosyltransferase polypeptide having a first substrate selectivity (e.g., an ?1-2-fucosyltransferase polypeptide), a second fucosyltransferase polypeptide having a second substrate specificity (e.g., an ?1-3-fucosyltransferase polypeptide), a nucleotide sugar pyrophosphorylase polypeptide, a lactose transporter polypeptide, and an L-fucose transporter polypeptide are expressed, and in which the oligosaccharide acceptor is converted to the difucosylated oligosaccharide. Recombinant cells for use in the methods are also described.
    Type: Application
    Filed: August 15, 2023
    Publication date: January 11, 2024
    Applicant: The Regents of the University of California
    Inventors: Shota ATSUMI, Angela ZHANG, Xi CHEN, Yuanyuan BAI, Hai YU, John B. McARTHUR
  • ATHERMAL WDM MULTISTRIPE ARRAYED WAVEGUIDE GRATING INTEGRATED-CAVITY LASER
    Publication number: 20240014635
    Abstract: The disclosed embodiments provide a system that implements a multiwavelength laser. This system includes a set of reflective semiconductor operational amplifiers (RSOAs) and a broadband loop mirror having an input and an output. The system also includes an arrayed waveguide grating (AWG) multiplexer having inputs that are coupled to outputs of the set of RSOAs, and having an output that feeds into the input of the loop mirror. During operation of the system, each RSOA in the set of RSOAs forms a wavelength-specific lasing cavity with a specific passband of the AWG multiplexer and the broadband loop mirror. The wavelength-specific laser signals produced by the wavelength-specific lasing cavities combine at the output of the loop mirror to produce a multiwavelength signal, which is emitted through an output of the system.
    Type: Application
    Filed: June 16, 2021
    Publication date: January 11, 2024
    Applicant: The Regents of the University of California
    Inventor: Sung-Joo Ben Yoo
  • CMV VECTORS AND USES THEREOF
    Publication number: 20240011047
    Abstract: In one aspect, the present invention provides recombinant polynucleotides. In some embodiments, the recombinant polynucleotides comprise a cytomegalovirus (CMV) genome, or a portion thereof, and a nucleic acid sequence encoding an antigen, wherein the CMV genome or portion thereof comprises a mutation within a interleukin-10-like gene sequence. Methods for preventing and treating diseases such as infectious diseases and cancer are also provided herein.
    Type: Application
    Filed: December 12, 2022
    Publication date: January 11, 2024
    Applicants: The Regents of the University of California, The UAB Research Foundation
    Inventors: Peter Barry, Dennis Hartigan-O'Connor, Ellen Sparger, William Chang, Mark Walter, Corey Miller
  • MINI-ORGAN INSERT FOR IN VITRO CO-CULTURE STUDIES
    Publication number: 20240010961
    Abstract: In one embodiment, the present disclosure provides a tissue culture well insert for use with a multi-wells tissue culture plate. The cylindrical well insert is configured to be inserted into the tissue culture wells, wherein the well insert comprises a carrier or platform section on which liver cells or other cells are deposited, and the carrier or platform section is positioned in the tissue culture wells so as to be suspended off the bottom of the tissue culture wells. The well insert is useful for co-culturing multiple cell types to create in vitro biological systems. One specific application is high-throughput anti-tumor drug screening in which the liver cells or other cells carried by the carrier or platform section of the insert are co-cultured with tumor organoids deposited or bioprinted to the bottom of the tissue culture well.
    Type: Application
    Filed: December 7, 2021
    Publication date: January 11, 2024
    Applicant: The Regents of the University of California
    Inventors: Alice SORAGNI, Peyton John TEBON
  • DIRECT DRIVE HEARING AID STIMULATION METHODS
    Publication number: 20240015456
    Abstract: A direct hearing device includes an inner actuator element that interacts with a subject's tympanic membrane, the inner actuator element sitting in the subject's ear canal. The direct hearing device further includes an outer component that houses a microphone, circuitry that processes a signal from the microphone, and a battery. The outer component is configured to sit laterally in the subject's ear canal. Advantageously, the outer component is separable form the inner actuator element.
    Type: Application
    Filed: August 20, 2021
    Publication date: January 11, 2024
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: Hamid DJALILIAN
  • Estrogen therapy for brain gray matter atrophy and associated disability
    Patent number: 11865122
    Abstract: Provided are methods for slowing, halting, and reversing gray matter atrophy and progression of disability in certain neurodegenerative diseases, including multiple sclerosis, using estrogen, alone or in combination with another agent.
    Type: Grant
    Filed: October 28, 2020
    Date of Patent: January 9, 2024
    Assignee: The Regents of the University of California
    Inventor: Rhonda R. Voskuhl