Patents Assigned to The Regents of the University of
  • Subtyping prostate cancer to predict response to hormone therapy
    Patent number: 11873532
    Abstract: The present invention relates to methods, systems and kits for the diagnosis, prognosis and the determination of progression of cancer in a subject. The invention also provides biomarkers that define subgroups of prostate cancer, clinically useful classifiers for distinguishing prostate cancer subtypes, bioinformatic methods for determining clinically useful classifiers, and methods of use of each of the foregoing. The methods, systems and kits can provide expression-based analysis of biomarkers for purposes of subtyping prostate cancer in a subject. Further disclosed herein, in certain instances, are probe sets for use in subtyping prostate cancer in a subject. Classifiers for subtyping a prostate cancer are provided. Methods of treating cancer based on molecular subtyping are also provided.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: January 16, 2024
    Assignees: Decipher Biosciences, Inc., 2. The Regents of the University of Michigan
    Inventors: Elai Davicioni, Nicholas Erho, Shuang G. Zhao, S. Laura Chang, Felix Y. Feng
  • Solid-state lithium-ion conductor and methods of manufacture thereof
    Patent number: 11876225
    Abstract: A solid-state ion conductor including a compound of Formula 1: Li1+(4?a)yAayM1?yXO5??Formula 1 wherein, in Formula 1, A is an element of Groups 1 to 3 or 11 to 13, or a combination thereof, wherein an oxidation state a of A is 1?a?3, M is an element having an oxidation state of +4 of Groups 4 or 14, or a combination thereof, X is an element having an oxidation state of +5 of Groups 5, 15, 17, or a combination thereof, and 0<y?1.
    Type: Grant
    Filed: May 17, 2021
    Date of Patent: January 16, 2024
    Assignees: SAMSUNG ELECTRONICS CO., LTD., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, LAWRENCE BERKELEY NATIONAL LABORATORY
    Inventors: KyuJung Jun, Gerbrand Ceder, Yan Wang, Lincoln Miara, Yan Zeng, Yihan Xiao
  • GABA agonists in the treatment of disorders associated with metabolic syndrome and GABA combinations in treatment or prophylaxis of type I diabetes
    Patent number: 11872200
    Abstract: In certain embodiments methods are provided for the therapeutic or prophylactic amelioration of one or more symptoms or disorders associated with metabolic syndrome. In various embodiments the methods involve administering to a subject in need thereof, a GABA receptor agonist, in an amount sufficient to ameliorate said one or more symptoms. In certain embodiments methods are provided for the prophylaxis or treatment of type I diabetes and related pathologies that involve the use of GABA or GABA agonists in combination with certain other compounds (e.g., one more antigens (e.g., GAD) that have a therapeutic effect in type I diabetes and/or an anti-CD3 antibody, an anti-CD20 antibody, exendin-4, and/or or a pro-insulin therapeutic).
    Type: Grant
    Filed: March 22, 2021
    Date of Patent: January 16, 2024
    Assignee: The Regents of the University of California
    Inventors: Daniel L Kaufman, Jide Tian
  • High numerical aperture selective plane illumination microscopy
    Patent number: 11874451
    Abstract: In one embodiment, a microscopy system includes a first objective positioned adjacent to a sample to be imaged, the first objective being configured to both illuminate the sample with light and collect light from the sample, and a remote imaging module positioned remotely from the first objective and the sample, the remote imaging module being configured to rotate the image plane of the collected light.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: January 16, 2024
    Assignee: The Regents of the University of California
    Inventors: Bo Huang, Bin Yang
  • AUTONOMOUS MICROSYSTEM FOR IMMERSION INTO FLUID
    Publication number: 20240011593
    Abstract: In various aspects, the present disclosure provides an example autonomous microsystem for immersion into a fluid. The autonomous microsystem includes electronics, a power source, and a packaging system that surrounds the electronics and the power source. The electronics can be configured to sense and record one or more environmental conditions. The packaging system may include a deformable shell that defines an internal space and a plurality of filler particles disposed in the internal space and configured to control a density of the autonomous microsystem in relation to the fluid. The filler particles may comprise a low-density material having a bulk density greater than or equal to about 100 kg/m3 and less than or equal to about 1,000 kg/m3 and have a packing density greater than or equal to about 1011/m3 and less than or equal to about 1021/m3.
    Type: Application
    Filed: November 6, 2020
    Publication date: January 11, 2024
    Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, TOTALENERGIES ONETECH
    Inventors: Yogesh B. GIANCHANDANI, Alexander BENKEN, Neeharika VELLALURU, Partha DUTTA, John-Richard ORDONEZ-VARELA, Aurelie LE-BEULZE, Jean-Gregoire BOERO-ROLLO
  • MINI-ORGAN INSERT FOR IN VITRO CO-CULTURE STUDIES
    Publication number: 20240010961
    Abstract: In one embodiment, the present disclosure provides a tissue culture well insert for use with a multi-wells tissue culture plate. The cylindrical well insert is configured to be inserted into the tissue culture wells, wherein the well insert comprises a carrier or platform section on which liver cells or other cells are deposited, and the carrier or platform section is positioned in the tissue culture wells so as to be suspended off the bottom of the tissue culture wells. The well insert is useful for co-culturing multiple cell types to create in vitro biological systems. One specific application is high-throughput anti-tumor drug screening in which the liver cells or other cells carried by the carrier or platform section of the insert are co-cultured with tumor organoids deposited or bioprinted to the bottom of the tissue culture well.
    Type: Application
    Filed: December 7, 2021
    Publication date: January 11, 2024
    Applicant: The Regents of the University of California
    Inventors: Alice SORAGNI, Peyton John TEBON
  • CMV VECTORS AND USES THEREOF
    Publication number: 20240011047
    Abstract: In one aspect, the present invention provides recombinant polynucleotides. In some embodiments, the recombinant polynucleotides comprise a cytomegalovirus (CMV) genome, or a portion thereof, and a nucleic acid sequence encoding an antigen, wherein the CMV genome or portion thereof comprises a mutation within a interleukin-10-like gene sequence. Methods for preventing and treating diseases such as infectious diseases and cancer are also provided herein.
    Type: Application
    Filed: December 12, 2022
    Publication date: January 11, 2024
    Applicants: The Regents of the University of California, The UAB Research Foundation
    Inventors: Peter Barry, Dennis Hartigan-O'Connor, Ellen Sparger, William Chang, Mark Walter, Corey Miller
  • DIRECT DRIVE HEARING AID STIMULATION METHODS
    Publication number: 20240015456
    Abstract: A direct hearing device includes an inner actuator element that interacts with a subject's tympanic membrane, the inner actuator element sitting in the subject's ear canal. The direct hearing device further includes an outer component that houses a microphone, circuitry that processes a signal from the microphone, and a battery. The outer component is configured to sit laterally in the subject's ear canal. Advantageously, the outer component is separable form the inner actuator element.
    Type: Application
    Filed: August 20, 2021
    Publication date: January 11, 2024
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: Hamid DJALILIAN
  • ATHERMAL WDM MULTISTRIPE ARRAYED WAVEGUIDE GRATING INTEGRATED-CAVITY LASER
    Publication number: 20240014635
    Abstract: The disclosed embodiments provide a system that implements a multiwavelength laser. This system includes a set of reflective semiconductor operational amplifiers (RSOAs) and a broadband loop mirror having an input and an output. The system also includes an arrayed waveguide grating (AWG) multiplexer having inputs that are coupled to outputs of the set of RSOAs, and having an output that feeds into the input of the loop mirror. During operation of the system, each RSOA in the set of RSOAs forms a wavelength-specific lasing cavity with a specific passband of the AWG multiplexer and the broadband loop mirror. The wavelength-specific laser signals produced by the wavelength-specific lasing cavities combine at the output of the loop mirror to produce a multiwavelength signal, which is emitted through an output of the system.
    Type: Application
    Filed: June 16, 2021
    Publication date: January 11, 2024
    Applicant: The Regents of the University of California
    Inventor: Sung-Joo Ben Yoo
  • ENGINEERED T CELL RECEPTORS TARGETING EGFR ANTIGENS AND METHODS OF USE
    Publication number: 20240009241
    Abstract: This disclosure provides for engineered T cell Receptors (TCRs), cells comprising the TCRs, and methods of making and using the TCRs. The current disclosure relates to TCRs that specifically recognize EGFR neoantigens comprising L858R mutations and restricted to HLA class I A31 and A33 allotypes. Accordingly, aspects of the disclosure relate to a polypeptide comprising an antigen binding variable region comprising the amino acid sequence of a CDR3 of the disclosure or an amino acid sequence with at least 80% sequence identity to a CDR3 of the disclosure.
    Type: Application
    Filed: November 4, 2021
    Publication date: January 11, 2024
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Patrick HWU, Cassian YEE, Geogory LIZEE
  • MOLECULAR SUBTYPING OF SMALL CELL LUNG CANCER TO PREDICT THERAPEUTIC RESPONSES
    Publication number: 20240011103
    Abstract: Provided herein are methods for determining a subtype of a small cell lung cancer in a patient based on the express status of ASCL1, NEUROD1, and POU2F3, which are expressed in a mutually exclusive fashion. The subtype of the cancer can be used to determine the sensitivity of the cancer to certain anti-cancer therapies. As such, also provided are methods of treating patients having small cell lung cancer based on the subtyping results.
    Type: Application
    Filed: June 29, 2023
    Publication date: January 11, 2024
    Applicant: Board of Regents, The University of Texas System
    Inventors: Carl M. GAY, Lauren A. BYERS, John V. HEYMACH
  • VISION-AIDED INERTIAL NAVIGATION
    Publication number: 20240011776
    Abstract: Localization and navigation systems and techniques are described. An electronic device comprises a processor configured to maintain a state vector storing estimates for a position of the electronic device at poses along a trajectory within an environment along with estimates for positions for one or more features within the environment. The processor computes, from the image data, one or more constraints based on features observed from multiple poses of the electronic device along the trajectory, and computes updated state estimates for the position of the electronic device in accordance with the motion data and the one or more computed constraints without computing updated state estimates for the features for which the one or more constraints were computed.
    Type: Application
    Filed: October 31, 2022
    Publication date: January 11, 2024
    Applicant: Regents of the University of Minnesota
    Inventors: Stergios I. Roumeliotis, Anastasios I. Mourikis
  • METHODS FOR PRODUCTION OF FUCOSYLATED OLIGOSACCHARIDES IN RECOMBINANT CELL CULTURE
    Publication number: 20240011064
    Abstract: Methods for producing oligosaccharide products such as difucosylated oligosaccharides are disclosed. The methods include culturing recombinant cells in a cell culture medium comprising L-fucose, an oligosaccharide acceptor, and a carbon source. The cells are cultured under conditions in which a first fucosyltransferase polypeptide having a first substrate selectivity (e.g., an ?1-2-fucosyltransferase polypeptide), a second fucosyltransferase polypeptide having a second substrate specificity (e.g., an ?1-3-fucosyltransferase polypeptide), a nucleotide sugar pyrophosphorylase polypeptide, a lactose transporter polypeptide, and an L-fucose transporter polypeptide are expressed, and in which the oligosaccharide acceptor is converted to the difucosylated oligosaccharide. Recombinant cells for use in the methods are also described.
    Type: Application
    Filed: August 15, 2023
    Publication date: January 11, 2024
    Applicant: The Regents of the University of California
    Inventors: Shota ATSUMI, Angela ZHANG, Xi CHEN, Yuanyuan BAI, Hai YU, John B. McARTHUR
  • ENGINEERED T CELL RECEPTORS TARGETING EGFR ANTIGENS AND METHODS OF USE
    Publication number: 20240009240
    Abstract: This disclosure provides for engineered T cell Receptors (TCRs), cells comprising the TCRs, and methods of making and using the TCRs. The current disclosure relates to TCRs that specifically recognize EGFR neoantigens comprising L858R mutations and restricted to HLA class I A11 allotype. Accordingly, aspects of the disclosure relate to a polypeptide comprising an antigen binding variable region comprising the amino acid sequence of a CDR3 of the disclosure or an amino acid sequence with at least 80% sequence identity to a CDR3 of the disclosure.
    Type: Application
    Filed: November 4, 2021
    Publication date: January 11, 2024
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Patrick HWU, Fenge LI, Gregory LIZEE
  • INDIVIDUAL OPTIMAL MODE OF DELIVERY
    Publication number: 20240013925
    Abstract: A method can include receiving, at a computer system, characteristic values of a pregnancy of a subject. As an example, the characteristic values can include a numerical value for a live birth order of the pregnancy for the subject. The computer system can store a machine learning model that receives a first set of input features and provides a second set of one or more output values. In some embodiments, the first set of input features can correspond to the characteristic values of the pregnancy of the subject. The second set of one or more output values can include a probability of a Cesarean delivery. The characteristic values can be input into the machine learning model to obtain the probability of the Cesarean delivery being required for the subject during an attempt of a vaginal delivery. The Cesarean delivery can be performed based on the probability.
    Type: Application
    Filed: November 4, 2021
    Publication date: January 11, 2024
    Applicant: Board of Regents, The University of Texas System
    Inventors: Radek Bukowski, Karl Schulz
  • 6-THIO-2'-DEOXYGUANOSINE (6-THIO-DG) RESULTS IN TELOMERASE DEPENDENT TELOMERE DYSFUNCTION AND CELL DEATH IN VARIOUS MODELS OF THERAPY-RESISTANT CANCER CELLS
    Publication number: 20240009223
    Abstract: The present disclosure provide for methods of using 6-thio-2?-deoxyguanosine (6-thio-dG) to treat telomerase-positive cancers that exhibit (a) one or more TERT promoter mutations, and/or (b) enriched telomere transcriptional signature(s). In particular, melanomas, including those who are not sensitive or have become resistant to immune checkpoint inhibition and/or MAPKi therapy are targets for this therapy.
    Type: Application
    Filed: June 5, 2023
    Publication date: January 11, 2024
    Applicants: The Board of Regents of The University of Texas System, The Wistar Institute of Anatomy and Biology
    Inventors: Jerry W. SHAY, Gao ZHANG
  • ROLL-TO-ROLL BASED 3D PRINTING THROUGH COMPUTED AXIAL LITHOGRAPHY
    Publication number: 20240012330
    Abstract: A roll-to-roll computed axial lithography system includes an optical illumination system; an optical modulation system to receive light from the optical illumination system and to output an illumination pattern of light; and a web-handling system to receive and transport a web having a photosensitive material layer such that a portion of the web will be in an optical path of the modulation system. The web-handling system includes a development module to render three-dimensional structures from the layer exposed to the illumination pattern of light. The illumination pattern of light provides predetermined three-dimensional regions within a bulk of the layer that are exposed beyond a photo-responsive threshold for the photosensitive material providing volumetric patterning.
    Type: Application
    Filed: February 22, 2022
    Publication date: January 11, 2024
    Applicant: The Regents of the University of California
    Inventors: Joseph Toombs, Hayden Taylor
  • LIPOCATIONIC DENDRIMERS AND USES THEREOF
    Publication number: 20240010614
    Abstract: Modular dendrimers with cationic groups and lipophilic groups are provided herein. In some aspects, the dendrimers provided herein may be formulated in compositions which contain a nucleic acid and one or more helper excipients. In some aspects, these compositions may also be used to treat diseases or disorders with a therapeutic nucleic acid.
    Type: Application
    Filed: June 15, 2023
    Publication date: January 11, 2024
    Applicant: The Board of Regents of The University of Texas System
    Inventors: Daniel J. SIEGWART, Kejin ZHOU
  • Estrogen therapy for brain gray matter atrophy and associated disability
    Patent number: 11865122
    Abstract: Provided are methods for slowing, halting, and reversing gray matter atrophy and progression of disability in certain neurodegenerative diseases, including multiple sclerosis, using estrogen, alone or in combination with another agent.
    Type: Grant
    Filed: October 28, 2020
    Date of Patent: January 9, 2024
    Assignee: The Regents of the University of California
    Inventor: Rhonda R. Voskuhl
  • Neuropsychological and neurological rehabilitation headgear device
    Patent number: 11865328
    Abstract: A customizable headgear assembly for neuropsychological and neurological treatment, monitoring, or testing of a patient. The headgear assembly comprising a structural frame having a plurality of anatomical landmark tabs each individually configured to be located upon an anatomical landmark of a patient's head. The structural frame having first and second portions releasably coupled to enable the first and second portions to be at least partially separated for placement and removal from the patient's head. A plurality of electrode holders being operable coupled to the structural frame each configured to locate an electrode upon a predetermined neurological position of the patient.
    Type: Grant
    Filed: March 1, 2021
    Date of Patent: January 9, 2024
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, The United States Government as represented by the Department of Veterans Affairs
    Inventors: Benjamin Hampstead, Allena Holzworth, Kevin Kramer, Alexander Rothmann, Shannon Ryan