Patents Assigned to The Regents of the University of Minnesota
  • Patent number: 11406697
    Abstract: In one embodiment, the present invention is a method of treating glioma and medulloblastoma brain tumors using the Zika virus and a tumor vaccine.
    Type: Grant
    Filed: March 4, 2020
    Date of Patent: August 9, 2022
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Walter C. Low, Maple Shiao, Andrew Crane, Christopher J. Sipe, Clairice Pearce, Joseph Voth, Nikolas Toman, Craig Bierle, Matthew Chrostek
  • Patent number: 11408008
    Abstract: This document provides oilseed plants (e.g., pennycress plants) having increased levels of one or more saturated fatty acids, increased levels of one or more polyunsaturated fatty acids (PUFAs), altered (e.g., increased or decreased) levels of oleic acid, and/or altered (e.g., increased or decreased) levels of erucic acid. For example, oilseed plants having reduced polypeptide levels and/or reduced polypeptide activity of one or more polypeptides involved in triglyceride synthesis (e.g., diacylglycerol O-acyltransferase 1 (TAG1) can have increased levels of stearic acid, increased levels of one or more PUFAs, altered levels of oleic acid, and/or altered levels of erucic acid. Also provided herein are methods and materials for making and using oilseed plants having increased levels of one or more saturated fatty acids, increased levels of one or more PUFAs, altered levels of oleic acid, and/or altered levels of erucic acid.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: August 9, 2022
    Assignee: Regents of the University of Minnesota
    Inventors: Michael David Marks, Ratan Chopra
  • Publication number: 20220240499
    Abstract: A cryopreservative composition includes a sugar component with a total concentration of sugar components in the composition of 300 mM or less; a sugar alcohol component, with a total concentration of sugar alcohol components in the composition of 2 M or less; and at least one of a polymer component and albumin, with the proviso that the composition includes less than a cryopreservative amount of dimethyl sulfoxide (DMSO). A method of cryopreserving a cell includes adding a cell to the cryopreservative composition; freezing the composition; storing the frozen composition; thawing the composition; removing the cell from the thawed composition; and culturing the cell under conditions effective for the cell to remain viable. The freezing may include cooling at a rate of 0.1° C./min to 5° C./min. The method may be performed without a washing step after thawing.
    Type: Application
    Filed: April 24, 2020
    Publication date: August 4, 2022
    Applicant: Regents of the University of Minnesota
    Inventors: Rui Li, Allison Hubel
  • Publication number: 20220239309
    Abstract: A digital-to-analog converter device including a set of components, each component included in the set of components including a number of unit cells, each unit cell being associated with a unit cell size indicating manufacturing specifications of the unit cell is provided by the present disclosure. The digital-to-analog converter device further includes a plurality of switches, each switch included in the plurality of switches being coupled to a component included in the set of components, and an output electrode coupled to the plurality of switches. The digital-to-analog converter device is configured to output an output signal at the output electrode. A first unit cell size associated with a first unit cell included in the set of components is different than a second unit cell size associated with a second unit cell included in the set of components.
    Type: Application
    Filed: April 5, 2022
    Publication date: July 28, 2022
    Applicant: Regents of the University of Minnesota
    Inventors: Zhi Yang, Anh Tuan Nguyen, Diu Khue Luu, Jian Xu
  • Patent number: 11396571
    Abstract: Block copolymers that include one or more galactose based blocks and one or more cationic blocks; polyplexes including disclosed block copolymers and one or more nucleic acids; and methods of delivering a nucleic acid to a cell which can include delivering a polyplex to the cell.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: July 26, 2022
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Theresa M. Reineke, Yogesh Khemchandra Dhande, Bharat Sanjay Wagh
  • Patent number: 11396657
    Abstract: This document provides materials and methods for generating oilseed (e.g., pennycress) plants that having low levels of erucic acid. For example, oilseed plants having reduced expression levels of one or more polypeptides involved in erucic acid metabolism (e.g., fatty acid elongase 1 (FAE1)), as well as materials and methods for making and using oilseed plants having low levels of erucic acid are provided.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: July 26, 2022
    Assignees: Regents of the University of Minnesota, The Board of Trustees of Illinois State University
    Inventors: Michael David Marks, John C. Sedbrook, Donald L. Wyse, Kevin Dorn
  • Patent number: 11399240
    Abstract: A hearing system to activate an auditory system using cerebrospinal fluids includes at least one processor configured to receive an audio signal captured using a sound sensor (e.g., a microphone), extract temporal and spectral features from the audio signal, and create modulated ultrasound signals in a range of 20 Hz to 20 kHz with ultrasound carrier frequencies in the range of 50 kHz to 4 MHz, which are ultrasound frequencies that are well-suited to reach the cerebrospinal fluids (e.g., can pass across the skull/bones to reach the cerebrospinal fluids). The system further includes at least one ultrasonic transducer which receives the modulated signal and delivers the modulated signal to the body and activates the auditory system via vibration of cerebrospinal fluids that vibrate cochlear fluids, bypassing the normal conductive pathway that uses middle ear bones and minimizing bone conduction and distortion through the skull.
    Type: Grant
    Filed: January 21, 2021
    Date of Patent: July 26, 2022
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Hubert H. Lim, Mark Hamilton, Hongsun Guo, Cory Gloeckner
  • Patent number: 11390848
    Abstract: This disclosure provides miRNA/mRNA pairs that can be used to increase the efficacy of T cells or to down-modulate T cell efficacy and restore equilibrium.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: July 19, 2022
    Assignees: Regents of the University of Minnesota, Regents of the University of Michigan, The Ohio State University
    Inventors: Bruce R. Blazar, Keli Hippen, Pavan Reddy, Yaping Sun, Ramiro Garzon
  • Patent number: 11382929
    Abstract: Disclosed herein are compositions comprising a membranolytic polymer or a salt thereof and a chemotherapeutic agent or a salt thereof and compositions comprising a membranolytic polymer or a salt thereof and a shielding polymer or a salt thereof. Also disclosed are methods and uses for treating diseases such as cancer with these compositions.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: July 12, 2022
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Chun Wang, Samuel Hanson
  • Patent number: 11384360
    Abstract: Systems and methods for gene targeting in plants, including systems and methods that include the use of geminiviruses and customizable endonucleases.
    Type: Grant
    Filed: September 2, 2020
    Date of Patent: July 12, 2022
    Assignee: Regents of the University of Minnesota
    Inventors: Daniel F. Voytas, Nicholas J. Baltes
  • Publication number: 20220214333
    Abstract: In certain embodiments, the present invention provides methods of identifying and treating a transplant recipient patient having transplantation tolerance induced by apoptotic donor leukocytes infused under cover of transient immunotherapy.
    Type: Application
    Filed: April 16, 2020
    Publication date: July 7, 2022
    Applicant: Regents of the University of Minnesota
    Inventors: Bernhard J. HERING, Sabarinathan RAMACHANDRAN, Amar SINGH
  • Publication number: 20220213435
    Abstract: The invention is directed to compositions of cell aggregates and methods for making and using the cell aggregates where the aggregates comprise cells that are not embryonic stem cells but can differentiate into cell types of at least two of ectodermal, endodermal, and mesodermal embryonic germ layers, e.g., stem cells.
    Type: Application
    Filed: January 13, 2022
    Publication date: July 7, 2022
    Applicants: Regents of the University of Minnesota, Katholieke Universiteit Leuven
    Inventors: Wei-Shou Hu, Kartik Subramanian, Catherine M. Verfaillie
  • Patent number: 11379677
    Abstract: The techniques and systems described herein relate to manufacturing, characterizing, and/or identifying one or more types of magnetic nanowires (MNWs). One or more types of MNWs may be associated with different objects, and a system may identify the objects based on the magnetic nanowires associated with the objects. For example, such techniques may involve characterizing the types of MNWs based on magnetic field transmission characteristics and ferromagnetic resonance characteristics of each type of MNW. In some examples, the techniques described herein may enable the identification of each of a plurality of types of MNWs present in a sample or object based on a combined transmission value of the sample. Such techniques may enable the development and use of barcode-like systems of different types of MNWs for labeling and identifying objects of interest.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: July 5, 2022
    Assignee: Regents of the University of Minnesota
    Inventors: Rhonda R. Franklin, Wen Zhou, Jaime F. Modiano, Bethanie J Stadler
  • Publication number: 20220206358
    Abstract: The present disclosure provides an acousto-optic device comprising an acousto-optic layer, an electromagnetic radiation source, and an acoustic source. In an embodiment, the acousto-optic layer has a substantially planar shape defining an x-y plane and functions as an optical waveguide to optical waves and as an acoustic waveguide to acoustic waves propagating in the x-y plane. In an embodiment, the electromagnetic radiation source is optically coupled to the acousto-optic layer and configured to deliver electromagnetic radiation therein. In an embodiment, the acoustic source is acoustically coupled to the acousto-optic layer and configured to deliver acoustic energy therein and is configured to adjust a wavelength of the acoustic energy. In an embodiment, the electromagnetic radiation source and the acoustic energy source are positioned to provide an intersection between the electromagnetic radiation and the acoustic energy, which at least partially scatters light from the intersection out of the x-y plane.
    Type: Application
    Filed: April 10, 2020
    Publication date: June 30, 2022
    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Mo Li, Huan Li, Qiyu Liu
  • Patent number: 11369988
    Abstract: Methods of curtain coating substrates are disclosed. In some embodiments, the methods include applying two or more liquid layers simultaneously to a substrate, wherein the multiple layers include a bottom liquid layer comprising a shear thinning liquid, and another liquid layer comprising a viscoelastic liquid. In some embodiments, the disclosed methods include formulating a bottom layer liquid comprising a shear thinning liquid, formulating another layer liquid comprising a viscoelastic liquid, pumping the bottom layer liquid and the other layer liquid through coating dies simultaneously and onto a moving substrate such that the bottom layer liquid impinges on the substrate thereby forming a bottom layer, and the other layer liquid forms another liquid layer above the bottom liquid layer. The inclusion of a bottom liquid layer comprising a shear thinning liquid and other layer comprising a viscoelastic liquid provides for enlargement of the curtain coating window.
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: June 28, 2022
    Assignees: DOW GLOBAL TECHNOLOGIES LLC, REGENTS OF THE UNIVERSITY OF MINNESOTA, ROHM AND HAAS COMPANY
    Inventors: Alireza Mohammad Karim, Saswati Pujari, Wieslaw J. Suszynski, Lorraine F. Francis, Marcio S. Carvalho, Vinita Yadav
  • Patent number: 11370825
    Abstract: This disclosure describes, generally, a modified form of CD16, genetically-modified cells that express the modified CD16, and methods that involve the genetically-modified cells. The modified form of CD16 can exhibit increased anti-tumor and/or anti-viral activity due, at least in part, to reduced susceptibility to ADAM17-mediated shedding upon NK cell stimulation.
    Type: Grant
    Filed: April 19, 2021
    Date of Patent: June 28, 2022
    Assignee: Regents of the University of Minnesota
    Inventors: Bruce Kenneth Walcheck, Dan Samuel Kaufman, Jianming Wu, Yawu Jing, Zhenya Ni
  • Patent number: 11374774
    Abstract: An apparatus includes a first feed-forward PUF, a second feed-forward PUF and an exclusive-or circuit configured to perform an exclusive-or operation of an output of the first feed-forward PUF and an output of the second feed-forward PUF.
    Type: Grant
    Filed: April 28, 2020
    Date of Patent: June 28, 2022
    Assignee: Regents of the University of Minnesota
    Inventors: Keshab K. Parhi, S. V. Sandeep Avvaru
  • Publication number: 20220195689
    Abstract: One example is directed to an end effector position estimation system for an off-road vehicle, which includes at least one inertial measurement unit (IMU) configured to be positioned on at least one of actuators and links of the vehicle that together move the end effector of the vehicle, and configured to generate measurement signals. The position estimation system includes at least one other IMU configured to be positioned on a base of the vehicle, and configured to generate other measurement signals. The position estimation system includes an estimation unit to estimate a position of the end effector of the vehicle based at least in part on the measurement signals and the other measurement signals, wherein the estimation unit is configured to perform an estimation method that removes an influence of terrain-induced vibrations and terrain slope in the measurement signals based on the other measurement signals.
    Type: Application
    Filed: December 17, 2021
    Publication date: June 23, 2022
    Applicant: Regents of the University of Minnesota
    Inventors: Rajesh Rajamani, Gregory W. Johnson
  • Patent number: 11357743
    Abstract: Pharmaceutical formulations comprising ketamine, propofol, and a lipid are provided. Methods of making the formulations and methods of using the formulations to provide sedation, amnesia, analgesia, anxiolysis, and/or stable hemodynamics are also provided.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: June 14, 2022
    Assignees: Mayo Foundation for Medical Education and Research, Regents of the University of Minnesota
    Inventors: Nathan J. Smischney, Wayne T. Nicholson, Jayanth Panyam
  • Publication number: 20220169995
    Abstract: A trans-disciplinary system for cell-free biosynthesis includes a cell-free transcription-translation (TX-TL) tool and modular, generalizable microfluidic architectures. Both components of the system are independently functional and are combinable into a cell-free biosynthesis platform. In the first component, modular plasmid libraries are used to program bacterial cell-free TX-TL systems. Each plasmid holds one gene or operon, and all the genes are controlled by the same promoter, so that the stoichiometry of enzyme synthesis is determined by the stoichiometry of plasmids in the reaction. In the second part, in order to facilitate high throughput mixing and matching of gene units from the modular plasmid libraries, a modular, reconfigurable, flexible, and scalable microfluidic architecture is employed.
    Type: Application
    Filed: October 6, 2021
    Publication date: June 2, 2022
    Applicants: Massachusetts Institute of Technology, Regents of the University of Minnesota
    Inventors: Andreas Mershin, Vincent Noireaux, James Francis Pelletier, Neil A. Gershenfeld